• Asian Pacific Journal of Cancer Prevention
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• 제15권10호
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• pp.4271-4274
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• 2014

The epithelial to mesenchymal transition (EMT) is a key step during embryonic morphogenesis and plays an important role in drug resistance and metastasis in diverse solid tumors. We previously reported that 48 h treatment of anti-cancer drug doxorubicin could induce EMT in human gastric cancer BGC-823 cells. However, the long term effects of this transient drug treatment were unknown. In this study we found that after 48 h treatment with $0.1{\mu}g/ml$ doxorubicin, most cells died during next week, while a minor population of cells survived and formed colonies. We propagated the surviving cells in drug free medium and found that these long term cultured drug survival cells (abbreviated as ltDSCs) retained a mesenchymal-like cell morphology, and expressed high levels of EMT-related molecules such as vimentin, twist and ${\beta}$-catenin. The expression of chromatin reprogramming factors, Oct4 and c-myc, were also higher in ltDSCs than parental cells. We further demonstrated that the protein level of p300 was upregulated in ltDSCs, and inhibition of p300 by siRNA suppressed the expression of vimentin. Moreover, the ltDSCs had higher colony forming ability and were more drug resistant when compared to parental cells. Our results suggested that an epigenetic mechanism is involved in the EMT of ltDSCs.

• 보건행정학회지
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• 제31권4호
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• pp.385-386
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• 2021

The 2022 Presidential election is approaching. Because health policies are intimately connected to other policies and involve multiple stakeholders, it is difficult to promote policy changes. Hence, the presidential election, during which policymakers are replaced, is a great timing for making policy improvements. Several important policies have been introduced and promoted throughout the presidential election process. However, these policies have been implemented without going through sufficient discussion among the experts but rather through the voices of minority groups with stronger political will. This eventually posed an obstacle to the balanced development of the entire health care system. The current medical system faces challenges that need to be addressed in the medium and long term. In particular, we should be wary of the populistic approach. We look forward to seeing more policy commitments, proposed through the evidence-based policy process and sufficient amount of discussion among the experts.

• 한국방재학회 논문집
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• 제8권6호
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• pp.67-71
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• 2008

본 연구는 그동안 지자체 및 각종 연구기관에서 조사된 교통 현황 및 각종 통계자료와 도시철도 현황을 재분석하고 교통과 인구의 관계, 서울의 지역별 산업분포와 종사자와의 관계, 승용차 등록대수 현황과 증가추이를 통해서 중장기적인 변화와 문제점을 예측하기 위해 연구되었으며, 서울도시철도의 발전적 건설방향과 안정적인 도시철도 건설을 위한 재원확보라는 양 측면에서 대안을 제시하였다.

• 통상정보연구
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• 제11권4호
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• pp.419-444
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• 2009

In this paper, we use case studies to analyze the supporting programs of policy funds for Korean and Japanese small and medium-sized enterprises(SMEs). It is found that supporting firms are suitable to the excluded companies from financial institutions and excellent corporate credit rating. It is also shown that subordinated loan program as well as loan limit can be enlarged policy funds with priming water of private funds. Moreover, it shows that credit guarantee funding has a positively significant influence on long-term funding facility. Therefore, this findings can improve the complementary relationship between policy funds and financial institutions.

• 기록학연구
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• 제36호
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• pp.3-33
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• 2013

기록관 도서관 박물관 등 문화유산기관의 중장기 발전 전략은 이들 기관의 협력을 가능하게 하는 매우 중요한 요소 가운데 하나이다. 본고는 이와 같은 문제의식을 바탕으로 국가 대표 문화유산기관의 발전 전략 추진 배경, 추진과제 등을 비교 분석하고, 정책의 공통점과 차이점을 도출했다. 아울러 문화유산기관의 낮은 위상으로부터 비롯된 발전 전략의 한계에 대해서도 서술하였다. 이와 같은 분석을 바탕으로 문화유산기관의 협력을 위해서는 독자적 발전 전략을 폐기하고, 공동 발전 전략으로의 전환이 필요함을 주장하였다.

• 국제학술발표논문집
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• The 5th International Conference on Construction Engineering and Project Management
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• pp.628-633
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• 2013

Knowledge-based Service Industry is an industry that creates added value through the production, processing, and use of knowledge. Comparing to other service industries, it is innovation-oriented business endeavors having the characteristics that exert the great influences on other fields. Meanwhile, however, research efforts thereof are yet insignificant. In this study, we analyzed the innovation performance of architectural design office which creates knowledge services, having raised the necessity of innovation of the design office. The innovation performance were classified according to the extent of efficiency of the architectural design office making use of DEA-Tier analysis, and, for those architectural design offices that showed significant differences in efficiency, we presented the case studies of the firms that were substantial benchmarking targets from short, medium, and long-term perspectives.

• 한국건설관리학회논문집
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• 제18권1호
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• pp.17-26
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• 2017

국내 해외 플랜트 수주액은 2015년 기준 전년도 대비 약 51% 감소하였고 플랜트산업 중 약 63%로서 가장 높은 비중을 차지하는 화공플랜트의 수주액은 약 43% 감소하였다. 현재 해외국가들의 플랜트 건설업체는 고도의 기술력과 경험 및 축적된 노하우를 바탕으로 엔지니어링 분야에서 우위를 선점하고 있다. 이에 세계 플랜트 산업에서 국내 기업의 경쟁력 확보를 위한 대책이 필요하며, 건설기술력 발전을 통한 국가경쟁력 향상을 위해 생산성 관리는 매우 중요한 현안이다. 또한 생산성은 장기적인 성장에 영향을 미치는 중요한 요소임에 따라 경쟁력 확보를 위해 수정 IPA를 이용하고 화공플랜트로 범위를 한정하여 생산성 저해요인을 분석하고자 한다. 이를 통해 해외 화공플랜트와 관련된 생산성 저해요인의 개선방안 및 대책을 제시한다. 그리고 생산성을 향상시킬 수 있는 요인이 무엇인가를 파악하고 생산성 향상을 위한 시사점을 제시함으로서 중 장기적인 대책을 마련할 수 있을 것으로 기대된다.

• 한국비블리아학회지
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• 제35권1호
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• pp.273-300
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• 2024

전자기록 환경에서는 아날로그 기록물의 디지털화 방안에 대한 논의와 함께, 전자적으로 생산, 접수된 기록물에 대한 유형별 보존전략 마련이 중요하게 인식된다. 같은 맥락에서, 문서유형 외 데이터세트, 시청각 유형 전자기록물의 장기보존을 목표로 보존포맷 선정체계를 적용하기 위한 논의가 필요하다. 시청각 기록물은 이미지, 오디오, 비디오와 같이 매체별 특성에 적합한 보존전략을 적용해야 한다. 본 연구는 시청각 중 오디오 유형 전자기록물의 보존포맷 선정을 위한 고유기준을 문헌 조사에 바탕을 둔 필수보존속성 분석을 통해 수립하고, 오디오 유형 보존포맷 적합성 평가항목을 구성하고 이를 적용한 결과를 토대로 권고포맷을 제안했다.

• 천문학회보
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• 제44권2호
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• pp.49.2-49.2
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• 2019

We present results from our long-term observing campaign, using the NASA IRTF at Maunakea, to obtain 2 - 4 ㎛ spectra of 118 red point sources in the line of sight to the Galactic Center (GC). Our sample is largely composed of point sources selected from near- and mid-infrared photometry, but also includes a number of massive young stellar objects. Many of these sources show high foreground extinction as shown by deep 3.4 ㎛ aliphatic hydrocarbon absorption feature, which is a characteristic of the diffuse ISM and comes from the long line of sight through the diffuse medium toward the Central Molecular Zone (CMZ), the central 300 pc region of the GC. The deep 3.1 ㎛ H₂O ice absorption band coming from the local, dense material in the GC CMZ suggests that most sources are likely located in the GC CMZ. A few of these sources show weak CCH₃OH ice absorption at 3.535 ㎛, which can provide a strong constraint on the CCH₃OH ice formation in the unique environment of the CMZ. From the best-fitting models, the optical depths of these features are determined and used to generate a well-rounded view of the ice composition across the GC CMZ and the spectral characteristics of massive YSOs in the GC.

• Journal of the Korean Wood Science and Technology
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• 제2권3호
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• pp.39-41
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• 1974

Bastard indigo, prevailing shrub species planted in erosion control work to constitute vegetation, is proved to be usefull for pulp material other than existing usage of green manure or fuel. Pulp made from bastard indigo is good enough for filler pulp though the quality of it is not remarkably excellent. (1) Sorts of paper possible to make from this pulp. Packing paper of medium grade. (general packing paper except heavy packing) (2) Traits of this pulp as for pulp material (A) It is more preferable than annual plants in these respects, ego collection, transport and storage of pulp material, and yield, freeness and chemical consumption of pulp. (B) Annual probable production of pulp material per ha from this plant is higher than that from long-term tree species or similar to that from fast growing species. (C) Its cultivation on eroded area is welcomed and consecutive annual production of material by copice method is also proved possible.