• BMB Reports
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• 제42권11호
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• pp.697-704
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• 2009

Membrane proteins play important roles in the biology of the cell, including intercellular communication and molecular transport. Their well-established importance notwithstanding, the high-resolution structures of membrane proteins remain elusive due to difficulties in protein expression, purification and crystallization. Thus, accurate prediction of membrane protein topology can increase the understanding of membrane protein function. Here, we provide a brief review of the diverse computational methods for predicting membrane protein structure and function, including recent progress and essential bioinformatics tools. Our hope is that this review will be instructive to users studying membrane protein biology in their choice of appropriate bioinformatics methods.

• 한국막학회:학술대회논문집
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• 한국막학회 1995년도 추계 총회 및 학술발표회
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• pp.80-93
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• 1995

Membrane Technology, which has been in use for over twenty five years, has established itself as one of the principle separation methods. With improved technology, Reverse Osmosis ("RO") has been applied to large volume water treatment facilities. UF and MF Membrane Technology has, up until recently, been applied to small scale water treatment facilities. The fouling of membrane has restricted the growth of Membrane Technology in Water Treatment. Membrane fouling compound found in water causes the loss of flux across the membrane by absorbing to membrane and plugging their pores. Various methods have been used in the reduction and prevention of membrane fouling. For RO, a conventional pre-treatment system removes the pollutants, preventing the function decline of RO membrane by keeping SDI < 4 as the standard condition of feed water. UF and MF Membrane Technology that must have pre-treatment function within itself, are required to keep its ability not to be influenced by fouling.y fouling.

• 한국공간구조학회논문집
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• 제23권4호
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• pp.97-105
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• 2023

The membrane structure should maintain the membrane materials in tension for structural stability guaranty. The anchoring part in the membrane structure is an important part. It has the function to introduce tension into membrane materials and function to transmit stress which membrane materials receives to boundary structure such as steel frames. In this paper, it grasps anchoring system of the anchoring part in the membrane structure concerning the fracturing characteristic condition of membrane structure, and the influence which is caused to yield it designates the stress state when breaking the membrane structure which includes the anchoring part and that stress transition mechanism is elucidated as purpose. This paper follows to previous paper, does 1 axial tensile test concerning the bolting part specimen, grasp of fracturing progress of the bolting part and the edge rope and hardness of the rubber, does the appraisal in addition with the difference of bolt tightening torque. As a result, the influence which the bolt anchoring exerts on the fracturing characteristics of the membrane material in the membrane structure anchoring part is examined.

• 한국해양공학회지
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• 제13권3호통권33호
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• pp.29-35
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• 1999

At the design of Mark III membrane type LNG tank, an analytical and experimental approach on the fatigue strengths of membrane and its welds are very important in order to assist designers and surveyors. In this study, fatigue tests of lap weld of Mark III membrane type LNG tank were carried out and cumulative damage factor was calculated in order to estimate the fatigue life by probability density function and rule methods. It contained the following tests and reviews : 1) The fatigue tests of lap weld of stainless steel according to statistical testing method recommended by JSME, 2)Preparation of S-N curve for lap welds considering the statistical properties of the results of fatigue tests. 3) Procedure for estimating the initiation life of fatigue crack of lap welds under variable loads by the rule lf classification society and probability density function, 4) Guideline for inspection of lap welds fo membrane type LNG tank.

• BMB Reports
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• 제49권8호
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• pp.414-423
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• 2016

MG53 is a member of the TRIM-family protein that acts as a key component of the cell membrane repair machinery. MG53 is also an E3-ligase that ubiquinates insulin receptor substrate-1 and controls insulin signaling in skeletal muscle cells. Since its discovery in 2009, research efforts have been devoted to translate this basic discovery into clinical applications in human degenerative and metabolic diseases. This review article highlights the dual function of MG53 in cell membrane repair and insulin signaling, the mechanism that underlies the control of MG53 function, and the therapeutic value of targeting MG53 function in regenerative medicine.

• 멤브레인
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• 제10권1호
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• pp.47-53
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• 2000

인공폐는 실제 폐의 기능을 대행하는 장치이며, 주요 기능은 정맥혈에서 이산화탄소를 제거하고 산소를 첨가하여 동맥혈화하여 개심수술시 신체의 모든 조직에 충분한 양의 동맥혈을 공급한다. 또한 체외순환 생명보조장치(ECLS 또는 ECMO)는 심한 호흡부전증에 일반적으로 이용되지만 미래의 폐 이식에 사용될 것이다. 현재 미세다고엉 폴리프로필렌 중공사를 사용하고 있는 막형 인공 폐는 두 가지 문제가 있다. 환자의 체계적인 항응고가 필요하며, 오랜 기간의 사용은 막을 통하여 혈액 쪽에서 가스 쪽으로 혈청 누출을 일으킨다. 본 연구는 미세다공성 폴리프로필렌(PP)막에 폴리디메틸실록산(PDMS)을 적충한 PP/PDMS막을 제조하고, 폴리프로필렌 막에서 유발하는 혈청 누출을 최소화하는 기술에 대하여 연구하였다. Lee-White법에 의한 whole blood의 혈전형성 실험 후 사용된 막의 기체 투과도는 PP막에서는 크게 저하되었지만, PP/PDMS막에서는 거의 동일하게 유지되었다. 그러므로 PP막에서 유발되는 혈청 누출을 PP/PDMS막에서는 해결할 수 있었다. 또한, PP/PDMS막에서는 이산화탄소의 기체토과율이 산소보다 11.5배였다.

• Journal of Dairy Science and Biotechnology
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• 제15권1호
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• pp.27-32
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• 1997

Most lipids in milk are dispetsed as the form of fat globules. Apical portion of plasma membrane is coated with fat globules, which are synthesized from mammary epithelial cells and then secreted into the lumen. The unique phenomenon in separation of the plasma membrane from the cell is observed only in mammary system. It has been suggested that milk fat globule membrane(MFGM) is formed from endoplasmic reticulum, Golgi apparatus, secretory granule to plasma membrane. For this reason MFGM is important for nuderstanding the structure and function of biological membrane. Because MFGM also plays an important role in inhibition of lipase action, stimulation of nutrient digestion and absorption, emulsion or function as natural liposome, study of the major components in MFGM will provide the opportunity for more broad industrial uses of MFGM in the future.

• BMB Reports
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• 제31권6호
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• pp.542-547
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• 1998

The main function of adipocytes in various species is to store nutrient energy in the form of triglycerides, and this function may he closely related with hormonal signaling through the plasma membrane of adipocytes. Using SDS-PAGE, two-dimensional gel electrophoresis, and a membrane biotinylation technique, we have identified a 55KDa protein (55K protein) from the plasma membrane fraction of adipocytes, with an isoelectric point (pI) of 8.1-8.3. However, this 55K protein was not observed with a two-dimensional gel electrophoresis carried out on plasma membrane fractions prepared from the liver, heart, and kidney tissues. An analysis of the 12 amino acids sequence at the N-terminal of the 55K protein showed that it has a similar sequence to that of bovine serum albumin.

• 한국공간구조학회논문집
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• 제20권3호
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• pp.91-98
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• 2020

For form stability of membrane structures, membrane material is required to be in tension. Therefore, in planning and maintenance management, the engineer should consider enough about introduction of stress during construction and re-introduction of stress after completion. Clamping part is an important portion with the function for introducing tension into membrane materials, and the function to transmit stress to boundary structures, such as steel frames. Then, the purpose of this research is to clarify stress condition and stress transfer mechanism including clamping part of membrane structures, and to grasp the changing tendency of membrane structures with the passage of time. In this research, following previous one, we perform well-balanced evaluation by conducting tensile fractured tests of clamping part's specimens, and by measuring individually the amount of displacement of not only overall specimen's length but membrane material and clamping part. Thereby, we consider the influence the difference in the hardness of edge rope and the difference in the direction of thread affect modification and fracture load.

• 한국해안해양공학회지
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• 제7권3호
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• pp.219-226
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• 1995

본 연구에서는 PVC나 PU와 같은 유연성이 있는 유연막 방파제와 임의의 입사각을 갖는 파의 상호작용문제를 다루었다. 유연막 방파제에 작용하는 파랑하증을 구하기 위하여 고유함수전개법(eigen-function expansion method)을 사용하였다. 이때 유연막의 변형이 유체장에 미치는 영향은 경계조건식으로부터 표현된다. 경계조건식에서 유연막의 변형은 막 방정식을 풀어 구한다. 계산 예로 유연막에 작용하는 장력과 계류삭의 강성계수 그리고 유연막의 높이를 변화시키면서 투과율과 반사율의 차이를 비교하였고, 입사각도의 변화에 따른 방파 효과의 차이를 살펴보았다. 결론적으로 유연막 구조물을 적절히 설계한다면 미래의 훌륭한 방파제로 활용이 가능하다고 여겨진다.