• Journal of Pharmaceutical Investigation
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• v.36 no.1
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• pp.23-29
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• 2006

A rapid, selective and sensitive reversed-phase HPLC method for the determination of promethazine in human serum was developed, validated, and applied to the pharmacokinetic study of promethazine. Promethazine and internal standard, chlorpromazine, were extracted from human serum by liquid-liquid extraction with n-hexane containing 0.8% isopropanol and analyzed on a Capcell Pak CN column with the mobile phase of acetonitrile-0.2 M potassium dihydrogen phosphate (42:58, v/v, adjusted to pH 6.0 with 1 M NaOH). Detection wavelength of 251 nm and flow rate of 0.9 mL/min were fixed for the study. The assay robustness for the changes of mobile phase pH, organic solvent content, and flow rate was confirmed by $3^{3}$ factorial design using a fixed promethazine concentration (10 ng/mL) with respect to its peak area and retention time. In addition, the ruggedness of this method was investigated at three different laboratories using same quality control (QC) samples. This method showed linear response over the concentration range of 1-40 ng/mL with correlation coefficients greater than 0.999. The lower limit of quantification using 1 mL of serum was 1 ng/mL, which was sensitive enough for pharmacokinetic studies. The overall accuracy of the quality control samples ranged from 96.15 to 105.40% for promethazine with overall precision (% C.V.) being 6.70-11.22%. The relative mean recovery of promethazine for human serum was 63.54%. Stability (freeze-thaw and short-term) studies showed that promethazine was stable during storage, or during the assay procedure in human serum. However, the storage at $-80^{\circ}C$ for 4 weeks showed that promethazine was not stable. Extracted serum sample and stock solution were not allowed to stand at ambient temperature for 12 hr prior to injection. The peak area and retention time of promethazine were not significantly affected by the changes of mobile phase pH, organic solvent content, and flow rate under the conditions studied. This method showed good ruggedness (within 15% C.V.) and was successfully used for the analysis of promethazine in human serum samples for the pharmacokinetic studies of orally administered Himazin tablet (25 mg as promethazine hydrochloride) at three different laboratories, demonstrating the suitability of the method.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.12 no.5
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• pp.810-816
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• 2001

This paper proposes a Truncated Type-II Hybrid ARQ scheme using an adaptive modulation system to achieve high throughput data transmission systems for mobile communication systems. In this paper, the adaptive modulation system analyzed in Nakagami (m-distribution) fading channel environment. The adaptive modulation system controls the modulation level and symbol rate according to the Nakagami fading parameter(m). When the received $E_bN_0$ is high or the Nakagami fading parameter m is high, the propose system selects higher modulation level and higher symbol rate to increase throughput. On the other hand, this system selects lower modulation level and lower symbol rate to prevent throughput performance degradation when the received $E_bN_0$ is low. The modulation method have been adopted QPSK(Quadrature Phase Shift Keying), 16 QAM(Quadrature Amplitude Modulation), 64 QAM, 256 QAM. Therefore, Adaptive Modulation Systems with Truncated Type-II Hybrid ARQ Scheme is proper for mobile and radio for mobile and radio data communication system that require high reliability and delay-limited applications.

• Journal of Korea Multimedia Society
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• v.13 no.3
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• pp.349-358
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• 2010

Adaptability is an important issue in video streaming over mobile environments, since the clients may request videos with great differences in their workload. In this paper, we propose the issues in limited bandwidth scheduling for efficient MPEG-4 video stream transmission over a mobile or wireless network. In the phase of admission control, the amount of bandwidth allocated to serve a video request is the mean bandwidth requirement of its requested video. The dynamic allocation of bandwidth in the phase of scheduling depends on the playback buffer levels of the clients with an objective to make it more adaptive to the playback situation of individual clients. In the proposed RTA scheduling protocol, more bandwidth may be allocated temporarily to the client whose buffer level is low. By employing the buffer level based scheduling policy, this protocol attempts to maximize the real-time performance of individual playback while minimizing the impact of transient overloading. Extensive simulation experiments have been performed to investigate the performance characteristics of the RTA protocol as comparing with BSBA protocol. This RTA protocol shows the better performance by transferring more frames than BSBA protocol.Computer simulations reveals that the standard deviation of the bit rate error of the proposed scheme is 50% less than that of the conventional method.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.1
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• pp.164-171
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• 2008

Adaptive equalizers are inevitable schemes in digital communication systems for compensating the transmission channel distortion. Additionally, to obtain the required BER(Bit Error Rate), the adaptive algorithms appropriate to the mobile communication channels are required. In this paper, we propose the NPDFE (Noise-Predictive Decision Feedback Equalizer) for communication systems performance improvement in mobile communication channels. The performance of the proposed NPDFE with QPSK (Quadrature Phase Shift Keying) is simulated under AWGN (Additive White Gaussian Noise), Ricean fading, ETSI (European Telecommunications Standards Institute) fading, and Rayleigh fading channels. The equalizers used in simulations are a LE (Linear Equalizer), a DFE (Decision Feedback Equalizer), and a NPDFE. Moreover, the equalizer performance criterion of the QPSK is the BER.

• Wind and Structures
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• v.34 no.3
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• pp.275-290
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• 2022

Mobile sand barriers are a new type sand-retaining structure that can be moved and arranged according to the engineering demands of sand control. When only used for sand trapping, mobile sand barriers could be arranged in single row. For the dual purposes of sand trapping and sand stabilization, four rows of mobile sand barriers can be arranged in a staggered form. To reveal the effect of plane layout, the included angle between sand barrier direction and wind direction on the characteristics of flow fields and the sand control laws of mobile sand barriers, numerical computations and wind tunnel tests were conducted. The results showed that inflows deflected after passing through staggered arrangement sand barriers due to changes in included angle, and the sand barrier combination exerted successive wind resistance and group blocking effects. An analysis of wind resistance efficiency revealed that the effective protection length of staggered arrangement sand barriers approximately ranged from the sand barrier to 10H on the leeward side (H is sand barrier height), and that the effective protection length of single row sand barriers roughly ranged from 1H on the windward side to 20H on the leeward side. The distribution of sand deposit indicated that the sand interception increased with increasing included angle in staggered arrangement. The wind-breaking and sand-trapping effects were optimal when included angle between sand barrier direction and wind direction is 60°-90°.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.24 no.1
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• pp.31-36
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• 2024

Recently, mobile apps that utilize AI technologies are increasing. In the personal mobile environment, performance degradation may occur during the training phase of large AI workload due to limitations in memory capacity. In this paper, we extract memory reference traces of AI workloads and analyze their characteristics. From this analysis, we observe that AI workloads can cause frequent storage access due to weak temporal locality and irregular popularity bias during memory write operations, which can degrade the performance of mobile devices. Based on this observation, we discuss ways to efficiently manage memory write operations of AI workloads using persistent memory-based swap devices. Through simulation experiments, we show that the system architecture proposed in this paper can improve the I/O time of mobile systems by more than 80%.

• Applied Chemistry for Engineering
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• v.10 no.5
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• pp.672-676
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• 1999

Adsorption isotherm is the most fundamental information in adsorption separation-process. Directly from the elution profile of a peak, the elution-curve method and frontal analysis(FA) were utilized to measure the adsorption isotherm in this work. Using RP-HPLC, sample and the buffer added in mobile phase were 5'-GMP and sodium phosphate, respectively. In this experimental condition, the retention time was decreased with increase in the injected mass of sample. And the front part of a peak was very stiff, so Langmuir adsorption isotherm might be applied. By the elution-curve method, the parameters used in the isotherm were obtained by optimization method, while by the FA, the concentrations of stationary phase were measured from the elution curve and the isotherm was determined by regression analysis. Compared to FA, the consumption of sample was less, and only one or two injections were needed by the elution-curve method. Finally, the effect of concentration of sodium phosphate in mobile phase on the parameters of the isotherm was investigated.

• Korean Journal of Clinical Pharmacy
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• v.15 no.1
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• pp.46-49
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• 2005

A simple HPLC method was employed for the determination of pentoxifylline in human serum. After addition of internal standard (IS, 50 uL of 3 ug/mL chloramphenicol methanol solution) into the serum sample, the drug and IS were extracted by dichloromethane. Following a 1-min vortex-mixing and a 15-min centrifugation at 3500 게m, the organic phase was transferred and evaporated to dryness under a vacuum. The residue was reconstituted with 120 ${\mu}L$ of mobile phase and 50 ${\mu}L$ was injected into C18 column with a mobile phase composed of 0.034 M phosphoric acid adjusted to pH 4 with 10 M NaOH and acetonitrile (75:25, v/v). The samples were detected using an ultraviolet detector at 273 nm. The method was simple, specific and validated with a limit of 10 ng/mL. Intra- and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification. The applicability of this method was evaluated by analysis of human serum after oral administration of a single 400 mg dose to 8 healthy subjects. The pharmacokinetic parameters for pentoxifylline in human subjects were calculated using WinNonlin program. As a result, $AUC_{t},\;C_{max},\;T_{max}$ and $t_{1/2}$ were $962.28{\pm}645.69\;ng{\cdot}/mL$, $132.82{\pm}42.05$ ng/mL, $2.06{\pm}2.68$ hr and $8.74{\pm}4.38$ hr, respectively. Based on the results, this validated method appears to be useful fur the pharmnacokinetic study of pentoxifylline in humans.

• Analytical Science and Technology
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• v.7 no.1
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• pp.25-31
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• 1994

As for analytes which did not represent the differences of the selectivity on the stationary and mobile phase, secondary chemical equilibrium theory was applied to study pH effects on the separation of alkylphenols. Mobile phase was consisted of an aqueous sodium carbonate-bicarbonate buffer and acetonitrile. The maximum selectivity for adjacent peak pairs was predicted from those values of $k^{\prime}_{HA}/k^{\prime}_{A-}$ and ${\Delta}pK$. The optimum pH determined by this method was 11.18 pH and solvent selectivity were considered at the same time to invoke the full range of selectivity effects possible for separations. Quaternary mixture composed of methanol, acetonitrile, tetrahydrofuran and water was adjusted to optimum pH 11.18. As the statistical simplex technique of an overlapping resolution map (ORM) was used to predict the optimized solvent system. The optimum solvent, which gives complete separation of alkylphenols, was determined as follws MeOH : ACN : THF = 14.4 : 81.8 : 2.8.

• Analytical Science and Technology
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• v.30 no.2
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• pp.57-67
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• 2017

This study was conducted to develop an analytical technique for determination of chlorite and chlorate concentrations in fresh-cut food and dried fish products by an ion chromatography/conductivity detection method using a hydroxide mobile phase. Deionized water was added to homogenized samples, which were then extracted by ultrasound extraction and centrifuged at high speed (8,500 rpm). Subsequently, a Sep-Pak tC18 cartridge was used to purify the supernatant. Chlorite and chlorate ions were separated using 20 mM KOH solution as the mobile phase and Dionex IonPac AS27 column as the stationary phase. Ethylenediamine was used as sample preservative and dibromoacetate was added to adjust for the disparity in extraction efficiencies between the food samples. The method detection limit) for chlorite and chlorate were estimated to be 0.2 mg/kg and 0.1 mg/kg, respectively, and the coefficient of determination ($r^2$) that denotes the linearity of their calibration curves were correspondingly measured to be 0.9973 and 0.9987. The recovery rate for each ion was 92.1 % and 96.3 %, with relative standard deviations of 7.47 % and 6.18 %, respectively. Although neither chlorite nor chlorate was detected in the food samples, the analytical technique developed in this study may potentially be used in the analysis of disinfected food products.