• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.3
• /
• pp.851-856
• /
• 2012

Objective: NBS1 plays a key role in the repair of DNA double-strand break (DSB). We conducted this study to investigate the effect of two critical polymorphisms (rs1805794 and rs13312840) in NBS1 on treatment response and prognosis of advanced non-small cell lung cancer (NSCLC) patients with platinum-based chemotherapy. Methods: Using TaqMan methods, we genotyped the two polymorphisms in 147 NSCLC patients. Odds ratios (ORs) and their 95% confidential intervals (CIs) were calculated as a measure of difference in the response rate of platinum-based chemotherapy using logistic regression analysis. The Kaplan-Meier and log-rank tests were used to assess the differences in progression-free survival (PFS) and overall survival (OS). Cox proportional hazards model was applied to assess the hazard ratios (HRs) for PFS and OS. Results: Neither of the two polymorphisms was significantly associated with treatment response of platinum-based chemotherapy. However, patients carrying the rs1805794 CC variant genotype had a significantly improved PFS compared to those with GG genotype (16.0 vs. 8.0 months, P = 0.040). Multivariable cox regression analysis further showed that rs1805974 was a significantly favorable prognostic factor for PFS [CC/CG vs. GG: Adjusted HR = 0.62, 95% CI: 0.39-0.99; CC vs. CG/GG: Adjusted HR = 0.56, 95% CI: 0.32-0.97). Similarly, rs13312840 with a small sample size also showed a significant association with PFS (CC vs. CT/TT: Adjusted HR = 25.62, 95% CI: 1.53-428.39). Conclusions: Our findings suggest that NBS1 polymorphisms may be genetic biomarkers for NSCLC prognosis especially PFS with platinum-based chemotherapy in the Chinese population.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.5
• /
• pp.2897-2901
• /
• 2013

Gastric cancer is the second most common cause of cancer-related deaths in the world. Although certain dietary factors and lifestyles have been suggested to be associated with gastric carcinogenesis, there have been few investigations focusing on rural areas. A case-control study was therefore carried out to investigate the risk factors of gastric cardia cancer (GCC) in rural areas of Linzhou. A total of 470 newly diagnosed cases of GCC and 470 healthy controls were included. Face-to-face interviews were conducted, using a uniform questionnaire containing questions on demographics, per capita income, living habits, dietary habits and family history of tumors. The relationship between putative risk factors and GCC was assessed by odds ratios (OR) and their 95% confidence intervals (95%CI) derived from conditional logistic regression model by the COXREG command using SPSS 12.00. Multivariate logistic regression analysis was used to evaluate simultaneously the effects of multiple factors and other potential confounding factors. Multivariate logistic analysis showed that smoking (OR=1.939, 95%CI:1.097-3.426), alcohol drinking (OR=2.360, 95%CI: 1.292-4.311), hot food consumption (OR=2.034, 95%CI: 1.507-2.745), fast eating (OR=1.616, 95%CI: 1.171-2.230), mouldy food (OR=4.564, 95%CI: 2.682-7.767), leftover food (OR=1.881. 95%CI: 1.324-2.671), and family history of tumor (OR=2.831, 95%CI: 1.588-5.050) were risk factors for GCC. High per capita income (OR=0.709, 95%CI: 0.533-0.942), high education level (OR=0.354, 95%CI: 0.163-0.765), consumption of fresh fruits (OR=0.186, 95%CI: 0.111-0.311) and vegetables (OR=0.243, 95%CI: 0.142-0.415), and high BMI (OR=0.367, 95%CI: 0.242-0.557) were protective factors for GCC. Our data indicate that unhealthy lifestyle and dietary habits might be important contributors to GCC in this population.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.7
• /
• pp.3515-3519
• /
• 2016

Background: In Thailand, a national treatment protocol for childhood leukemia and lymphoma (LL) was implemented in 2006. Access to treatment has also improved with the National Health Security system. Since these innovations, survival of childhood LL has not been fully described. Materials and Methods: Trends and survival of children under 15 with childhood cancers diagnosed between 1993 and 2012 were investigated using the hospital-based data from the Khon Kaen Cancer Registry, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Thailand. Childhood cancers were classified into 12 diagnostic groups, according to the ICCC based on the histology of the cancer. Survival rates were described by period, depending on the treatment protocol. For leukemias and lymphomas, survival was assessed for 3 periods (1993-99, 2000-5, 2006-12) while for solid tumors it was for 2 periods (before and after 2000). The impacts of sex, age, use of the national protocol, and catchment area on leukemia and lymphoma were evaluated. Overall survival was calculated using the Kaplan-Meier method while the Cox proportional hazard model was used for multivariate analysis. Trends were calculated using the R program. Results: A total of 2,343 childhood cancer cases were included. Survival for acute lymphoblastic leukemia (ALL) from 1993-9, 2000-5, and 2006-12 improved significantly (43.7%, 64.6%, and 69.9%). This was to a lesser extent true for acute non-lymphoblastic leukemia (ANLL) (28.1%, 42.0%, and 42.2%). Survival of non-Hodgkin lymphoma (NHL) also improved significantly (44%, 65.5%, and 86.8%) but not for Hodgkin disease (HD) (30.1%, 66.1%, and 70.6%). According to multivariate analysis, significant risk factors associated with poor survival in the ALL group were age under 1 and over 10 years, while not using the national protocol had hazard ratios (HR) of 1.6, 1.3, and 2.3 respectively. In NHL, only non-use of national protocols was a risk factor (HR 3.9). In ANLL and HD, none of the factors influenced survival. Survival of solid tumors (liver tumors, retinoblastomas) were significantly increased compared to after and before 2000 while survival for CNS tumors, neuroblastoma and bone tumors was not changed. Conclusions: The survival of childhood cancer in Thailand has markedly improved. Since implementation of national protocols, this is particularly the case for ALL and NHL. These results may be generalizable for the whole country.

• Journal of Korean Society for Geospatial Information Science
• /
• v.6 no.2 s.12
• /
• pp.105-117
• /
• 1998

The main object of this study was to prove the effectiveness of satellite Image data for extraction of the pine needle gall midge damaged area in the part of Kangwon-do area, and to present the detailed procedure of a digital image processing for extraction of those damaged area. The effectiveness of extraction of damaged area was improved by using the BRCT(Backwards Radiance Correction Transformation) with DEM for the normalization of topographic effects. The topographic surface analysis of the extracted damaged area revealed that the general damaged area was at south-west and south-east aspect with the slope of 31 to 38 degrees, the temperature of 21 to 25, and 23% to 39% of the highest altitude mountains. The new damaged area in which expanded area was at 27 to 30 degree of slope, the aspect of 46 to 180 degrees, the temperature of $11^{\circ}C\;to\;12^{\circ}C$ and 27% to 39% of the highest altitude mountains. The NDI(New Damaged Index) was developed using the environment factor and simple vegetation index.

• The Journal of the Korea Contents Association
• /
• v.11 no.10
• /
• pp.19-29
• /
• 2011

A Blog provides commentary, news, or content on a particular subject. The important part of many blogs is interactive format. Sometimes, there is a heated debate on a topic and any article becomes a political or sociological issue. In this paper, we proposed a method to predict the popularity of an article in advance. First, we used hit count as a factor to predict the popularity of an article. We defined the saturation point and derived a model to predict the hit count of the saturation point by a correlation coefficient of the early hit count and hit count of the saturation point. Finally, we predicted the virtual temperature of an article using 4 types(explosive, hot, warm, cold). We can predict the virtual temperature of Internet discussion articles using the hit count of the saturation point with more than 70% accuracy, exploiting only the first 30 minutes' hit count. In the hot, warm, and cold categories, we can predict more than 86% accuracy from 30 minutes' hit count and more than 90% accuracy from 70 minutes' hit count.

• Journal of Distribution Science
• /
• v.16 no.7
• /
• pp.77-86
• /
• 2018

Purpose - In the insurance distribution channel, the salespeople plays a role of representing the company, and recognizes the needs of the customers and plays a role in responding to them. Therefore, their turnover can have a great influence on the company performance. The purpose of this study is to investigate the structural relationship between salespeople's personal - environmental fit and organizational commitment and turnover intention. Research design, data, and methodology - Data collection was conducted a self-filling questionnaire for salespeople for about one month from July 24, 2017 to August 30, 2017. The subjects of the questionnaire were the insurance salespeople who work in the sales line such as K life, S fire. A total of 450 copies were distributed and 432 copies of the questionnaire were used for final analysis. The analysis program used SPSS 22.0 and AMOS 22.0 programs. Analysis method was Frequency Analysis, Reliability & Confirmatory Factor Analysis, Correlation Analysis and Structural Equation Model(SEM). Results - As a result of Hypothesis 1, Person-Supervisor Fit had significant influence only on Continuance Commitment. Person-Job Fit did not have a significant effect on Organizational Commitment. Person-Coworker Fit had a significant effect on Continuance Commitment and Affective Commitment. Person-Organization Fit had a significant impact on Affective Commitment. Therefore, only , , , , were adopted. As a result of Hypothesis 2, Continuance Commitment had a significant effect on turnover intention. Therefore, only was adopted. Conclusions - This study suggests that it is necessary to manage the human resources in the sales field through studies related to salespeople's extension of the research scope and salespeople's turnover intention. Based on the results of this study, the conclusion suggests some implications for the efficient human resources management of insurance companies in sales channels. It is expected that it will be helpful for the salespeople to find out what kind of Person-Environment Fit affects the organizational commitment and how to manage the organizational commitment among the three dimensions of organizational commitment to reduce turnover intention.

• Ocean and Polar Research
• /
• v.25 no.spc3
• /
• pp.361-371
• /
• 2003

The effect of bottom friction on the steady wind-driven circulation in the Yellow Sea and the East China Sea (YSECS) has been studied using a two-dimensional numerical model with and without tidal forcing. Upwind flow experiment in YSECS has also been carried out with a schematic time variation in the wind field. The surface water setup and circulation pattern due to steady wind forcing are found to be very sensitive to the bottom friction. When the effects of tidal currents are neglected, the overall current velocities are overestimated and eddies of various sizes appear, upwind flow is formed within the deep trough of the Yellow Sea, forming a part of the topographic gyre on the side of Korea. When tidal forcing is taken into account, the wind-induced surface elevations are smoothed out due to the strong tide-induced bottom friction, which is aligned almost normal to the wind stresses; weak upwind flow is farmed in the deep trough of the Yellow Sea, west and south of Jeju. Calculation with wind forcing only through a parameterized linear bottom friction produces almost same results from the calculation with $M_2$ tidal forcing and wind forcing using a quadratic bottom friction, supporting Hunter (1975)'s linearization of bottom friction which includes the effect of tidal current, can be applied to the simulation of wind-driven circulation in YSECS. The results show that steady wind forcing is not a dominant factor to the winter-time upwind flow in YSECS. Upwind flow experiment which considers the relaxation of pressure gradient (Huesh et al. 1986) shows that 1) a downwind flow is dominant over the whole YSECS when the northerly wind reaches a maximum speed; 2) a trend of upwind flow near the trough is found during relaxation when the wind abates; 3) a northward flow dominates over the YSECS after the wind stops. The results also show that the upwind flow in the trough of Yellow Sea is forced by a wind-induced longitudinal surface elevation gradient.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.18 no.10
• /
• pp.642-651
• /
• 2017

This study aimed to examine the changes in the health status, social network and satisfaction of caregivers as a result of caregiving using a structural equation model. As a result, it was found that caregiving increased the level of depression and decreased the subjective health status in both men and women. The social network and satisfaction were found to differ according to gender. For the women caregivers, caregiving affected their subjective health status and depression. In the case of the men caregivers, the total effect of caregiving on their subjective health was 1.087(p<.05), while the indirect effect was 0.546(p<.05). Also, caregiving affected the subjective health status of the male caregivers through the functional family network as a mediating factor(0.42, p<.01). The results suggest the necessity to take these gender differences into consideration when discussing the health of caregivers. Also, the functional family network needs to be strengthened to prevent the deterioration of the health status of male caregivers.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.18 no.10
• /
• pp.373-381
• /
• 2017

This study was conducted to establish and verify a theoretical model that explains the factors and pathways influencing the psychological well-being of nurses. The subjects of this study were nurses working in four general hospitals with over 200 beds in B city and G province. The results of verifying the path coefficient of the nurses' job rotation stress showed that job rotation stress had a significant effect on challenge stress, hindrance stress, and nurses' psychological well-being, while hindrance stress had a negative effect on nurses' psychological well-being. Nurses' job rotation stress had direct effects on challenge stress, hindrance stress, and psychological well-being. Hindrance stress had a direct effect on psychological well-being. In addition, nurses' job rotation stress had an indirect effect on psychological well-being through hindrance stress. Nurses who experienced job rotation showed challenge and hindrance stress. Since hindrance stress interferes with the psychological well-being of nurses, it is necessary to manage stress and make efforts in the nursing organization. Therefore, nursing organizations should establish a positive organizational environment and develop systematic strategies so that job rotation can be a challenging stress factor for nurses.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.21 no.10
• /
• pp.334-344
• /
• 2020

This was descriptive research aimed at determining the effects of emotional labor, nursing informatics competency, and nursing service environment on the nursing performance of convalescent hospital nurses. One hundred thirty-one nurses participated in this survey. The collected data were analyzed using the SPSS statics18 program. The distribution of the research variables and general characteristics were analyzed by frequency analysis and descriptive statistics. The correlation between emotional labor, nursing informatics competency, nursing service environment, and nursing performance was analyzed by the Pearson correlation, and the influencing factors were hierarchical multiple regression analysis. As a result of the study, the average nursing performance was 65.5 (±8.5) points, emotional labor was 27.2 (±5.6) points, nursing informatics competency was 91.3 (±15.7), and the nursing service environment was 88.2(±16.0) points. The nursing performance showed a positive correlation with the nursing informatics competency (r=.32, p<.001) and nursing service environment (r=.25, p=.005). Nursing informatics competency was the biggest factor affecting nursing performance, and the nursing service environment had no significant influence. Among the general characteristics, marriage status and position also affected the nursing performance. The explanatory power of this regression model was 35.2% and was statistically significant (F=9.815, p<.001).