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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Bioinformatic approaches for the structure and function of membrane proteins

  • Nam, Hyun-Jun (School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology) ;
  • Jeon, Jou-Hyun (Division of Molecular and Life Science, Pohang University of Science and Technology) ;
  • Kim, Sang-Uk (School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology)
  • Published : 2009.11.30
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Abstract

Membrane proteins play important roles in the biology of the cell, including intercellular communication and molecular transport. Their well-established importance notwithstanding, the high-resolution structures of membrane proteins remain elusive due to difficulties in protein expression, purification and crystallization. Thus, accurate prediction of membrane protein topology can increase the understanding of membrane protein function. Here, we provide a brief review of the diverse computational methods for predicting membrane protein structure and function, including recent progress and essential bioinformatics tools. Our hope is that this review will be instructive to users studying membrane protein biology in their choice of appropriate bioinformatics methods.

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