• Title/Summary/Keyword: miR34a

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Age and Growth of the Brackish Water Clam, Corbicula japonica Prime on the West Coast of Korea (한국 서해산 일본재첩, Corbicula japonica Prime의 연령과 성장)

  • Ryu, Dong-Ki;Chung, Ee-Yung;Kim, Yeong-Hye
    • The Korean Journal of Malacology
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    • v.21 no.1
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    • pp.57-64
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    • 2005
  • Samples of Corbicula japonica Prime of Jujin estuary in Gochang were collected from July 2000 to September 2001. Age of C. japonica was determined from the rings on the shell. The relationship between shell length and ring radius in each ring group was expressed as a regression line. Therefore, there is a correspondence in each ring formation. Based on the monthly variation of the marginal index (MI') of the shell, it is assumed that the ring of this species was formed once a year during the period of February and March. The relationship between shell length (SL; mm) and total weight (TW; g) was expressed by the following equation: TW = 1.0942 ${\times}10^{-4}SL^{3.3217}$ ($r^2$ = 0.9905). Shell length (SL) and shell height (SH; mm) was highly correlated with shell height as the following equation: SH = 0.9174 SL - 0.9935 ($r^2$ = 0.9885). The shell length (SL) - shell width (SW) relation was also expressed by the following equation; SW = 0.5925 SL - 1.1706 ($r^2$ = 0.9726). Growth curves for shell length and total weight fitted to the von Bertalanffy's growth curve were expressed as: $$SL_t = 46.4861[1-e^{-0.3383(t+0.0958)}]$$, $$TW_t = 34.54[1-e^{-0.3383(t+0.0958)}]^3.3217$$.

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Relationship between Physical Disability, Cognitive Disorder and Body Image in Stroke Patients (뇌졸중 환자의 신체적 장애, 인지장애 및 신체상간의 관계)

  • Hong, Mi-Soon;Nam, Mee-Ra;Lee, Jin-Hee;Jeong, Kyung-In
    • The Korean Journal of Rehabilitation Nursing
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    • v.9 no.1
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    • pp.34-41
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    • 2006
  • Purpose: This study was to analyze the relationship the physical disability, cognitive disorder and body image. Method: The research was a descriptive relationship study. A sample is composed of 101 hospitalized stroke patients. Data were collected from November, 2005 to December, 2005. The survey instruments used in the study Sharon and Glen's physical disability scale, Lim's cognitive disorder scale and Osgood's body image scale. The collected data were analyzed frequency, percentage, mean, standard deviation, ANOVA, Duncan test, Pearsons' correlation coefficients. Result: The level of physical disability the score was 2.26, cognitive disorder 1.84 and body image 3.54. and they were relation to significant correlation. The body image showed significant negative correlation with physical disability, cognitive disorder. Physical disability showed significant positive correlation with cognitive disorder(r=.639, p=.000), and significant negative correlation with body image(r=-.420, p=.000). Cognitive disorder showed significant negative correlation with body image(r=-.620, p=.000). There were significant differences of body image by general characteristics as follows: age(p=.000), occupation(p=.004), education(p=.008), disease(p=.007). monthly income(p=.006), burden of medical expenses(p=.001), duration of stroke(p=.008). Conclusion: There was a significant correlation between physical disability, cognitive disorder and body image. there will be considered useful nursing intervention effect to physical disability, cognitive disorder and body image of stroke patients.

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A case of mosaic ring chromosome 13 syndrome (13번 환염색체의 모자이크 증후군)

  • Kim, Soo Young;Oh, Soo Min;Kim, Mi Jeong;Song, Eun Song;Kim, Young Ok;Choi, Young Youn;Woo, Young Jong;Hwang, Tai Ju
    • Clinical and Experimental Pediatrics
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    • v.52 no.2
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    • pp.242-246
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    • 2009
  • The clinical features of ring chromosome 13 include mental and growth retardation, CNS anomalies, facial dysmorphism, cardiac defects, genital malformations, limb anomalies, skeletal deformities and anal malformations. Although many cases of ring chromosome 13 have been reported worldwide, only 6 cases have been reported in Korea, and the latter cases were not mosaic but pure ring chromosome 13. Here we report a case with mosaic ring chromosome 13. The baby boy was born at 37 weeks of gestation by induced vaginal delivery due to intrauterine growth restriction (IUGR). He was the second baby of a 28-year-old hepatitis B carrier mother and a 32-year-old father. There was no family history of chromosomal anomalies. The baby was a symmetric IUGR with a birth weight of 1,860 g, length of 44.8 cm, and head circumference of 29.4 cm. The physical examination revealed microcephaly, trigonocephaly, flat occiput, large ears, short neck and dysmorphic facial features, including microophthalmia, hypertelorism, antimongoloid slanting palpebral fissures, a flat nasal bridge, and micrognathia. The karyotype of this patient performed by peripheral blood lymphocytes was 46,XY,r(13)(p13q34)/45,XY,-13/46,XY,dic r(13;13)(p13q34;p13q34). The baby showed failure to thrive, hypotonia, and developmental delay. We report the first case of mosaic ring chromosome 13 in a male baby in Korea and compare this case with other Korean cases of non-mosaic ring chromosome 13.

Correlations Between the Incidence of National Notifiable Infectious Diseases and Public Open Data, Including Meteorological Factors and Medical Facility Resources

  • Jang, Jin-Hwa;Lee, Ji-Hae;Je, Mi-Kyung;Cho, Myeong-Ji;Bae, Young Mee;Son, Hyeon Seok;Ahn, Insung
    • Journal of Preventive Medicine and Public Health
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    • v.48 no.4
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    • pp.203-215
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    • 2015
  • Objectives: This study was performed to investigate the relationship between the incidence of national notifiable infectious diseases (NNIDs) and meteorological factors, air pollution levels, and hospital resources in Korea. Methods: We collected and stored 660 000 pieces of publicly available data associated with infectious diseases from public data portals and the Diseases Web Statistics System of Korea. We analyzed correlations between the monthly incidence of these diseases and monthly average temperatures and monthly average relative humidity, as well as vaccination rates, number of hospitals, and number of hospital beds by district in Seoul. Results: Of the 34 NNIDs, malaria showed the most significant correlation with temperature (r=0.949, p<0.01) and concentration of nitrogen dioxide (r=-0.884, p<0.01). We also found a strong correlation between the incidence of NNIDs and the number of hospital beds in 25 districts in Seoul (r=0.606, p<0.01). In particular, Geumcheon-gu was found to have the lowest incidence rate of NNIDs and the highest number of hospital beds per patient. Conclusions: In this study, we conducted a correlational analysis of public data from Korean government portals that can be used as parameters to forecast the spread of outbreaks.

EFFECT OF ACIDULATED PHOSPHATE FLUORIDE ON THE SURFACE OF COMPOSITE RESIN (산성 불소가 복합레진 표면에 미치는 영향)

  • Yang, Kyu-Ho;Yook, Geun-Young;Choi, Nam-Ki;Kim, Sun-Mi
    • Journal of the korean academy of Pediatric Dentistry
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    • v.34 no.2
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    • pp.255-263
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    • 2007
  • Composite resin restorations are widely used to restore decayed teeth or preventive restoration in children. Children often receive topical fluoride treatments on a semiannual basis. However there is concern that topical acidulated phosphate fluorides (APF) may cause deterioration of composite resins. The aim of this study was to evaluate the surface changes in composite resins due to topical fluoride application. Composite resins(Solitaire $2^{(R)}$, Metafil $CX^{(R)}$, Composan $LCM^{(R)}$, $Charmseal^{(R)}$) in topical fluoride agents were immersed and their surface roughness, weight loss and SEM findings were evaluated. The results were as follows: 1. The 4 minutes-immersion group showed more roughened surface than 1 minute-immersion group and the control group showed the smoothest surface among all the materials, and there was statistically significant difference between the groups except the Composan $LCM^{(R)}$ (P<0.05). 2. There was no significant difference between the 1 minute-immersion group and 4 minutes-immersion group in weight loss (P>0.05) 3. The experimental group treated with topical fluoride gel showed generally more roughened surface than control group in the SEM findings.

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Diagnostic Performance of Radial Probe Endobronchial Ultrasound without a Guide-Sheath and the Feasibility of Molecular Analysis

  • Moon, Seong Mi;Choe, Junsu;Jeong, Byeong-Ho;Um, Sang-Won;Kim, Hojoong;Kwon, O Jung;Lee, Kyungjong
    • Tuberculosis and Respiratory Diseases
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    • v.82 no.4
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    • pp.319-327
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    • 2019
  • Background: Radial probe endobronchial ultrasound (R-EBUS), is effective for tissue diagnosis of lung lesions. We evaluated the diagnostic performance of R-EBUS both a guide-sheath and fluoroscopy and identified factors associated with accurate diagnosis. The feasibility of molecular and genetic testing, using specimens obtained by R-EBUS, was also investigated. Methods: The study retrospectively reviewed 211 patients undergoing R-EBUS without a guide-sheath and fluoroscopy, June 2016-May 2017. After excluding 27 patients of which the target lesion was not reached, 184 were finally included. Multivariate logistic regression was used, to identify factors associated with accurate diagnosis. Results: Among 184 patients, R-EBUS-guided biopsy diagnosed malignancy in 109 patients (59%). The remaining 75 patients (41%) with non-malignant results underwent additional work-ups, and 34 were diagnosed with malignancy. Based on final diagnosis, diagnostic accuracy was 80% (136/170), and sensitivity and specificity for malignancy were 76% (109/143) and 100% (27/27), respectively. In multivariate analysis, peripheral location (adjusted odds ratio [aOR], 3.925; 95% confidence interval [CI], 1.203-12.811; p=0.023), and central position of the probe (aOR, 2.435; 95% CI, 1.424-7.013; p=0.035), were associated with accurate diagnosis of malignancy. Molecular and genetic analyses were successful, in all but one case, with inadequate specimens. Conclusion: R-EBUS-guided biopsy without equipment, is effective for tissue diagnosis. Peripheral location and central position of the radial probe, were crucial for accurate diagnosis. Performance of molecular and genetic testing, using samples obtained by R-EBUS, was satisfactory.

The Influential Factors on Premenstrual Syndrome College Female Students (여대생의 월경전증후군에 영향을 미치는 요인)

  • Jung, Geum-Sook;Oh, Hyun-Mi;Choi, In-Ryoung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.5
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    • pp.3025-3036
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    • 2014
  • This study was conducted to figure out the influential factors on premenstrual syndrome(PMS) of college female students which are to be utilized as the basic data to develop and apply programs for preventing and controlling such symptom. The subjects were 330 college female students. The data were collected from April 2, 2012 to April 6, 2012. From the results, There has been significant correlation between stress and PMS(r=.36, p<.001) and the attitude to menstruation has appeared to have significant positive correlation with PMS as well(r=.34, p<.001). Multiple regression analysis has been employed to identify the influential factors on PMS and the result has shown that menstrual attitude, grade point average for stress, smoking and dysmenorrhea have been the most significant influential factors with 27% of explanatory power. The level of significance has been high in menstrual attitude(${\beta}$=.28, p<.001), grade point average for stress(${\beta}$=.27, p<.001), smoking(${\beta}$=.20, p<.001) and dysmenorrhea(${\beta}$=.15, p<.001) respectively. In conclusion, it needs to find nursing interventions for PMS related to psychosocial factors and suggest a narrative study for improving quality of life of women with PMS.

Deoxyribonucleic Acid Was Responsible for the Anticoagulatory Effect of an Earthworm, Lumbricus rubellus

  • Paik, Seung-R.;Woo, Jeong-Im;Kim, Gyoung-Mi;Cho, Jin-Mo;Yu, Kyoung-Hee;Chang, Chung-Soon
    • BMB Reports
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    • v.30 no.1
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    • pp.37-40
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    • 1997
  • Earthworm extracts are known for anti-inflammatory, analgesic. antipyretic, and anticancer effects but can also influence blood circulation. It was previously shown that an earthworm, Lumbricus rubelius. contained a water-extractable anticoagulant which was a heat- and acid-stable molecule with hydrophilic property. In order to uncover the biochemical nature of this molecule, the anticoagulant was processed with various hydrolases such as trypsin, DNase, RNase. and lysozome. When the digested samples were analyzed with an in vitro coagulation test measuring activated partial thromboplastin time (APTT) and agarose gel electrophoresis, the anticoagulant proved to be a relatively homogeneous DNA fragment with relative molecular size around 72 base pairs. Interestingly, the activity was further stimulated with a trypsin digestion. RNA. on the other hand, did not prolong the APTT. It was also demonstrated that the DNA accelerated the antithrombin III (AT-III) inhibition of thrombin from $IC_{50}$ of 0.34 to 0.16 unit determined with S-2238 as a substrate, whereas heparin, a popular anticoagulant. shifted the value to 0.05. Therefore, it is suggested that the DNA could be considered as an alternative antithrombotic agent to heparin, which would exhibits bleeding side effects.

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Isolation Rate of Methicillin-Resistant Staphylococcus aureus (MRSA) from Nasal cavity inferior regions and Cellular phones

  • Kim, Chung Hwan;Lee, Jun Young;Kim, Mi Kyeong;Kim, Sung Hwan;Park, Geun Young;Bae, So Yeon;Seo, Myeong Jin;Go, In Hyeog
    • Korean Journal of Clinical Laboratory Science
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    • v.44 no.3
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    • pp.118-123
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    • 2012
  • Nosocomial infection and community-acquired infection with Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), has become a strong concern in human body sites and related effects. The aim of this study is investigate the isolation rate of MRSA from nasal cavity inferior regions and cellular phones to assess the risk factor of nosocomial infection and community-acquired infection. 34.7% and 37.2% isolates were MRSA from the nasal cavity inferior regions and cellular phones according to a Mannitol salt agar (added oxacillin $6{\mu}g/mL$) culture and PCR according to S. aureus specific 16S rRNA and mecA primers. Thus, the distribution of S. aureus and the isolation rate of MRSA represent a very high risk factor regards nosocomial infection and community-acquired infection.

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A study on the distribution of latent fingerprints on paper knife sheaths (간이 칼집에서의 잠재지문 분포에 관한 연구)

  • Kim, Hyo-Mi;Park, Gi-Hyun;Lee, Su-Bhin;Yu, Je-Seol
    • Analytical Science and Technology
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    • v.34 no.6
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    • pp.251-258
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    • 2021
  • Knives are most frequently used as weapons in violent crimes. Criminals leave behind knife sheaths made of paper and tape at crime scenes. It is difficult to develop fingerprints using tape attached to a porous surface, resulting in the need to explore effective techniques for identifying fingerprints as well as the distribution of fingerprints on each surface, when evidence such as paper knife sheaths are found. In this study, 50 knife sheaths were prepared. The cyanoacrylate fuming (CA fuming) method was applied to develop fingerprints on the non-adhesive side of the tape, and a dual-purpose 1,2-indanedione/Zn (1,2-IND/Zn) reagent was used to separate tape from paper while simultaneously developing fingerprints on the paper. The fingerprints on the adhesive side of the tape were developed using Wet Powder Black®. Using the R statistical analysis program (The R Foundation for Statistical Computing), we used a heat map to indicate the location of fingerprints developed from each surface. More fingerprints were detected at the ends than in the center of the adhesive side of the tape, and although the non-adhesive sides of tape and paper did not present clear distribution patterns, many fingerprints were developed that had sufficient clarity for personal identification. The results of this study may be applicable for processing evidence when paper sheaths are found at crime scenes.