• Molecules and Cells
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• v.43 no.8
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• pp.718-727
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• 2020

The imbalance between the proliferation and apoptosis of B-cell precursors is an important contributor to the pathogenesis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), while its specific regulatory mechanism remains perplexing. This study aimed to expound the underlying mechanism of the proliferation and apoptosis of BCP-ALL cells from the perspective of non-coding RNA. In this study, long non-coding RNA colorectal neoplasia differentially expressed (LncRNA CRNDE) was upregulated in the bone marrow of BCP-ALL patients and BCP-ALL cell lines (NALM-6 and RS4;11). Functionally, LncRNA CRNDE knockdown restrained cell proliferation and boosted cell apoptosis in NALM-6 and RS4;11 cells. The subsequent investigation confirmed that LncRNA CRNDE bound to miR-345-5p and negatively regulated miR-345-5p expression. The overexpression of miR-345-5p suppressed cell proliferation and boosted cell apoptosis in NALM-6 and RS4;11 cells. Further experiments revealed that miR-345-5p downregulated cyclic AMP response element-binding protein (CREB) expression by targeting its mRNA directly. CREB overexpression reversed the effect of miR-345-5p mimic on cell proliferation and apoptosis in NALM-6 and RS4;11 cells. Finally, in vivo experiments showed that LncRNA CRNDE knockdown prolonged the survival of mice xenotransplanted with NALM-6 cells. In conclusion, LncRNA CRNDE upregulated CREB expression by suppressing miR-345-5p, thus promoting cell proliferation and reducing cell apoptosis in BCP-ALL.

• Journal of Digital Convergence
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• v.18 no.6
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• pp.345-352
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• 2020

This purpose of this study was to examine relationships among empowerment, academic resilience and positive psychological capital and identify the factors that influence on positive psychological capital in the nursing students. The data were collected from 200 nursing students in the three colleges located Y and S city and 20 April 2019 to 10 May 2019. Data were analyzed by descriptive statistics, T-test, one-way ANOVA, Scheffe test, Pearson's correlation coefficient, and multiple regression using SPSS/WIN 20.0. program. Positive psychological capital in nursing students was significantly correlated with empowerment(r=.610, p<.001) and academic resilience(r=669, p<.001). The result of the multiple regression indicates the academic resilience predict 58.7%(F=19.47, p<.001) of positive psychological capital. Therefore, it is necessary to develop academic resilience increase education program for strategy positive psychological capital in nursing students.

• Journal of Digital Convergence
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• v.14 no.11
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• pp.333-345
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• 2016

This study was to determine the relationship between nurse DISC personality types, self-efficacy, clinical performance. Data were collected from 302 nurses in 5 hospitals in K city. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient. With regard to self-efficacy and clinical performance, D type showed a higher score than type I type and S type. The lower region of the clinical performance showed the nursing process, nursing skills, higher score than the D Type S Type in professional development. With regard to personality and self-efficacy, and clinical performance, the type D (r=.56, p<.01), I type (r=.66, p<.01), S type (r=.6, p<.01) showed a positive correlation with type C (r=.52, p<.01). As shown by these results, each personality type has a different correlation with self-efficacy and clinical performance ability. This factor should be considered in the assignment of nurses to departments or individual training programs so that they can deliver the most effective job performance.

• Journal of Korean society of Dental Hygiene
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• v.12 no.2
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• pp.345-353
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• 2012

Objectives : The author has studied about correlation of gingival exposure upon smiling and oral facial status that reduce facial aesthetic. Methods : The subjects in this study are 91 female vulunteers who were in aged $21.4{\pm}1.89$ in Suwon. Objectives should be normal oral and facial status without the prosthodontic, orthodontic appliance or conqenital missing tooth, and agree to be examined the oral status and impression taking. 1.Measure the length of gingival exposure upon smiling. 2.Measure of the size on central incisor. 3.Measure of Facial. SPSS(SPSS 10.0 for windows, SPSS Inc, Chicago, USA) was utilized for calculating the correlation coefficient between gingival exposure upon smiling and facial status. Regression analysis was calculated in order to predict the R square for gingival exposure upon smiling. Results : 1.Correlation coefficient between the gingival exposure and length of maxillary central incisor was calculated as reversed correlation(r=-.302, p<0.01), and between the gingival exposure and the ratio of the length of central incisor/width of central incisor was revealed as reversed correlation(r=-.250, p<0.05) on smiling. 2.There was correlation between the gingival exposure and the facial height(r=.351, p<0.01), the lower facial height(r=.454, p<0.01) and the upper lip height(r=.274, p<0.01) upon smiling. 3.There was correlation between the gingival exposure and the ratio of the facial height/facial width(r=.358, p<0.05), the ratio of the upper facial height/facial width(r=.214, p<0.05), and the ratio of the lower facial height/facial height(r=.383, p<0.01) upon smiling. 4.The equation of the regression analysis for gingival exposure upon smiling could be estimated as gingival exposure upon smiling=-5.139+.279${\times}$lower facial height-.615${\times}$maxillary central incisal length-.05${\times}$nasolabial angle. Conclusions : Considering these results, it recommended that treatment planning should be designed in consideration of such factors as the length of maxillary central incisor, facial height, upper lip height and lower facial height, in order to promote the easthetic problems of face on smiling.

• Proceedings of the Korea Contents Association Conference
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• 2012.05a
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• pp.345-346
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• 2012

본 연구는 치과진료실의 실내 공기질에 영향을 미치는 요인과 종사자의 실내자각증상과 관련성을 조사하여 치과위생사 개인의 발전과 건강 증진에 필요한 기초자료를 마련하고자 본 연구를 시행하였다. 전국(서울, 경기, 대구, 포항)의 종합병원, 치과병원, 치과의원의 치과위생사 210명을 대상으로 2011년 10월 1일부터 20일까지 자기기입식 설문지 조사를 시행한 후 회수하여 응답이 불분명한 5명을 제외한 205명에 대해서 분석 하였다. 수집된 자료는 SPSS WIN 15.0 프로그램을 이용하여 분석하였다. 그 결과 근무 중 휴식시간 유무별로는 근무 중 휴식시간이 없는 치과위생사가 67.3%로 높은 분포를 보였고, 건물 밖 외출 여부별로는 때때로가 54.6%로 절반 이상을 차지하였으며, 건물 밖 외출횟수별로는 1회 86.1%로 대부분을 차지하였으며, 근무기관의 계절별 자연환기 정도별로는 봄, 여름, 가을, 겨울 모두 1일 2회 이내가 절반 이상을 차지하였으며, 다음으로 1일 4회 이내 19.0%, 기타 9.8%, 1일 10회 이내와 하루 종일 2.4% 순이었다. 실내자각증상 호소율에 대해 살펴본 결과는 4점 만점 중 전체 평균이 2.45로 나타났다. 먼저 영역별로는 평균이 '목증상'과 '눈증상'이 각각 2.54로 가장 높았으며, 문항 중에는 평균이 '눈이 잘 피로해진다'가 3.00으로 가장 높게 나타났다. 근무환경 특성에 따른 실내자각증상은 야간진료 여부별로는 야간진료를 하는 치과위생사가 그렇지 않은 치과위생사보다 실내자각증상이 낮았으며, 야간진료 여부에 따라 유의한 차이를 보였다(t=2.07, p<.05). 실내자각증상과 직무스트레스의 관계는 물리환경(r=.259, p<.001)과 직무요구(r=.311, p<.001), 관계갈등(r=.172, p<.05), 조직체계(r=.158, p<.05), 보상 부적절(r=.197, p<.01), 그리고 직무스트레스(r=.275, p<.001)와 통계적으로 유의한 상관관계를 보였다.

• Journal of dental hygiene science
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• v.8 no.3
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• pp.155-161
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• 2008

The purpose of this study was to provide information on goal setting for elementary oral-health education. The subjects in this study were 513, fourth and sixth graders from an elementary school located in the city of Iksan, north Jeolla province. It investigated the interrelation of the knowledge regarding the oral health of the elementary school student and conduct and with afterwords it got a same conclusion.: 1. The oral health knowledge degree of the investigation object people in 14 perfect score is not high is not with 8.77, the school girl oral health knowledge degree is higher the south student and than it was visible the difference which considers. 2. Also the student one recording oral health knowledge degree which is school dental health education experience appeared highly, considers statistically the difference which it was visible. 3. Oral health behavior degree the result which it investigates at 5 Likert scales, the whole average is not high was not with 3.13, it followed considers the difference which it was visible in grade. 4. The student one recording oral health behavior degree where the oral health knowledge is high appears highly, it was visible the difference which oral health knowledge and conduct considers. 5. Oral health knowledge and oral health behavior and school dental health education experience was a just fanshaped higher officer and the oral health knowledge degree was high and highly the possibility of knowing the burden there was also oral health behavior. 6. Relationship without the necessity of school oral health disappointment necessity and the oral healthy charge teacher was recognizing in gender and grade.

• Journal of the Korean Society of Food Science and Nutrition
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• v.35 no.9
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• pp.1159-1165
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• 2006

Our preliminary study showed that genistein and daidzein improved blood glucose level in type 2 diabetic mice by enhancing the glucose and lipid metabolism. The objective of this study was to evaluate whether genistein and daidzein are associated with alterations in antioxidant defense mechanism of type 2 diabetic mice. Male C57BL/KsJ-db/db (db/db) mice and age-matched non-diabetic littermates (db/+) were used in this study. The db/db mice were divided into control, genistein (0.02%, w/w) and daidzein (0.02%, w/w) groups. The relative weights of liver, epididymal adipose tissue and perirenal adipose tissue were significantly higher in the db/db group than in the db/+ group, whereas heart weight was lower. The genistein and daidzein supplement did not affect the organ weights in db/db mice. The blood glucose level was positively correlated with superoxide dismutase (SOD, r=0.380, p<0.05) and catalase (CAT, r=0.345, p<0.05) activities and negatively correlated with glutathione peroxidase (GSH Px, r= 0.404, p<0.05) activity in erythrocyte. Therefore, the erythrocyte SOD and CAT activities were significantly elevated in the db/db group compared to the db/+ group and the GSH-Px activity was lowered. However, the supplementation of genistein and daidzein reversed erythrocyte CAT and GSH-Px activities in type 2 diabetic mice. In this current study, the SOD activities in liver, kidney and heart were significantly not different between the groups. The CAT and GSH-Px activities in liver and GSH-Px activity in kidney were significantly higher in the db/db group than in the db/+ group, while the CAT activity in kidney, CAT and GSH-Px activities in heart were lowered. The supplementation of genistein and daidzein significantly attenuated the changes of CAT and/or GSH-Px activities in liver and heart. The supplementation of genistein and daidzein elevated GSH levels in kidney and heart compared to the db/db control group. The lipid peroxide levels in liver, kidney and heart were significantly lowered in the genistein and daidzein supplemented groups compared to the db/db control group. These results suggest that genistein and daidzein might be beneficial for the prevention of type 2 diabetic complication via suppressing changes of antioxidant enzymes activities with simultaneous reduction of lipid peroxidation.