• 제목/요약/키워드: miR-23a

검색결과 297건 처리시간 0.028초

액션러닝 적용 간호과정 교육이 비판적 사고성향, 셀프리더십, 자기주도적 학습능력에 미치는 효과 (The Effect of Teaching Nursing Process with Action Learning on Critical Thinking Disposition, Self-Leadership, and Self-Directed Learning Ability.)

  • 이은미;오윤정
    • 디지털융복합연구
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    • 제20권5호
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    • pp.47-52
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    • 2022
  • 본 연구의 목적은 액션러닝을 적용한 간호과정 교육이 간호대학생의 비판적 사고성향, 셀프리더십, 자기주도적 학습능력에 미치는 효과를 확인하기 위함이다. 연구대상은 총 96명이며, 자료수집은 2021년 9월부터 12월까지였다. 자료분석은 spss/win 23을 이용하여 빈도와 백분율, 대응표본 t-검정을 이용하였다. 연구결과 자기주도적 학습능력(t=-3.76, p<.001)이 유의하게 향상되었다. 또한 비판적 사고성향과 셀프리더십(r=.730, p<.001), 비판적 사고성향과 자기주도적 학습능력(r=.701, p<.001), 셀프리더십과 자기주도적 학습능력(r=.734, p<.001) 간에는 통계적으로 유의한 양의 상관관계가 있었다. 본 연구결과 액션러닝 적용 간호과정 교육은 간호대학생의 자기주도적 학습능력에 긍정적인 영향을 미치는 것을 알 수 있다. 추후 다양한 교수학습 방법에 따른 효과를 확인하는 연구가 필요하다.

마사지 요법과 운동요법이 비만여성의 신체조성과 혈중 콜레스테롤에 미치는 영향 (The Effect of Massage Therapy and Exercise Therapy on Body Composition and Blood Cholesterol in the Obese women)

  • 이미선;한미정;이영선
    • 한국패션뷰티학회지
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    • 제2권1호
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    • pp.93-102
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    • 2004
  • The purpose of this study is to examine the effect of massage therapy and exercise therapy on body composition and blood cholesterol in the obese women. Sixteen college women were randomly assigned to aged $20.1{\pm}2.7$ years who had not exercised regurlarly, volunteered to participate in the present study as subjects. They completed a 12 weeks massage therapy and exercise therapy performed 3 times/week, for 60min/session. Massage put in exercise treatment effect of 12 weeks in BMI has shown a significant decrease those are before test $25.1{\pm}2.2$ to after test $23.7{\pm}3.2$(p<0.05). The waist measure/height has a difference by before test r=0.5 to after a test r=0.47, and waist measure/hips measure by before test r=0.8 to after test r=0.75. A total cholesterol(TC) average value has $187.6{\pm}36.9$ before test to $168{\pm}32.4$(p<0.05) after test, a significant difference. Also average value of LDLC has $114{\pm}33.8$ before test to $99.2{\pm}30.4$(p<0.05) that shows a difference, but HDLC was $52{\pm}7.5$ before test to $52.3{\pm}7.7$(p<0.05) after test which means a none difference. HDLC does not have any difference but total cholesterol and LDLC were significantly different. It was a short program of 3 times a week, 60 min/session but, a dance meditation exercise program with high strength self massage had given a big effect in consideration. Using these scientific studies data, wish a program related by obese could make an activation in a beauty part.

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Dietary Iron Intake and Body Iron Status of Myocardial Infarction Patients in Chunan Area

  • Kim, Hee-Seon
    • Journal of Community Nutrition
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    • 제1권2호
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    • pp.140-147
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    • 1999
  • It has been known for some time that elevated body iron could be a risk factor for coronary heart disease. The present study was conducted to determine body iron status and dietary iron intake of patients with myocardial infarction(MI). Seventy five patients from the Chunam area with their first MI history within he past 2 months were recruited. The serum iron concentration, total iron binding capacity(TIBC) and percent transferrin saturation(TS) were selected as indicators of body iron status. Twenty four hour recall was conducted by trained interviewers to asses the dietary intake. Most women (91.3%) showed waist to hip ratio(W/H) greater than 0.85 while 17.3% of men were assessed to have a tendency of abdominal obesity(W/H>0.95). The average BMI of women was 25.80 and that of men was 23.98. The average diet intake of participants was below the recommended dietary allowances (RDA) for most nutrients. He average dietary iron intake was 10.03 mg/day for all subjects while women's iron intake was significantly lower than men's. However, a great proportion of participants (77%) showed a tendency to have normal iron status. About 9% of the participants were assessed as iron deficient and 14% had an iron overload. The mean serum iron concentration was 125 g/dl ranging from 13.3 to 280.6 g/dl. Iron intake from animal sources were significantly associated with body iron status (r=0.257, p=0.026) when TIBC was used as an iron status indicator. When iron status was assessed with TS, it was directly associated with iron intake from animal sources(r=0.278, p=0.05) for he subjects in the normal iron status group. He results of the present study showed that the nutrient intake of Mi patients in Chunan was not quite adequate while iron status was mostly in the normal range. Further studies are needed to investigated whether there is a possible difference in iron metabolism of the MI patients.

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응급구조사의 스트레스와 건강과의 관계 연구 (A Study on the Relationship between the Stress and Health of the Emergency Medical Technician)

  • 이강오;정지연
    • 한국응급구조학회지
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    • 제5권1호
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    • pp.23-35
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    • 2001
  • This study was done to examine the relationship between stress and coping methods of 86 emergency medical technicians with the 1st or 2nd grade qualifications who serve at 36 fire stations in Gwangju and Jeonnam region from Aug. 1 to Aug. 31, 2001. Data collection was done by questionnaire. The research instruments used the stress measure tool developed by Cho Hee et al.(1999) and revised and complemented by the researcher to measure firemen's stress, and health instrument revised by Suh Mi Hye et al(1993). Data were analyzed by t-test, ANOVA, and Pearson's correlation using SPSS. The results of this study were as follows : 1. The mean score of perceived stress was 3.4. The mean score of coping methods was 2.11. 2. The levels of stress according to the general characteristics of subjects were significantly different at marital status(t=7.054, p=.009) and in relation with organization(t=3.989, p=.049). 3. The relationship between levels of stress and health status was significantly correlated(r=.325, p=.000), and so the hypothesis of this research, "the less levels of stress, the better health status is." was supported. 4. The relationship between stress and health status was significantly different at crisis status(r=.393, p=.000), relation with organization(r=.348, p=.001), the characteristics of subjects(r=.387, p=.000), special knowledge and technology(r=.337, p=.001), and the roll complication as a professional(r=.343, p=.001).

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간호사 극복력 측정도구 개발 (Development of Resilience Scale for Nurses)

  • 박미미;박지원
    • 기본간호학회지
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    • 제23권1호
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    • pp.32-41
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    • 2016
  • Purpose: This study was done to develop a measure resilience in nurses. Method: Forty preliminary items were extracted from a view of the literature on concept analysis and scale development, and from in-depth interviews with nurses. These items were examined for content validity, reliability and validity. The scale was verified with 496 nurses working in three advanced general hospitals located in Seoul and Gyeonggido. Results: Factor analysis resulted in the creation of the final scale, which consisted of 30 items that were grouped into 5 factors: dispositional pattern, relational pattern, situational pattern, philosophical pattern and professional pattern. The explanatory variance was 56.25%. The reliability of the scale was Cronbach's ${\alpha}=.95$. Correlation of the scale with the Korean version of the Connor-Davidson Resilience Scale (K-CD-RISC), established its construct and concurrent validity (r=.74, p<.001). Conclusion: The resilience scale for nurses was found to have reliability and validity, and as developed in this study reflects nurses' disposition and was confirmed as a basis for developing and evaluating programs to increase nurses' resilience.

PHYTOCHROME-SPECIFIC TYPE 5 PHOSPHATASE CONTROLS LIGHT SIGNAL FLUX BY ENHANCING PHYTOCHROME STABILITY AND AFFINITY FOR A SIGNAL TRANSDUCER.

  • Ryu, Jong-Sang;Kim, Jeong-Il;Kunkel, Tim;Kim, Byung-Chul;Cho, Dae-Shik;Hong, Sung-Hyun;Kim, Seong-Hee;Fernndez, Aurora Pias;Kim, Yu-Mi;Alonso, Jose M.;Ecker, Joseph R.;Nagy, Ferenc;Lim, Pyung-Ok;Song, Pill-Soon;Schfer, Eberhard;Nam, Hong-Gil
    • 한국광과학회:학술대회논문집
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    • 한국광과학회 2005년도 제12회 학술대회 논문초록
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    • pp.21-23
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    • 2005
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The Change in Regional Cerebral Oxygen Saturation after Stellate Ganglion Block

  • Park, Hyeon-Min;Kim, Tae-Wan;Choi, Hong-Gyu;Yoon, Kyung-Bong;Yoon, Duck-Mi
    • The Korean Journal of Pain
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    • 제23권2호
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    • pp.142-146
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    • 2010
  • Background: Stellate ganglion block (SGB) is known to increase blood flow to the innervations area of the stellate ganglion. Near infrared spectroscopy reflects an increased blood volume and allows continuous, non-invasive, and bedside monitoring of regional cerebral oxygen saturation ($rSO_2$). We investigated the influence of SGB on bilateral cerebral oxygenation using a near infrared spectroscopy. Methods: SGB was performed on 30 patients with 1% lidocaine 10 ml using a paratracheal technique at the C6 level and confirmed by the presence of Horner's syndrome. The blood pressure (BP), heart rate (HR) and rSO2 were measured before SGB and 5, 10, 15 and 20 minutes after SGB. Tympanic temperature of each ear was measured prior to SGB and 20 minutes after SGB. Results: The increments of the $rSO_2$ on the block side from the baseline were statistically significant at 5, 10, 15 and 20 minutes. The $rSO_2$ on the non-block side compared with the baseline, however, decreased at 15 and 20 minutes. The difference between the block and the non-block sides was significant at 15 and 20 minutes. The BP at 10, 15 and 20 minutes was increased and the HR was increased at 10 and 15 minutes. Conclusions: We observed an increment of the $rSO_2$ on the block side from the baseline; however, the $rSO_2$ on the non-block side decreased.

사상성격검사(SPQ)의 임상 타당화 연구 (Clinical Validation of the Sasang Personality Questionnaire)

  • 장은수;이수진;박수현;이시우;주종천;이미숙;김윤희;채한
    • 동의신경정신과학회지
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    • 제23권3호
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    • pp.23-32
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    • 2012
  • Objectives : The purpose of this study was to validate the Sasang Personality Questionnaire (SPQ), based on the diagnosis of Sasang constitutional medicine clinical specialist. Methods : We performed Sasang type differentiation of 103 college students by certified specialist, and analyzed biopsychological traits of each groups with SPQ, Temperament and Character Inventory (TCI), Positive and Negative Affection Schedule (PANAS) and Body Mass Index (BMI). Results : The SPQ score of So-Yang ($33.1{\pm}0.79$), Tae-Eum ($29.03{\pm}0.67$) and So-Eum ($25.76{\pm}0.98$) Sasang groups showed significant differences from each other. The SPQ showed significant correlation with TCI Novelty-Seeking (r=.346), TCI Harm-Avoidance (r=-.348) and TCI Persistence (r=.346). But the BMI and PANAS did not show significant correlation with SPQ, although the PANAS Positive Affection (r=.332) has significant correlation with SPQ-Behavior. Conclusions : We confirmed the clinical validity of SPQ with clinical specialist and established biopsychosocial instruments. This study would contribute to a more objective diagnosis and studies on biopsychosocial mechanism of Sasang constitutional medicine.

Korean Red Ginseng extract induces angiogenesis through activation of glucocorticoid receptor

  • Sung, Wai-Nam;Kwok, Hoi-Hin;Rhee, Man-Hee;Yue, Patrick Ying-Kit;Wong, Ricky Ngok-Shun
    • Journal of Ginseng Research
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    • 제41권4호
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    • pp.477-486
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    • 2017
  • Background: Our previous studies have demonstrated that ginsenoside-Rg1 can promote angiogenesis in vitro and in vivo through activation of the glucocorticoid receptor (GR). Furthermore, microRNA (miRNA) expression profiling has shown that Rg1 can modulate the expression of a subset of miRNAs to induce angiogenesis. Moreover, Rb1 was shown to be antiangiogenic through activation of a different pathway. These studies highlight the important functions of miRNAs on ginseng-regulated physiological processes. The aim of this study was to determine the angiogenic properties of Korean Red Ginseng extract (KGE). Methods and Results: Combining in vitro and in vivo data, KGE at $500{\mu}g/mL$ was found to induce angiogenesis. According to the miRNA sequencing, 484 differentially expressed miRNAs were found to be affected by KGE. Among them, angiogenic-related miRNAs; miR-15b, -23a, -214, and -377 were suppressed by KGE. Meanwhile, their corresponding angiogenic proteins were stimulated, including vascular endothelial growth factor, vascular endothelial growth factor receptor-2, endothelial nitric oxide synthase, and MET transmembrane tyrosine kinase. The miRNAs-regulated signaling pathways of KGE were then found by Cignal 45-Pathway Reporter Array, proving that KGE could activate GR. Conclusion: KGE was found capable of inducing angiogenesis both in vivo and in vitro models through activating GR. This study provides a valuable insight into the angiogenic mechanisms depicted by KGE in relation to specific miRNAs.

The Tumor Suppressor, p53, Negatively Regulates Non-Canonical NF-κB Signaling through miRNA-Induced Silencing of NF-κB-Inducing Kinase

  • Jang, Hanbit;Park, Seulki;Kim, Jaehoon;Kim, Jong Hwan;Kim, Seon-Young;Cho, Sayeon;Park, Sung Goo;Park, Byoung Chul;Kim, Sunhong;Kim, Jeong-Hoon
    • Molecules and Cells
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    • 제43권1호
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    • pp.23-33
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    • 2020
  • NF-κB signaling through both canonical and non-canonical pathways plays a central role in immune responses and inflammation. NF-κB-inducing kinase (NIK) stabilization is a key step in activation of the non-canonical pathway and its dysregulation implicated in various hematologic malignancies. The tumor suppressor, p53, is an established cellular gatekeeper of proliferation. Abnormalities of the TP53 gene have been detected in more than half of all human cancers. While the non-canonical NF-κB and p53 pathways have been explored for several decades, no studies to date have documented potential cross-talk between these two cancer-related mechanisms. Here, we demonstrate that p53 negatively regulates NIK in an miRNA-dependent manner. Overexpression of p53 decreased the levels of NIK, leading to inhibition of the non-canonical NF-κB pathway. Conversely, its knockdown led to increased levels of NIK, IKKα phosphorylation, and p100 processing. Additionally, miR-34b induced by nutlin-3 directly targeted the coding sequences (CDS) of NIK. Treatment with anti-miR-34b-5p augmented NIK levels and subsequent non-canonical NF-κB signaling. Our collective findings support a novel cross-talk mechanism between non-canonical NF-κB and p53.