• KSBB Journal
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• v.16 no.3
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• pp.237-240
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• 2001

Epithelial cell migration plays an important role in many physiological processes such as morphogenesis and wound healing, and cell mobility requires the release of the cell from its adhesion site. This is directed, at least in part, by limited proteolysis of matrix molecules by matrix metalloproteinases (MMPs). MMPs are zinc-dependent proteases produced by a variety of cell types, and have a fundamental role in tissue remodelling, tumour invasion and metastasis. In addition, the ability of cells to mediate fibrinolytic agent, plasmin. The purpose of this study was to test if vascular endothlial growth factor (VEGF) can regulate the production of MMPs and plasmin by keratinocyte cells. Supernatants from a human keratinocyte cell line grown in the presence or absence of VEGF (10ng/mL) produced ?2.5 fold increases in cell proliferation, and ?3.0 fold increses in MMP-2 and plasmin levels. Our results suggest that VEGF may modulate keratinocyte cell proliferating activity by increasing the abundance of MMP-2 and plasmin, and indicates a role for VEGF in the regulation of keratinocyte behaviour in wound healing and tissue remodelling.

• Journal of the Korean Geotechnical Society
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• v.15 no.6
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• pp.297-306
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• 1999

In this research, the frost heave mechanism of the weathered tuff soil sampled from the area tying between Ulanbator and Beijing was studied. The frost heave tests were carried maintaining the constant temperature at both upper$(+5^{\circ}C)\; and\; lower(-5^{\circ}C)$ ends of the sample. Here, main emphasis is given on variation of the freezing point depression with the variation of applied overburden pressure. The expansion of ice lens and migration of the pore water towards freezing front were observed in the test. It was found that with the increase in overburden pressure there is decrease in heave rate and increase in the absolute value of a segregation-freezing temperature. Hence the equation between segregation-freezing temperature and overburden pressure could be suggested. Also the water content of the samples at the frozen side was shown to be higher than those at the unfrozen side. Similarly, the water at warmer part of the frozen tuff was found much higher than that of the cooler part.

• Bulletin of the Korean Space Science Society
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• 2011.04a
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• pp.26.3-27
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• 2011

Formation of a steep plasma density gradient in the middle-latitude ionosphere during geomagnetic storms and the latitudinal migration of its location depending on the storm phase are suggested to be associated with the ionospheric signature of the plasmapause. We test this idea by using the satellite and ground observation data during the 11 April 2001 storm. The locations of the steep plasma density gradient identified by TOPEX/Poseidon (2001 LT) and DMSP (1800 and 2130 LT) satellites coincide with the ionospheric footprints of the plasmapause identified by the IMAGE satellite. This observation may support the dependence of the middle-latitude plasma density gradient location on the plasmapause motion, but does not explain why the steep density gradient whose morphology is largely different from the morphology of the middle-latitude ionization trough during quiet period is formed in association with the plasmapause. The ionospheric disturbances in the total electron content (TEC) maps shows that the steep TEC gradient is formed at the boundary of the positive ionospheric storm in low-middle latitudes and the negative ionospheric storm in middle-high latitudes. We interpret that the thermospheric neutral composition disturbance in the dayside is confined within the middle-high latitude ionospheric convection zone. The neutral composition latitudes and, therefore, the locations of the steep plasma density gradient coincide with the footprints of the plasmapause. The TEC maps show that the appearance of the steep plasma density gradient in the pre-midnight sector during the recovery phase is related to the co-rotation of the gradient that is created during the main phase.

• Journal of the Korean Geotechnical Society
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• v.28 no.5
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• pp.85-94
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• 2012

Recently, growing interests in frozen ground have stimulated us to advance fundamental theories and systematic researches on soil behavior under freezing conditions. Unlike the well-established soil mechanics theory, temperature variation and phase change of pore-water cause water migration to cold side, ground heaving, sharp increase in earth pressure, etc., which bring about serious problems in frozen geotechnical structures. Elasto-plastic mechanical constitutive model for frozen/unfrozen soil subjected to fully coupled THM phenomena is formulated based on a new stress variable that is continuous in frozen-unfrozen transitional regions. Numerical simulations are conducted to discuss numerical reliability and applicability of the developed constitutive model: one-dimensional heaving pressure, tri-axial compression test, and one-side freezing tests. The numerical results show that developed model can efficiently describe complex THM phenomena of frozen soil, and they can be utilized to analyze and design the geotechnical structures under freezing conditions, and predict their long-term behavior.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7223-7228
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• 2014

The MYH11 gene may be related to cell migration and adhesion, intracellular transport, and signal transduction. However, its relationship with prognosis is still uncertain. The aim of this study was to investigate correlations between MYH11 gene expression and prognosis in 58 patients with stage II and III colorectal cancer. Quantitative real-time polymerase chain reaction was performed in fresh CRC tissues to examine mRNA expression, and immunohistochemistry was performed with paraffin-embedded specimens for protein expression. On univariate analysis, MYH11 expression at both mRNA and protein levels, perineural invasion and lymphovascular invasion were related to disease-free survival (p<0.05; log-rank test). Cancers with lower MYH11 expression were more likely to have a poor prognosis. Otherwise, MYH11 expression was unrelated to patient clinicopathological features. On multivariate analysis, low MYH11 expression proved to be an independent adverse prognosticator (p<0.05). These findings show that MYH11 can contribute to predicting prognosis in stage II and III colorectal cancers.

• Geophysics and Geophysical Exploration
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• v.20 no.3
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• pp.129-136
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• 2017

3D seismic data processing methods such as full waveform inversion or reverse-time migration require 3D wave propagation modeling and heavy calculations. We compared efficiency and accuracy of a Xeon Phi coprocessor to those of a high-end server CPU using 3D frequency-domain wave propagation modeling. We adopted the OpenMP parallel programming to the time-domain finite difference algorithm by considering the characteristics of the Xeon Phi coprocessors. We applied the Fourier transform using a running-integration to obtain the frequency-domain wavefield. A numerical test on frequency-domain wavefield modeling was performed using the 3D SEG/EAGE salt velocity model. Consequently, we could obtain an accurate frequency-domain wavefield and attain a 1.44x speedup using the Xeon Phi coprocessor compared to the CPU.

• Advances in concrete construction
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• v.9 no.5
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• pp.449-457
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• 2020

The influence of subsequent curing on the performance of fly ash contained mortar under steam curing was studied. Mortar samples incorporated with different content (0%, 20%, 50% and 70%) of Class F fly ash under five typical subsequent curing conditions, including standard curing (ZS), water curing(ZW) under 25℃, oven-dry curing (ZD) under 60℃, frozen curing (ZF) under -10℃, and nature curing (ZN) exposed to outdoor environment were implemented. The unsteady chloride diffusion coefficient was measured by rapid chloride migration test (RCM) to analyze the influence of subsequent curing condition on the resistance to chloride penetration of fly ash contained mortar under steam curing. The compressive strength was measured to analyze the mechanical properties. Furthermore, the open porosity, mercury intrusion porosimetry (MIP), x-ray diffraction (XRD) and thermogravimetric analysis (TGA) were examined to investigate the pore characteristics and phase composition of mortar. The results indicate that the resistance to chloride ingress and compressive strength of steam-cured mortar decline with the increase of fly ash incorporated, regardless of the subsequent curing condition. Compared to ZS, ZD and ZF lead to poor resistance to chloride penetration, while ZW and ZN show better performance. Interestingly, under different fly ash contents, the declining order of compressive strength remains ZS>ZW>ZN>ZD>ZF. When the fly ash content is blow 50%, the open porosity grows with increase of fly ash, regardless of the curing conditions are diverse. However, if the replacement amount of fly ash exceeds a certain high proportion (70%), the value of open porosity tends to decrease. Moreover, the main phase composition of the mortar hydration products is similar under different curing conditions, but the declining order of the C-S-H gels and ettringite content is ZS>ZD>ZF. The addition of fly ash could increase the amount of harmless pores at early age.

• Journal of the Korea Institute of Building Construction
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• v.9 no.6
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• pp.71-78
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• 2009

The analysis of the effect of loading on chloride penetration into concrete is very important. In this study, we confirmed that the chloride penetration rates for plain and BFS concrete were increased by 47% and 89% under compressive stress, respectively. The diffusion coefficient of BFS concrete was lower than for conventional concrete with no BFS, no loads, and under stressed states. Therefore, BFS substitution plays an important role in the repression of chloride penetration even under compressive stress. Under compressive stress,the diffusion coefficient for BFS concrete was higher with increasing stress, and this was also the case for plain concrete. However, BFS concrete was strongly influenced by compressive stress in comparison to plain concrete. We investigated the effect of the difference of specific surfaces on the diffusion coefficient. As a result, the larger specific surface of BFS exhibited a lower diffusion coefficient. This tendency was most pronounced under the high stress conditions.

• Economic and Environmental Geology
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• v.29 no.3
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• pp.325-333
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• 1996

numerical model is developed to estimate gas flow in the landfill site. Darcy's law, the mass conservation law, and the ideal gas state equation are combined to compose the governing equation for the steady-state and transient-state gas flows. The finite element method (FEM) is used as the numerical solution scheme. Two-dimensional radial symmetric triangular ring element is used to discretize the simulation domain. The steady state model developed in this study is compared with AIRFLOW that is a commercial model developed by Hydrologic Inc. Mass balance test is performed on the transient gas flow simulation. The developed model is applied to analyze the gas extraction experiment performed by Daewoo Institute of Construction Technology at the Nanjido landfill in 1993. The developed model was registered at Korea Computer Program Protection Foundation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.2
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• pp.1461-1468
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• 2015

Mostly mine support(Rock bolt and Support) which is currently general for reinforcements of a large scale tunnel is applied, Some executing a reinforcement to Poor ground by cast-in-place shotcrete. However On domestic mine conditions that couldn't having every time after mine tunnel excavation, it couldn't ensure the field batch plant which is a fixed in an issue of economies and site security, constructing it by supply gets from shotcrete materials combined in neighborhood ready mixed concrete manufacturing plants. carried shotcrete in ready mixed concrete manufacturing plants as migration length and time are falling off in quality. But, it is difficult for construction quality control By quality control arbitrariness absence at on-scene. In the present study, carry out Laboratory Test by kinds and percentages of accelerating agent for evalution of Mechanical Property and Durability of Shotcrete.