• Biomolecules & Therapeutics
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• v.21 no.6
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• pp.462-469
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• 2013

Eucommia ulmoides Oliv. Bark (EUE) is commonly used for the treatment of hypertension, rheumatoid arthritis, lumbago, and ischialgia as well as to promote longevity. In this study, we tested the effects of EUE aqueous extract in graded doses to protect and enhance cognition in scopolamine-induced learning and memory impairments in mice. EUE significantly improved the impairment of short-term or working memory induced by scopolamine in the Y-maze and significantly reversed learning and memory deficits in mice as measured by the passive avoidance and Morris water maze tests. One day after the last trial session of the Morris water maze test (probe trial session), EUE dramatically increased the latency time in the target quadrant in a dose-dependent manner. Furthermore, EUE significantly inhibited acetylcholinesterase (AChE) and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus and frontal cortex in a dose-dependent manner. EUE also markedly increased brain-derived neurotrophic factor (BDNF) and phosphorylation of cAMP element binding protein (CREB) in the hippocampus of scopolamine-induced mice. Based on these findings, we suggest that EUE may be useful for the treatment of cognitive deficits, and that the beneficial effects of EUE are mediated, in part, by cholinergic signaling enhancement and/or protection.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.16 no.3
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• pp.7-12
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• 2016

DRAM is commonly used as a smartphone memory medium, but extending its capacity is challenging due to DRAM's large battery consumption and density limit. Meanwhile, smartphone applications such as social network services need increasingly large memory, resulting in long latency due to additional storage accesses. To alleviate this situation, we adopt emerging nonvolatile memory (NVRAM) as smartphone's buffer cache and propose an efficient management scheme. The proposed scheme stores all dirty data in NVRAM, thereby reducing the number of storage accesses. Moreover, it separately exploits read and write histories of data accesses, leading to more efficient management of volatile and nonvolatile buffer caches, respectively. Trace-driven simulations show that the proposed scheme improves I/O performances significantly.

• Journal of KIISE:Computing Practices and Letters
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• v.16 no.3
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• pp.371-375
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• 2010

SSD is a storage medium based on NAND Flash memory. Because of its short latency, low power consumption, and resistance to shock, it's not only used in PC but also in server computers. Most SSDs use FTL to overcome the erase-before-overwrite characteristic of NAND flash. There are several types of FTL, but page mapped FTL shows better performance than others. But its usefulness is limited because of its large memory footprint for the mapping table. For example, 64MB memory space is required only for the mapping table for a 64GB MLC SSD. In this paper, we propose a novel caching scheme for the mapping table. By using the mapping-table-meta-data we construct a fully associative cache, and translate the address within O(1) time. The simulation results show more than 80 hit ratio with 32KB cache and 90% with 512KB cache. The overall memory footprint was only 1.9% of 64MB. The time overhead of cache miss was measured lower than 2% for most workload.

• Journal of KIISE:Computing Practices and Letters
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• v.14 no.5
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• pp.542-546
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• 2008

Recently dual-port SDRAM (DPSDRAM) architecture tailored for dual-processor based mobile embedded systems has been announced where a single memory chip plays the role of the local memories and the shared memory for both processors. In order to maintain memory consistency from simultaneous accesses of both ports, every access to the shared memory should be protected by a synchronization mechanism, which can result in substantial access latency. We propose two optimization techniques by exploiting the communication patterns of target applications: lock-priority scheme and static-copy scheme. Further, by dividing the shared bank into multiple blocks, we allow simultaneous accesses to different blocks thus achieve considerable performance gain. Experiments on a virtual prototyping system show a promising result - we could achieve about 20-50% performance gain compared to the base DPSDRAM architecture.

• Biomolecules & Therapeutics
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• v.20 no.2
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• pp.207-213
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• 2012

The present study examined the effects of krill-derived phosphatidylserine (Krill-PS) on the learning and memory function and the neural activity in rats with trimethyltin (TMT)-induced memory deficits. The rats were administered vehicle (medium-chain triglyceride: MCT) or Krill-PS (50, 100 mg/kg, p.o.) daily for 21 days. The cognitive improving efficacy of Krill-PS in TMT-induced amnesic rats was investigated by assessing the Morris water maze test and by performing choline acetyltransferase (ChAT), acetylcholinesterase (AChE) and cAMP responsive element binding protein (CREB) immunohistochemistry. The rats with TMT injection showed impaired learning and memory of the tasks and treatment with Krill-PS produced a significant improvement of the escape latency to find the platform in the Morris water maze at the $2^{nd}$ and $4^{th}$ day compared to that of the MCT group (p<0.05). In the retention test, the Krill-PS+MCT groups showed increased time spent around the platform compared to that of the MCT group. Consistent with the behavioral data, Krill-PS 50+MCT group significantly alleviated the loss of acetylcholinergic neurons in the hippocampus and medial septum compared to that of the MCT group. Treatment with Krill-PS significantly increased the CREB positive neurons in the hippocampal CA1 area as compared to that of the MCT group. These results suggest that Krill-PS may be useful for improving the cognitive function via regulation of cholinergic marker enzyme activity and neural activity.

• The Transactions of the Korea Information Processing Society
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• v.6 no.4
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• pp.1098-1105
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• 1999

The caches in distributed shared memory systems enhance the performance by reducing memory access latency and communication overhead, but they must solve the cache coherence problem. This paper proposes a new directory protocol to solve the cache coherence problem and to improve the system performance in distributed shared memory systems. To maintain the cache coherence of shared data, processors within a limited distance reduce the communication overhead by using a bit-vector like the full directory scheme. Processors over a limited distance store pointers in a directory pool. Since the bit-vector and the directory pool remove the unnecessary cache invalidations, the proposed scheme reduces the communication traffic and improves the system performance. The dynamic limited directory scheme reduces the communication traffic up to 66 percents compared with the limited directory scheme and the number of directory access up to 27 percents compared with the dynamic pointer allocation scheme.

• The Journal of Korean Medicine
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• v.21 no.2
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• pp.25-36
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• 2000

Objectives : This study demonstrates the effects of Daejo-hwan on learning and memory impairment induced by L-NAME (75 mg/kg) treatment and on cerebral ischemic damage induced by middle cerebral artery (MCA) occlusion in rats. Methods : Daejo-hwan emulsion (73.3 mg/100 g/l ml) was administered to rats along a timed study schedule. The Moms water maze was used for learning and memory test of the rats. The MCA was occluded by using the intraluminal thread method. The brain slices were stained by 2 % triphenyl tetrazolium chloride (TTC) and 1 % cresyl violet solution. Infarct size, neuron cell number and size in penumbra was measured by using computer image analysis system. Results : 1. The escape latency of the Daejo-hwan treated group decreased significantly with respect to the control group. 2.The memory score of the Daejo-hwan treated group showed increase tendency, And the swimming distance was not different between the normal, the control, and the Daejo-hwan treated group. 3. The infarct size of the Daejo-hwan treated group decreased significantly with respect to the control group. 4. The total infarct volume of the Daejo-hwan treated group showed decrease tendency. And the brain edema index of the Daejo-hwan treated group decreased significantly with respect to the control group. 5. The neuron cell number and cell size in penumbra of the Daejo-hwan treated group increased significantly with respect to the control group. Conclusions : According to the above results, it is supposed that Daejo-hwan is clinically applicable to the vascular dementia.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.46 no.4
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• pp.82-88
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• 2009

Video proxy server which is located near clients can store the frequently requested video data in storage space in order to minimize initial latency and network traffic significantly. However, due to the limited storage space in video proxy server, an appropriate video selection method is needed to store the videos which are frequently requested by users. Thus, we present a virtual caching technique to efficiently store the video in video proxy server. For this purpose, we employ a virtual memory in video poky server. If the video is requested by user, it is loaded in virtual memory first and then, delivered to the user. A video which is loaded in virtual memory is deleted or moved into the storage space of video poxy sewer depending on the request condition. In addition, virtual memory is divided into each segment area in order to store the segments efficiently and to avoid the fragmentation. The simulation results show that the proposed method performs better than other methods in terms of the block hit rate and the number of block deletion.

• YAKHAK HOEJI
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• v.49 no.2
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• pp.168-173
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• 2005

Alzheimers disease (AD) is the most prevalent form of neurodegenerations associated with aging in the human population. This disease is characterized by the extracellular deposition of beta-amyloid (A ${\beta}$) peptide in cerebral plaques. The A ${\beta}$ peptide is derived from the ${\beta}$-amyloid precursor protein ( ${\beta}$APP). Photolytic processing of ${\beta}$APP by ${\beta}$-secretase(beta-site APP-cleaving enzyme, BASE) and ${\gamma}$-secretase generates the A ${\beta}$ peptide. Several lines of evidence support that A ${\beta}$-induced neuronal cell death is major mechanisms of development of AD. Accordingly, the ${\beta}$-and ${\gamma}$-secretase have been implicated to be excellent targets for the treatment of AD. We previously found that sesaminol glucosides have improving effect on memory functions through anti-oxidative mechanism. In this study, to elucidate possible other mechanism (inhibition of ${\beta}$-and ${\gamma}$-secretase) of sesaminol glucosides, we examined the improving effect of sesaminol glucosides in the scopolamine (1 mg/kg/mouse)-induced memory dysfunction using water maze test in the mice. Sesaminol glucosides (3.75, 7.5 mg/kg/6ml/day p.o., for 3 weeks) reversed the latency time, distance and velocity by scopolamine in dose dependent manner. Next, ${\beta}$-and ${\gamma}$-secretase activities were determined in different regions of brain. Sesaminol glucosides dose-dependently attenuated scopolamine-induced ${\beta}$-secretase activities in cortex and hippocampous and ${\gamma}$-secretase in cortex. This study therefore suggests that sesaminol glucosides may be a useful agent for prevention of the development or progression of AD, and its inhibitory effect on secretase may play a role in the improving action of sesaminol glucosides on memory function.

• The Journal of the Korea Contents Association
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• v.21 no.7
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• pp.157-163
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• 2021

A single write operation in a file system can modify multiple data, but these changes in the file system are not atomically written to disk. Thus, for the consistency of the file system, conventional journaling guarantees crash consistency instead of sacrificing the system performance. It is known that using non-volatile memory as a journal space can alleviate performance degradation due to low latency and byte-level accessibility of non-volatile memory. However, none of the journaling techniques considering non-volatile memory provide scalability. In this paper, journal space on non-volatile memory is divided into multiple regions for scalable journaling, thus dispersing concentrated operations in one region. Second, the journal area-specific operator structure is used to accelerate data write operations to storage devices. We apply the proposed technique to JFS to evaluate it on multi-core servers equipped with high-performance storage devices. The evaluation results show that the proposed technique performs better than the existing technique of the NVM-based journaling file system.