• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.6 no.2
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• pp.140-151
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• 2003

Purpose: We tried to evaluate the long term efficacy and positive predictive factors of interferon-alpha treatment in children with chronic hepatitis B. Methods: The study population included 113 children who received interferon therapy between May 1982 and July 2002 (20 years) for chronic hepatitis B in Department of Pediatrics, Yonsei University College of Medicine. Male to female ratio was 2.3 : 1 and the mean age at diagnosis was $11.1{\pm}4.1$ years old. Response to treatment was defined as normalization of alanine aminotransferase (ALT), disappearance of HBeAg and HBV-DNA Eighty two children responded while 32 did not. Interferon-alpha was given intramuscularly for 6 months at a dosage of $3{\times}10^6$ unit, 3 times weekly. In relapsed cases, lamivudine or interferon retreatment was done. Results: Seroconversion rate was 77.0% in terms of HBeAg, 74.3% in terms of HBV-DNA, and 80.5% in terms of ALT normalization after treatment. Seroconversion rate of both HBeAg and HBV-DNA was 72.6%. Analyzed by life table method, the effect of the treatment had been maintained over 10 years after cessation of therapy. Pre-treatment ALT level was the only significant positive predictive factor of response. Eleven cases (13.4%) relapsed, and 2 out of 3 showed response when treated with lamivudine and 1 out of 3 with interferon retreatment. Conclusion: Interferon-alpha showed significant efficacy in the treatment of chronic hepatitis B in our study. Further studies about the effect of interferon therapy on complications of hepatitis such as hepatocarcinoma, cirrhosis are warranted.

• Journal of KIISE:Databases
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• v.33 no.1
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• pp.102-116
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• 2006

Electronic catalogs (or e-catalogs) hold information about the goods and services offered or requested by the participants, and consequently, form the basis of an e-commerce transaction. Catalog management is complicated by a number of factors and product classification is at the core of these issues. Classification hierarchy is used for spend analysis, custom3 regulation, and product identification. Classification is the foundation on which product databases are designed, and plays a central role in almost all aspects of management and use of product information. However, product classification has received little formal treatment in terms of underlying model, operations, and semantics. We believe that the lack of a logical model for classification Introduces a number of problems not only for the classification itself but also for the product database in general. It needs to meet diverse user views to support efficient and convenient use of product information. It needs to be changed and evolved very often without breaking consistency in the cases of introduction of new products, extinction of existing products, class reorganization, and class specialization. It also needs to be merged and mapped with other classification schemes without information loss when B2B transactions occur. For these requirements, a classification scheme should be so dynamic that it takes in them within right time and cost. The existing classification schemes widely used today such as UNSPSC and eClass, however, have a lot of limitations to meet these requirements for dynamic features of classification. In this paper, we try to understand what it means to classify products and present how best to represent classification schemes so as to capture the semantics behind the classifications and facilitate mappings between them. Product information implies a plenty of semantics such as class attributes like material, time, place, etc., and integrity constraints. In this paper, we analyze the dynamic features of product databases and the limitation of existing code based classification schemes. And describe the semantic classification model, which satisfies the requirements for dynamic features oi product databases. It provides a means to explicitly and formally express more semantics for product classes and organizes class relationships into a graph. We believe the model proposed in this paper satisfies the requirements and challenges that have been raised by previous works.

• Imaging Science in Dentistry
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• v.50 no.2
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• pp.105-115
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• 2020

Purpose: This study investigated the position of the hyoid bone and its relationship with airway dimensions in different skeletal malocclusion classes using cone-beam computed tomography (CBCT). Materials and Methods: CBCT scans of 180 participants were categorized based on the A point-nasion-B point angle into class I, class II, and class III malocclusions. Eight linear and 2 angular hyoid parameters(H-C3, H-EB, H-PNS, H-Me, H-X, H-Y, H-[C3-Me], C3-Me, H-S-Ba, and H-N-S) were measured. A 3-dimensional airway model was designed to measure the minimum cross-sectional area, volume, and total and upper airway length. The mean crosssectional area, morphology, and location of the airway were also evaluated. Data were analyzed using analysis of variance and the Pearson correlation test, with P values <0.05 indicating statistical significance. Results: The mean airway volume differed significantly among the malocclusion classes(P<0.05). The smallest and largest volumes were noted in class II (2107.8±844.7 ㎣) and class III (2826.6±2505.3 ㎣), respectively. The means of most hyoid parameters (C3-Me, C3-H, H-Eb, H-Me, H-S-Ba, H-N-S, and H-PNS) differed significantly among the malocclusion classes. In all classes, H-Eb was correlated with the minimum cross-sectional area and airway morphology, and H-PNS was correlated with total airway length. A significant correlation was also noted between H-Y and total airway length in class II and III malocclusions and between H-Y and upper airway length in class I malocclusions. Conclusion: The position of the hyoid bone was associated with airway dimensions and should be considered during orthognathic surgery due to the risk of airway obstruction.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.10B
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• pp.1937-1945
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• 1999

In paper, we propose a 3D polygonal mesh simplification technique based on vertex clustering. The proposed method differentiates the size of each cluster according to the local property of a 3D object. We determine the size of clusters by considering the normal vector of triangles and the vertex distribution. The subdivisions of cluster are represented by octree. In this paper, we use the Harsdorff distance between the original mesh and the simplified one as a meaningful error value. Because proposed method adaptively determine the size of cluster according to the local property of the mesh, it has smaller error as compared with the previous methods and represent the small regions on detail. Also it can generate a multiresolution model and selectively refine the local regions.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.11B
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• pp.1261-1271
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• 2009

Emergence of new mobile communication services has generated new demand for spectrum. Because spectrum is a scarce public resource, demand for spectrum would exceed supply. As the demand for spectrum grows, the spectrum management policy becomes one of the most important issues in mobile telecommunications industry. Huge license charges for spectrum usage may obstruct the growth of mobile telecommunications industry. We analyze spectrum charges by international comparison for the case of 3G mobile telecommunication spectrum assignment. There are mainly two types of methods in spectrum assignment of 3G service, one is the auction and the other is the beauty contest. This article aims to analyze factors which influence on spectrum charges and to study the characteristic of spectrum charges of some selected countries. This study suggests the multiple regression model about spectrum charges.

• Clinical and Experimental Pediatrics
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• v.60 no.11
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• pp.365-372
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• 2017

Purpose: The mechanism for the pathogenesis of adriamycin (ADR)-induced cardiomyopathy is not yet known. Different hypotheses include the production of free radicals, an interaction between ADR and nuclear components, and a disruption in cardiac-specific gene expression. Apoptosis has also been proposed as being involved in cardiac dysfunction. The purpose of this study was to determine if apoptosis might play a role in ADR-induced cardiomyopathy. Methods: Male Sprague-Dawley rats were separated into 2 groups: the control group (C group) and the experimental group (ADR 5 mg/wk for 3 weeks through intraperitoneal injections; A group). Echocardiographic images were obtained at week 3. Changes in caspase-3, B-cell leukemia/lymphoma (Bcl)-2, Bcl-2-associated X (Bax), interleukin (IL)-6, tumor necrosis $factor-{\alpha}$, brain natriuretic peptide (BNP), troponin I, collagen 1, and collagen 3 protein expression from the left ventricle tissues of C and A group rats were determined by Western blot. Results: Ascites and heart failure as well as left ventricular hypertrophy were noted in the A group. Ejection fraction and shortening fraction were significantly lower in the A group by echocardiography. The expression of caspase-3, Bax, IL-6, BNP, collagen 1, and collagen 3 were significantly higher in the A group as compared with the C group. Protein expression of Bcl-2 decreased significantly in the A group compared with the C group. Conclusion: ADR induced an upregulation of caspase-3, Bax, IL-6, and collagen, as well as a depression in Bcl-2. Thus, apoptosis and fibrosis may play an important role in ADR-induced cardiomyopathy.

• Research in Community and Public Health Nursing
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• v.7 no.2
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• pp.384-399
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• 1996

The concept of parish nursing began in the late 1960s in the United States when increasing numbers of churches employed registered nurses (RNs) to provide holistic, preventive health care to the members of their congregations. Parish nursing role was developed in 1983 by Lutheran chaplain Granger Westberg, and provides care to a variety of church congregation of various denominations. The parish nurse functions as health educator, counselor, group facilitator, client advocate, and liaison to community resources. Since these activities are complementary to the population-focused practice of community health' CNSs, parish nurses either have a strong public health background or work directly with both baccalaureate-prepared public health nurses and CNSs. In a Midwest community in U.S.A., the Healthy People 2000(1991) objectives are being addressed in health ministries through a coalition between public health nurses and parish nurses. Parish nursing is in the beginning state in Korea and up untill now, there has been no research was conducted on concrete role of korean parish nurses. The main purpose of this study was to identify, classify and analyze activities of parish nurses. The other important objective of this study was to establish an effective approach and direction for parish nursing and provide a database for korean parish nursing model through analysis and' classification of the content of the nursing record which included nursing activities. This study was a descriptive survey research. The parish nurses were working in churches where the demonstration project developed on parish nursing. The study was done on all nursing records which were working in churches where the demonstration project developed on parish nursing. The study was done on all nursing records which were documented by parish nurses in three churches from March, 1995 to February, 1996. Namsan, Taegu Jeei and Nedang presbyterian churches in Taegu and Keimyung nursing college incooperated together for the parish nursing demonstration project. The data analysis procedure was as follows: First, a record analysis tool was developed and second, the data was collected, coded and analyzed, the classification for nursing activities was developed through a literature review, from which the basic analysis tool was produced and cotent validity review was also done. The classification of the activities of parish nurses showed 7 activitity categories. 7 activity categories consisted of visitation nursing, health check-ups, health education, referring, attending staff meetings, attending inservices and seminar, volunteers coordinating. The percentage of activities were as follows: Visitation nursing(A: 51.6%, B: 55%, C: 42.6%) Health check-ups(A: 13.5%, B: 12.1%, C: 22.3%) Health education(A: 13.5%, B: 13.2%, C: 18.2%) Referring(A: 1.4%, B: 4.2%, C: 2.4%) Attending staff meeting(A: 18.8%, B: 13.0%, C: 12.2%) Attending inservices and seminar(A: 1.5%, B: 2.2%, C: 2.1%) Volunteers coordinating(A: 0.3%, B: 0.4%, C: 0.0%) To establish and develope parish nursing delivery network in Korea, parish nurses role, activities and boundaries of practice should be continuously monitored and refined every 2 years. Also, It is needed to develope effective nursing recording system based on the need assessment research data of various congregation members. role, activities and boundaries of practice and arrangement of the working structure, continuing education, cooperation with community resources and structuring and organizing parish nursing delivery network. Also, It is needed to develope effective nursing recording system based on the need assessment research data of various congregation members.

• International Commerce and Information Review
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• v.18 no.4
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• pp.3-29
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• 2016

Recently, the market size of the global electronic-commerce is rapidly growing. The global market size of an overseas direct-purchase is expected to reach 1 trillion won by 2020. This study intends to determine the decision making factors of B2B overseas direct-purchase(DP) and reverse direct-purchase(RDP), and the impact on the vitalization of the small to middle-sized companies'(SMC) overseas DP and RDP. Ultimately, the purpose of this study is to provide a policy insight on the expansion of exports by SMC. For this, we determined the necessary elements for getting good results by Korean SCM in the overseas DP and RDP market through a preceding research based on resource-based theory and industry structure theory. Afterwards, we used the multiple regression model for positive analysis of the survey documents. We were able to confirm through analysis that the company information, logistics delivery, customs process, law and regulations have positive effects on the overseas DP and RDP. This study surveyed the entire overseas DP market, rather than focusing on the cases of harm and responses of the overseas DP, which was the topic for the preceding research, and can be differentiated from the previous study by deducting influence factors for the Korean SMC to succeed in the overseas DP and RDP market. Moreover, the results of this study is meaningful in proposing a strategic direction for the SMC participating in the overseas DP market and the government enacting policies.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.47 no.3
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• pp.23-31
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• 2010

The increasing demands on low-power, and low-complexity video encoder have been motivating extensive research activities on distributed video coding (DVC) in which the encoder compresses frames without utilizing inter-frame statistical correlation. In DVC encoder, contrary to the conventional video encoder, an error control code compresses the video frames by representing the frames in the form of syndrome bits. In the meantime, the DVC decoder generates side information which is modeled as a noisy version of the original video frames, and a decoder of the error-control code corrects the errors in the side information with the syndrome bits. The noisy observation, i.e., the side information can be understood as the output of a virtual channel corresponding to the orignal video frames, and the conditional probability of the virtual channel model is assumed to follow a Laplacian distribution. Thus, performance improvement of DVC systems depends on performances of the error-control code and the optimal reconstruction step in the DVC decoder. In turn, the performances of two constituent blocks are directly related to a better estimation of the parameter of the correlation channel. In this paper, we propose an algorithm to estimate the parameter of the correlation channel and also a low-complexity version of the proposed algorithm. In particular, the proposed algorithm minimizes squared-error of the Laplacian probability distribution and the empirical observations. Finally, we show that the conventional algorithm can be improved by adopting a confidential window. The proposed algorithm results in PSNR gain up to 1.8 dB and 1.1 dB on Mother and Foreman video sequences, respectively.

• Asian-Australasian Journal of Animal Sciences
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• v.25 no.2
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• pp.151-162
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• 2012

Analysis for back fat thickness (BFAT) and daily body weight gains from birth to the end of a performance test were conducted to find an optimal method for estimation of weaning age effects and to ascertain impacts of weaning age on the growth performance of purebred Berkshire pigs from a closed population in Korea. Individual body weights were measured at birth (B), at weaning (W: mean, 22.9 d), at the beginning of the performance test (P: mean, 72.7 d), and at the end of the performance test (T: mean, 152.4 d). Further, the average daily gains in body weight (ADG) of 3,713 pigs were analyzed for the following periods: B to W (DGBW), W to P (DGWP), P to T (DGPT), B to P (DGBP), B to T (DGBT), and W to T (DGWT). Weaning ages ranged from 17 to 34 d, and were treated as fixed (WF), random with (WC) and random without (WU) consideration of an empirical relationship between weaning ages in the models. WF and WC produced the lowest AIC (Akaike Information Criterion) and least fractions of error variance components in multi-traits analysis, respectively. The fractions of variances due to diverse weaning age and the weaning age correlations among ADGs of different stages (when no overlapping allowed) by WC ranged from 0.09 to 0.35 and from -0.03 to 0.44, respectively. The maximum weaning age effects and optimal back fat thicknesses were attained at weaning ages of 27 to 32 d. With the exception of DGBW, the effects of weaning age on the ADGs increased (ranging from 1.50 g/d to 7.14 g/d) with increased weaning age. In addition, BFAT was reduced by 0.106 mm per increased day in weaning age. In conclusion, WC produced reasonable weaning age correlations, and improved the fitness of the model. Weaning age was one of crucial factors (comparable with heritability) influencing growth performance in Berkshire pigs. Further, these studies suggest that increasing weaning age up to 32 d can be an effective management strategy to improve growth performance. However, additional investigations of the costs and losses related to extension of the suckling period and on the extended range of weaning age are necessary to determine the productivity and safety of this practice in a commercial herd and production system.