• Journal of the Korea Society for Simulation
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• v.18 no.4
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• pp.21-28
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• 2009

In the past, most of battle occurred in flatland and simple military force size gave a big influence in combat result. However, after the World War I, most of battles took place at the various terrain features such as forest, downtown, jungle and many others. Therefore, terrain factor exerts big influence on battle with weapon system in the ground warfare. However, effect of terrain has been explained only by quantitative manner in the battle. Furthermore, combat simulation and modeling applied a method that lower the combat capability of battle factors. In this paper, we present instrumentation that evaluate impact of terrain using fractal dimension. We determine the fractal dimension value by the "box counting dDimension" and density to calculate impact of terrain. Furthermore, we analyzed correlation with fractal dimension and density for battle result that obtained from the EINSTein model which is an agent-based simulation. We compare with 'Stalingrad battle' result out of battle example and analyzed. This study presented a method combat effectiveness that effect of terrain calculate quantitatively using fractal dimension.

• Journal of Korea Society of Industrial Information Systems
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• v.14 no.2
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• pp.32-50
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• 2009

Since 1990 when order communication system(OCS) was first introduced, the use of information technology in medical service has been widely accepted in order to enhance quality and customer relationship as well as to increase managerial efficiency. Medical information system is rapidly increasing and is trying to make ubiquitous healthcare environment through telemedicine system. Especially, medical profession and government have taken interest in electronic medical record (EMR) system which can digitalize and manage all medical records in hospitals. By recording patient's medical information in real time, EMR system can improve service efficiency and customer service quality including short waiting time, various utilization of clinic information, and reduced cost.

• Molecules and Cells
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• v.46 no.7
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• pp.420-429
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• 2023

Age-related macular degeneration (AMD) is one of the leading causes of blindness in elderly individuals. However, the currently used intravitreal injections of anti-vascular endothelial growth factor are invasive, and repetitive injections are also accompanied by a risk of intraocular infection. The pathogenic mechanism of AMD is still not completely understood, but a multifactorial mechanism that combines genetic predisposition and environmental factors, including cellular senescence, has been suggested. Cellular senescence refers to the accumulation of cells that stop dividing due to the presence of free radicals and DNA damage. Characteristics of senescent cells include nuclear hypertrophy, increased levels of cell cycle inhibitors such as p16 and p21, and resistance to apoptosis. Senolytic drugs remove senescent cells by targeting the main characteristics of these cells. One of the senolytic drugs, ABT-263, which inhibits the antiapoptotic functions of Bcl-2 and Bcl-xL, may be a new treatment for AMD patients because it targets senescent retinal pigment epithelium (RPE) cells. We proved that it selectively kills doxorubicin (Dox)-induced senescent ARPE-19 cells by activating apoptosis. By removing senescent cells, the expression of inflammatory cytokines was reduced, and the proliferation of the remaining cells was increased. When ABT-263 was orally administered to the mouse model of senescent RPE cells induced by Dox, we confirmed that senescent RPE cells were selectively removed and retinal degeneration was alleviated. Therefore, we suggest that ABT-263, which removes senescent RPE cells through its senolytic effect, has the potential to be the first orally administered senolytic drug for the treatment of AMD.

• Journal of Korean Neurosurgical Society
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• v.66 no.5
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• pp.525-535
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• 2023

Objective : We performed an expanded multi-ethnic meta-analysis to identify associations between inflammation-related loci with intracranial aneurysm (IA) susceptibility. This meta-analysis possesses increased statistical power as it is based on the most data ever evaluated. Methods : We searched and reviewed relevant literature through electronic search engines up to August 2022. Overall estimates were calculated under the fixed- or random-effect models using pooled odds ratio (OR) and 95% confidence intervals (CIs). Subgroup analyses were performed according to ethnicity. Results : Our meta-analysis enrolled 15 studies and involved 3070 patients and 5528 controls including European, Asian, Hispanic, and mixed ethnic populations. Of 17 inflammation-related variants, the rs1800796 locus (interleukin [IL]-6) showed the most significant genome-wide association with IA in East-Asian populations, including 1276 IA patients and 1322 controls (OR, 0.65; 95% CI, 0.56-0.75; p=3.24#x00D7;10^-9) under a fixed-effect model. However, this association was not observed in the European population (OR, 1.09; 95% CI, 0.80-1.47; p=0.5929). Three other variants, rs16944 (IL-1β), rs2195940 (IL-12B), and rs1800629 (tumor necrosis factor-α) showed a statistically nominal association with IA in both the overall, as well as East-Asian populations (0.01<p<0.05). Conclusion : Our updated meta-analysis with increased statistical power highlights that rs1800796 which maps on the IL-6 gene is associated with IA, and in particular confers a protective effect against occurrence of IA in the East-Asian population.

• Journal of Creative Information Culture
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• v.5 no.3
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• pp.329-343
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• 2019

This study designed, developed and evaluated an application to improve the social skills of students with Autism Spectrum Disorders(ASD) based on the stage of the ADDIE model. The design stage aimed to factor in the characteristics and needs of students with ASD, and created guide maps and story boards accordingly. In the development stage, the application was made through a total of fourteen processes and four official tests. In the evaluation stage, heuristic usability evaluation was conducted on 10 teachers based on the their experience of using the application in the implementation stage. The results of the evaluation were all close to 'very good' in the areas of educational value, content implementation technology, content information and convenience. Finally, the application was fully developed after reflecting the corrections in accordance with the result of the usability evaluation. It is expected that this study have a role in invigorating the development of special educational software content.

• Economic Analysis
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• v.26 no.4
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• pp.65-97
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• 2020

The purpose of this paper is to analyze the effects of exports on Korea's employment and to decompose driving factors of change in Korea's employment embodied in exports (EEX). This study uses a multi-regional input-output (MRIO) and structural decomposition analysis (SDA) for empirical analysis, and uses a dataset of World Input-Output Tables (WIOTs) and Socio-Economic Accounts (SEAs) from the World Input-Output Database (WIOD). The main findings of the empirical results are summarized as follows. First, Korea's EEX continues to increase and Korea's share of EEX compared to total employment shows an upward trend. However, Korea's employment inducement coefficient of value-added exports showed a downward trend during the 2000-2014 period. Second, final demand from three countries (China, the United States, and the Rest of the World (RoW)) has affected a significant portion of Korea's EEX. Finally, from the results of the SDA, the effect of changes in final demand was the most important driving factor for the increase in Korea's EEX. Based on the results of this empirical analysis, this study discusses useful policy implications that could increase domestic employment in Korea.

• Korean Journal of Transplantation
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• v.28 no.3
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• pp.154-159
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• 2014

Background: Lung transplantation (LTx) is a life-saving treatment for patients with end-stage lung disease; however, the shortage of donor lungs has been a major limiting factor to increasing the number of LTx. Growing experience following LTx using donor lungs after cardiac death (DCD) has been promising, although concerns remain. The purpose of this study was to develop a DCD lung harvest model using an ex vivo lung perfusion (EVLP) system and to assess the function of presumably damaged lungs harvested from the DCD donor in pigs. Methods: The 40 kg pigs were randomly divided into the control group with no ischemic lung injury (n=5) and the study group (n=5), which had 1 hour of warm ischemic lung injury after cardiac arrest. Harvested lungs were placed in the EVLP circuit and oxygen capacities (OC), pulmonary vascular resistance (PVR), and peak airway pressure (PAP) were evaluated every hour for 4 hours. At the end of EVLP, specimens were excised for pathologic review and wet/dry ratio. Results: No statistically significant difference in OC (P=0.353), PVR (P=0.951), and PAP (P=0.651) was observed in both groups. Lung injury severity score (control group vs. study group: 0.700±0.303 vs. 0.870±0.130; P=0.230) and wet/dry ratio (control group vs. study group: 5.89±0.97 vs. 6.20±0.57; P=0.560) also showed no statistically significant difference between the groups. Conclusions: The function of DCD lungs assessed using EVLP showed no difference from that of control lungs without ischemic injury; therefore, utilization of DCD lungs can be a new option to decrease the number of deaths on the waiting list.

• Geomechanics and Engineering
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• v.32 no.2
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• pp.159-177
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• 2023

In the present work, a simple and refined shear deformation theory is used to analyze the effect of visco-elastic foundation on the buckling response of exponentially-gradient sandwich plates under various boundary conditions. The proposed theory includes indeterminate integral variables kinematic with only four generalized parameters, in which no shear correction factor is used. The visco-Pasternak's foundation is taken into account by adding the influence of damping to the usual foundation model which characterized by the linear Winkler's modulus and Pasternak's foundation modulus. The four governing equations for FGM sandwich plates are derived by employing principle of virtual work. To solve the buckling problem, Galerkin's approach is utilized for FGM sandwich plates for various boundary conditions. The analytical solutions for critical buckling loads of several types of powerly graded sandwich plates resting on visco-Pasternak foundations under various boundary conditions are presented. Some numerical results are presented to indicate the effects of inhomogeneity parameter, elastic foundation type, and damping coefficient of the foundation, on the critical buckling loads.

• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.27-39
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• 2023

Extensive research supported the therapeutic potential of curcumin, a naturally occurring compound, as a promising cytokine-suppressive anti-inflammatory drug. This study aimed to investigate the synergistic anti-inflammatory and anti-cytokine activities by combining 6-shogaol and 10-shogaol to curcumin, and associated mechanisms in modulating lipopolysaccharides and interferon-γ-induced proinflammatory signaling pathways. Our results showed that the combination of 6-shogaol-10-shogaolcurcumin synergistically reduced the production of nitric oxide, inducible nitric oxide synthase, tumor necrosis factor and interlukin-6 in lipopolysaccharides and interferon-γ-induced RAW 264.7 and THP-1 cells assessed by the combination index model. 6-shogaol-10-shogaol-curcumin also showed greater inhibition of cytokine profiling compared to that of 6-shogaol-10-shogaol or curcumin alone. The synergistic anti-inflammatory activity was associated with supressed NFκB translocation and downregulated TLR4-TRAF6-MAPK signaling pathway. In addition, SC also inhibited microRNA-155 expression which may be relevant to the inhibited NFκB translocation. Although 6-shogaol-10-shogaol-curcumin synergistically increased Nrf2 activity, the anti-inflammatory mechanism appeared to be independent from the induction of Nrf2. 6-shogaol-10-shogaol-curcumin provides a more potent therapeutic agent than curcumin alone in synergistically inhibiting lipopolysaccharides and interferon-γ induced proinflammatory mediators and cytokine array in macrophages. The action was mediated by the downregulation of TLR4/TRAF6/MAPK pathway and NFκB translocation.

• Convergence Security Journal
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• v.23 no.1
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• pp.89-95
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• 2023

In order to help reduce the medical expenses of patients with auto insurance accidents, this study predicted the treatment period, which is the most important factor in the medical expenses of patients in their 40s and 50s, and analyzed the factors affecting the treatment period. To this end, a mechine learning model using five algorithms such as Decision Tree was created, and its performance was compared and analyzed between models. There were three algorithms that showed good performance including Decison Tree, Gradient Boost, and XGBoost. In addition, as a result of analyzing the factors affecting the prediction of the treatment period, the type of hospital, the treatment area, age, and gender were found. Through these studies, easy research methods such as the use of AutoML were presented, and we hope that the results of this study will help policies to reduce medical expenses for automobile insurance accidents.