• Microbiology and Biotechnology Letters
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• v.44 no.2
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• pp.124-129
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• 2016

The extraction and purification of the anti-hyperglycemic α-glucosidase inhibitor from an edible mushroom, Pleurotus cornucopiae, were investigated. The inhibitor was maximally extracted when the P. cornucopiae fruiting body was treated with distilled water at 30℃ for 12 h. Purification was achieved using Sephadex G-100 and G-50 filtration chromatography, pepsin hydrolysis, and reverse-phase HPLC. The compound’s solid yield and inhibitory activity were 12.2% and 9.10 mg/ml of IC₅₀, respectively. The purified inhibitor contained two hexapeptides with Thr-Ile-Ala-Phe-Ile-Asp (A) and Tyr-Tyr-Ala-Ile-Gly-Asp (B) sequences and molecular weights of 678.79 Da (A) and 643.7 Da (B). The purified inhibitor showed a mixed inhibition pattern to α-glucosidase and a dose-dependent anti-hyperglycemic effect in a streptozotocininduced diabetic Sprague-Dawley rat model, exhibited by decreased blood glucose levels at doses of 50 and 300 mg/kg.

• Journal of Life Science
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• v.26 no.8
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• pp.983-989
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• 2016

All cells composing of our body undergo their destiny such as proliferation, differentiation, necrosis, apoptosis and senescence depending on their circumstance with time. The errors occurring in these processes develop several aberrations in phenotypes including cancer, inflammation, aging and diseases. New strategy and approach are required to screen anti-aging compounds derived from natural products. Therefore, here we explain the target proteins to play a key role in aging mechanism. In the first place, matrix metalloproteinases (MMPs) are involved in metastasis, chronic inflammation and skin aging as an aging marker. In particular, histone deacetylases (HDACs) give a great attention to aging researchers who try to extend the life span of animal model. In addition, we describe the signaling pathway related to senescence which p53, IGF-1 and SIRT1 play an important role in. Furthermore, autophagy is involved in the signaling pathway associated with aging. Several new compounds modulating the signaling pathway of senescence are introduced in this review. Here, we try to provide a new insight in the molecular basis for the aging mechanism and development of aging marker. In addition, the compounds introduced here could be available for pharmaceutical applications for the prevention and the treatment of diseases related to aging.

• Korean Journal of Food Science and Technology
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• v.38 no.1
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• pp.147-151
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• 2006

Effects of wild plant extract (Lak) based on Korea traditional prescription on maximal exercise performance and endurance were evaluated using calorie-restriction animal model. In acute forced swimming test with 10% body weight attached to tail, dietary Lak supplementation increased exercise performance endurance by increasing concentrations of ATP and insulin-like growth factor-1 (IGF-1) under calorie-restriction condition, and decrement of blood lactic acid concentration and increment of muscle ATP content were observed. These results suggest Lak is very effective for decreasing side-effects of obesity therapy using very low calorie diet.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.11
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• pp.4656-4663
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• 2010

In this study, the 3D computational fluid dynamics (CFD) was performed in relation to the internal fluid characteristics, flow distribution, air mean ages, and residence time for the development of the most optimal model in the complex post-disposal device. As it is expected that a channeling (drift) would be made by the semi-dry reactor due to the large difference in the flow distribution by the compartment in the bag filter, a structural improvement should be urgently made for more uniformed flow distribution in the bag filter. In addition, it showed the possibility that the velocity field and distribution characteristics of the residence time could be improved through a modification to inlet structure of the spray dryer reactor. The complex post-disposal device, modified and supplemented with this analysis, integrated the semi-dry reactor and the bag filter in a single body, so it follows that the improvement can make the device compact, the installation area, the operation fee, and management more convenient.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.1
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• pp.61-65
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• 2013

Purpose: This study was performed to identify the relations between glaucoma and dietary patterns in Korean adults, aged 30 years or older. Methods: 6,453 subjects (male 2,759, female 3,694 subjects) who aged 30 years or older from the Korea National Health and Nutrition Examination Survey were included. Glaucoma was assessed based on the subjects were diagnosed by a doctor. At first, waist circumference and body mass index (BMI) were compared to investigate the association between glaucoma and obesity index. Secondly, dietary patterns using factor analysis for external blue colored fish(mackerel), seaweed(seaweed, laver), bean(bean, soybean milk), vegetables(sprout, spin, carrot, cabbage, cucumber, pepper, tomato, pumpkin) and fruits(tangerine, apple, pear, strawberry, grape, peach) were obtained. Lastly, regression analysis was used for glaucoma and emerged dietary factors. Results: In glaucoma and normal group, waist circumference and BMI were $82.25{\pm}9.96cm$ and $23.27{\pm}2.84kg/m^2$, $75.79{\pm}13.79cm$ and $22.39{\pm}4.06kg/m^2$, respectively. There was statistically significant difference (p<0.05). Three dietary patterns were emerged from the factor analysis, and factor 1 was included sprout, spin, carrot, cabbage, seaweed, cucumber, mackerel, laver. The factor 1 of dietary pattern was inversely related to the prevalence of glaucoma (OR: 0.697, 95%CI: 0.496-0.980, p=0.038), and model adjusting for age and sex was showed the same trend (OR: 0.698, 95%CI: 0.497-0.982, p=0.039). Conclusions: This study was analysed first with glaucoma and dietary pattern in Korean, and vegetables, laver and mackerel significant associated to reduce the risk of glaucoma.

• Child Health Nursing Research
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• v.19 no.3
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• pp.187-197
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• 2013

Purpose: The purpose of the study was to develop an emotional self-regulation program for obese children and to examine the program's effectiveness on depression, eating habits, and body mass index. Methods: The emotional self-regulation program was developed from theory-based strategies and a pre-post pilot study was conducted with 46 children (19: intervention, 27: control). The program included 6 weekly group sessions over 2 months. The embedded experimental model of concurrent mixed methods was used to better understand research outcomes by converging both quantitative and qualitative data. Anthropometric measurements and surveys were performed before and after the intervention. Three focus group interviews were conducted with all participants after intervention to explore their experiences. Results: The intervention group displayed decreased depression levels in the quantitative outcomes. The participants also expressed positive outcomes such as improvements in confidence, impulse management, intimacy, happiness, and losing weight. Conclusion: These findings suggest that emotional self-regulation skills are crucial factors for obese children not only to manage their emotional problems but also to control their weight. Further research is needed with a larger sample size and randomized controlled trials.

• Journal of Animal Environmental Science
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• v.15 no.2
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• pp.131-138
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• 2009

This study was conducted to find ways to control environment with the difference between body temperature and background temperature based on swine activity, and to apply to the environment control system of swine barns based on the findings. Following are the results. 1. Swine activity related to background temperature was achieved as color images and swine activity status was categorized into cold, comfortable, and hot periods with visualization system (thermal image system). 2. Thermal image system consisted of an infrared CCD camera, an image processing board - DIF (TH3100), an main computer (400Hz, 128M, 586 Pentium model) with C++ program installed. 3. Thermal image system categorizing temperatures into cold, comfortable, and hot was applicable to the environment control system of swine barns 4. Feed intake was higher in cold temperature, and finishing weight and weight gain per day in cold temperature were lower than others (p<0.05).

• Korean Journal of Clinical Laboratory Science
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• v.53 no.4
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• pp.342-352
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• 2021

We used data from the 7th Korea National Health and Nutrition Examination Survey (KNHANES) (2016~2018) to investigate an association between high sensitivity C-reactive protein (hsCRP) and uric acid in the obese. Obesity was defined as a body mass index (BMI) of 25 kg/m² or more, severe obesity as a BMI of 30 kg/m² or more, and morbid obesity as a BMI of 35 kg/m² or more. In the complex samples multiple logistic regression, despite adjustment by adding major risk factors, the odds ratio (OR) for obesity was higher in the group with high levels of both, hsCRP and uric acid than the reference group at all stages (obesity, OR 1.89, P<0.001 vs. severe obesity, OR 5.04, P<0.001 vs. morbid obesity, OR 8.20, P<0.001). The association between hsCRP and uric acid in obese patients increased from 1.89 to 8.20 as the obesity level increased, suggesting that participants with increased BMI were significantly affected by hsCRP and uric acid. Moreover, the interaction between hsCRP and uric acid was statistically significant even in the model corrected for major confounding factors (P for interaction=0.009).

• Journal of the Korea Society for Simulation
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• v.18 no.3
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• pp.23-34
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• 2009

In the railroad rolling stock depot, long-term maintenance tasks is done regularly every two or four year basis to maintain the functionality of equipments and rolling stock body or for the repair operation of the heavily damaged rolling stocks by fatal accidents. This paper addresses the computer simulation model building for the rolling stock maintenance shop for the CDC(Commuter Diesel Car) and Generator Car planned to be constructed at Daejon Rolling Stock Depot, which will be moved from Yongsan Rolling Stock Depot. We evaluated the processing capacity of two layout design alternatives based on the maintenance process chart through the developed simulation models. The performance measures are the number of processed cars per year, the cycle time, shop utilization, work in process and the average number waiting car for input. The simulation result shows that one design alternative outperforms another design alternative in every aspect and superior design alternative can process total 340 number of trains per year 15% more than the proposed target within the current average cycle time.

• Journal of the Korean Society of Safety
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• v.11 no.4
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• pp.143-150
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• 1996

This is an explicit-Implicit, finite element analysis for linear as well as nonlinear hygrothermal stress problems. Additional features, such as moisture diffusion equation, crack element and virtual crack extension(VCE ) method for evaluating J-integral are implemented in this program. The Linear Elastic Fracture Mechanics(LEFM) Theory is employed to estimate the crack driving force under the transient condition for and existing crack. Pores in materials are assumed to be saturated with moisture in the liquid form at the room temperature, which may vaporize as the temperature increases. The vaporization effects on the crack driving force are also studied. The Ideal gas equation is employed to estimate the thermodynamic pressure due to vaporization at each time step after solving basic nodal values. A set of field equations governing the time dependent response of porous media are derived from balance laws based on the mixture theory Darcy's law Is assumed for the fluid flow through the porous media. Perzyna's viscoplastic model incorporating the Von-Mises yield criterion are implemented. The Green-Naghdi stress rate is used for the invariant of stress tensor under superposed rigid body motion. Isotropic elements are used for the spatial discretization and an iterative scheme based on the full newton-Raphson method is used for solving the nonlinear governing equations.