• Proceedings of the KOR-KST Conference
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• 1999.10a
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• pp.211-216
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• 1999

• 한국전산유체공학회:학술대회논문집
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• 2003.10a
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• pp.166-166
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• 2003

• Proceedings of the Korean Nuclear Society Conference
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• 1999.10a
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• pp.272-272
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• 1999

• Herbal Formula Science
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• v.26 no.3
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• pp.207-221
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• 2018

Objectives : Present study investigated hepatoprotective effect of Haegan-jeon extract (HE) and tried to elucidate molecular mechanism involved. According to molecular mechanism, present study optimized herbal composition of HE (op-HE) and compared in vitro and in vivo hepatoprotective effects of op-HE to HE. Methods : For in vitro experiments, HepG2 cells were exposed to arachidonic acid (AA, $10{\mu}M$) and iron ($5{\mu}M$) for inducing oxidative stress. Cell viability, GSH contents, $H_2O_2$ production, mitochondrial membrane potential, immunoblot and reporter gene assay were performed to investigate cytoprotective effects and responsible molecular mechanisms. For in vivo experiments, hepatoprotective effect of HE and op-HE were assessed on $CCl_4-induced$ liver injury mice model. Results : HE pretreatment prevented AA+iron-mediated hepatocytes apoptosis. In addition, AA+iron-induced mitochondrial dysfunction, $H_2O_2$ production, glutathione depletion were reduced by HE pretreatment. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation, antioxidant response element (ARE)-driven reporter gene activity, and antioxidant genes expression were increased by HE. Based on reporter gene and MTT assays, we found that op-HE consisting three medicinal herbs also significantly increased transactivation of Nrf2 and reduced the AA+iron-mediated cytotoxicity. Moreover, in $CCl_4-induced$ liver injury mice model, HE-op had an ability to ameliorate $CCl_4-mediated$ increases in serum alanine transferase and aspartate aminotransferase activity, hepatic degeneration, inflammatory cell infiltration, and collagen deposition. Hepatoprotective effects of op-HE were comparable to those of HE. Conclusions : Present study suggests that op-HE as well as HE exhibit hepatoprotective effect against oxidative stress-mediated liver injury via Nrf2 activation.

• Food Science and Biotechnology
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• v.17 no.3
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• pp.642-650
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• 2008

A mathematical model was developed for predicting the growth rate of Enterobacter sakazakii in tryptic soy broth medium as a function of the combined effects of temperature (5, 10, 20, 30, and $40^{\circ}C$), pH (4, 5, 6, 7, 8, 9, and 10), and the NaCl concentration (0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10%). With all experimental variables, the primary models showed a good fit ($R^2=0.8965$ to 0.9994) to a modified Gompertz equation to obtain growth rates. The secondary model was 'In specific growth $rate=-0.38116+(0.01281^*Temp)+(0.07993^*pH)+(0.00618^*NaCl)+(-0.00018^*Temp^2)+(-0.00551^*pH^2)+(-0.00093^*NaCl^2)+(0.00013^*Temp*pH)+(-0.00038^*Temp*NaCl)+(-0.00023^*pH^*NaCl)$'. This model is thought to be appropriate for predicting growth rates on the basis of a correlation coefficient (r) 0.9579, a coefficient of determination ($R^2$) 0.91, a mean square error 0.026, a bias factor 1.03, and an accuracy factor 1.13. Our secondary model provided reliable predictions of growth rates for E. sakazakii in broth with the combined effects of temperature, NaCl concentration, and pH.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.18 no.2_spc
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• pp.247-260
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• 2020

A multi-regression model was developed to estimate the decommissioning cost for Kori unit 1 using foreign nuclear power plant (NPP) decommissioning cost data. First, the decommissioning cost data were collected for 13 boiling water reactors and 16 pressurized water reactors and converted into the values as of November 2019. Then, for the regression model, the decommissioning cost was chosen as the dependent variable, and two variables were selected as independent variables: a contamination factor that was designed to reflect the operational characteristics of the decommissioned NPP and the decommissioning period. A statistical package in the R language was used to derive the regression model. Finally, the regression model was applied to estimate the decommissioning cost for Kori unit 1. The estimated decommissioning cost for Kori unit 1 was 663.40~928.32 million US dollars (782,812~1,095,418 million Korean won).

• Journal of Korea Game Society
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• v.17 no.1
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• pp.7-16
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• 2017

The 3D game graphic technology has become an important factor in the contents field with the game contents development. In particular, game character technology provides a realistic technique and visual pleasure, as well as an intermediate step in the immersion of the game in which the game might create an optical illusion that enables the player to enjoy heroic adventure in the game. The high expression level of characters in 3D games is a key factor in the development process, with details and carefulness of the character setting work [3]. In this paper, we propose a character representative technique applied to mobile games using mathematical model of radiosity energy, spectral radiance model, and ray tracing model method using 3D unity game engine with sensible AI algorithm for game implementation. As a practical application to the game contents, it was found that the projection of the surface in the rendering process and the game simulation might change according to the lighting condition of the game content environment, so that the high quality of game characters was simulated.

• The Journal of Society for e-Business Studies
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• v.21 no.4
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• pp.119-136
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• 2016

Precedent studies revealed that success of IT project strongly depends on the competency of PMO(project management offices), however, there are only few studies which show the importance of PMO competency. In this study, we will suggest an evaluation model of IT PMO competency using the Pentagon Model which is a tool to assess the performance of project organization, and the Analytic Hierarchy Process. We classified effect factor of PMO competency into 25 items in 5 fields such as Structure, Technology, Culture, Interaction, Social Relations and Networks based on pentagon model, also analysis of criticality between the effect factors was conducted by AHP. The study result shows 3 factors of Structure were included in the top 10, while 2 factors of Technology, Culture, Interaction were included separately. In terms of Social Relations and Networks, only 1 factor was included in the top 10. Therefore Structure of PMO should be aggressively considered for the successful IT project.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.12 no.5
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• pp.772-772
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• 2001

In this paper, we proposed the image-based 3D ray-tracing indoor propagation model using patch scattering model which can calculate the scattering phenomenon of the indoor structures. A patch scattering model for modeling indoor structures defines a scattering phenomenon by using RCS(Radar Cross Section) about rectangular patch without complex calculation, for example generating image antennas about each indoor structures. RCS is simply defined as a ratio of scattering power to incident power, and we use bistatic PCS which is simplified numerically by Physical Optics. Also, a simple indoor compensation factor is defined as empirical constant from measured data instead of complex numerical expression because basic patch scattering model cannot include important multipath components, so we san use patch scattering model in indoor environment using indoor compensation factor.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.12 no.5
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• pp.722-733
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• 2001

In this paper, we proposed the image-based 3D ray-tracing indoor propagation model using patch scattering model which can calculate the scattering phenomenon of the indoor structures. A patch scattering model for modeling indoor structures defines a scattering phenomenon by using RCS(Radar Cross Section) about rectangular patch without complex calculation, for example generating image antennas about each indoor structures. RCS is simply defined as a ratio of scattering power to incident power, and we use bistatic PCS which is simplified numerically by Physical Optics. Also, a simple indoor compensation factor is defined as empirical constant from measured data instead of complex numerical expression because basic patch scattering model cannot include important multipath components, so we san use patch scattering model in indoor environment using indoor compensation factor.