• Title/Summary/Keyword: micro-spike

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Micro-tissue collecting tool for diagnosis of micro-spike biopsy (마이크로 스파이크로 채취한 조직의 진단을 위한 미세 조직회수도구)

  • Jeong, Hyo-Young;Koo, Kyo-In;Lee, Sang-Min;Ban, Jae-Won;Park, Ho-Soo;Bang, Seoung-Min;Song, Si-Young;Cho, Dong-Il Dan
    • Journal of Sensor Science and Technology
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    • v.18 no.2
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    • pp.122-127
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    • 2009
  • We have developed and reported several micro-spikes for minimally invasive biopsy. In this paper, a micro-tissue collecting tool for tissue diagnosis extracted by micro-spike is presented. Using proposed polydimethy-siloxane (PDMS) micro-tissue collecting tool, which has a negative micro-spike structure in a porous chamber, the extracted tissue in a micro-spike is effectively detached. The gastro-intestinal tissue of a pig is extracted in an in vivo environment, and then it is detached from a micro-spike using the PDMS micro-tissue collecting tool. A fine clinical picture of the detached tissue is acquired.

Development of Diagnosis Protocol for Micro-spike Biopsy Using Paraffin-based Tissue Collecting tool (파라핀 기반의 조직회수도구를 사용한 채취 조직의 진단 프로토콜 개발)

  • Jeong, Hyo-Young;Koo, Kyo-In;Lee, Sang-Min;Park, Ho-Soo;Hong, Suk-Jun;Bang, Seoung-Min;Song, Si-Young;Cho, Dong-Il
    • Journal of Biomedical Engineering Research
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    • v.31 no.3
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    • pp.234-239
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    • 2010
  • We have developed and reported several micro-spikes for minimally invasive biopsy. This paper presents a diagnosis protocol for micro-spike biopsy using paraffin-based tissue collecting tool. Using the proposed tissue collecting tool, which has a negative micro-spike structure in a porous chamber, the biopsied tissue in a micro-spike is effectively detached. The proposed diagnosis protocol prevents the loss of tissues in a paraffin embedding and sectioning process. Hence, it is compatible with conventional histopathology without additional reagents and processes. The gastro-intestinal tissue of a pig is biopsied in an in vivo environment, and then it is detached from a micro-spike using the paraffin-based tissue collecting tool. A histopathological photomicrograph of the detached tissue is acquired with the proposed diagnosis protocol. The acquired image offers clinical quality. This result shows that the paraffin-based tissue collecting tool is applicable to the medical practice.

Controlled Surface Functionalities of metals using Femtosecond Laser-induced Nano- and Micro-scale Surface Structures (펨토초 레이저 유도 나노 및 마이크로 구조물을 활용한 금속 표면 기능성 제어)

  • Taehoon Park;Hyo Soo Lee;Hai Joong Lee;Taek Yong Hwang
    • Design & Manufacturing
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    • v.17 no.2
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    • pp.55-61
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    • 2023
  • With femtosecond (fs) laser pulse irradiation on metals, various types of nano- and micro-scale structures can be naturally induced at the surface through laser-matter interaction. Two notable structures are laser-induced periodic surface structures (LIPSSs) and cone/spike structures, which are known to significantly modify the optical and physical properties of metal surfaces. In this work, we irradiate fs laser pulses onto various types of metals, cold-rolled steel, pickled & oiled steel, Fe-18Cr-8Ni alloy, Zn-Mg-Al alloy coated steel, and pure Cu which can be useful for precise molding and imprinting processes, and adjust the morphological profiles of LIPSSs and cone/spike structures for clear structural coloration and a larger range of surface wettability control, respectively, by changing the fluence of laser and the speed of raster scan. The periods of LIPSSs on metals used in our experiments are nearly independent of laser fluence. Accordingly, the structural coloration of the surface with LIPSSs can be optimized with the morphological profile of LIPSSs, controlled only by the speed of the raster scan once the laser fluence is determined for each metal sample. However, different from LIPSSs, we demonstrate that the morphological profiles of the cone/spike structures, including their size, shape, and density, can be manipulated with both the laser fluence and the raster scan speed to increase a change in the contact angle. By injection molding and imprinting processes, it is expected that fs laser-induced surface structures on metals can be replicated to the plastic surfaces and potentially beneficial to control the optical and wetting properties of the surface of injection molded and imprinted products.

Micro-Tribological Investigation for Temperature Rise in Multi-layered Thin Films (다층 박막의 온도상승에 대한 마이크로 트라이볼로지적 조사)

  • Kim, Joon-Hyun;Shin, Kyung-Ho
    • Proceedings of the KSME Conference
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    • 2000.04a
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    • pp.760-765
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    • 2000
  • The study deals with the development of a computational procedure for evaluating the temperature rise in dry and lubricated multi-layered contacts of head/disk interface. A transient computational model with a transformed rectangular computational domain is utilized. A model and a computational method for micro-contact with sub-lubricated zone, including friction heat generation, have been presented. The model was applied, taking full account of the changes in contact area and contact load due to frictional heating. The computational distribution of temperature is obtained with the analytical findings for various composition and contact conditions. Especially, a rapid rise ($220^{\circ}C$ or above) in read head temperature lese to a saturation in the influence of a thermal spike on signal performance. This general class of problems can be treated provided that heat generation distribution and layer properties are known.

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Flow Visualization of Flowfield Structures around an Aerospike Nozzle using LIF and PSP

  • NIIMI Tomohide;MORI Hideo;TANIGUCHI Mashio
    • 한국가시화정보학회:학술대회논문집
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    • 2004.12a
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    • pp.75-80
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    • 2004
  • Aerospike nozzles have been expected to be used for an engine of a reusable space shuttle to respond to growing demand for rocket-launching and its cost reduction. In this study, the flow field structures in any cross sections around clustered linear aerospike nozzles are visualized and analyzed, using laser induced fluorescence (LIF) of nitrogen monoxide seeded in the carrier gas of nitrogen. Since flow field structures are affected mainly by pressure ratio, the clustered linear aerospike nozzle is set inside a vacuum chamber to carry out the experiments in the wide range of pressure ratios from 75 to 200. Flow fields are visualized in several cross-sections, demonstrating the complicated three-dimensional flow field structures. Pressure sensitive paint (PSP) of PtTFPP bound by poly- IBM -co-TFEM is also applied to measurement of the complicated pressure distribution on the spike surface, and to verification of contribution of a truncation plane to the thrust. Finally, to examine the effect of the sidewalls attached to the aerospike nozzle, the flow fields around the nozzle with the sidewalls are compared with those without sidewalls.

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Converter Simulation by the Micro Modeling and Macro Modeling of GTO Thyristor (GTO 다이리스터의 미시적 모델링과 거시적 모델링에 의한 변환기 시뮬레이션)

  • Seo, Young-Soo;Baek, Dong-Hyun;Kim, Young-Chun;Cho, Moon-Taek;Seo, Soo-Ho
    • Proceedings of the KIEE Conference
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    • 1993.07b
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    • pp.781-783
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    • 1993
  • The GTO model is based on the Ebers-Moll equation extened to include the three-junction devices and a detailed description of the implementation of the model equation as well as defferent tests are discussed. Problems to be considered for the snubber design, such as voltage spike reduction, maximum GTO anode current, and switching power, were discussed using the calculation model. The macro model is very useful for simulation of GTO circuit and high power circuit switch in high frequency and complex structure.

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Optimal Operating Method of PV+ Storage System Using the Peak-Shaving in Micro-Grid System (Micro-Grid 시스템에서 Peak-Shaving을 이용한 PV+ 시스템의 최적 운영 방법)

  • Lee, Gi-hwan;Lee, Kang-won
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.43 no.2
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    • pp.1-13
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    • 2020
  • There are several methods of peak-shaving, which reduces grid power demand, electricity bought from electricity utility, through lowering "demand spike" during On-Peak period. An optimization method using linear programming is proposed, which can be used to perform peak-shaving of grid power demand for grid-connected PV+ system. Proposed peak shaving method is based on the forecast data for electricity load and photovoltaic power generation. Results from proposed method are compared with those from On-Off and Real Time methods which do not need forecast data. The results also compared to those from ideal case, an optimization method which use measured data for forecast data, that is, error-free forecast data. To see the effects of forecast error 36 error scenarios are developed, which consider error types of forecast, nMAE (normalizes Mean Absolute Error) for photovoltaic power forecast and MAPE (Mean Absolute Percentage Error) for load demand forecast. And the effects of forecast error are investigated including critical error scenarios which provide worse results compared to those of other scenarios. It is shown that proposed peak shaving method are much better than On-Off and Real Time methods under almost all the scenario of forecast error. And it is also shown that the results from our method are not so bad compared to the ideal case using error-free forecast.

Genetic Diversity of Barley Cultivars as Revealed by SSR Masker

  • Kim, Hong-Sik;Park, Kwang-Geun;Baek, Seong-Bum;Suh, Sae-Jung;Nam, Jung-Hyun
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.47 no.5
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    • pp.379-383
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    • 2002
  • Allelic diversity of 44 microsatellite marker loci originated from the coding regions of specific genes or the non-coding regions of barley genome was analyzed for 19 barley genotypes. Multi-allelic variation was observed at the most of marker loci except for HVM13, HVM15, HVM22, and HVM64. The number of different alleles ranged from 2 to 12 with a mean of 4.0 alleles per micro-satellite. Twenty-one alleles derived from 10 marker loci are specific for certain genotypes. The level of polymorphism (Polymorphic Information Content, PIC) based on the band pattern frequencies among genotypes was relatively high at the several loci such as HVM3, HVM5, HVM14, HVM36, HVM62 and HVM67. In the cluster analysis using genetic similarity matrix calculated from microsatellite-derived DNA profiles, two major groups were classified and the spike-row type was a major factor for clustering. Correlation between genetic similarity matrices based on microsatellite markers and pedigree data was highly significant ($r=0.57^{**}$), but these two parameters were moderately associated each other. On the other hand, RAPD-based genetic similarity matrix was more highly associated with microsatellite-based genetic similarity ($r=0.63^{**}$) than coefficient of parentage.

A Novel Active Clamp Switching Method To Improve of Efficiency For Photovoltaic MIC (태양광 MIC 시스템의 효율향상을 위한 새로운 Active Clamp 스위칭 기법)

  • Park, Byung-Chul;Park, Ji-Ho;Song, Sung-Geun;Park, Sung-Jun;Shin, Joong-Rin
    • The Transactions of the Korean Institute of Power Electronics
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    • v.18 no.5
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    • pp.477-484
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    • 2013
  • This paper proposes a novel switching method of active clamp snubber for efficiency improvement of PV module integrated converter(MIC) system. Recently, MIC solar system is researched about the efficiency and safety. PV MIC system is used active clamp method of snubber circuit for the price and reliability of the system. But active clamp snubber circuit has the disadvantage that system efficiency is decreased for switch operating time because of heat loss of resonant between snubber capacitor and leakage inductance. To solve this problem, this paper proposes a novel switching method of the active clamp. The proposed method is a technique to reduce power consumption by reducing the resonance of the snubber switch operation time and through simulations and experiments proved the validity.

A Study on the Mixing of Pulverization Matters when the Contrast Medium is connected to the Automatic Injection Device using the Syringe Connector (Syringe Connector를 이용하여 조영제를 자동 주입장치에 연결 시 분쇄물 혼입에 관한 연구)

  • Kim, Hyeon ju;Kim, Ji eun;Han, Yu bean;Choi, Seung hyun;Kang, Yun ki;Jung, Yu jin;Jung, Min young;Lee, Hoo min
    • Journal of the Korean Society of Radiology
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    • v.12 no.6
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    • pp.777-783
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    • 2018
  • The purpose of this study was to investigate the degree of tearing of the rubber when the spike of the syringe connector was connected to the bottle of the contrast medium composed of the rubber compound type and to investigate the presence of the synthetic rubber due to tearing and grinding and the size of the pulverized product when the pulverized matters rubber was detected. As a result, in the case of tearing degree, the front side of the first contact with the end of the syringe connector was torn more than the back side by about $3.14{\pm}0.04mm$, and the pulverized matters was detected on average 7 to 15 on the 10 contrast mediums. The average particle size was measured to be about $7.89{\pm}0.31{\mu}m$. In addition, it is necessary to develop a micro_filter type automatic injection system for blocking off the pulverized matters as well as additional experiments through various experiments and analysis methods, and it is considered that interest of related organizations will be needed in preparation of fatal accidents when pulverized matters is introduced.