• Journal of Acupuncture Research
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• v.36 no.2
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• pp.92-99
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• 2019

Background: This study was conducted to evaluate the effects of pharmacopuncture and dermal application of Sebalgukhwa-san extracts on hair growth in an alopecia mouse model. Methods: Twenty-one C57BL/6 mice were divided into 3 groups; control group-normal saline injection or vehicle solution application, positive control group-minoxidil (MNXD), experimental group-pharmacopuncture and applied Sebalgukhwa-san (SGS) extract. The effects of the treatment on hair growth, were determined through photographs, and phototrichogram analysis by folliscope. Hair follicle morphometry by hematoxylin-eosin staining was performed, and hair growth-related protein expression of vascular endothelial growth factor, insulin like growth factor-1, and transforming growth factor-beta 1 were monitored by Western blotting. Serum levels of aspartate aminotransferase and alanine aminotransferase were measured for liver function test. Results: Body weight increased consistently in all groups. Hair growth was improved in the MNXD and SGS groups compared with the control. Hair density and thickness improved statistically significantly in the MNXD and SGS groups compared with the control p < 0.05. The number of hair follicles improved in the MNXD and SGS groups compared with the control but the size did not. The expression of vascular endothelial growth factor and insulin like growth factor-1 increased, and there was a decrease in the expression of transforming growth factor-beta 1 in the MNXD and SGS groups compared with the control, however, there was no significant difference. Sebalgukhwa-san treatment had no toxicity in liver function tests. Conclusion: Pharmacopuncture and dermal application of Sebalgukhwa-san extract may be therapeutically beneficial for the treatment of alopecia.

• Journal of People, Plants, and Environment
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• v.23 no.4
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• pp.475-484
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• 2020

Background and objective: Horticultural activity is one of the most basic elements of horticultural therapy, which brings about therapeutic effects for participants through various plant-related activities. The main objective of this study was to verify the results of previous research, which suggested six types of activities from the exploratory factor analysis. Methods: To meet the purpose of this study, a questionnaire was designed to determine the preferences for 6 types of the horticultural therapy activities. The survey was conducted on 703 people from March 7 to June 20, 2019. The data of 674 cases were used into the final analysis, excluding unreliable responses. Descriptive statistics, and reliability analysis were performed using IBM SPSS Statistics 25, and confirmatory factor analysis was performed using IBM SPSS Amos 21. Results: First, horticultural therapy activities were classified into 6 types from the exploratory factor analysis, as conducted in previous research. The confirmatory factor analysis provided that the fit of the final model was satisfactory with χ² = 1,300.590 (p < .001), RMR = .045, GFI = .876, RMSEA = .062, NFI = .914, TLI = .905, CFI = .914. Conclusion: This result revalidated that the mode with 6 types of horticultural therapy activities from previous research is appropriate criteria for the classification of horticultural activities. The model could be used to design more systematic horticultural therapy programs that meet the needs or circumstances of the subject, or that are suitable for necessary therapeutic intervention methods.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.2
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• pp.95-111
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• 2022

Chronic obstructive pulmonary disease (COPD) is an important healthcare problem worldwide. Often, glucocorticoid (GC) resistance develops during COPD treatment. As a classic hypoglycemic drug, metformin (MET) can be used as a treatment strategy for COPD due to its anti-inflammatory and antioxidant effects, but its specific mechanism of action is not known. We aimed to clarify the role of MET on COPD and cigarette smoke extract (CSE)-induced GC resistance. Through establishment of a COPD model in rats, we found that MET could improve lung function, reduce pathological injury, as well as reduce the level of inflammation and oxidative stress in COPD, and upregulate expression of nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), multidrug resistance protein 1 (MRP1), and histone deacetylase 2 (HDAC2). By establishing a model of GC resistance in human bronchial epithelial cells stimulated by CSE, we found that MET reduced secretion of interleukin-8, and could upregulate expression of Nrf2, HO-1, MRP1, and HDAC2. MET could also increase the inhibition of MRP1 efflux by MK571 significantly, and increase expression of HDAC2 mRNA and protein. In conclusion, MET may upregulate MRP1 expression by activating the Nrf2/HO-1 signaling pathway, and then regulate expression of HDAC2 protein to reduce GC resistance.

• The Proceedings of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.9 no.4
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• pp.49-54
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• 1995

This paper is an experimental study on the influence of the demonstration effect by color and light source in show window. This experiment used semantic differentical method in model show window of actual size. The important outcomes of this study are summarized below. 1. In the result by factor analysis, three factors are classified. They are diversity, emotion, lightness. 2. In the study on the influence by light source, incandescence lamp is the most effective light source in every items. 3. In the result of the study on the influence by color source, according to each factor bring out following result ; Green is the most effective in diversity factor and ligthness factor. Yellow is the most effective in emotion factor.

• Journal of Korean Institute of Industrial Engineers
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• v.29 no.2
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• pp.145-149
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• 2003

We consider the estimation of failure rate and acceleration factor under type-I censoring without using acceleration model when testing is conducted in only one highly accelerated condition. Failure times of an item are assumed to be exponentially distributed. It is also assumed that the uncertainty about the acceleration factor, the failure time contraction ratio between accelerated condition and use condition, can be modeled by the uniform or gamma prior distribution of appropriate parameters. We respectively use Bayes and maximum likelihood approaches to estimate acceleration factor and failure rate in the use condition. An example is given to show how the method can be applied.

• Korean Institute of Interior Design Journal
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• v.20 no.6
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• pp.71-78
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• 2011

Although the recognition and emotion about space is subjective and individual, if standard is proposed through common factor, objective, quantified space image evaluation will be available. In addition, space image evaluation standard caused by recognitive-emotional factor can meet requests of space users and increase psychological satisfactions. The purpose of this study is to grasp the space image caused by recognitive-emotional factor in space with PAD model and analyze the evaluation of space image giving visual, recognitive and emotional effects. The analysis result revealed that 'joyfulness' and access-avoidance had a very similar distribution. The result means that space is evaluated with the degree of 'joyfulness' for space and it is led by approach-avoidance behavior. The recognition factor that forms and evaluates space image and decides approach-avoidance is expressed as adjective images such as 'fresh, joyful, light and static and its emotional factors are adjective images such as 'calm, allowable, joyful and quiet'.

• Proceedings of the KIPE Conference
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• 2016.07a
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• pp.231-232
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• 2016

This paper investigates the design of multi-winding coupled inductor for minimum inductor current ripple. Based on the general circuit model of coupled inductor together with the operating principles of dc-dc converter, the relationship between the ripple size of inductor current and the coupling factor is derived under the different duty ratio. The optimal coupling factor of n-phase multi-winding coupled inductor which corresponds to a minimum inductor ripple current becomes -(1/n-1), i.e. a complete inverse coupling without leakage inductance, as the duty ratio of steady-state operating point approaches 1/n, 2/n, ${\cdots}$ or (n-1)/n. In an opposite manner, the optimal coupling factor value of zero, i.e. zero mutual inductance, is required when the duty ratio of steady-state operating point approaches either zero or one. Therefore, coupled inductors having optimal coupling factor can minimize the ripple current of inductor and inductor size.

• 한국데이터정보과학회:학술대회논문집
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• 2003.10a
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• pp.39-47
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• 2003

The Bayes factors with improper noninformative priors are defined only up to arbitrary constants. So, it is known that Bayes factors are not well defined due to this arbitrariness in Bayesian hypothesis testing and model selections. The intrinsic Bayes factor by Berger and Pericchi (1996) and the fractional Bayes factor by O'Hagan (1995) have been used to overcome this problems. This paper suggests intrinsic priors for testing the equality of two lognormal means, whose Bayes factors are asymptotically equivalent to the corresponding fractional Bayes factors. Using proposed intrinsic priors, we demonstrate our results with a simulated dataset.

• The KSFM Journal of Fluid Machinery
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• v.2 no.3 s.4
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• pp.17-23
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• 1999

In the present numerical analysis, investigation of the effect of blade loadings from design shape on the slip factor variation was studied. Both the Eckardt radial bladed impeller and the backswept impeller were analyzed. In addition, a new design of the blade profile was arbitrarily attempted to generate a center-loading pattern in the original backswept impeller. Three dimensional compressible Navier-Stokes flow analysis with the Baldwin-Lomax turbulence model was applied to get the numerical slip factor at each impeller exit plane using the mass-averaging technique. The numerical slip (actors are in good agreement with the experimental ones and the Wiesner's slip factors deviate further from the numerical and experimental ones in both backswept impellers. Deviation angles and meridional channel loadings are found in no relation with the trend of change of the slip factor. Blade-to-blade loadings in midspan location are, however, found to have a direct relationship, especially at the sections where maximum loadings we to be expected. That information can be utilized in establishing an improved expression for slip factors in the future.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.7
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• pp.1380-1385
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• 2009

This paper was studied about the aging judgment method by ultraviolet rays image to happen in electric power equipment using ultraviolet rays camera. We established the aging judgment method as follows; 20% within of risk factor of insulation state of electrical facility that ultraviolet rays image does not show is "good or recognition". 30$^{\sim}$50% within of risk factor is "check", 50$^{\sim}$60% within of risk factor is "inspection" and 60% above of risk factor is "replacement". This method will be utilized for the inspection about electrical facilities.