• Archives of Pharmacal Research
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• v.24 no.6
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• pp.601-606
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• 2001

A simple assay method of recombinant human epidermal growth factor (rhEGF) in a pharmaceutical preparation was studied and validated by capillary electrophoresis (CE) using micellar electrokinetic chromatography (MEKC) techniques. Factors affecting the migration behavior and separation performances of the peptide; type of buffers pH, butler concentration, and concentration of sodium dodecyl sulfates (SDS) were investigated to optimize the analytical performance. CE was performed using running buffers 50.0 mM borate (pH 8.5) containing 12.5 mM SDS at 20 $mutextrm{V}$ of the applied voltage. Calibration curves for the rhEGF showed good linearity (r>0.999) over the wide dynamic range from 1.25 to $100{\mu\textrm{g}}/ml$. Sample analysis was performed by using standard addition method to eliminate the matrix effects of dosage vehicle. This method is assumed to be useful for quality control (QC) of various forms of pharmaceutical products of the peptide.

• Geomechanics and Engineering
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• v.17 no.1
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• pp.19-30
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• 2019

Recent research on the behavior of silty sand tends to advocate the use of equivalent skeleton void ratio to characterize the density state of this type of soil. This paper presents an investigation to explore the physical meaning of the equivalent skeleton void ratio by means of DEM simulations for assemblies of coarse and fine particles under biaxial shear. The simulations reveal that the distribution pattern of fine particles in the soil skeleton plays a crucial role in the overall macroscopic response: The contractive response observed at the macro scale is mainly caused by the movement of fine particles out of the force chains whereas the dilative response is mainly associated with the migration of fine particles into the force chains. In an assembly of coarse and fine particles, neither all of the fine particles nor all of the coarse ones participate in the force chains to carry the external loads, and therefore a more reasonable definition for equivalent skeleton void ratio is put forward in which a new parameter d is introduced to take into account the fraction of coarse particles absent from the force chains.

• Corrosion Science and Technology
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• v.19 no.6
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• pp.281-287
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• 2020

Chloride ion is one of the most important corrosive agents in atmospheric corrosion, especially in marine environments. It has high adsorption rate and increases the conductivity of electrolytes. Since chloride ions affect the protective properties and the surface composition of the corrosion product, they increase the corrosion rate. A low level of chloride ions leads to uniform corrosion, whereas a high level of chloride ions may induce localized corrosion. However, higher solution temperatures tend to increase the corrosion rate by enhancing the migration of oxygen in the solution. This work focused on the effect of NaCl concentration and temperature on galvanic corrosion between A516Gr.55 carbon steel and AA7075T6 aluminum alloys. When AA7075T6 aluminum alloy was galvanically coupled to A516Gr.55 carbon steel, AA7075T6 was severely corroded regardless of NaCl concentration and solution temperature, unlike the corrosion properties of single specimen. The combined effect of surface treatment involving carbon steel and aluminum alloy on corrosion behavior was also discussed.

• Nuclear Engineering and Technology
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• v.54 no.12
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• pp.4474-4480
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• 2022

Deep geological disposal using a multibarrier system is a promising solution for treating high-level radioactive (HLRW) waste. The HLRW canister represents the first barrier for the migration of radionuclides into the biosphere, therefore, the corrosion behavior of canister materials is of significance. In this study, the electrochemical behaviors of SS316L, Ti-Gr.2, Alloy 22, and Cu in naturally aerated KAERI underground research tunnel (KURT) groundwater solutions were examined. The corrosion potential, current, and impedance spectra of the test materials were recorded using electrochemical methods. According to polarization and impedance measurements, Cu exhibits relatively higher corrosion rates and a lower corrosion resistance ability than those exhibited by the other materials in the given groundwater condition. In the anodic dissolution tests, SS316L exposed to the groundwater solution exhibited the most uniform corrosion, as indicated by its surface roughness. This phenomenon could be attributed to the extremely low concentration of chloride ions in KURT groundwater.

• International Journal of Computer Science & Network Security
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• v.24 no.4
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• pp.147-154
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• 2024

The continuous increase in urban population due to migration of mases from rural areas to big cities has set urban water supply under serious stress. Urban water resources face scarcity of available water quantity, which ultimately effects the water supply. It is high time to address this challenging problem by taking appropriate measures for the improvement of water utility services linked with better understanding of demand side management (DSM), which leads to an effective state of water supply governance. We propose a dynamic framework for preventive DSM that results in optimization of water resource management. This paper uses Agent Based Modeling (ABM) with Digital Twin (DT) to model water consumption behavior of a population and consequently forecast water demand. DT creates a digital clone of the system using physical model, sensors, and data analytics to integrate multi-physical quantities. By doing so, the proposed model replicates the physical settings to perform the remote monitoring and controlling jobs on the digital format, whilst offering support in decision making to the relevant authorities.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.29 no.4
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• pp.527-536
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• 1996

The patterns of diel horizontal migration (DHM) of 7 copepod species are compared as part of a general investigation of the zooplankton adaptations to the surf zone habitats. In a sandy shore surf zone of Yongil Bay, 3 sites such as the bottom and surface of 1 m water depth and water's edge are sampled with a sledge net(n=108). The surf zone copepod assemblage is dominated by 7 species; Acartia hudsonica, Fseudodiaptomus marinus, Paracalanus indicus, Calanus sinicus, Oithona similis, Sinocalanus tenellus and Labidocera bipinnata. Threefold variations in copepod abundance are observed within a diel cycle. Abundances of 7 dominant species and total copepods captured in the surface exhibit significant diel differences, but those taken in the bottom are not significantly affected by diel period. It is shown that about $90\%$ of the surf zone copepods performed DHM. The nocturnal high densities of copepods occurred for a neap tide when the offshore winds prevailed, suggesting the animals' ability for horizontal orientation and an active locomotion without invoking passive transportation by currents. Photoreactive behavior of copepods triggered by relative changes in light intensity may be a primary factor inducing DHM by aggregating in the surf zone during the night and spreading out at day; then copepods may reduce encounters with visual predators. In A. hudsonica, ontogenetic variations in timings of DHM are evident. Such variations are likely to minimize intraspecific competition for diets. Data on shoreward migration of copepods indicate that A. hudsonica, P. indicus, O. similis and S. tenellus can maintain swimming velocities of about $20m\;h^{-1}$ for durations of more than an hour. Our observations of strong diel difference in abundances point out the need for both day and night samplings in surf zone habitats, if the importance of these habitats to planktonic copepods are to be fully understood.

• Progress in Medical Physics
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• v.20 no.3
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• pp.119-124
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• 2009

Stents are frequently used throughout the human body. They keep pathways open in vascular or nonvascular duct for a long time. Therefore its stability is very important factor. In recent years, aconsiderable amount of research has been carried out in order to estimate mechanical properties of the stent such as expansion pressure behavior, radial recoil and longitudinal recoil using FEM (Finite element analyses). However, published works on simulation of stent fatigue behavior using FEM are relatively rare. In this paper, a nonlinear finite-element methodwas employed to analyses the compression of a stent using external pressure and fatigue behavior. Finite element analyses for the stent system were performed using NASTRAN FX. In conclusion this paper shows how the stent is behaved in the body, and its fatigue behavior.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2008.06a
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• pp.546-546
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• 2008

Copper (Cu) Chemical mechanical polishing (CMP) has been an essential process for Cu wifing of DRAM and NAND flash memory beyond 45nm. Copper has been employed as ideal material for interconnect and metal line due to the low resistivity and high resistant to electro-migration. Damascene process is currently used in conjunction with CMP in the fabrication of multi-level copper interconnects for advanced logic and memory devices. Cu CMP involves removal of material by the combination of chemical and mechanical action. Chemicals in slurry aid in material removal by modifying the surface film while abrasion between the particles, pad, and the modified film facilitates mechanical removal. In our research, we emphasized on the role of chemical effect of slurry on Cu CMP, especially on the effect of amine functional group on removal rate selectivity between Cu and Tantalum-nitride (TaN) film. We investigated the two different kinds of complexing agent both with amine functional group. On the one hand, Polyacrylamide as a polymer affected the stability of abrasive, viscosity of slurry and the corrosion current of copper film especially at high concentration. At higher concentration, the aggregation of abrasive particles was suppressed by the steric effect of PAM, thus showed higher fraction of small particle distribution. It also showed a fluctuation behavior of the viscosity of slurry at high shear rate due to transformation of polymer chain. Also, because of forming thick passivation layer on the surface of Cu film, the diffusion of oxidant to the Cu surface was inhibited; therefore, the corrosion current with 0.7wt% PAM was smaller than that without PAM. the polishing rate of Cu film slightly increased up to 0.3wt%, then decreased with increasing of PAM concentration. On the contrary, the polishing rate of TaN film was strongly suppressed and saturated with increasing of PAM concentration at 0.3wt%. We also studied the electrostatic interaction between abrasive particle and Cu/TaN film with different PAM concentration. On the other hand, amino-methyl-propanol (AMP) as a single molecule does not affect the stability, rheological and corrosion behavior of the slurry as the polymer PAM. The polishing behavior of TaN film and selectivity with AMP appeared the similar trend to the slurry with PAM. The polishing behavior of Cu film with AMP, however, was quite different with that of PAM. We assume this difference was originated from different compactness of surface passivation layer on the Cu film under the same concentration due to the different molecular weight of PAM and AMP.

• Journal of the Korean Institute of Landscape Architecture
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• v.51 no.3
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• pp.122-138
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• 2023

Today, fishing villages are on the verge of extinction due to severe aging within the population and outward migration. Recent projects and studies targeting fishing villages viewed the fishing villages from an outsider-centered perspective, without a local-centered understanding of the village as a daily living space. Therefore, to understand the settlement environment of fishing villages, this study analyzed empirical data on the usage behavior of fishing village residents to gain insight into the characteristics of the outdoor space uses of residents in fishing villages. In this regard, a face-to-face survey was conducted among residents, and a village map drawn by the villagers showedthe spatial perception of the villagers. Empirical data on the behavior of fishing villagers using the village space was collected and analyzed through GPS. The study results suggested that residents of fishing villages tend to focus on productive activities, such as fishing, leading to a lack of awareness of other leisure activities and spaces. This monotonous pattern of space utilization within the village appears to stem from an absolute lack of available facilities within the target area. Therefore, in future village regeneration projects aimed at improving the quality of life for residents in fishing villages, it is essential to consider the residents' perception and utilization of space as a priority. The results of this study can be considered valuable foundational data for understanding the utilization of spaces within fishing villages and can be effectively utilized in planning initiatives to enhance quality of life.

• Korean Journal of Social Welfare
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• v.62 no.3
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• pp.163-191
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• 2010

The purpose of this study is to explore the factors affecting the welfare needs of the rural marriage migrant females. A survey was conducted on 300 rural marriage migration females using probability sampling and for the analysis stepwise regression was used. The major findings of this study can be summarized as follows. The welfare needs of counselling on husband' behavior problem were higher in cases of worse mental health, better physical health, younger age and lower participation in the meetings with her fellow countrymen. The welfare needs on the children raising and education were relatively higher among the migrant females from Vietnam and younger age. The needs on the job skills training were lower in cases of the migrant females from Philippines, China(the Chinese) and were higher in cases of lower level of family understanding. The welfare needs on the job placement were higher among older and lower community affinity, and were lower in cases of the migrant females from Philippines. The results suggest that the welfare services should be differently provided to the migrant females in reflection of the age, education level, nationality and community resources. Further, the mental health screening test and treatment services for migrant females are needed since the welfare needs increase when the migration females have worse mental health condition.