• Environmental and Resource Economics Review
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• v.22 no.2
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• pp.393-410
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• 2013

We employ a threshold vector error correction models (TVECM) to investigate the nonlinear dynamic adjustment of gasoline prices in Korea. We consider 10 regional gasoline markets including Seoul, Busan, Daegu, Incheon, Kwangju, Daejeon, Ulsan, Kangwon, Chungbuk, Jeonbuk and construct 9 price differences against Seoul. We use the bootstrap procedure suggested by Hansen (1999) and generalized by Lo and Zivot (2001) to show that three-regime TVECM is suitable for our analysis. Results indicate the gasoline price adjustment processes are nonlinear. Our estimation shows that Seoul-Daejeon, Seoul-Daegu and Seoul-Ulsan have bigger transaction costs than other market pairs and thus gasoline prices of these three regional markets are lower than that of Seoul. Gasoline prices of the other 6 regional markets are close to Seoul's price. One interesting finding is that the transaction costs are not proportional to geographical distances. This implies that transportation costs are not the main factor of the transaction costs. The transaction costs may depends on the competition intensity of gasoline markets in supply side.

• Reproductive and Developmental Biology
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• v.38 no.3
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• pp.99-105
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• 2014

In this study, to further understand the mechanism of animal growth and to develop a miniature transgenic animal model, we constructed and tested tetracycline-inducible RNAi system using shRNA targeting the mRNA of mouse insulin-like growth factor (mIGF-1) or mouse growth hormone receptor (mGHR) gene. Quantitative real-time PCR analysis of mouse liver cell (Hepa1c1c7) cells transfected with these vectors showed 85% or 90% of expression inhibition effect of IGF-1 or GHR, respectively. In ELISA analysis, the protein level of IGF-1 in the cells expressing the shRNA targeting IGF-1 mRNA was reduced to 26% of non-transformed control cells. Unexpectedly, in case of using shRNA targeting GHR, the IGF-1 protein level was decreased to 75% of control cells. Further experiments are needed to explain the lower interference effect of GHR shRNA in IGF-1 protein. Accumulated knowledge of this approach could be applicable to a variety of related biological area including gene function study, gene therapy, development of miniature animals, etc.

• Design & Manufacturing
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• v.14 no.2
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• pp.1-6
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• 2020

Recently, research and commercialization related to the field of cell-based therapeutic drug development has been actively conducted. In order to maintain cell viability and prevent contamination, refrigeration preservation devices, such as CRF (controlled rate freezer) or vapor type LN2 tanks have been developed. On the other hand, the storage container for liquid nitrogen tanks currently on sale minimizes the flow structure to prevent structural defects when stored in a liquid nitrogen tank having a high thermal conductivity than vapor nitrogen. If the cell-based treatment drug is stored in the gaseous LN2 tank as it is, the cell survival after thawing is greatly reduced. It was estimated that the existing storage container structure was a factor that prevented the rapid entry and circulation of gaseous nitrogen into the container. Therefore, this study intends to propose a new supercellular storage container model that can maintain the mechanical strength while maximizing the fluid flow structure. To this end, we estimated that the structural change of the storage container effects on the equivalent stress formed around the through-holes of them when exposed to a cryogenic environment using thermal-structural coupled field analysis. As a result of storage experiments in the gas phase tank of the cell-based therapeutic agent using the developed storage container, it was confirmed that the cell growth rate was improved from 66% to 77%, which satisfied the transportation standards of the FDA(Food and Drug Administration) cell-based therapeutic agent.

• The Journal of Engineering Geology
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• v.26 no.4
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• pp.461-471
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• 2016

Numerical modules based on a conventional thermo-hydrological numerical model, TOUGH2, are developed to provide a numerical modeling technique for a standing column well (SCW). Cooling and heating operations for two different types of SCW are then simulated using these modules. Modeling showed these operations to be significantly influenced by heat exchange and fluid mixing between the SCW and the adjacent geologic formation and groundwater. The results also reveal that heat exchange between the oppositely flowing outflow and inflow in the PVC or PE pipe and the SCW borehole is an important factor. Overall, the numerical modeling technique developed here can reasonably simulate fluid flow and heat transport phenomena in the complex internal structures of a SCW. The proposed technique can be used practically for the quantitative analysis of heat exchange in a SCW at the design, construction, and operation stages.

• The Korean Journal of Physiology and Pharmacology
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• v.3 no.6
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• pp.539-546
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• 1999

Bone is a complex tissue in which resorption and formation continue throughout life. The bone tissue contains various types of cells, of which the bone forming osteoblasts and bone resorbing osteoclasts are mainly responsible for bone remodeling. Periodontal disease represents example of abnormal bone remodeling. Osteoclasts are multinucleated cells present only in bone. It is believed that osteoclast progenitors are hematopoietic origin, and they are recruited from hematopoietic tissues such as bone marrow and circulating blood to bone. Cells present in the osteoclast microenvironment include marrow stromal cells, osteoblasts, macrophages, T-lymphocytes, and marrow cells. These cells produce cytokines that can affect osteoclast formation. In vitro model systems using bone marrow cultures have demonstrated that $IL-l{\beta},\;IL-3,\;TNF-{\alpha},$ bFGF can stimulate the formation of osteoclasts. In contrast, IL-4 inhibits osteoclast formation. Knowledge of cytokines and bFGF that affect osteoclast formation and their capacity to modulate the bone-resorbing process should provide critical insights into normal calcium homeostasis and disorders of bone turnover such as periodontal disease, osteoporosis and Paget's disease.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.11 no.4
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• pp.75-90
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• 2008

The golf course has many problems that are a pollution of river, a extinction of habitat by destructing a forest and a simplication of species composition. Therefore, this study was carried out to examine the ecological characteristics of vascular plants in construct-reserved site of golf course. The results were as follow. The vascular plants were summarized as 342 taxa; 86 families, 231 genera, 295 species, 42 varieties and 5 forma. In the results by the location environments of vegetation, Salix caprea community and wetland species like Persicaria thunbergii were appeared in the swamp. Especially, S. caprea will be made use of promoting a landscape. In the stream, Stephanandra incisa community has a functions like an ecological axis and a corridor of wild animals. The planting technique will be applied to using Atractylodes japonica and Ainsliaea acerifolia in the lower part of Pinus densiflora and Quercus mongolica. Because Rhododendron schlippenbachii and Convallaria keiskei grew by layer in Q. variabilis community, this will be made use of natural vegetation model. The rare plants were 2 taxa; Aristolochia contorta and Iris ensata var. spontanea. To preserve their community, we will prohibit a development and remove a threatening factor. The endemic plants were 4 taxa; Salix caprea, Clematis trichotma, Spiraea prunifolia for. simpliciflora and Weigela subsessilis. The naturalized plants were 19 taxa; Rumex crispus, Bildedykia dumetora and so on. To establish the quantitative management plan, we will obtain a ecological information about a naturalized plants in accumulating by season, community and land use pattern.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.23 no.2
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• pp.17-31
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• 2020

In the field of environmental landscape architecture, the internet medium is used as an effective communication tool not only in the private level but also in the policy level. Recently, the active utilization of mobile web service is emphasized as the time changes, but there is not much improvement or advance in services due to lack of relevant studies. Therefore, this study is intended to provide basic data needed for improvement and advance by researching the quality of mobile web service among multichannel services provided in environmental landscape architecture related internet media. The model for measuring service quality is SERVQUAL, which was verified in the study of Choi(2015), Choi and Koo(2016), and the final valid samples are total 230. First, the subjects were analyzed as the representative media that are possible to acquire comprehensive knowledge related to environmental landscape architecture. Second, the highest importance level in each subsection was 'protection and security maintenance of customer information' followed by 'Reliability about accurate information supply'. Regarding performance level, 'Reliability about accurate information supply' and 'professional knowledge to communicate with users' are highly evaluated. Third, regarding Importance-Performance Analysis(IPA), the first priority management should is 'Tangibles', and the next are 'Responsibility' and 'Empathy'. The ones for maintenance of the status quo are 'Reliability' and 'Assurance', and there is none for effort reduction. Meanwhile, regarding the importance of each factor and difference in the quality of PC web service and mobile web service studied before, the biggest difference is in 'Tangibles', followed by 'Assurance', 'Empathy', 'Responsibility' and 'Reliability'. It is suggested that the revitalization of Landscape information science(LB1106) presented in the National Science&Technology Standard Classification System is needed. In the future, it is necessary to research the change trend on users' response through continuous evaluation of improved mobile web service.

• Science of Emotion and Sensibility
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• v.12 no.4
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• pp.403-410
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• 2009

The purpose of this study was to find whether there is sound quality difference among mobile service providers in terms of ringtone in mobile phones, and identify factors that contribute to the difference of sound quality. A series of experiments were performed to identify the source of sound difference while controlling brand factor of the leading company. Mobile service provider, phone manufacturer, phone model variation, specific music genre and contents provider factors were examined. The results showed there was sound quality difference among mobile service providers. The difference comes from mobile phones provided to service provider and sound contents. There was difference in sound quality among same models that provided to different service providers. The different sound making process contributed to the difference of sound quality. The genre effect was not clear. To complement the limitation of samples used, an interview with the sound expert of mobile device was performed. The results showed hardware parts used and careful tuning of the device can influence to the sound quality of the mobile phone.

• Journal of the Korean Institute of Gas
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• v.22 no.2
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• pp.29-33
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• 2018

Accident likelihood is growing due to a correlation for gas and electricity installed in the area of dense energy consumption like traditional market and underground shopping center. In order to prevent and respond accident risks related to gas and electricity in this area, it should be monitored and predicted for factors of gas leak or electricity by developing safety management system. This study is about accident prediction model development considering fire risk factor related to gas accident. The temperature variation characteristic near a gas burner was analyzed. Also, accident prediction algorithm and related module were developed to prevent fire in the area of dense energy consumption.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.11 no.1
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• pp.29-35
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• 1993

The vegetation such as grass, shrub, tree has been used to control the erosion and stabilize the slope for a long time. But the effects of vegetation on slope area is usually neglected in traditional stability analyses. There are many errors in slope analyses in thin soil mantles. Therefore the effects of vegetation is an important factor. But it is difficult and complex to represent the vegetation influence quantitatively in stability analysis. In this study, authors choose the landslide region at the Kum sung dong Kum-jung ku Pusan as a model area. Authors analyzed the degree of slope with the aerial photo interpretation and DTM data extracted from the topographic map, and the relationship of D.B.H. (diameter of breast height), height, and age of tree in field investigation data. Finally authors know the fact that landslide take place approximately 10 or 20 years later in arbitrary afforestable area where the degree of slope is 27. The prevention effect must be considered in the control of vegetation.