• Title/Summary/Keyword: migration process

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Location of the umbilicus in Korean women and its changes after breast reconstruction with an ipsilateral pedicled rectus abdominis musculocutaneous flap

  • Oh, Sangho;Jeon, Hyojin;Son, Daegu
    • Archives of Plastic Surgery
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    • v.45 no.5
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    • pp.425-431
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    • 2018
  • Background The umbilicus makes an important contribution to the natural appearance of the abdomen. To date, studies on its position in Korean women are lacking, and no standards have been established. The purpose of this study was to investigate the position of umbilicus in Korean women and to review changes in its position after ipsilateral pedicled rectus abdominis musculocutaneous (IP-RAM) flap. Methods This research consisted of two studies. In first study, 100 females who visited the emergency department with gastroenteritis between 2007 and 2011 were included. In second study, 40 women who underwent IP-RAM flap in the same period were included. Using abdominal computed tomography, we measured the distance between xiphoid process and umbilicus, represented by value a, and the distance between umbilicus and symphysis pubis, represented by value b. Thus, the location of the umbilicus was represented by the ratio a/b. The data were analyzed using Pearson correlation test and paired t-test. Results In study 1, the mean value of a/b was 1.07. Pearson correlation test revealed a significant correlation between age and a/b. In study 2, the mean value of a/b was 1.16 in preoperative measurements and 1.01 in postoperative measurements. The paired t-test showed a significant difference between preoperative and postoperative measurements, indicating cephalic migration of the umbilicus after surgery. Conclusions The natural position of the umbilicus showed caudal migration with aging. Additionally, in a comparison of preoperative and postoperative measurements in patients who underwent IP-RAM flap, cephalic migration of the umbilicus was observed after surgery.

Investigation of Chemotactic Activities in Differentiated HL-60 Cells by a Time-lapse Videomicroscopic Assay

  • Jung, Yun-Jae;Woo, So-Youn;Ryu, Kyung-Ha;Jang, Myoung-Ho;Miyasaka, Masayuki;Seoh, Ju-Young
    • IMMUNE NETWORK
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    • v.6 no.2
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    • pp.76-85
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    • 2006
  • Background: Chemotaxis is one of the cardinal functions of leukocytes, which enables them to be recruited efficiently to the right place at the right time. Analyzing chemotactic activities is important not only for the study on leukocyte migration but also for many other applications including development of new drugs interfering with the chemotactic process. However, there are many technical limitations in the conventional in vitro chemotaxis assays. Here we applied a new optical assay to investigate chemotactic activities induced in differentiated HL-60 cells. Methods: HL-60 cells were stimulated with 0.8% dimethylformamide (DMF) for 4 days. The cells were analyzed for morphology, flow cytometry as well as chemotactic activities by a time-lapse videomicroscopic assay using a chemotactic microchamber bearing a fibronectin-coated cover slip and an etched silicon chip. Results: Videomicroscopic observation of the real cellular motions in a stable concentration gradient of chemokines demonstrated that HL-60 cells showed chemotaxis to inflammatory chemokines (CCL3, CCL5 and CXCL8) and also a homeostatic chemokine (CXCL12) after DFM-induced differentiation to granulocytic cells. The cells moved randomly at a speed of $6.99{\pm}1.24{\mu}m/min$ (n=100) in the absence of chemokine. Chemokine stimulation induced directional migration of differentiated HL-60 cells, while they still wandered very much and significantly increased the moving speeds. Conclusion: The locomotive patterns of DMF-stimulated HL-60 cells can be analyzed in detail throughout the course of chemotaxis by the use of a time-lapse videomicroscopic assay. DMF-stimulated HL-60 cells may provide a convenient in vitro model for chemotactic studies of neutrophils.

Legacy Migration Development Methodology for Construction of Web environment system (웹 환경 시스템 구축을 위한 레거시 마이그레이션 개발방법론)

  • Lee, Jun-Woong;Yang, Hae-Sool
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.8 no.6
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    • pp.1428-1442
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    • 2007
  • Nowadays, as IT environment is changing rapidly, traditional infra system such as hardware, software, and development methodology are changing as well. Legacy system has been filled with Intellectual property such as invested budget and development period for the time of IT is developing. Many countries around the world are having troubles with how to manage the legacy system. It is time to study on a development method and the implementation of supporting tool to reuse or process the legacy system. In this paper, it proves the definition, concept and also background of legacy system by showing real market and technology trend. Developed to handle the concrete development methodology, procedure and reference. We can get more profitability and productivity advance by reuse of legacy system and maintenance cost-saving through legacy migration.

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Design and Implementation of Tool Constructing Migration of Legacy System (레거시시스템의 마이그레이션을 위한 지원도구의 설계 및 구현)

  • Yang, Hae-Seung;Park, Pyung-Hyung;Yang, Hae-Sool
    • The KIPS Transactions:PartD
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    • v.14D no.7
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    • pp.763-772
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    • 2007
  • Due to increased software development cost, interest about the method and automated tool for reusing legacy system have been running high. Therefore, In this study, it proves the definition, concept and also background of legacy system by showing real market and technology trend. Automation tool is designed and developed to handle the concrete development methodology, procedure and reference. Also, we implemented the process that analyze the legacy system and extract, refine, store and reuse the candidate components by using LM(Legacy to Modern System) supporting tool presented in this paper. If LM supporting tool is applied to legacy system migration, we can expect cutting costs, shortening the developing period and succeeding the intellectual property by software re-engineering.

Extracts of Aster species Inhibit Invasive Phenotype and Motility of H-ras MCF10A Human Breast Epithelial Cells Possibly via Downregulation of MMP-2 and MMP-9

  • Ahn, Seong-Min;Lee, Kang-Ro;Moon, A-Ree
    • Biomolecules & Therapeutics
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    • v.10 no.4
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    • pp.240-245
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    • 2002
  • Cancer metastasis represents the most important cause of cancer death and antitumor agents that may inhibit this process have been extensively pursued. Invasion and metastasis of malignantly transformed cells involve degradation of the extracellular matrix (ECM) components by matrix metalloproteinases (MMP), especially MMP-2 and -9. We previously showed that H-ras-induced invasive phenotype may involve MMP-2, rather than MMP-9, in MCF10A cells. In the present study, we investigated the chemopreventive effect of Aster, a widely used culinary vegetable in Korea. We screened twelve extracts from three Aster species (Aster scaber, Aster oharai and Aster glehni) for the inhibitory effect on MMP activities of H-ras MCF10A human breast epithelial cells. All of the extracts tested in this study efficiently inhibited the gelatinolytic activities of MMP-2 and MMP-9. A more prominent inhibition was observed in MMP-2 activity compared to MMP-9. Out of twelve extracts, eight extracts showed>90% inhibition of MMP-2 activity in H-ras MCF10A cells while only one extract showed>90% inhibition of MMP-9 activity. We selected three extracts (AO-3, AG-3 and AS-EA) for further studies since they exerted a marked inhibition in the ratio of MMP-2 to MMP-9. Treatment with AO-3, AG-3 and AS-EA in H-ras MCF10A cells caused a significant inhibition of invasive phenotype and migration, proving a chemopreventive potential of these extracts. Taken together, our results demonstrate that extracts of Aster effectively inhibit invasion and migration of highly malignant human breast cells, possibly via downregulation of MMP-2 and MMP-9.

Computational analysis of cancer angiogenesis using two dimensional model (2차원 모델을 이용한 암의 혈관생성에 대한 수치적 연구)

  • Shim Eun Bo;Ko Hyung Jong;Deisboeck Thomas
    • Proceedings of the KSME Conference
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    • 2002.08a
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    • pp.709-710
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    • 2002
  • Cancer angiogenesis is simulated using a two dimensional model. Governing equation of angiogenesis is a TAE (Tumor angiogenesis factor) conservation equation in time and space. A stochastic process model is utilized to simulate vessel formation, proliferation, and migration to a cancer pellet. Numerical results are presented especially in case of growing cancer.

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Process Migration Facility in OSF/1 AD (OSF/1 AD 운영체제의 프로세스 이전 기법)

  • Jo, Il-Yeon;Lee, Jae-Gyeong;Kim, Hae-Jin
    • Electronics and Telecommunications Trends
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    • v.12 no.4 s.46
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    • pp.31-38
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    • 1997
  • OSF/1 AD는 여러 대의 워크스테이션을 연결한 클러스터링 시스템에서부터 인텔 파라곤(Paragon)과 같은 massively parallel(MPP) 시스템에 이르는 다양한 시스템 상에서 단일시스템 이미지를 효과적으로 제공하는 다중컴퓨터용 운영체제이다. 본 고에서는 OSF/1 AD 운영체제의 기본구조와 분산 시스템의 부하 분산 기능 구현의 핵심 요소인 프로세서 이전 기법의 구현 방법에 대하여 살펴보았다.

Effects of Human Capital on Regional Growth: Evidence from US County Data (인적자원이 지역경제성장에 미치는 효과: 미국 카운티 데이터를 이용한 실증연구)

  • Kim, Young-Bae
    • Journal of Digital Convergence
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    • v.11 no.2
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    • pp.71-78
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    • 2013
  • The purpose of the paper is to empirically investigate the role of human capital and labour market conditions in the growth process. To do so, cross-sectional data for 3062 counties across 50 states of the US. Firstly, findings from the empirical estimation suggest income convergence among US counties. Secondly, the stock of human capital appears to have the growth enhancing effect while education expenditures turn out to retard economic growth. Thirdly, it is found that the unemployment rate would have a negative association with regional growth whereas the net migration rate is likely to have a positive relationship with growth. Once the sample counties are divided into both the poor group and the rich group, finally, such main empirical results overall remain unchanged and statistically significant.

Case Study of Risk Management for Digital Resources (디지털 자원의 위험관리 사례연구)

  • Lee, Mi-Hwa
    • Journal of Information Management
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    • v.37 no.1
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    • pp.131-148
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    • 2006
  • This paper is to probe foreign cases about risk management and to develop a method for the risk management of the digital resources, This is under the perception that the risk management is necessary for digital archiving implementation. OCLC and Cornell University Library are the leading institutions in the area of risk management. They are the best examples because they make a decision about the risk management through the testing and experimentation. Based on case studies, identification of element of risk management process in our environment, the foundation of national center for risk management, and testing file format and migration program as practical plan of risk management for digital resources are suggested.

Proliferative and Synthetic Responses of Airway Smooth Muscle in Asthma (천식에서 기도평활근의 증식과 합성 반응에 대한 최신지견)

  • Shim, Jung Yeon
    • Clinical and Experimental Pediatrics
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    • v.48 no.6
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    • pp.580-587
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    • 2005
  • New evidence is emerging that airway smooth muscle(ASM) may act as an immunomodulatory cell by providing pro-inflammatory cytokines and chemokines, polypeptide growth factors, extracellular matrix proteins, cell adhesion receptors and co-stimulatory molecules. ASM can promote the formation of the interstitial extracellular matrix, and potentially contribute to the alterations within the extracellular matrix in asthma. In addition, extracellular matrix components can alter the proliferative, survival, and cytoskeletal synthetic function of ASM cells through integrin-directed signaling. Increased ASM mass is one of the most important features of the airway wall remodeling process in asthma. Three different mechanisms may contribute to the increased ASM mass : cell proliferation, increased migration and decreased rate of apoptosis. The major signaling pathways of cell proliferation activated by ASM mitogens are those dependent on extracellular signal-regulated kinase and phosphoinositide 3'-kinase. The key signaling mechanisms of cell migration have been identified as the p38 mitogen-activated protein kinase and the p21-activated kinase 1 pathways. ASM cells contain ${\beta}2$-adrenergic receptors and glucocorticoid receptors. They may represent a key target for ${\beta}2$-adrenergic receptor agonist/corticosteroid interactions which have antiproliferative activity against a broad spectrum of mitogens.