Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Updated Trans-Ethnic Meta-Analysis of Associations between Inflammation-Related Genes and Intracranial Aneurysm

  • Eun Pyo Hong (Institute of New Frontier Research, Hallym University College of Medicine) ;
  • Sung Min Cho (Department of Neurosurgery, Yonsei University Wonju College of Medicine) ;
  • Jong Kook Rhim (Department of Neurosurgery, Jeju National University College of Medicine) ;
  • Jeong Jin Park (Department of Neurology, Konkuk University Medical Center) ;
  • Jun Hyong Ahn (Department of Neurosurgery, Kangwon National University Hospital) ;
  • Dong Hyuk Youn (Institute of New Frontier Research, Hallym University College of Medicine) ;
  • Jong-Tae Kim (Institute of New Frontier Research, Hallym University College of Medicine) ;
  • Chan Hum Park (Institute of New Frontier Research, Hallym University College of Medicine) ;
  • Younghyurk Lee (Institute of New Frontier Research, Hallym University College of Medicine) ;
  • Jin Pyeong Jeon (Department of Neurosurgery, Hallym University College of Medicine) ;
  • the First Korean Stroke Genetics Association Research (The FirstKSGAR) Study (the First Korean Stroke Genetics Association Research)
  • Received : 2023.01.02
  • Accepted : 2023.02.21
  • Published : 2023.09.01
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Abstract

Objective : We performed an expanded multi-ethnic meta-analysis to identify associations between inflammation-related loci with intracranial aneurysm (IA) susceptibility. This meta-analysis possesses increased statistical power as it is based on the most data ever evaluated. Methods : We searched and reviewed relevant literature through electronic search engines up to August 2022. Overall estimates were calculated under the fixed- or random-effect models using pooled odds ratio (OR) and 95% confidence intervals (CIs). Subgroup analyses were performed according to ethnicity. Results : Our meta-analysis enrolled 15 studies and involved 3070 patients and 5528 controls including European, Asian, Hispanic, and mixed ethnic populations. Of 17 inflammation-related variants, the rs1800796 locus (interleukin [IL]-6) showed the most significant genome-wide association with IA in East-Asian populations, including 1276 IA patients and 1322 controls (OR, 0.65; 95% CI, 0.56-0.75; p=3.24#x00D7;10-9) under a fixed-effect model. However, this association was not observed in the European population (OR, 1.09; 95% CI, 0.80-1.47; p=0.5929). Three other variants, rs16944 (IL-1β), rs2195940 (IL-12B), and rs1800629 (tumor necrosis factor-α) showed a statistically nominal association with IA in both the overall, as well as East-Asian populations (0.01<p<0.05). Conclusion : Our updated meta-analysis with increased statistical power highlights that rs1800796 which maps on the IL-6 gene is associated with IA, and in particular confers a protective effect against occurrence of IA in the East-Asian population.

Keywords

Acknowledgement

This research was supported by a grant of the Hallym University Research Fund (HURF-2021-35). This work was supported by the Korea Bio Data Station (K-BDS) with computing resources including technical support from 2022 to 2023.

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