• Title/Summary/Keyword: miR-144

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Development and Effect of Exercise Program to Prevent Osteoporosis in Working Women (직장여성의 골다공증 예방 운동프로그램 개발 및 효과)

  • Lee, Ho-Yeon;Wang, Mi-Suk;Lim, Nan-Young
    • Journal of muscle and joint health
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    • v.16 no.2
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    • pp.135-144
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    • 2009
  • Purpose: The purpose of this study was to develop an exercise program to prevent osteoporosis in working women and to examine its effects on bone mineral density (BMD). Method: The subjects of the study were 55 working women. The experimental group participated three times per week for twelve weeks in this exercise program. T-test and ANOVA, Pearson's correlation coefficients were used to analyze the data. Results: The BMD of the experimental group prior to participating in the exercise program was 0.9301 $(\pm08620)g/cm^2$. However, after the exercise program, the BMD increased to 0.9415 $(\pm1117)g/cm^2$ (t=-2.338, p=.026). Moreover, in relations to BMD and physiological variables, there were significant correlations between BMD and physical activity (r=.294, p=.030), as well as between BMI and physical activity (r=.267, p=.049). Conclusion: In this study, BMD in the experimental group had significantly increased after their participation, while the control group had decreased. Thus, this study showed that the exercise program developed for working women is effective in maintaining BMD and consequently preventing osteoporosis.

Intensive Care Unit Nurses' Death Perception, End of Life Stress and End of Life Nursing Attitudes (중환자실 간호사의 죽음에 대한 인식, 임종간호 스트레스 및 임종간호 태도에 관한 연구)

  • Kim, Sera;No, Mi Jin;Moon, Kyung Eun;Cho, Hee Ju;Park, Young;Lee, Nam Joo;Lee, Soon Haeng;Shim, Mi Young
    • Journal of Korean Clinical Nursing Research
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    • v.24 no.2
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    • pp.255-262
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    • 2018
  • Purpose: This study aimed to identify the view of life and death among ICU nurses and to analyze the problems related to end-of-life care in the current ICUs. Methods: A descriptive study design was used. The participants were 975 nurses working in the intensive care units of 16 general hospitals. Using a descriptive survey design, data were collected from August to December in 2016 and were analyzed using descriptive statistics, t-test, ANOVA, correlation analysis, and multiple regression analysis. Results: As a result of a correlation analysis of the data, Death perception had a significant positive correlation with EOL of nursing attitudes(r=.100, p=.002), and negative correlation with EOL stress care(r=-.221, p=<.001). The regression model explained for individual characteristics in the model, age(${\beta}=.126$, p<.001) and death perception(${\beta}=.182$, p<.001), Satisfaction of the EOL care(${\beta}=.173$, p<.001), Healing training needs on the EOL(${\beta}=-.144$, p<.001) were the most influential factors for EOL stress. Conclusion: Results reveal that ICU nurses have a moderate level of EOL stress, and that individual, age, death perception, Satisfaction of the EOL care, Healing traning needs on the EOL relevant in ICU nurses' EOL stress. Programs or interventions to reduce EOL stress and to should be developed taking into account these multidimensional factors.

Kidney size estimation in Korean children with Technesium-99m dimercaptosuccinic acid scintigraphy

  • Lee, Min Jung;Son, Mi Kyung;Kwak, Byung Ok;Park, Hye Won;Chung, Sochung;Kim, Kyo Sun
    • Clinical and Experimental Pediatrics
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    • v.57 no.1
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    • pp.41-45
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    • 2014
  • Purpose: Renal size is an important indicator to determine adequate organ growth in children. The aim of this study was to estimate renal size with Technesium-99m dimercaptosuccinic acid (DMSA) scan and propose a simple formula for predicting renal length in normal Korean children. Methods: This study included 346 children (148 boys and 198 girls; age range, 1 month to 17 years) in whom renal length was measured using the DMSA scan. Patients with anatomical renal abnormalities or acute pyelonephritis were excluded. Children were divided into two groups: 214 children (61.8%) were less than a year old (group 1) and 132 (38.2%) were ${\geq}1$ year (group 2). Results: Renal length was larger on the left side than the right side, and there was no significant gender-related difference in renal length. We propose the following formula for renal length based on the analysis of the 346 children in our study: the formula was as follows: $4.682{\times}age(month)^{0.137}$, $R^2=0.780$. In group 1, the formula was renal length $(cm)=0.127{\times}age(month)+5.144$, $R^2=0.354$, and in group 2, the formula was $0.334{\times}age(year)+6.477$, $R^2=0.829$. Conclusion: It is difficult to establish simple formulae in infants ($R^2=0.354$). Therefore, further studies including relevant variables are needed for this age group. We proposed formulae to estimate renal length in Korean children over 1 year of age by using the DMSA scan.

Assessment of Daily Steps, Physical Activity and Activity Coefficient of the Elementary School Children in the Rural Area (농촌지역 초등학생의 1일 평균 보행수, 활동량 및 활동계수 평가)

  • Lee, Hyun-Mi;Kim, Eun-Kyung
    • Korean Journal of Community Nutrition
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    • v.12 no.3
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    • pp.361-371
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    • 2007
  • The purpose of this study was to assess the daily steps, physical activities and activity coefficient of the elementary school children in the rural area. Body weight, height and daily steps were measured and one-day activity diaries were collected by interviewing children. The average age of the subjects was $9.96{\pm}1.02$ years. Average height, weight, obesity index, body fat and muscle of subjects were $136.2{\pm}8.9cm,\;35.2{\pm}8.5kg,\;99.6{\pm}18.8%,\;22.9{\pm}8.5%\;and\;35.8{\pm}6.0%$, respectively. The average daily steps of the subjects was 17,584 and daily steps (19,314) of 3rd grade students was significantly higher than that (15,712) of 5th grade children. But there was no significant difference in daily steps and activity coefficients between boys and girls. Daily steps (23,347) of exercise group showed the significantly higher than that (16,144) of non-exercise group. Gender and grade of subjects did not have significant influence on activity coefficients, but there was a significant difference in activity coefficient on weekdays between the exercise group ($1.82{\pm}0.30$) and non-exercise group ($1.50{\pm}0.21$). Analysis of variance revealed stronger associations between daily steps and body fat (%) than between daily steps and BMI. Daily steps showed significant negative correlation with body fat (%) measured using two methods r=-0.321 and r=-0.365, respectively. Activity coefficient was significantly correlated (r=0.436) with daily steps, thus increasing daily steps cm prevent and treat childhood obesity by increasing the energy expenditure. The higher activity coefficients (weekday 1.56, weekend 1.53) of the subjects was caused by the fact that rural students spent more time outside and enjoyed stronger activities than urban students. The results of this study can be used to estimate energy requirements for Korean children based on exercise levels and living areas.

Predictors of Vascular Complications among Patients with Type 2 Diabetes (제2형 당뇨 환자의 혈관합병증 위험 예측인자)

  • Ha, Jung-Mi;Lee, Hae-Jung;Kim, Dong-Hee;Kim, Yong-Suk;Lee, Wha-Za
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.16 no.2
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    • pp.144-152
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    • 2009
  • Purpose: The purpose of this study was to predict the risk factors for vascular complications among patients with type 2 diabetes. Method: The data were collected from August to September, 2007 using clinical examination and questionnaires. Patients (N=101) were recruited from the endocrinology department of P University hospital in D city. Descriptive statistics, Pearson correlation coefficients and multiple linear regression were used to analyze the data. Results: The cardiovascular risk of patients with diabetes was significantly related to self care behavior, family history, and smoking status. The risk of peripheral vascular complications was not related to predictors included in the study. With multivariate analyses, significant predictors of cardiovascular risk for these patients were self care behavior, family history, and smoking status ($R^2=.40$, p<.0001). Conclusion: The findings of this study indicate that smoking cessation and improving self-care behavior are essential to reduce the risk of cardiovascular complications among patients with diabetes. To enhance self-care practices for the patients with diabetes, nursing interventions, such as telephone counseling, problem focused nursing counseling, and peer group activities should be considered.

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Offsprings Produced by Transcervically Inseminating Frozen-thawed Semen into Uterus of a Estrus-induced Saanen Goat during Non-breeding Season

  • Yong, Hwan-Yul;Kim, Min-Ah;Bae, Bok-Soo;Kim, Seung-Dong;Jo, Shin-Il;Lim, Yang-Mook;Yoo, Mi-Hyun;Ha, Yong-Hee;Oh, Chang-Shik;Kim, Doo-Hee
    • Journal of Embryo Transfer
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    • v.25 no.2
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    • pp.89-92
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    • 2010
  • We report herein the successful results of estrus induction, sperm cryopreservation and kids born by transcervical insemination of frozen-thawed semen in a Saanen goat. Flugestone acetate (FGA: 60 mg) was inserted into vagina for 15 days. The goat was intramuscularly injected with 400 IU PMSG and 200 IU hCG ($PG600^{(R)}$: Intervet, Korea) a day before withdrawal of the FGA sponge. Follicles and corpora lutea were identified on both ovaries by laparoscopy. Artificial insemination was performed 46 hours after removal of FGA sponge. The concentration of frozen-thawed semen was $3.975{\times}10^8/ml$ and 0.5 ml of frozen-thawed semen was transcervically inseminated into uterine body under anesthesia. Three kids, all females, were born 144 days after artificial insemination. This is the first report producing kids by transcervical insemination of frozen-thawed semen in a Saanen goat of which the estrus was induced by FGA sponges, PMSG and hCG during non-breeding season in Korea.

Analysis of Cadaverine and Its Worker Honeybee Venom Content (Apis mellifera L.) (꿀벌(Apis mellifera L.) 일벌독의 생체아민 cadaverine 함량 및 분석법)

  • Choi, Hong Min;Kim, Hyo Young;Kim, Se Gun;Han, Sang Mi
    • Journal of Life Science
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    • v.31 no.2
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    • pp.144-148
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    • 2021
  • This study aimed to analyze the content and composition of a biological amine, cadaverine, isolated from the venom of worker honeybees (Apis mellifera L.). This biological amine―which has diverse functionality, such as anti-inflammatory and antibacterial effects―has not been previously reported in bee venom. An assay completed in 13 minutes was developed for the cadaverine present in the bee venom using an ultra-performance liquid chromatograph and a Halo C18 column with acetonitrile and water as the mobile phase. The specificity, accuracy, and precision of the assay were verified, and the assay was validated. The linearity for cadaverine in the bee venom was R2=0.99 or above, indicating a moderate level. The limit of detection and limit of quantification were both 0.3 ㎍/ml, and the rate of recovery was 97.6%-99.1%. The relative standard deviation (RSD) of the intra-day precision and inter-day precision for cadaverine was 0.25%-0.44% and 0.25%-1.25%, respectively, with an RSD that fell within 5% indicating excellent precision. Through this novel assay, it was found that the mean content of cadaverine was 1.10±0.05 mg/g. Our results indicated that the linearity, limit of detection, limit of quantification, and rate of recovery of the cadaverine assay were of a satisfactory level, and the cadaverine content of the bee venom was ably determined. This study provides basic data on cadaverine in bee venom, which will prove useful in further studies on the bioactivity of this component.

BD Andromedae의 주기 변화와 광도곡선 분석

  • Song, Mi-Hwa;Kim, Cheon-Hwi;U, Su-Wan;Yun, Yo-Ra;Bae, Tae-Seok;Jo, Yeong;Jin, Hye-Jin;Han, Won-Yong;Choe, Yong-Jun;Mun, Hong-Gyu;Im, Hong-Seo
    • Bulletin of the Korean Space Science Society
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    • 2011.04a
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    • pp.21.2-21.2
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    • 2011
  • 2010년 11월 05일부터 11월 29일 중 총 12일간 진천 소재 충북대학교 천문대의 60cm 반사망원경과 ST-8 CCD 카메라를 이용하여 BD And의 BVR CCD 측광 관측을 수행하여 처음으로 BVR 광도 곡선을 완성하였다. 또한, 극심시각 결정을 위한 측광관측이 레몬산 천문대 1m 반사망원경과 충북대학교 천문대의 35cm 망원경으로 수행되었다. 우리의 관측과 SWASP 관측을 통하여 모두 31개의 극심시각을 새로이 결정하였다. 새로운 관측은 이 별의 공전주기가 이전까지 알려진 0.4629일이 아니라 그 두 배인 0.9258일이며, 기산점도 반주기 바뀌어야 함을 보여 준다. BD And의 광도요소를 Min I = HJD 2434962.8602 + 0.d9258054 E으로 새롭게 개정하였다. 이 광도요소로 작성한 우리의 BVR 광도곡선은 제1식과 제2식의 깊이가 거의 비슷하며, 식바깥 부분에 잘 발달된 파형 모양을 보인다. 이는 BD And가 짧은 주기의 RS CVn형 식쌍성임을 나타내는 것이다. 우리의 극심시각을 포함한 총 144개의 극심시각에 대한 (O-C)도를 작성한 결과, BD And의 공전주기가 규칙적으로 변화하는 것을 발견하였다. 이 변화를 보이지 않는 제3천체에 의한 광시간 효과로 가정하여, 궤도이심율이 0.78이며, 9.19년의 주기를 가진 광시간 궤도를 결정하였다.우리의 광도곡선을 2003년 Wilson-Devinney 쌍성 모형으로 분석하여 광도곡선 해를 질량비 q=1.1822, 궤도경사각 i=$86.^{\circ}16$, $T_1$=6358(K), $T_2$=6250(K), $r_1$=1.117(Rsun), $r_2$=1.321(Rsun)와 같이 산출하였다. 식바깥에서 나타나는 파형 모양의 변화는 주성의 표면에 매우 큰 흑점으로 잘 설명되며, BVR 광도곡선에서 각각 전체 광도의 각 6.4%, 8.1%, 9.9%에 해당되는 제3 광도가 검출되었다. 이는 주기연구에서 제안된 제3천체의 존재 가능성을 더 공고히 한다.

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Factors Affecting Posttraumatic Stress in New Firefighters (신임 소방대원의 외상 후 스트레스 영향요인)

  • Baek, Mi Lye
    • Journal of the Korean Society of Safety
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    • v.29 no.5
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    • pp.123-128
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    • 2014
  • This study investigated a posttraumatic stress, social support, and work burden and identified related factors which exerted influence on posttraumatic stress of new firefighters. Data were gathered from total of 144 new firefighters. Also, 22 PTS items, 20 work burden items, and 8 social support items were analyzed by SPSSWIN 21.0 program. Posttraumatic stress according to general characteristics showed significant difference in gender(t=-2.57, p=0.01), experience of self danger(t=3.06, p=0.00), experience of rescuee danger(t=2.41, p=0.02), and experience of colleague danger(t=3.43, p=0.00). High risk group of PTS was 20.1%. Posttraumatic stress, social support, and work burden showed significant difference in the high and low risk group. Posttraumatic stress was correlated with work burden(r=0.34, p=0.00), social support(r=-0.29,p=0.00). Factors influencing PTS were Experience of colleague danger(${\beta}$=1.274, 95% CI=0.08-0.96), social support(${\beta}$=-0.090, 95% CI=0.85-0.98) and work burden(${\beta}$=0.057, 95% CI=1.02-1.10). We need to reduce the work burden caused by influencing variable of traumatic stress and create more preventive discipline of traumatic stress for the new firefighters to improve the social support at work or home. Also, posttraumatic stress has to be managed consistently with support by changing the social attitudes and we need to seek the new system that anybody can get a consultation of a specialist.

Characteristics and Preparation of Manganese Oxide Electrode by Using Pulse Voltammetry Electrodeposition for Electrolysis (펄스 전착법을 이용한 전기분해용 망간 산화물 전극의 제조 및 특성)

  • Yang, Jeong-Jin;Lee, Mi-Young;Kim, Jeong-Sik;Shin, Hyun-Soo;Park, Soo-Gil
    • Journal of the Korean Electrochemical Society
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    • v.13 no.2
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    • pp.138-144
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    • 2010
  • In order to investigate the electrochemical propertied of titanium electrode for electrolysis, manganese oxide was electrodeposited on surface of mesh titanium by pulse voltammetry. The morphological changes and impedance results of manganese oxide electrodeposited electrode were analyzed by SEM and EDX. The size of electrodeposited manganese oxide on mesh titanium was increased with first cycle pulse time increase, and approximately 100 non-uniform manganese oxide was grown at 10 ms pulse polarization time. Charge transfer resistance($R_{ct}$) of near the overpotential was analyzed by EIS measurement and the feasibility of prepared electrode was evaluated by the overpotential calculated from Tafel plots.