• BMB Reports
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• v.48 no.7
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• pp.407-412
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• 2015

The 12 kDa FK506-binding protein (FK506BP12), an immunosuppressor, modulates T cell activation via calcineurin inhibition. In this study, we investigated the ability of PEP-1-FK506BP12, consisting of FK506BP12 fused to the protein transduction domain PEP-1 peptide, to suppress catabolic responses in primary human chondrocytes and in a mouse carrageenan-induced paw arthritis model. Western blotting and immunofluorescence analysis showed that PEP-1-FK506BP12 efficiently penetrated chondrocytes and cartilage explants. In interleukin-1β (IL-1β)-treated chondrocytes, PEP-1-FK506BP12 significantly suppressed the expression of catabolic enzymes, including matrix metalloproteinases (MMPs)-1, -3, and -13 in addition to cyclooxygenase-2, at both the mRNA and protein levels, whereas FK506BP12 alone did not. In addition, PEP-1-FK506BP12 decreased IL-1β-induced phosphorylation of the mitogen-activated protein kinase (MAPK) complex (p38, JNK, and ERK) and the inhibitor kappa B alpha. In the mouse model of carrageenan-induced paw arthritis, PEP-1-FK506BP12 suppressed both carrageenan-induced MMP-13 production and paw inflammation. PEP-1-FK506BP12 may have therapeutic potential in the alleviation of OA progression. [BMB Reports 2015; 48(7): 407-412]

• BMB Reports
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• v.46 no.12
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• pp.594-599
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• 2013

The anti-inflammatory activity of eriodictyol and its mode of action were investigated. Eriodictyol suppressed tumor necrosis factor (mTNF)-${\alpha}$, inducible nitric oxide synthase (miNOS), interleukin (mIL)-6, macrophage inflammatory protein (mMIP)-1, and mMIP-2 cytokine release in LPS-stimulated macrophages. We found that the anti-inflammatory cascade of eriodictyol is mediated through the Toll-like Receptor (TLR)4/CD14, p38 mitogen-activated protein kinases (MAPK), extracellular-signal-regulated kinase (ERK), Jun-N terminal kinase (JNK), and cyclooxygenase (COX)-2 pathway. Fluorescence quenching and saturation-transfer difference (STD) NMR experiments showed that eriodictyol exhibits good binding affinity to JNK, $8.79{\times}10^5M^{-1}$. Based on a docking study, we propose a model of eriodictyol and JNK binding, in which eriodictyol forms 3 hydrogen bonds with the side chains of Lys55, Met111, and Asp169 in JNK, and in which the hydroxyl groups of the B ring play key roles in binding interactions with JNK. Therefore, eriodictyol may be a potent anti-inflammatory inhibitor of JNK.

• Journal of Biosystems Engineering
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• v.30 no.6 s.113
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• pp.366-372
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• 2005

The objective of this study was to evaluate the bump crossing and loading stability of a proto-type mini-forwarder under development. The evaluation was performed by computer simulation using a multi-body dynamic analysis program, Recur- Dyn 5.21. The proto-type was modeled and its properties such as mass, mass center, and mass moment of inertia were determined using 3D CAD modeler, Solid Edge 8.0. The $\%$ errors of masses, mass center, mass moment of inertia, and vertical motion of the model were within less than $10\%$ and the model's behavior agreed relatively well with those of the proto-type when traversing over a rectangular bump. Using the validated model, bump crossing of the proto-type was simulated and the loading limit was determined. It was found that effects of the shapes of bump on the bump crossing performance was insignificant within the practical heights of bumps. Stability of bump crossing increased with loading. However, loading of longer logs than 2.7 m made the crossing unstable because the ends of logs contacted ground when traversing over the bump. The maximum loading capacity of the proto-type was estimated to be 7.8 kN of 2.7 m long logs.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.3B
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• pp.224-231
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• 2006

The location information of wired 112, 119 emergency call is provided immediately by subscriber database of KT. But emergency call made by mobile phone should be ask location information to mobile network. This paper proposes the network protocol for mobile emergency service refer to TIA/EIA/J-STD-036-A with reviews about technical issues, legacy factors and related researches. The mobile emergency service is divided to mobile emergency rescue service and mobile emergency alert service. The network reference model for mobile emergency rescue service is released in domestic sector. In this paper, the interfaces between modules of the network reference model, and service scenarios, message flows are defined. Supplement to mobile emergency rescue service, the network reference model, interfaces and message flows for mobile emergency alert service are developed.

• The Journal of Information Technology
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• v.6 no.1
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• pp.85-105
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• 2003

The study revealed that the companies are still reluctant to stop using document-based payment methods although they are aware the use of electronic payment system would reduce express and save time. Considering problems that are suggested in the conventional payment method, more companies will introduce and utilize the electronic payment system. Moreover, as the refined electronic payment system is essential in electronic trade, active studies on this field would greatly contribute to the development of electronic payment system. The prevailing settlement of international trade still relies on trading documents while the legal issues are not finalized for electronic bill of lading (B/L) and electronic bill. This research purpose on comparing some e-trading models in character and presenting the obstacles of e-trading activation and the solutions. e-trading models this research has studied are BOLERO, TradeCard, electronic L/C etc. Comparing characteristic points of the e-trading model in this article are as follows; 1)Access ways as a global e-trading model, 2)Structural and Functional characteristic, 3)Role as a global e-trading model, 5)Legal and Application issues in practice, 6)Security issues for Technology. But Further studies on this subject would be needed.

• Journal of the Korean Institute of Gas
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• v.6 no.1 s.17
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• pp.1-9
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• 2002

This paper presents simple models for flow and the PIG dynamics when it passes through a $90^{\circ}$ curved section of pipeline. The simulation has been done with two different operational boundary conditions. The solution fur non-linear hyperbolic partial equations for flow is given by using MOC. The Runge-Kuta method is used to solve the initial condition equation fur flow and the PIG dynamics equation. The simulation results show that the proposed model and solution can be used fur estimating the PIG dynamics when the pig runs in the pipeline including curved section. In this paper, dynamic modeling and its analysis for the PIG flow through $90^{\circ}$ curved pipe with compressible and unsteady flow are studied. The PIG dynamics model is derived by using Lagrange equation under assumption that it passes through 3 different sections in the curved pipeline such that it moves into, inside and out of the curved section. The downstream and up stream flow dynamics including the curved sections are solved using MOC. The effectiveness of the derived mathematical models is estimated by simulation results fur a low pressure natural gas pipeline including downward and upward curved sections. The simulation results show that the proposed model and solution can be used for estimating the PIG dynamics when we pig the pipeline including curved section.

• Nuclear Engineering and Technology
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• v.53 no.7
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• pp.2364-2370
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• 2021

The ⁿMCP (Neutron sensitive microchannel plate) combined with advanced readout electronics is widely used in energy selective neutron imaging because of its good spatial and timing resolution. Neutron detection efficiency is a crucial parameter for the ⁿMCP. In this paper, a mathematical model based on the oblique cylindrical channel and elliptical pore was established to calculate the neutron absorption probability, the escape probability of charged particles and overall detection efficiency of ⁿMCP and analyze the effects of neutron incident position, pore diameter, wall thickness and bias angle. It was shown that when the doping concentration of the ⁿMCP was 10 mol%, the thickness of ⁿMCP was 0.6 mm, the detection efficiency could reach maximum value, about 24% for thermal neutrons if the pore diameter was 6 ㎛, the wall thickness was 2 ㎛ and the bias angle was 3 or 6°. The calculated results are of great significance for evaluating the detection efficiency of the ⁿMCP. In a subsequent companion paper, the mathematical model would be extended to the case of the spatial resolution and detection efficiency optimization of the coating ⁿMCP.

• Structural Engineering and Mechanics
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• v.85 no.2
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• pp.179-195
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• 2023

The performance of reinforced concrete (RC) beam specimens strengthened using a newly proposed Side Near Surface Mounted (S-NSM) technology was investigated experimentally in this work. In addition, analytical and nonlinear finite element (FE) modeling was exploited to forecast the performance of RC members reinforced with S-NSM utilizing steel bars. Five (one control and four strengthened) RC beams were evaluated for flexural performance under static loading conditions employing four-point bending loads. Experimental variables comprise different S-NSM reinforcement ratios. The constitutive models were applied for simulating the non-linear material characteristics of used concrete, major, and strengthening reinforcements. The failure load and mode, yield and ultimate strengths, deflection, strain, cracking behavior as well as ductility of the beams were evaluated and discussed. To cope with the flexural behavior of the tested beams, a 3D non-linear FE model was simulated. In parametric investigations, the influence of S-NSM reinforcement, the efficacy of the S-NSM procedure, and the structural response ductility are examined. The experimental, numerical, and analytical outcomes show good agreement. The results revealed a significant increase in yield and ultimate strengths as well as improved failure modes.

• Korean Medical Education Review
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• v.25 no.3
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• pp.273-284
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• 2023

According to the World Health Organization, for medical schools to fulfill their obligation of social accountability, it is necessary for medical education, research, and service areas to ref lect the healthcare system's relevance, quality, cost-effectiveness, and equity. This study utilized Boelen and Heck's (1995) social accountability grid model to analyze the degree to which the Accreditation Standards of Korean Institute of Medical Education and Evaluation 2019 (ASK2019) standards apply the World Federation for Medical Education's (WFME) standards. The social accountability characteristics of the former were compared to those of the WFME, the Liaison Committee on Medical Education, and the Australian Medical Council. Experts with experience and certification in medical education and evaluation classified the ASK2019 standards according to the grid model, evaluated social accountability perspectives, and categorized them according to the process, content, and outcome. Of the 92 standards, 61 (66.30%) were selected as social accountability standards; these encompassed all areas. There was a particular focus on outcome-related areas, such as "mission and outcomes," "student assessment," "educational evaluation," and "continuous improvement." Education and quality were the most common (33, 54.11%), followed by 18 standards related to education and relevance. However, the standards on cost effectiveness and equity corresponding to education, research, and service were significantly insufficient. As a result of classification using a logic model, many criteria were incorporated into the process, producing results similar to those of international accreditation institutions. Therefore, to fulfill medical schools' social accountability, it is necessary to develop cost effectiveness and equity standards with reference to grid models and expand them beyond education to include research and service areas. Developing content and outcome standards is also required.

• Membrane and Water Treatment
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• v.14 no.4
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• pp.163-173
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• 2023

The presence of high amounts of organic and inorganic contaminants in textile wastewater is a major environmental concern. Therefore, the treatment of textile wastewater is an urgent issue to save the aquatic environment. The disposal of large quantities of untreated textile wastewater into inland water bodies can cause serious water pollution. In this study, synthetic dye wastewater samples were prepared using orange dye in the laboratory. The synthetic samples were then treated by a batch adsorption process using the prepared activated carbon (AC) from date pits. The wastewater parameters studied were the pH, total dissolved solids (TDS), total suspended solids (TSS), electrical conductivity (EC) and salinity. The activated adsorption process showed that the maximum removal efficiencies of electric conductivity (EC), salinity, TDS and TSS were 65%, 92%, 89% and 90%, respectively. The removal efficiencies were proportional to the increase in contact time (30-120 min) and AC adsorbent dose (1, 3 and 5 g/L). The adsorption profile indicates that 5 g/L of adsorbent delivers better results for TDS, EC, TSS and salinity at contact time of 120 min. The adsorption characteristics are better suited to the pseudo-second-order kinetic model than to the pseudo-first-order kinetic model. The Langmuir and Freundlich isotherms were well suited for describing the adsorption or contact behavior of EC and TSS within the studied system.