• BMB Reports
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• v.52 no.3
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• pp.202-207
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• 2019

Keloids are the most common pathological form of trauma healing, with features that seriously affect appearance and body function, are difficult to treat and have a high recurrence rate. Emerging evidence suggests that miRNAs are involved in a variety of pathological processes and play an important role in the process of fibrosis. In this study, we investigated the function and regulatory network of miR-152-5p in keloids. The miRNA miR-152-5p is frequently downregulated in keloid tissue and primary cells compared to normal skin tissue and fibroblasts. In addition, the downregulation of miR-152-5p is significantly associated with the proliferation, migration and apoptosis of keloid cells. Overexpression of miR-152-5p significantly inhibits the progression of fibrosis in keloids. Smad3 is a direct target of miR-152-5p, and knockdown of Smad3 also inhibits fibrosis progression, consistent with the overexpression of miR-152-5p. The interaction between miR-152-5p and Smad3 occurs through the Erk1/2 and Akt pathways and regulates collagen3 production. In summary, our study demonstrates that miR-152-5p/Smad3 regulatory pathways involved in fibrotic progression may be a potential therapeutic target of keloids.

• Journal of Digital Convergence
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• v.19 no.11
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• pp.607-614
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• 2021

This study was attempted to find out the effect of major satisfaction and clinical practice satisfaction of nursing college students on job-seeking stress. For this study, from May to June 2021, 152 4^th grade students were participated from M University in Jeolla-do Province, using a self-reported questionnaire. Descriptive statistics, t-test, ANOVA, Pearson's correlation analysis, and multiple regression analysis were used for data analysis. As a result of this study, it was revealed that there was a significant negative correlation between the job-seeking stress of nursing students on major satisfaction(r=-.356, p<.001), but clinical practice satisfaction was not((r=-.018, p=.825). Also, the factors affecting the job-seeking stress of nursing students were age(β=0.285, p<.001), G.P.A.(β=0.250, p=.001) and major satisfaction(β=-0.331, p<.001) with a total explanatory power of 25.3%. As the results of this study, to decrease the job-seeking stress of nursing students, it is necessary to develop and apply programs to increase major satisfaction, and also the programs should be considered the nursing students' ages and G.P.As.

• Journal of Korean Society for Atmospheric Environment
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• v.27 no.5
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• pp.523-533
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• 2011

This study had the aim of characteristics of $PM_{10}$ in subway cabins. $PM_{10}$ was measured by times of day (rush and non rush hours) and seasons with real time $PM_{10}$ sampler on the subway cabins of line 7. Filter samples were collected for evaluation of their elemental composition as well as identification of major sources of $PM_{10}$ using a receptor model, PMF. $PM_{10}$ concentration were the highest in the winter season both in the rush and non rush hours at 152.8 ${\mu}g/m^3$, 90.2 ${\mu}g/m^3$ respectively. The $PM_{10}$ concentrations in rush hour were 30% higher compared to non rush hours. Based on the chemical information, the composition rare of inorganic elements was 52.5%, anions were 10.2% and others were 37.3%. Fe was the most abundant element and significantly correlated (p.0.01) with Mn (r=0.97), Ti (r=0.91), Cr (r=0.88), Ni (r=0.89) and Cu (r=0.88). Characterized $PM_{10}$ sources by PMF in the cabin were soil and road dust related sources (27.2%), railroad related sources (47.5%), secondary nitrate sources (16.2%) and a Cl-factor mixed with a secondary sulfate source (9.1%).

• Sleep Medicine and Psychophysiology
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• v.17 no.2
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• pp.100-108
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• 2010

Objectives: "Internet-addiction" came into common use not only in clinical setting but also in everyday life. But, pathophysiology and diagnostic criteria of the internet addiction remain unknown. Because adolescents are in developing period, they might be vulnerable to the internet addiction, depression and sleep-related problem. The objectives of this study were to investigate the characteristics of internet addiction and its association with sleep pattern and depression in Korean adolescence. Methods: Subjects were 799 middle and high school students in Seoul, Korea. We administered a self-reported questionnaire including socio-demographic data, Korean versions of Young's Internet Addiction Scale (YIAS), Pittsburgh Sleep Quality Index (PS-QI), the Center for Epidemiologic Studies for Depression Scale (CES-D) and questions about internet using patterns. Data of 696 subjects were included in analysis. Chi-square tests were used to analyze proportional differences, and ANOVA with post-hoc tests were used to analyze differences among groups. Partial correlation analyses were performed to analyze the correlation of internet addiction with other variables (two-tailed, p<0.05). Results: Of the 696 participants (grade 2 of middle school; M2 135 vs. grade 1 of high school; H1 238 vs. grade 2 of high school; H2 323), 2.0% (n=14) were internet-addicted (IA), 27.7% (n=193) were over-using (OU) and 70.3% (n=489) were not-addicted (NA). The mean scores of YIAS, PSQI and CES-D scores were 35.24${\pm}$12.78, 5.53${\pm}$3.04 and 16.72${\pm}$8.69, respectively. In higher grade students, average total sleep time was shorter (M2 426.20${\pm}$67.68 min. vs. H1 380.47${\pm}$62.57 min. vs. H2 354.67${\pm}$73.37 min., F=51.909, p<0.001), and PSQI (4.69${\pm}$3.14 vs. 5.42${\pm}$3.15 vs. 5.97${\pm}$2.83, F=8.871, p<0.001) CES-D (13.53${\pm}$8.37 vs. 16.96${\pm}$8.24 vs. 17.87${\pm}$8.84, F=12.373, p<0.001) scores were higher than those of lower grade students. Comparing variables among IA, OU and NA groups, computer using time not for study (96.36${\pm}$63.31 min. vs. 134.92${\pm}$86.79 min. vs. 213.57${\pm}$136.87 min., F=34.287, p<0.001) and portable device using time not for study (84.22${\pm}$79.11 min. vs. 96.97${\pm}$91.89 min. vs. 152.31${\pm}$93.64 min., F= 5.400, p=0.005) were different among groups. PSQI (5.26${\pm}$2.97 vs. 6.08${\pm}$2.97 vs. 7.50${\pm}$4.41, F=8.218, p<0.001) and CES-D scores (15.40${\pm}$8.08 vs. 19.05${\pm}$8.42 vs. 30.43${\pm}$13.69, F=32.692, p<0.001) were also different among groups. YIAS score were correlated with computer using time not for study (r=0.356, p<0.001) and portable device using time not for study (r= 0.136, p<0.001). PSQI score (r=0.237, p<0.001) and CES-D score (r=0.332, p<0.001). YIAS score and PSQI score (r=0.131, p= 0.001), YIAS and CES-D score (r=0.265, p<0.001), PSQI score and CES-D score (r=0.357, p<0.001) were correlated each other. Conclusion: These results suggested that adolescents' internet-addiction was correlated with not only computer and portable device using time not for study but also depression and sleep-related problems. We should pay attention to depression and sleep-related problems, when evaluating internet-addiction in adolescents.

• Korean Journal of Microbiology
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• v.36 no.2
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• pp.130-135
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• 2000

Decomposition rate of organic matiter in the mud flat of Sunchon Bay was estimated. Physicochemical parameters, cellulose degradation rate. distribution of heterotrophic bacteria, and extracellular enzymatic activities were measured from August 1997 to July 1998. Soil temperatures, water contents, concentration of $PO_4$-P and organic matter were -1-~$30^{\circ}C$, 42.1-53.1%, 0.0779-0.1961 mgig and 1.99-7.64%, respectively. Decomposition rate of cellulose film ranged from 7.7 to 100%imonth, high in summer and low in winter. The number of heterotrophic bacteria ranged from $0.87{\times}10^6 to 3.6{\times}10^7 $CUFsIg dq soil. Enzymatic activities of phosphatase, $\alpha$-D-gluEosidase, $\beta$-D-glucosidase and cellobiohydrolase, which were measured as decomposition rate of methylumbelliferyl(MLiF)-substrate, were 152.23-1779.80 nMIhr, 2.67-202.18 nM/hr, 5.03-258.26 M h r and 3.42-63.07 nM/hr, respectively Cellulose degradaaon rate and extracellular extracellular enzymatic activities were conelated with each other, and showed high correlation coefticiency with soil temperature.

• Journal of the korean academy of Pediatric Dentistry
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• v.31 no.2
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• pp.144-152
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• 2004

The aim of this study was to evaluate the resistance to degradation of three commercial compomers in an alkaline solution. Dyract(Dentsply), Elan(Kerr) and F-2000(3M) polyacid modified resin composites(compomers) were used in this study. The resistance to degradation was evaluated on the basis of mass loss(%), degradation $depth({\mu}m)$ and Si, Al, Ba loss(ppm). The results were as follows : 1. The mass loss of each brand was $1.42%{\sim}2.14%$ and there was no statistically significant difference of mass loss among Dyract, F2000 and Elan. 2. The degradation layer depth of each brand was $182.92{\sim}227.7{\mu}m$ and there was no statistically significant difference of degradation layer depth among Dyract, F2000 and Elan. 3. There was statistically significant differences in Si-loss and Al-loss among three compomers (p<0.05). Si loss was the highest value in Dyract and Al loss was the highest value in F2000. 4. There was statistically significant correlation between mass loss and degradation layer depth (r=0.60, p<0.05). 5. In SEM finding, there was some destruction of compomer matrix-filler interface in post-exposure specimen to NaOH solution. As the matrix decreased, the filler particles distinguished and the periphery of the filler particles appeared whitish color due to degradation.