• The Korean Journal of Food And Nutrition
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• v.27 no.4
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• pp.673-677
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• 2014

HX106N은 용안육, 맥문동, 단삼 및 천마 등의 4가지 식물로 구성된 추출물로서, 선행 연구에서 amyloid ${\beta}$ peptide에 의한 생쥐의 기억력 저하 및 산화 손상을 억제하는 것으로 밝혀졌다. 이 연구에서는 HX106N이 비선택적 무스카린 수용체 길항제로 잘 알려진 스코폴라민(scopolamine)으로 유도한 콜린성 건망증(cholinergic amnesia)에 어떤 영향을 미치는지를 평가하였다. ICR 생쥐에게 스코폴라민(1 mg/kg body weight, i.p.)을 주입하기 1시간 전에 HX106N(100 mg/kg body weight, p.o.)을 투여하였다. 30분 후 수행한 Y-미로 시험(Y-maze test) 및 수동 회피 시험(passive avoidance test)에서 HX106N는 스코폴라민에 의해 감소되는 자발적 변경 행동(spontaneous alternation) 및 지체시간(step-through latency)을 유의미하게 억제하여 건망증을 개선시키는 것으로 나타났다. 또한 HX106N을 투약 1시간 후 생쥐의 해마와 대뇌피질 부위의 아세틸콜린에스테라제(acetylcholinesterase; AChE)의 활성을 측정한 결과 통계적으로 유의미한 정도의 활성 감소가 관찰되었다. 이러한 결과들을 종합할 때 HX106N은 AD에서 관찰되는 콜린성신경전달 장애로 인한 기억력 저하 억제에 사용될 수 있는 가능성을 가진 것으로 판단된다.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.40 no.2
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• pp.17-25
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• 2003

In this paper, a processor architecture is proposed based on the state space implementation technique for real time processing of 2-D discrete wavelet transform(DWT). It conducts 2-D DWT operations in consideration of row and column direction simultaneously, thus can reduce latency due to memory access for storing intermediate results. It is a VLSI architecture suitable for real time processing. The proposed architecture includes only four multipliers and four adders, and NK-N internal memory storage, where K denotes the length of filter. It has a small hardware complexity. Therefore it is very suitable architecture for real time, embedded applications such as web camera server. Since the processor is easily extended to array structure, it can be applied to various image processing applications.

• IEMEK Journal of Embedded Systems and Applications
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• v.11 no.2
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• pp.67-78
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• 2016

The emerging Spin-Transfer Torque RAM (STT-RAM) is a promising component that can be used to improve the efficiency as a result of its high storage density and low leakage power. However, the state-of-the-art STT-RAM is not ready to replace SRAM technology due to the negative effect of its write operations. The write operations require longer latency and more power than the same operations in SRAM. Therefore, a hybrid cache with SRAM and STT-RAM technologies is proposed to obtain the benefits of STT-RAM while minimizing its negative effects by using SRAM. To efficiently use of the hybrid cache, it is important to place write intensive data onto the cache. Such data should be placed on SRAM to minimize the negative effect. Thus, we propose a technique that optimizes placement of data in main memory. It drives the proper combination of advantages and disadvantages for SRAM and STT-RAM in the hybrid cache. As a result of the proposed technique, write intensive data are loaded to SRAM and read intensive data are loaded to STT-RAM. In addition, our technique also optimizes temporal locality to minimize conflict misses. Therefore, it improves performance and energy consumption of the hybrid cache architecture in a certain range.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.3
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• pp.431-437
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• 2011

Recently, there are so many studies that herbal composition has the effect on enhancing the memorial ability. But there are few studies whether it has effect on enhancing attentional ability. The purpose of present study is to prove the effects of a herbal composition(ChongA 100) on enhancing not only memorial but also attentional ability. The memorial ability interfered by amyloid-${\beta}$ was evaluated with passive avoidance test Y-maze task. The attentional ability was studied with attentional set-shifting task(ASST). The 200mg/kg of ChongA100 could significantly recover the shortened latency of passive avoidance test and the interfered alternation of Y-maze task. The number of trials in ASST was significantly reduced as well. Our study suggests that it has effects on enhancing both memorial and attentional ability.

• Journal of Oriental Neuropsychiatry
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• v.16 no.1
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• pp.43-66
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• 2005

Object : This study was designed to asses the protective effects of Kunneo tang on cognitive decline of the patients with early DAT. Method : Before administered with Kunneotang, 16 patients with early DAT were measured by auditory ERP, MMSE-K and K-DRS. During 12 months the patients with early DAT were administered with Kunneotang. After 12months the patients were measured by the same examinations again. Result : 1. The total score of MMSE-K decreased but it was not significant. 2. The total score of K-DRS increased but it was not significant. Among the five criteria(attention, memory, initiation/perseveration, construction, conceptualization), Initiation/perseveration score signifcantly decreased and there were no significant differences in the other scores. But, memory mean score had a tendency to increase. 3. The latency of ERP P300 component increased but it was not significant and the amplitude of ERP P300 component showed the significant difference. Conclusion : The results suggest that Kunneotang may have protective effects on cognitive decline in the patients with early DAT.

• Smart Structures and Systems
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• v.32 no.3
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• pp.179-193
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• 2023

This study explores an alternative to the existing centralized process for data anomaly detection in modern Internet of Things (IoT)-based structural health monitoring (SHM) systems. An edge intelligence framework is proposed for the early detection and classification of various data anomalies facilitating quality enhancement of acquired data before transmitting to a central system. State-of-the-art deep neural network pruning techniques are investigated and compared aiming to significantly reduce the network size so that it can run efficiently on resource-constrained edge devices such as wireless smart sensors. Further, depthwise separable convolution (DSC) is invoked, the integration of which with advanced structural pruning methods exhibited superior compression capability. Last but not least, quantization-aware training (QAT) is adopted for faster processing and lower memory and power consumption. The proposed edge intelligence framework will eventually lead to reduced network overload and latency. This will enable intelligent self-adaptation strategies to be employed to timely deal with a faulty sensor, minimizing the wasteful use of power, memory, and other resources in wireless smart sensors, increasing efficiency, and reducing maintenance costs for modern smart SHM systems. This study presents a theoretical foundation for the proposed framework, the validation of which through actual field trials is a scope for future work.

• Archives of Pharmacal Research
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• v.28 no.3
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• pp.335-342
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• 2005

The effects of ginsenosides Rg$_3$(R) , Rg$_3$(S) and Rg$_5$/Rk$_1$ (a mixture of Rg$_5$ and Rk$_1$ 1:1, w/w), which are components isolated from processed Panax ginseng C.A. Meyer (Araliaceae), on memory dysfunction were examined in mice using a passive avoidance test. The ginsenosides Rg3(R), Rg3(S) or Rg$_5$/Rk$_1$, when orally administered for 4 days, significantly ameliorated the memory impairment induced by the single oral administration of ethanol. The memory impairment induced by the intraperitoneal injection of scopolamine was also significantly recovered by ginsenosides Rg3(S) and Rg$_5$/Rk$_1$. Among the three ginsenosides tested in this study, Rg$_5$/Rk$_1$ enhanced the memory function of mice most effectively in both the ethanol­and scopolamine-induced amnesia models. Moreover, the latency period of the Rg$_5$/Rk$_1$­treated mice was 1.2 times longer than that of the control (no amnesia) group in both models, implying that Rg$_5$/Rk$_1$ may also exert beneficial effects in the normal brain. We also evaluated the effects of these ginsenosides on the excitotoxic and oxidative stress-induced neuronal cell damage in primary cultured rat cortical cells. The excitotoxicity induced by glutamate or N­methyl-D-aspartate (NMDA) was dramatically inhibited by the three ginsenosides. Rg$_3$(S) and Rg$_5$/Rk$_1$ exhibited a more potent inhibition of excitotoxicity than did Rg$_3$(R). In contrast, these ginsenosides were all ineffective against the H$_2$O$_2$- or xanthine/xanthine oxidase-induced oxidative neuronal damage. Taken together, these results indicate that ginsenosides Rg$_3$(S) and Rg$_5$/Rk$_1$ significantly reversed the memory dysfunction induced by ethanol or scopolamine, and their neuroprotective actions against excitotoxicity may be attributed to their memory enhancing effects.

• Sleep Medicine and Psychophysiology
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• v.1 no.1
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• pp.76-86
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• 1994

Objectives: This research was performed in order to observe the neuropsychological implication and functional anatomical source of event related potentials(ERP) by studying of correlations between event related potentials and neuropsychological tests. Methods: The latency and voltage of P100 of visual evoked potential (VEP), and N120 and P300 of event related potentials were studied in 56 patients and their correlations with neuropsychological tests were computed. Results: The tests showing significant correlation with latency P100 were visual continous performance test(VCPT) and contingent continous performance test(CCPT) without any significant correlation with voltage of P100. In latency of N120 category test and verbal IQ of KWIS showed significant correlation, and in voltage of N120, finger tapping test, VCPT, CCPT and digit symbol test displayed significant correlations. The latency of P300 had significant correlation with trail making A test and Stroop test. In the voltage of P300 significant correlations were shown with trail making B test, digit symbol test and Wechsler memory scale, finger tapping test, stroop test, VCPT and CCPT. Conclusion : N120 may be considered to reflect the function of medial frontal lobe and P300 may be considered to be developed from the subcortical connection of medial temporal lobe, hippocampus, thalamus, basal ganglia and medial frontal lobe.

• Journal of KIISE
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• v.44 no.10
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• pp.1005-1018
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• 2017

Recently, virtualization has become an essential component of cloud computing due to its various strengths, including maximizing server resource utilization, easy-to-maintain software, and enhanced data protection. However, since virtualization allows sharing physical resources among the VMs, the system performance can be deteriorated due to device contentions. In this paper, we first investigate the I/O overhead based on the number of VMs on the same server platform and analyze the block I/O process of the KVM hypervisor. We also propose an in-memory block cache mechanism, called QBic, to overcome I/O virtualization latency. QBic is capable of monitoring the block I/O process of the hypervisor and stores the data with a high access frequency in the cache. As a result, QBic provides a fast response for VMs and reduces the I/O contention to physical devices. Finally, we present a performance measurement of QBic to verify its effectiveness.

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.4
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• pp.331-338
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• 2013

AMP-activated protein kinase (AMPK), an important regulator of energy metabolism, is activated in response to cellular stress when intracellular levels of AMP increase. We investigated the neuroprotective effects of AMPK against scopolamine-induced memory impairment in vivo and glutamate-induced cytotoxicity in vitro. An adenovirus expressing AMPK wild type alpha subunit (WT) or a dominant negative form (DN) was injected into the hippocampus of rats using a stereotaxic apparatus. The AMPK WT-injected rats showed significant reversal of the scopolamine induced cognitive deficit as evaluated by escape latency in the Morris water maze. In addition, they showed enhanced acetylcholinesterase (AChE)-reactive neurons in the hippocampus, implying increased cholinergic activity in response to AMPK. We also studied the cellular mechanism by which AMPK protects against glutamate-induced cell death in primary cultured rat hippocampal neurons. We further demonstrated that AMPK WT-infected cells increased cell viability and reduced Annexin V positive hippocampal neurons. Western blot analysis indicated that AMPK WT-infected cells reduced the expression of Bax and had no effects on Bcl-2, which resulted in a decreased Bax/Bcl-2 ratio. These data suggest that AMPK is a useful cognitive impairment treatment target, and that its beneficial effects are mediated via the protective capacity of hippocampal neurons.