• The KIPS Transactions:PartA
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• v.12A no.1 s.91
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• pp.41-52
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• 2005

Memory reference instruction caused by cache miss is the critical factor that limits the processing power of processor. Cache prefetching technique is an effective way to reduce the latency due to memory access. However, excessively aggressive prefetch leads to cache pollution and finally to cancel out the advantage of prefetch. In this study, an active prefetch filtering scheme is introduced which dynamically decides whether to commence prefetching after referring a filtering table to reduce the cache pollution due to unnecessary prefetches. For the precision filtering, an evicted address referencing scheme has been proposed where the filter directly compares the current prefetch address with previous unnecessary prefetch addresses stored in filtering table. Moreover, a small sized exclusive prefetch cache has been introduced to increase the amount of eviction of unnecessarily prefetched addresses to enhance the accuracy of dynamic filtering. The exclusive prefetch cache also prevents useful demand data from being pushed out by prefetched data, while the evicted address direct referencing scheme enables the prefetch cache to keep most of useful prefetch data within its small size. Experimental results from commonly used general and multimedia benchmarks show that the average cache miss ratio has been decreased by $13.3{\%}$ by virtue of enhanced filtering accuracy compared with conventional schemes.

• Journal of KIISE:Computer Systems and Theory
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• v.35 no.1
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• pp.30-43
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• 2008

Memory reference instructions such as loads or stores are critical factors that limit the processing power of processor. The prefetching technique is an effective way to reduce the latency caused from memory access. However, excessively aggressive prefetch leads to cache pollution so as to cancel out the advantage of prefetch. In this study, four filtering schemes have been compared and evaluated which dynamically decide whether to begin prefetch after referring a filtering table to decrease cache pollution. First, A bi-states scheme has been shown to analyze the lock problem of the conventional scheme, this scheme such as conventional scheme used to be N:1 mapping, but it has the two state to 1bit value of each entries. A complete state scheme has been introduced to be used as a reference for the comparative study. A block address lookup scheme has been proposed as the main idea of this paper which exhibits the most exact filtering performance. This scheme has a length of the table the same as the bi-states scheme, the contents of each entry have the fields the same as the complete state scheme recently, never referenced data block address has been 1:1 mapping a entry of the filter table. Experimental results from commonly used general benchmarks and multimedia programs show that average cache miss ratio have been decreased by 10.5% for the block address lookup scheme(BAL) compare to conventional dynamic filter scheme(2-bitSC).

• Journal of Physiology & Pathology in Korean Medicine
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• v.36 no.2
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• pp.59-65
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• 2022

Rodent model for chronic cerebral hypoperfusion caused by bilateral carotid artery occlusion (BCAO) show clinically relevant evidences for vascular dementia and impairments of synaptic plasticity in the hippocampus. The purpose of this study was to evaluate effect of fermented garlic (F-Garlic) extract with NO metabolites on cognitive behaviors, synaptic plasticity, and molecular events in the hippocampus following BCAO. Adult male Sprague-Dawley rats were randomly divided three experimental groups into: control+water; BCAO+water; BCAO+F-Garlic. Animals were treated with oral administration of F-Garlic in tap water as a drinking water after surgery for 4 weeks. On passive avoidance test and Y-maze test, BCAO+water showed a significant decrease in step-through latency and spontaneous alteration, indicating deficit of hippocampal memory formation but the treatment of F-Garlic significantly increased these cognitive behaviors. In control+water, a robust increase in the amplitude of evoked field excitatory postsynaptic potentials was observed by theta burst stimulation to hippocampal neural circuit indicating formation of long-term potentiation (LTP) in the hippocampal CA1. BCAO+water showed a highly significant deficit in LTP induction 4 weeks after BCAO. On other hand, daily oral administration of F-Garlic extract caused the marked preservation of LTP induction. Moreover, parvalbumin was markedly reduced in the CA1, especially, in the stratum radiatum of BCAO+water. In contrast, BCAO+F-Garlic mitigate a significantly reduction of the parvalbumin. In summary, these results suggest that daily oral administration of F-Garlic extract can ameliorate cognitive memory deficit through the preservation of synaptic plasticity and interneurons integrity in the hippocampus in rodent model of chronic cerebral hypoperfusion.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.42 no.4 s.334
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• pp.19-28
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• 2005

In this paper, we proposed a parallel fast 2-D discrete wavelet transform hardware architecture based on lifting scheme. The proposed architecture improved the 2-D processing speed, and reduced internal memory buffer size. The previous lifting scheme based parallel 2-D wavelet transform architectures were consisted with row direction and column direction modules, which were pair of prediction and update filter module. In 2-D wavelet transform, column direction processing used the row direction results, which were not generated in column direction order but in row direction order, so most hardware architecture need internal buffer memory. The proposed architecture focused on the reducing of the internal memory buffer size and the total calculation time. Reducing the total calculation time, we proposed a 4-way data flow scheduling and memory based parallel hardware architecture. The 4-way data flow scheduling can increase the row direction parallel performance, and reduced the initial latency of starting of the row direction calculation. In this hardware architecture, the internal buffer memory didn't used to store the results of the row direction calculation, while it contained intermediate values of column direction calculation. This method is very effective in column direction processing, because the input data of column direction were not generated in column direction order The proposed architecture was implemented with VHDL and Altera Stratix device. The implementation results showed overall calculation time reduced from $N^2/2+\alpha$ to $N^2/4+\beta$, and internal buffer memory size reduced by around $50\%$ of previous works.

• Korean Journal of Food Science and Technology
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• v.36 no.4
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• pp.637-642
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• 2004

Effects of defatted sesame and perilla methanol extracts on cognitive function and antioxidant activity of learning- and memory-impaired animal model SAMP8 mice. Animals were divided into 4 groups and fed with diets containing 0.3%(w/w) defatted sesame (S) or defatted perilla methanol extracts (P) for 12 weeks. Step through latency of SAMP8 control group was significantly higher than that of SAM R1 normal group, whereas significantly increased in S and P groups compared with SAMP8 control on passive avoidance test (p<0.001). Acetylcholinesterase activity of brain in SAMP8 increased compared with SAMR1 but no difference between SAMP8 control group and sample-treated group. Brain TBARS contents of SAMP8 control significantly increased compared with SAMR1 and were lowered significantly by supplementation of defatted sesame and perilla methanol extracts. Defatted sesame and perilla methanol extracts attenuated increased brain superoxide dismutase and glutathione peroxidase activities in SAMP8. These results suggest defatted sesame and perilla methanol extracts could attenuate cognitive deficits induced by aging possibly through activation of antioxidant activity of defatted sesame and perilla methanol extracts.

• Journal of Oriental Neuropsychiatry
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• v.19 no.3
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• pp.69-84
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• 2008

Objective: This experiment was designed to investigate the effects of the KBHT hot water extract & ultra-fine powder on Alzheimer's Disease Model Induced by $\beta$A. Method: The effects of the KBHT hot water extract on expression of proinflammatory cytokine mRNA in BV2 microglial celll cell line treated by lipopolysacchaide(LPS). The effects of the KBHT hot water extract & ultra-fine powder on (1) the behavior (2) AChE in serum (3) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with $\beta$A were investigated. Results: 1. The KBHT hot water extract suppressed the expression of proinflammatory cytokine mRNA in BV2 microglial cell line treated with LPS. 2. The KBHT hot water extract & ultra-fine powder a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by $\beta$A in the Morris water maze experiment, which measured stop-through latency and distance movement-through latency 3. The KBHT hot water extract & ultra-fine powder suppressed the over-expression of AChE activity in the serum of the mice with Alzheimer's disease induced by $\alpha$A. 4. The KBHT hot water extract & ultra-fine powder suppressed the expression of TNF-$\alpha$, IL-l$\beta$ protein significantly in the microglial cell of mice with Alzheimer's disease induced by 1$\beta$A. 5. The KBHT ultra-fine powder reduced infarction area of hippocampus significantly in the mice with Alzheimer's disease induced by $\beta$A. Conclusions: These results suggest that the KBHT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the PMCMT hot water extract & ultra-fine powder for Alzheimer's disease is suggested for future research.

• Journal of KIISE:Computer Systems and Theory
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• v.29 no.5
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• pp.265-273
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• 2002

With the explosive growth of WWW traffic, there is an increasing demand for the high performance Web servers to provide a stable Web service to users. The cluster-based Web server is a solution to core with the heavy access from users, easily scaling the server according to the loads. In the cluster-based Web sewer, a back-end node may not be able to serve some HTTP requests directly because it does not have the requested contents in its main memory. In this case, the back-end node has to retrieve the requested contents from its local disk or other back-end nodes in the cluster. To reduce service latency, we introduce a new prefetch scheme. The back-end nodes predict the next HTTP requests and prefetch the contents of predicted requests before the next requests arrive. We develop three prefetch algorithms bated on some useful information gathered from many clients'HTTP requests. Through trace-driven simulation, the service latency of the prefetch scheme is reduced by 10 ~ 25% as compared with no prefetch scheme. Among the proposed prefetch algorithms, Time and Access Probability-based Prefetch (TAP2) algorithm, which uses the access probability and the inter-reference time of Web object, shows the best performance.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.8 no.2
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• pp.273-286
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• 1997

Objective：This study was designed to evaluate effects of methylphenidate(MPH) on event-related potentials(ERP) and continuous performance test(CPT) in attention-deficit hyperactivity disorder (ADHD) and to see the correlation between changes in ERP and changes in performance. Method：ERP and CPT were used to examine the acute effects of MPH(0.5mg/kg) in eleven ADHD boys(89-103 months old). Results：1) After MPH administration, P3 latency to nontarget stimuli at Fz was significantly decreased (p<0.01) and P2 amplitudes to target stimuli at Pz and at Oz and P3 amplitude to target stimuli at Cz were significantly increased(p<0.05). 2) Commission error and omission error in the CPT-X and commission error in the CPT-AX were decreased(p<0.01), and hits and perceptual sensitivity(d') in the CPT-X and d′ in the CPT-AX were increased(p<0.01). 3) The change of P3 latency to nontarget stimuli at Fz and the change of d′ in the CPT-X were negatively correlated(p<0.05), and the change of P2 amplitude to target stimuli at Pz and d′ in the CPT-AX were positively correlated(p<0.05). Conclusion：MPH improves change orienting reaction, the delivery of task relevant information, accuracy and perceptual sensitivity in ADHD. And the increase of ability to discriminate targets from non-targets reflects reduced evaluation time in large memory component task and enhanced change orienting reaction in simple task.

• Journal of Oriental Neuropsychiatry
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• v.17 no.2
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• pp.91-122
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• 2006

Objective : This research investigates the effect of the Jangwon-Dan,(JWD) on Alzheimer's disease. Method : The effects of the JWN extract on (1) $IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ mRNA of PC-12 cells treated with LPS; (2) amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA, the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA, $IL-1{\beta}$ mRNA, and $TNF-{\alpha}$ mRNA, (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with ${\beta}A$ were investigated. Result : 1. The JWN extract suppressed the expression of $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ mRNA in THP-1 cells treated with LPS. 2. The JWN extract suppressed the expression of APP, AChE, and GFAP mRNA in PC-12 cells treated with CT-105. 3. The JWN extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 4. For the JWN extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 5. The JWN extract suppressed the over-expression of $IL-1{\beta}$ protein, $TNF-{\alpha}$ protein, MDA, $IL-1{\beta}$ mRNA, $TNF-{\alpha}$ mRNA, and CD68/GFAP, in the mice with Alzheimer's disease induced by ${\beta}A$. 6. The JWN extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by ${\beta}A$. Conclusion : These results suggest that the JWN extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the JWN extract for Alzheimer's disease is suggested for future research.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.48 no.7
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• pp.48-56
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• 2011

Recently, new storage device SSD(Solid State Disk) based on NAND flash memory is gradually replacing HDD(Hard Disk Drive) in mobile device and thus a variety of research efforts are going on to find the cost-effective ways of performance improvement. By increasing the NAND flash channels in order to enhance the bandwidth through parallel processing, DRAM buffer which acts as a buffer cache between host(PC) and NAND flash has become the bottleneck point. To resolve this problem, this paper proposes an efficient low-cost scheme to increase SSD performance by improving DRAM buffer bandwidth through scheduling techniques which utilize DRAM multi-banks. When both host and NAND flash multi-channels request access to DRAM buffer concurrently, the proposed technique checks their destination and then schedules appropriately considering properties of DRAMs. It can reduce overheads of bank active time and row latency significantly and thus optimizes DRAM buffer bandwidth utilization. The result reveals that the proposed technique improves the SSD performance by 47.4% in read and 47.7% in write operation respectively compared to conventional methods with negligible changes and increases in the hardware.