• Title/Summary/Keyword: mixture toxicity

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Swelling Behavior of Biodegradable Crosslinked Gel based on Poly(aspartic acid) and PEG-diepoxide

  • Min, Suk-Kee;Kim, Ji-Heung;Chung, Dong-Jun
    • Macromolecular Research
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    • v.9 no.3
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    • pp.143-149
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    • 2001
  • Poly(aspartic acid), PASP, is a biodegradable, water-soluble polymer and offers a biodegradable alternative to polycarboxylates and other non-degradable water-soluble polymers. PASP one of poly (amino acid)s, possesses carboxylic acid pendant group in its repeating unit, which can be used for various further modification purposes. In this study we prepared high molecular weight polysuccinimide, as the precursor polymer for PASP, by thermal polycondensation ofL-aspartic acid in the presence of phosphoric acid. The polysuccinimide was hydrolyzed with 0.1 N sodium hydroxide, and then acidified to give PASP. High water-absorbent gels were produced by thermal crosslinking of freeze-dried mixture of partially-neutralized PASP and different amount of low moi. wt. PEG-diepoxide compounds in aqueous medium. The swelling behavior of the prepared gels from different size and composition of crosslinking reagent in different media was investigated and the results were discussed. This PASP-based hydrogel materials possessing inherent biodegradability, potential non-toxicity and biocompatibility, is expected to be used as a substrate for various biomedical applications as well as a general purpose super-absorbent polymer.

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Extraction of Lipids from Microalgae Using Polar and Nonpolar Bi-solvent Systems (이성분 용매 추출에 의한 미세조류로 부터의 바이오디젤용 지질 분리)

  • Hong, Yeon-Ki;Kim, Jeong-Bae;Ng, K.Y. Simon
    • Journal of the Korean Solar Energy Society
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    • v.31 no.6
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    • pp.66-71
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    • 2011
  • Various single solvents were tested to find the effective solvent for the extraction of algae oil from wet-form Chlorella minutissima. In the case of single solvents, their extractabilities for algae oil were increased with their polarity because the water in wet algae cell is to form a solvent shell around the lipids. Based on these results, the wet-form algae samples were treated with a polar alcohol solvent and then a nonpolar solvent was added in algae residue. In the algae oil extraction by ethanol/n-hexane, total lipid contents were 40-50% and composition of triglyceride in extracted oil was 46.50%. Considering solvent toxicity of conventional solvent mixture such as chloroform and methanol for algae oil extraction, the ethanol/n-hexane system was identified as the effective one for the oil extraction from wet-form Chlorella minutissima.

An investigation of autoignition characteristics of kerosene by decomposed hydrogen peroxide (분해된 과산화수소를 이용한 케로신의 자연점화특성 조사)

  • Jo, Sung-Kwon;Kwon, Se-Jin
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • 2008.11a
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    • pp.397-400
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    • 2008
  • Traditional propellants which have a hypergolic characteristic have a high performance but also have disadvantages of toxicity and complex handling requirement. In order to replace these propellants, one of the alternatives is hydrogen peroxide which generates high temperature oxygen and water vapor after catalytic reaction. In this paper, autoignition characteristics of kerosene by decomposed hydrogen peroxide were investigated to perform fundamental research for designing a thruster using hydrogen peroxide and kerosene propellants. Contraction ratio, whether flame holder exists or not, and feeding pressure of propellants were selected as variables. From the experiments for different mixture ratio, we confirmed the ignition stability is strongly affected by a feeding pressure of propellants.

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Effect of Ginsenosides on Bovine Liver Mitochondria Aldehyde Dehydrogenase Activity (인삼사포닌이 소의 간 미토콘드리아 ALDH 활성에 미치는 영향)

  • Kim, Sun-Jin;Lee, Hee-Bong;Joo, Chung-No
    • Journal of Ginseng Research
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    • v.18 no.1
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    • pp.10-16
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    • 1994
  • Effects of ginsenosides on the activities of bovine liver mitochondrial matrix ALDH and membrane bound ALDH were observed in vitro and it was found that both matrix and membrane bound ALDH were stimulated appreciably. The maximum activity for the matrix AkDH was found at the concentration of ginsenoside mixture being $10^{-7}$~$10^5$% and that for the membrane bound ALDH was at $10^{-6}$~$10^{-4}$%. It was also found that Km values of both ALDHS were lowered and their maximum velocity was increased. It was realized that the bovine liver mitochondrial matrix AkDH is Quite specific for the oxidation of low aliphatic aldehydes such as acetaldehyde and propionaldehyde. Therefore the increase of Vmax/Km value of the matrix ALDH in the presence of ginsenosides suggest that ginsenosides might stimulate the ALDH activity thereby resulting in the quick removal of harmful acetaldehyde from the liver to protect its toxicity.

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Effects of Extract Mixture (Yg-1) of Anti-Inflammatory Herbs on LPS-Induced Acute Inflammation in Macrophages and Rats (급성염증성 발열 모델에서의 항염증성 약재 혼합 추출물(YG-1)의 효과)

  • Song, In-Bong;Na, Ji-Young;Song, Kibbeum;Kim, Sokho;Lee, Ji-Hyun;Kwon, Young-Bae;Kim, Dae-Ki;Kim, Dae-Sung;Jo, Hyoung-Kwon;Kwon, Jungkee
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.44 no.4
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    • pp.497-505
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    • 2015
  • Traditional herbs, such as Lonicera japonica, Arctii Fructus, and Scutellariae Radix have been used as traditional drug due to their anti-inflammatory and anti-oxidant activities. The aim of this study was to investigate the anti-inflammatory effects of extract mixture (YG-1) in a model of lipopolysaccharide (LPS)-induced acute inflammation in both macrophage (RAW 264.7) cells and Sprague-Dawley rats. YG-1 did not show specific cellular toxicity in RAW 264.7 cells until a concentration of $100{\mu}g/mL$. YG-1 reduced various markers related to inflammation such as IL-$1{\beta}$, COX-2, and iNOS caused by LPS in RAW 264.7 cells. Consistent with these results, YG-1 exerted significant anti-inflammatory effects in an acute inflammation rat model. Acute fever and high concentration of IL-$1{\beta}$ in serum induced by LPS were significantly reduced by YG-1. These results were similar to flubiprofen, a commercial anti-inflammatory and anti-febrile drug. Therefore, these results indicate that YG-1 has beneficial effects on LPS-induced acute inflammation and suggest that YG-1 can serve as an effective anti-inflammatory and anti-febrile drug.

Improving Soil Washing/flushing Process using a Mixture of Organic/inorganic Extractant for Remediation of Cadmium (Cd) and Copper (Cu) Contaminated Soil (유/무기산 혼합용출제를 이용한 중금속(카드뮴,구리)오염토양 처리공법(soil washing/flushing) 개선에 대한 연구)

  • Lee, Hong-Kyun;Kim, Dong-Hyun;Jo, Young-Hoon;Do, Si-Hyun;Lee, Jong-Yeol;Kong, Sung-Ho
    • Journal of Soil and Groundwater Environment
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    • v.14 no.2
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    • pp.17-25
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    • 2009
  • The applicability of soil washing/flushing to treat a contaminated soil with cadmium (Cd) and copper (Cu) using a mixture of organic/inorganic extractant was evaluated in laboratory-scale batch and column tests. Citric acid was the effective extractant to remove Cd and Cu from the soil among various organic acids except EDTA. Carbonic acid was chosen as inorganic extractant which was not only low toxicity to environment, but also increasing soil permeability. Moreover, the optimum ratio of organic and inorganic extractant to remove Cd and Cu was 10 : 1, and this ratio of organic and inorganic extractant achieved removal efficiencies of Cd (46%) and Cu (39%), respectively. The increasing flow rate of extractant could explain the phenomena of soil packing when carbonic acid was used with organic extractant (i.e. EDTA and citric acid). Therefore, a mixture of organic extractant with inorganic extractant, especially carbonic acid, could resolve a problem of soil packing when this extractant was applied to a field application to remove Cd and Cu using in-situ soil flushing process.

Efficacy of an Integrated Biological Control of an Egg Parasitoid, Trichogramma evanescens Westwood, and Microbial Insecticide Against the Oriental Tobacco Budworm, Helicoverpa assulta (Guenée) Infesting Hot Pepper (고추를 가해하는 담배나방[Helicoverpa assulta (Guenée)]의 효과적 방제를 위한 쌀좀알벌(Trichogramma evanescens Westwood)과 미생물제제의 종합생물방제 효과)

  • Kim, Geun-Seob;Heo, Hye-Jung;Park, Jung-A;Yu, Yong-Suk;Hahm, Eun-Hye;Kang, Sung-Young;Kwon, Ki-Myeon;Lee, Keon-Hyung;Kim, Yong-Gyun
    • Korean journal of applied entomology
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    • v.47 no.4
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    • pp.435-445
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    • 2008
  • Due to internal feeding behavior, the oriental tobacco budworm, Helicoverpa assulta ($Guen\acute{e}e$), infesting hot pepper has been regarded to be effectively controlled by targeting egg and neonate larval stages just before entering the fruits. This study aimed to develop an efficient biological control method focusing on these susceptible stages of H. assulta. An egg parasitoid wasp, Trichogramma evanescens Westwood, was confirmed to parasitize the eggs of H. assulta. A mixture of Gram-positive soil bacterium, Bacillus thuringiensis subsp. kurstaki, and Gram-negative entomopathogenic bacterium, Xenorhabdus nematophila ANU101, could effectively kill neonate larvae of H. assulta. A sex pheromone trap monitored the occurrence of field H. assulta adults. The microbial insecticide mixture was proved to give no detrimental effects on immature development and adult survival of the wasp by both feeding and contact toxicity tests. A combined treatment of egg parasitoid and microbial pesticide was applied to hot pepper fields infested by H. assulta. The mixture treatment of both biological control agents significantly decreased the fruit damage, which was comparable to the chemical insecticide treatment, though either single biological control agent did not show any significant control efficacy. This study also provides morphological and genetic characters of T. evanescens.

Environmental Impact Assessment of Different Concrete Mixture Proportions according to Domestic Region and Season (국내의 지역 및 계절에 따른 콘크리트 배합별 환경영향평가)

  • Seo, Eun-A;Yang, Keun-Hyeok;Jung, Yeon-Back
    • Journal of the Korea Concrete Institute
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    • v.26 no.3
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    • pp.239-245
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    • 2014
  • This study analyzed a comprehensive database including 6331 ready-mixed concrete plant mixtures to quantitatively assess the environmental impact of concrete under mixture proportions variable according to the domestic region and season. The environmental impact indicator includes global warming, photochemical oxidant creation, abiotic resource depletion, acidification, eutrophication and human toxicity, which are determined from categorization, characterization, normalization and weighting process based on Korea lifecycle inventories. The determined environmental impact indicator was also normalized by concrete compressive strength ($f_{ck}$), which is defined as impact index, to calculate the environmental impact per unit strength of 1 MPa. The most common compressive strength of concrete used in the country is estimated to be 24 MPa and 27 MPa. For $f_{ct}$ of 24 MPa, the lowest environmental impact indicator is observed in Ulsan, whereas the highest region is Gwangju and Daegu. This difference according to domestic region is primarily resulted from by the replacement of different supplementary cementitious materials. Furthermore, the impact index of concrete with $f_{ck}$ of 24 MPa is higher by approximately 5% at wintertime than at summertime and standard season. The impact index gradually decreases with the increase of $f_{ck}$ up to 35 MPa, beyond which it remains constant.

Mechanical Properties of Recycled Powder mixing Concrete (재생미분말을 혼입한 콘크리트의 역학적 특성)

  • Lee, Seung-Hwan;Jung, Dae-Jin;Choi, Ik-Chang
    • Proceedings of the Korea Concrete Institute Conference
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    • 2008.04a
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    • pp.769-772
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    • 2008
  • The problem of disposing construction waste materials has become a national and social problem. Recycled powder generated in the process of making aggregate, and the recycled powder is land-filled in its entirety. Results of toxicity testing of recycled power show that it contains base-pair substituent mutagenicity. As recycled powder is disposed of as landfill, it can cause secondary contamination such as soil and underground water contamination. There has been very little research made on recycled powder. This study has examined the utilization of concrete mixture by using recycled powder in a mixture instead of cement and compared and analyzed the characteristics of dynamics and workability. This study has examined the application of recycled powder in concrete. Depending on the replacement rate and workability, test piece was manufactured using different mixing rate by CP, WCP, PCP. The CP was used to examine the physical property of concrete and characteristics its dynamics. The letters W of WCP and P of PCP are the initials of water and mixture. They were made using the standard mixing ratiosemphasizing the workability to determine the characteristic of dynamics of concrete based on the mixing ratio of recycled powder. With the increase in the replacement rate, CP had very little change in the strength. But with the decline of slump, the workability was not good. The result of manufacturing WCP and PCP using the standard mixing ratio showed that WCP had a drop in strength compared to the plain. PCP had almost the same value as the plain only when the replacement rate was 10%. When it was higher than that, a reduction in strength was observed.

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Evaluation of Susceptibility of Western Flower Thrips (Frankliniella occidentalis) and Garden Thrips (F. intonsa) to 51 Insecticides (꽃노랑총채벌레와 대만총채벌레에 대한 51종의 살충제 감수성 평가)

  • Cho, Sung Woo;Kyung, Yejin;Cho, Sun-Ran;Shin, Soeun;Jeong, Dae Hun;Kim, Sung Il;Park, Geun-Ho;Lee, Seung-Ju;Lee, Young-Su;Kim, Min-Ki;Jo, In-Jun;Koo, Hyun-Na;Kim, Hyun Kyung;Kim, Gil-Hah
    • Korean journal of applied entomology
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    • v.57 no.3
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    • pp.221-231
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    • 2018
  • The susceptibility of the western flower thrips, Frankliniella occidentalis and garden thrips, Frankliniella intonsa was evaluated using 51 commercial insecticides. 15 kinds of insecticides which showed more than 90% mortality against both thrips, F. occidentalis and F. intonsa was selected. Many active ingredients were misused and abused in commercial mixture formulation insecticides. Since the F. intonsa was more susceptible than F. occidentalis, it was considered that both thrips can be controlled by insecticides that showed insecticidal activity on the F. occidentalis. Lethal time ($LT_{50}$ and $LT_{95}$), systemic toxicity and residual toxicity of selected insecticides were compared. Both chlorpyrifos WP and chlorpyrifos + diflubenzuron WP revealed the fastest toxicity within 2 h ($LT_{95}$), while spinetoram WG revealed the slowest toxicity as 62.3 h ($LT_{95}$). Chlorfenapyr SC showed toxicity at foliar and drenching application while spinetoram WG was toxic only in foliar application. Chlorfenapyr SC showed residual effect at 3, 5, 7, 10, 15 days after treatment and both benfuracarb WG and chlorpyrifos WP showed residual effect at 3 days after treatment. As a result of treatment of selected insecticides for field population of F. occidentalis, the population collected from horticultural crops showed lower susceptibility than the population collected from vegetable crops.