• The Journal of Korean Medicine
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• v.20 no.1 s.37
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• pp.151-160
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• 1999

Nitric oxide(NO) is synthesized via the oxidation of L-arginine by a family of nitric oxide synthases(NOS), which are either constitutive(cNOS) or inducible(iNOS). The induction of iNOS in tissues can lead to the sustained production of high concentrations of NO which may exert pro-inflammatory effects including vasodilation. edema, cyototoxicity, and its activity can be mediated by various pro-inflammatory cytokine, including interferon ${\gamma}(INF-{\gamma})$. tumor necrosis factor, IL- 1 and IL-6. The enzyme, iNOS, became a new target for pharmacologcal research with the aim to find new substances for the treatment of chronic inflammatory disorders. Murine macrophages produce large amounts of NO when activated with $TFN-{\gamma}$ plus LPS. The murine macrophage-like cell line, RAW 264.7, is a suitable cell model on which to perform vitro studies regarding the iNOS system. Semen jugrandis is a fatty walnut seed found in Korea. The walnut have been used in foik medicine to improve virility, to relieved asthma, and to relieve constipation. Sesquiterpenelactones were isolated from this plant. In the course of screening for NO inhibitory activity from medicnial plants, the aqueous extract of this plant was found to have a significant activity. The result are summarized as followings. 1. The viability of cells incubated in the presence of semen jugrandis increased mare than non incubated cells. 2. Semen jugrandis suppressed the production of NO in tissues dependent on density. 3. Semen jugrandis suppressed the induction of iNOS in tissues dependent on density can lead to reduced production of NO. 4. Semen jugrandis suppressed the production of superoxide in tissue depend on density. According to the above mentioned results, semen jugrandis could be applied production of NO and superoxide can lead to reduction of chronic inflammatary. And as a depence matter come into a virus of microbe and tumor cells.

• CELLMED
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• v.6 no.2
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• pp.13.1-13.7
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• 2016

Fatigue is a common complaint and affects the quality of life in modern people. Physical stress may induce activation of certain immune cells. Fermented porcine placenta (FPP) has been used to alleviate fatigue. Inflammatory cytokines are produced by physical stress and results in symptoms of fatigue. However, the role of FPP on fatigue-associated inflammatory cytokine production has not been elucidated yet. Thus, we estimated the anti-fatigue effect of FPP and its active components, leucine (Leu) and lysine (Lys) in activated RAW264.7 macrophages and forced swimming test (FST) fatigue animal model. Pretreatment with FPP, Leu, or Lys significantly inhibited the lipopolysaccharide (LPS)-induced tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production without inducing cytotoxicity on LPS-stimulated RAW264.7 macrophages. FPP, Leu, or Lys inhibited the production of nitric oxide and downregulated the expression of inducible nitric oxide synthase on LPS-stimulated RAW264.7 macrophages. Furthermore, caspase-1 activities increased by LPS were significantly reduced by FPP, Leu, or Lys. In the FST, inflammatory cytokine levels of the mice administrated with FPP, Lys, and Leu were significantly reduced compared with the control group at 21 days. Collectively, these results show that anti-fatigue effect of FPP and its active components, Leu and Lys might be derived from the down-regulating of inflammatory mediators.

• Journal of Hospice and Palliative Care
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• v.23 no.1
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• pp.11-16
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• 2020

Purpose: D-dimer levels are known to be associated with poor outcomes in patients with various cancers, but their significance at the end of life remains unclear. This study investigated D-dimer levels as a prognostic indicator for terminal cancer patients in the last hours of life. Methods: The retrospective study was conducted at a palliative care unit of a tertiary cancer center, using a database to analyze the records of patients treated from January 1, 2010 to December 31, 2018. In total, 67 terminal cancer patients with available data on D-dimer levels were included. Patients' demographic data, clinical information, and laboratory values, including D-dimer levels, were collected. Survival was analyzed using the Kaplan-Meier method and the log-rank test. A Cox proportional-hazards model was used to identify prognostic factors of poor survival. Results: The most common site of cancer was the lung (32.8%) and the median survival time was 5 days. Most laboratory results, particularly D-dimer levels, deviated from the normal range. Patients with high D-dimer levels had a significantly shorter survival time than those with low D-dimer levels (4 days vs. 7 days; P=0.012). In the Cox regression analysis, only a high D-dimer level was identified as a predictor of a poor prognosis (hazard ratio, 1.83; 95% confidence interval, 1.09~3.07). Conclusion: Our results suggest that at the very end of life, D-dimer levels may serve as a prognostic factor for survival in cancer patients.

• Korean Journal of Environmental Agriculture
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• v.26 no.2
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• pp.171-178
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• 2007

Diffusion and accumulation of ethoprophos in fruit such as apple and two types of pears were examined by dipping them into the solution of ethoprophos. The effective diffusivities of ethoprophos at the skin and flesh of apple and pear were determined by simulation their experimental accumulation curves with calculated ones from the model assuming consecutive diffusion of ethoprophos from skin to flesh. Its effective diffusivity at the flesh with higher content of water were higher, $\sim10^{-10}\;m^2/s$, regardless of the types of fruits, while that at the skin was small, $\sim10^{-12}\;m^2/s$ and increased with the order of 'Niitaka' pear < 'Whangkeumbae' pear < 'Fuji' apple. The variation in the concentration of ethoprophos in its solution did not induce any change in affecting its effective diffusivity at the flesh of 'Whangkeumbae' pear, but the increase in the concentration caused the increase in its effective diffusivity at the skin. The penetration rate of ethoprophos at the skin was an important factor in determining its accumulation rate in fruit.

• Journal of the Earthquake Engineering Society of Korea
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• v.3 no.2
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• pp.55-66
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• 1999

Eight RC bridge plers have been made on a 1/3.4 scale model and have been tested in a quasi-static cyclic load so as to investigate their seismic performance. The ultimate objective of this experimental study is to investigate the hysteretic behavior of reinforced concrete plers, which have been widely used for urban transportation facilities in Korea. Improtant test parameters are hoop ratio, axial load, load pattern, and etc. And noninear behaviors of test columns have been evaluated through their yield and ultimate strength, energy dissipation, ductility and load-deflection characteristics under quasi-static cyclic loads. From the quasi-static tests on 8 bridge piers, it is concluded that energy dissipation, ultimate strength and curvature for a given displacement factor ${\mu}={\Delta}/{\Delta}_y$ are higher for the seismically designed columns than for the nonseismically designed columns.

• Journal of the Earthquake Engineering Society of Korea
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• v.3 no.2
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• pp.9-18
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• 1999

The seismic over-strength factor Ω is evaluated for 4-story reinforced concrete buildings in Korea, which has low seismic intensity. For this study, the seismic load suggested in' Aseismic guideline research- phase ll' (in Korea) is used. When 3D study-models are designed, span length and bay number are varied and accidental torsional moment is considered. And the models are analyzed by push-over analysis, in which external and internal frame are connected by rigid-link. As a result of numerical experiments, Ω is increased as the bay number or span length is increased. Because, by the including of accidental torsional moment in designing process, the increased ratio of strength of external columns is larger than the increased ratio of span length or bay number. And this makes the failure mode of model closer or strong-column and weak-beam mechanism.

• Journal of the Korea Society of Computer and Information
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• v.12 no.3
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• pp.235-241
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• 2007

The objective of this study plans on adopting the traceability system in domestic livestock production and marketing channels. This study will examine pork traceability system and investigate the problem and factor in domestic livestock production and marketing channels, and also to examine the international standard in traceability system of goods production and distribution and foreign traceability system. In this study, the traceability system of livestock products is defined as an ability to follow and trace the information about livestock product in the stage of production, processing, manufacturing, distribution, and marketing. The system of traceability for Meat products are Developed and managed that reflected situation of raising, marketing, gathering and of information of model farmers. The formation of system consists of surfing screen of consumers, registration of farming data by farmers, information input screen of gathering of meat products and supply of traceability information of production and gathering. The system should continue the system adjustment after checking effects and problems of traceability by surveying result of consumer, farmers and distributors.

• Journal of Korea Port Economic Association
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• v.28 no.1
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• pp.203-227
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• 2012

Based on the review of the existing studies, this study built the conceptual framework describing the structural relationships among port service quality dimensions(port internal service quality, external service quality, interaction quality), customer satisfaction, customer trust and customer loyalty. In specific, switching barrier was included as moderator in customer satisfaction and customer loyalty relationships. The subjects are the customers who use the Busan New Port. A survey using 317 customers was conducted, Confirmatory factor analysis was conducted to test the validity of the measurement model, and AMOS analysis approach was used to gain important insights into how customer retention in the port business can be ensured. Results in this paper indicate that customer trust and satisfaction are identified as antecedents of the port service quality dimensions. Customer satisfaction positively influences trust. Customer trust and satisfaction positively influence loyalty. Switching barrier positively moderates the relationship of customer satisfaction and customer loyalty. Finally, this study suggests that the implications of these findings and offers directions for future research.

• Journal of Korea Port Economic Association
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• v.30 no.2
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• pp.93-112
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• 2014

To study the business performance, this research reviewed the revenue of 2012 for shipping and logistics companies in Korea, then selected 10 shipping companies and 10 logistics companies according to annual sales amount. These 20 companies are divided into four groups considering their business structure and their financial performance are organized from 2005 to 2012. Then CCR, BCC model has been applied to static efficiency and dynamic changes in productivity for analysis. As an overall result, logistics companies are proven to be better than shipping company in efficiency, change of productivity, growth and profitability. Among the logistics companies, the performance of second party logistics companies are relatively better in those factor above than the third party logistics companies.

• Journal of Korea Port Economic Association
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• v.35 no.4
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• pp.67-84
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• 2019

In order to suggest ways to enhance service competitiveness in cruise and destination, this study developed a measure of cruise tour service and analyzed the impact and relative importance on customer satisfaction. Specifically, for the service quality analysis, based on the SERVPERF model, the specialty of the industry was reflected through the arguments of tourism and transport logistics, and the three factors of cruise service quality and destination service quality were derived and utilized as measurement tools. As an analysis method, factor and reliability analysis were conducted using data collected via a survey. Next, correlation analysis was conducted to analyze the relationship between variables and regression analysis was performed to check the impact of cruise tour service quality on customer satisfaction. The study found that both cruise service attributes and destination service attributes had a positive effect on customer satisfaction and that the relative importance of service attributes was identified. Accordingly, it was found that the service quality should be formed by reflecting arguments in the tourism and transport logistics sectors and that the service should be further improved and developed according to the importance of the service attributes so as to enhance cruise tour products.