• Journal of Integrative Natural Science
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• v.10 no.3
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• pp.141-147
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• 2017

Vascular endothelial growth factor (VEGF) is an important signaling protein involved in angiogenesis, which is the formation of new blood vessels from pre-existing vessels. Consequently, blocking of the vascular endothelial growth factor receptor (VEGFR-2) by small molecule inhibitors leads to the inhibition of cancer induced angiogenesis. In this study, we performed a two dimensional quantitative structure activity relationship (2D-QSAR) study of 38 N-Phenyl-N'-{4-(4-quinolyloxy) phenyl} urea derivatives as VEGFR-2 inhibitors based on hologram quantitative structure-activity (HQSAR). The model developed showed reasonable $q^2=0.521$ and $r^2=0.932$ values indicating good predictive ability and reliability. The atomic contribution map analysis of most active compound (compound 7) indicates that hydrogen and oxygen atoms in the side chain of ring A and oxygen atom in side chain of ring C contributes positively to the activity of the compounds. The HQSAR model developed and the atomic contribution map can serve as a guideline in designing new compounds for VEGFR-2 inhibition.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.45 no.8
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• pp.1-7
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• 2008

In this paper, we propose a lossy MTM transmission line unit cell and retrieve the parameter values related with radiation effects. Based on this unit cell model, we plot dispersion diagrams and analyze resonance conditions. We also discuss the input impedance or admittance behavior when we terminate the load as open or short. Then, we examine the quality factor and return loss bandwidth. We also design a very compact unit cell antenna using the provided lossy MTM-TL model. The results based on EM simulations and measurements are shown to be in good agreement with those based on circuit simulation.

• Steel and Composite Structures
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• v.18 no.3
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• pp.565-582
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• 2015

This paper is concerned with the dynamic analysis of simply-supported steel-concrete composite beams under moving loads. Considering the interface slip between steel girder and concrete slab, the governing motion equations are derived from the direct balanced method. By variable separation approach, the analytical solution of natural frequencies and mode shapes are obtained, as well as the orthogonal conditions. Then the dynamic responses of the composite beam under moving loads are analyzed, and compared with the experimental results. The analysis results show that the governing motion equations become more complicated when interface slip is taken into account, and the dynamic behaviors are significantly influenced by the shear connection stiffness. In the dynamic calculation of composite beams, the global stiffness should not be reduced as the same factor to all orders, but as different ones according to the dynamic stiffness reduction factor (DSRF), to which should be paid more attention in calculation, design and experiment, or else great deviation is inevitable.

• Food Science and Biotechnology
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• v.16 no.1
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• pp.43-48
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• 2007

Collagen-induced arthritis (CIA) is a model for some types of human autoimmune rheumatoid arthritis (RA). In this study, we examined whether ethanol extract of potato (Solanum tuberosum) is efficacious against CIA in mice. Potato extracts (100 and 200 mg/kg) were orally administered to DBA/1J mice once daily for 49 day after initial immunization with type II collagen. Clinical assessment of disease and measurement of paw edema were conducted throughout the study. The production of CIA-related rheumatoid factor, anti-type II collagen antibody, and cytokines were examined in DBA/1J mice. Serum levels of AST, ALT, creatinine, and lipids were measured, and antioxidant enzyme activity in the spleen was also determined. The arthritis score and paw edema were markedly suppressed in the groups treated with potato extract. Levels of rheumatoid factor, anti-type II collagen antibody, interleukin (IL)-1, IL-6, LDL-cholesterol, and malondialdehyde in sera were also reduced by potato extract treatment. The activities of glutathione peroxidase and glutathione reductase were increased in the spleens of CIA mice treated with potato extract. These findings suggest that potato extract has suppressive effects on type II collagen-induced arthritis, an animal model for human RA.

• Journal of Information Technology Applications and Management
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• v.17 no.2
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• pp.19-45
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• 2010

This research has analyzed the differentiated influence of organizational variables(an organization's learning culture and organizational support networks) and personal variables(the individual's motivation to learn and self-efficacy) on the process of gaining and using of knowledge. These two variables have been regarded as the major variables for the successful learning of 6Sigma, according to Social Cognitive Theory. In addition, this research has proven the role structure of the abovementioned two variables through a suitable methodology(Hierarchical Linear Model). In regard to this methodology, the different hierarchical level of the personal variable and organizational variable was especially focused on, and the effect of interaction between the high level and the low level was considered in detail. Considering the current situation, in that the importance of organizational factor and personal factor has been emphasized but the accurate role of each variable has not been verified, the research model is thought to help to establish an effective strategy to implement 6 Sigma.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.7B
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• pp.789-794
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• 2011

We analyze the capacity of CDMA base stations in the subway environment. We investigate the characteristics of multipath fading, cell structures, and propagation environment in the subway, analyze signal to noise ratio, sectorization gain, path-loss exponent, frequency reuse factor, and obtain the link capacity of a base station in the subway. We measure the peakedness factor and reveal that base stations in the subway have peaked traffic. We use Neal-Wilkinson model to obtain the Erlang capacity instead of Erlang-B model based on Poisson traffic.

• Journal of Power Electronics
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• v.17 no.3
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• pp.835-847
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• 2017

A transmitting coil with an optimal topology and number of turns can effectively improve the performance of the wireless power transfer (WPT) systems for endoscope robots. This study proposes the evaluation parameters of the transmitting coils related to the performance of the WPT system to standardize the design of the transmitting coils. It considers both the quality factor of transmitting coils and the coupling factor between the two sides. Furthermore, an analytical model of transmitting coils with different topologies is built to exactly estimate the evaluation parameters. Several coils with the specified topologies are wound to verify the analytical model and the feasibility of evaluation parameters. In the case of a constant power received, the related evaluation parameters are proportional to the transfer efficiency of the WPT system. Therefore, the applicable frequency ranges of transmitting coils with different topologies are determined theoretically. Then a transmitting coil with a diameter of 69 cm is re-optimized both theoretically and experimentally. The transfer efficiency of the WPT system is increased from 3.58% to 7.37% with the maximum magnetic field intensity permitted by human tissue. Finally, the standardized design of the transmitting coil is achieved by summing-up and facilitating the optimization of the coils in various situations.

• Journal of the Korea Institute of Building Construction
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• v.10 no.6
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• pp.87-96
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• 2010

This research analyzed the location of stores using a space syntax analysis model to measure the location of building interior stores in a quantitative way. Measure walk population of each space and analyzed analysis model and actuality measurement rent and difference to calculate value of store. With this, analyzed mad effect factor to rent. Drew effect factor of rent which is appropriated present. Had cleared that rent which consider walk population is required.

• Journal of Korean Society for Quality Management
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• v.44 no.1
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• pp.199-214
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• 2016

Purpose: The present study was designed to examine the casual relationships among performance and arts information service quality, initial trust, user satisfaction, reuse intention and prosumer activity in social network service(SNS). Also, we intended to explore significant factors on use performance of SNS through causal model analysis in the viewpoint of total effect. Methods: As a survey tool, questionnaire has obtained validity and reliability through literature survey, exploratory survey and pretest and sample 403 was selected. For statistical treatment of pretest and main analysis, SPSS18.0 and AMOS18.0 were employed and structural equation model was employed as analysis method. Results: Result of this study shows as follows. Two factors (precision and reciprocal action) have an effect on user satisfaction, initial trust, reuse intention and prosumer activity. We found that with an importance of initial trust, prosumer activity can be a useful and significant factor in causal relationship of SNS. Conclusion: The present study shows that two factors(precision and reciprocal action) in via of initial trust, were important factors that related companies have to emphasize to raise performance, And also we confirmed new factor 'prosumer activity' through this study. However, the present study has some limitations to be studied in the future.

• International Journal of Highway Engineering
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• v.18 no.2
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• pp.51-60
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• 2016

PURPOSES : The applicability of the mechanics-based similarity concept (suggested by Feng et al.) for determining scaled variables, including length and load, via laboratory-scale tests and discrete element analysis, was evaluated. METHODS: Several studies on the similarity concept were reviewed. The exact scaling approach, a similarity concept described by Feng, was applied in order to determine an analytical solution of a free-falling ball. This solution can be considered one of the simplest conditions for discrete element analysis. RESULTS : The results revealed that 1) the exact scaling approach can be used to determine the scale of variables in laboratory tests and numerical analysis, 2) applying only a scale factor, via the exact scaling approach, is inadequate for the error-free replacement of small particles by large ones during discrete element analysis, 3) the level of continuity of flowable materials such as SCC and cement mortar seems to be an important criterion for evaluating the applicability of the similarity concept, and 4) additional conditions, such as the kinetics of particle, contact model, and geometry, must be taken into consideration to achieve the maximum radius of replacement particles during discrete element analysis. CONCLUSIONS : The concept of similarity is a convenient tool to evaluate the correspondence of scaled laboratory test or numerical analysis to physical condition. However, to achieve excellent correspondence, additional factors, such as the kinetics of particles, contact model, and geometry, must be taken into consideration.