• Journal of Physiology & Pathology in Korean Medicine
• /
• v.34 no.2
• /
• pp.81-87
• /
• 2020

Cognitive impairment is symptoms of dementia, a degenerative brain disease that is drawing attention in a rapidly aging society. This study was conducted to investigate the improvement of cognitive function of Leonurus japonicus on scopolamine-induced memory impairment in mice and the effect and mechanism of memory recovery. In vivo studies were conducted on mice orally pretreated with L. japonicus in doses of 50, 100 and 200 mg/kg (p.o.) and scopolamine (1 mg/kg, i.p.) were injected 30 min before the behavioral task. Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay, and acetylcholinesterase (AChE) inhibition activity evaluated by Ellman's method. In behavior studies showed that L. japonicus has an improved the memory of scopolamine-treated mice in Y-maze, passive avoidance and Morris water maze test. In addition, L. japonicus was also exerted free radical scavenging activity and inhibited acetyl cholinesterase activity. These results suggest that L. japonicus improves short-term and long-term memory in scopolamine-induced memory decline model and prevents scopolamine-induced memory impairments through in reduced oxidative stress and acetyl cholinesterase inhibition effect. Thus, L. japonicus is related to functional medicinal materials for prevention and treatment of human dementia patients.

• Composites Research
• /
• v.17 no.5
• /
• pp.54-60
• /
• 2004

A new three-dimensional model for predicting the relationship between the prestrain of the composite and the amount of phase transformation of shape memory alloy inducing shape memory effect has been proposed by using Eshelby's equivalent inclusion method with Mori-Tanaka's mean field theory. The model composite is aluminum matrix reinforced with short TiNi fiber shape memory alloy, where the matrix is work-hardening material of power-law type. The analytical results predicted by the current model show that most of the prestrain is induced by the plastic deformation of the matrix, except the small prestrain region. The strengthening mechanism of the composite by the shape memory effect should be explained by excluding its increase of yield stress due to the work-hardening effect of the matrix.

• The Korea Journal of Herbology
• /
• v.30 no.2
• /
• pp.43-48
• /
• 2015

Objectives : The aim of this study was to investigate the memory enhancing properties of extract of Hoelen Cum Radix (HCR) and its possible mechanism in mice of normal condition. Methods : We evaluated the effects of HCR on cognitive function and memory enhancement in normal mice. Male ICR mice were orally administrated with HCR 100 mg/kg for 7 days and equal volume of saline was administrated to the control group in the same condition. We conducted two behavioral tests which measure the spatial working memory (Y-maze test) and cognitive fear memory (passive avoidance test). We also investigated whether HCR affects the hippocampal neurogenesis in the brain. To assess the effects of HCR on neural progenitor cell differentiation and neurite outgrowth in the early stage of hippocampal neurogenesis, we performed doublecortin (DCX), a direct neurogenesis marker, immunohistochemical analysis in the dentate gyrus (DG) of the mouse hippocampus. Results : HCR significantly enhanced memory and cognitive function as determined by the Y-maze test (p<0.05) and passive avoidance test (p<0.001). Moreover, HCR increased DCX positive cells (p<0.01) and neurite length (p<0.01) compared to the control group. These results indicated that HCR stimulates differentiation of neural progenitor cells and promotes neurite outgrowth in hippocampal DG of the mice. Conclusion : We concluded that HCR shows memory enhancing effects through the stimulation of hippocampal neurogenesis as a consequence of accelerated neuronal differentiation and neurite outgrowth in the DG of the hippocampus after HCR treatment.

• The KIPS Transactions:PartA
• /
• v.8A no.4
• /
• pp.319-330
• /
• 2001

In virtual memory system, when a process attempts to access a page that is not resident in memory, the system generates and handles a page fault that causes unpredictable delay. So virtual memory system is not appropriate for the real-time system, because it can increase the deadline miss ratio of real-time task. In multimedia system, virtual memory system may degrade the QoS(quality of service) of multimedia application. Furthermore, in general-purpose operating system, whenever a new task is dynamically loaded, virtual memory system suffers from extensive page fault that cause transient overloading state. In this paper, we present efficient overloading control mechanism called RBPFH (Rate-Based Page Fault Handling). A significant feature of the RBPFH algorithm is page fault dispersion that keeps page fault ratio from exceeding available bound by monitoring current system resources. Furthermore, whenever the amount of available system resource is changed, the RBPFH algorithm dynamically adjusts the page fault handling rate. The RBPFH algorithm is implemented in the Linux operating system and its performance measured. The results demonstrate RBPFH\`s superior performance in supporting multimedia applications. Experiment result shows that RBPFH could achieve 10%∼20% reduction in deadline miss ratio and 50%∼60% reduction in average delay.

• Proceedings of the KSRS Conference
• /
• 2004.10a
• /
• pp.475-478
• /
• 2004

The DCSU performs satellite payload data acquisition and storage functions before sending the data to the ground station. While imaging, the DCSU makes a file per each input channel and store into memory stack. For the successful imaging mission, proper DCSU mission parameters should be uploaded before the mission such as file name, file size, output channel for the download transmission and so on. This paper will describe the DCSU recording mechanism and some notices that might be helpful for the ground operators.

• Journal of the Korean Society of Safety
• /
• v.10 no.3
• /
• pp.42-46
• /
• 1995

To purpose of this study is to model design and motion analysis of tangential cam mechanism using personal computer system. The CAD(Computer Aided Design) system used in this study was constructed with CPU(Central Processing Unit) 80486, RAM(Random Access Memory) 8M, CGA graphic card. By using developed program for tangential cam mechanism, we designed tangential cam models and analysed displacement, velocity, acceleration of follower.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2002.11b
• /
• pp.582-587
• /
• 2002

Current information storage devices, such as HDD, CD/DVD-ROM/RW, probe-based memory and hologram memory, are compared with biological information storage mechanisms in DNA and brain memory. Newly developed approaches to overcome the limit of storage capacity are introduced in both magnetic and optical recording devices. Linear and areal density of information stored in the biological and mechanical storages are compared for the applications and developments of new storage devices.

• Journal of the Korean Institute of Telematics and Electronics
• /
• v.14 no.2
• /
• pp.10-16
• /
• 1977

Memory switching of the amorphous chalcogenide Ge-Te-Si memory devices were observed at various thicknesses and temperatures. For a given thickness, the distribution of threshold voltages shows a strong peaks, which is attributed to the intrinsic switching mechanism. The plot of Vth versus thickness indicates that threshold voltages were lowered and switching fields were raised as thickness was decreased. And threshold voltage sagged as temperature was raised and the fact that threshold voltage can be lowered at the temperature range under Tg was obtained.

• IEIE Transactions on Smart Processing and Computing
• /
• v.4 no.2
• /
• pp.78-82
• /
• 2015

General-purpose graphics processing units (GPGPUs) provide tremendous computational and processing power. Despite the latency hiding mechanism, a GPU architecture requires high memory bandwidth and lower latency between computational units and the memory system. For this reason, the current GPU architecture has private L1 caches in each core and a shared L2 cache to increase performance by reducing memory latency. But in some cases, this CPU-like cache design is not suitable for GPGPUs. In this paper, we analyze detailed cache performance related to GPGPU application characteristics, and suggest technical alternatives for the GPGPU architecture as future work.

• Journal of the Semiconductor & Display Technology
• /
• v.20 no.1
• /
• pp.54-58
• /
• 2021

The RGO with controllable oxygen functional groups is a novel material as the active layer of resistive switching memory through a reduction process. We designed a nanoscale conductive channel induced by local oxygen ion diffusion in an Au / RGO+GQD / Al resistive switching memory structure. A strong electric field was locally generated around the Al metal channel generated in BIL, and the local formation of a direct conductive low-dimensional channel in the complex RGO graphene quantum dot region was confirmed. The resistive memory design of the complex RGO graphene quantum dot structure can be applied as an effective structure for charge transport, and it has been shown that the resistive switching mechanism based on the movement of oxygen and metal ions is a fundamental alternative to understanding and application of next-generation intelligent semiconductor systems.