• Proceedings of the PSK Conference
• /
• 2001.10a
• /
• pp.272.2-272.2
• /
• 2001

• Journal of Microbiology and Biotechnology
• /
• v.27 no.6
• /
• pp.1078-1089
• /
• 2017

Biofilm formation of Staphylococcus aureus is one of its mechanisms of drug resistance. Anti-biofilm screening of 106 compounds from marine-derived fungi displayed that 12 compounds inhibited S. aureus biofilm formation by >50% at the concentration of $100{\mu}g/ml$, and only secalonic acid D (SAD) and B inhibited by >90% at $6.25{\mu}g/ml$ without inhibiting cell growth after 24-h incubation. Meanwhile, it was found that the double bond between C-1 and C-10 of citrinin derivatives and the C-C connection position of two chromone monomers may be important for their anti-biofilm activities. Moreover, SAD slightly facilitated biofilm eradication and influenced its architecture. Furthermore, SAD slowed the cell growth rate in the preceding 18-h incubation and differentially regulated transcriptional expression of several genes, such as agr, isaA, icaA, and icaD, associated with biofilm formation in planktonic and biofilm cells, which may be the reason for the anti-biofilm activity of SAD. Finally, SAD acted synergistically against S. aureus growth and biofilm formation with other antibiotics. These findings indicated that various natural products from marine-derived fungi, such as SAD, could be used as a potential biofilm inhibitor against S. aureus.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.18 no.6
• /
• pp.1388-1394
• /
• 2014

Recently, medical expenses are increasing because of the accelerated aging phenomenon, thus study for the medical service of high quality and reduction of medical expenses should be continued as yet. Especially, U-health is performed by intelligent medical service which is derived by smart devices, wireless network, sensing technology and it could be more extensible in the medical fields as time goes on. On this study, we analyze message transmission structure of HL7 standard and will suggest improved processing methodology of HL7 message.

• Korean Journal of Plant Resources
• /
• v.3 no.1
• /
• pp.41-63
• /
• 1990

The plants medicinal resources of Mt. Chu-woL were investigated 21times from APril, 1975 to August , 1977 and from JuLy, 1988 to August 1989In orther to analyze the vegetation of Chu-woL mountain area , medical wildplants structure and distribution. MedicaL wild plants of Chu-woL moun-tain consisted of 113 familis, 428 species in alL. The resources of important herb drugs were Polypodiaceae, Graminea, Liliaceae , Polygonaceae,Ranunculaceae, Brassicaceae, Rosaceae , Fabaceae, Apiaceae, tabiatae, so-lanaceae, Scrophulariaceae, Campanulaceae, Compositae. The herb drugswere comparatively more than in other mountains in our country .

• Journal of the Korean Association of Geographic Information Studies
• /
• v.24 no.2
• /
• pp.29-39
• /
• 2021

The global aging phenomenon and new lifestyles have a worldwide attention to the new tourism form of health tourism. The purpose of this study is to analyze and suggest the competitive types of health tourism. Through the literature review, the theoretical base on the concept and type of health tourism and hierarchical spatial types such as medical space, semi-medical space, non-medical space, and natural healing space, based on medical intervention was established. A questionnaire survey was conducted for the professionals in Jeju area about tourism, health care, policy. As a result of analysis based on competitiveness advantage factors of Jeju health tourism, Jeju health tourism was confirmed to have higher importance in the natural healing space than the health service center space. Three kinds of resources such as natural resources, healing resources, and active resources of Jeju type health tourism were derived and applied to two hierarchical spaces, natural healing space and non-medical healing space, based on medical intervention.

• The Journal of the Korean dental association
• /
• v.32 no.3 s.298
• /
• pp.215-224
• /
• 1994

• Journal of the Korean Regional Science Association
• /
• v.34 no.2
• /
• pp.3-19
• /
• 2018

The objective of this study is to observe the efficiency of clinical performance on the supply and demand of medical resources in Korea. For the empirical analysis, we constructed the dataset on age standardized mortality rate, the number of physician, specialist, surgery, medical institution, ratio of general hospitals of 16 provinces in Korea from 2006 to 2013. The panel probability frontier model is employed as an analysis method and considered heteroscedasticity and autocorrelation of the error in panel data. In addition, the demographic and socioeconomic characteristics of the 16 provinces, unemployment rate, elderly population ratio, GRDP per capita, and ratio of hospitals in comparison to the general hospitals are used to find the effect on the technical efficiency of clinical performance on supply and demand of medical resources. The results are as follows. First, for the clinical performance, the supply side of human resources such as doctors and specialists and the demand side factors such as chronic illness clinic per unit population have a significant influence, respectively. Second, the technical efficiency of clinical performance on the supply and demand of medical resources of each input component was 59-70% in terms of clinical efficiency in each region. Third. estimates of technical efficiency of inputs that affect clinical performance showed a slight increase in all regions during the analysis period, but the increase trend decreased slightly. Fourth, the ratio of the elderly population and GRDP per capita have a positive influence on the technical efficiency of clinical performance on the supply and demand of medical resources. The difference of each efficiency by region is due to the regional differences of the input medical resources and the combination of them and the demographic and socioeconomic characteristics of the region. It is understood that the differences in technological efficiency due to the complexity of supply and demand of medical resources, demographic structure and economic difference affecting clinical performance by region are different.

• Biomolecules & Therapeutics
• /
• v.27 no.1
• /
• pp.54-62
• /
• 2019

Cis-3-O-p-hydroxycinnamoyl ursolic acid (HCUA), a triterpenoid compound, was purified from Elaeagnus oldhamii Maxim. This traditional medicinal plant has been used for treating rheumatoid arthritis and lung disorders as well as for its anti-inflammation and anticancer activities. This study aimed to investigate the anti-proliferative and apoptotic-inducing activities of HCUA in oral cancer cells. HCUA exhibited anti-proliferative activity in oral cancer cell lines (Ca9-22 and SAS cells), but not in normal oral fibroblasts. The inhibitory concentration of HCUA that resulted in 50% viability was $24.0{\mu}M$ and $17.8{\mu}M$ for Ca9-22 and SAS cells, respectively. Moreover, HCUA increased the number of cells in the sub-G1 arrest phase and apoptosis in a concentration-dependent manner in both oral cancer cell lines, but not in normal oral fibroblasts. Importantly, HCUA induced p53-mediated transcriptional regulation of pro-apoptotic proteins (Bax, Bak, Bim, Noxa, and PUMA), which are associated with mitochondrial apoptosis in oral cancer cells via the loss of mitochondrial membrane potential. HCUA triggered the production of intracellular reactive oxygen species (ROS) that was ascertained to be involved in HCUA-induced apoptosis by the ROS inhibitors YCG063 and N-acetyl-L-cysteine. As a result, HCUA had potential antitumor activity to oral cancer cells through eliciting ROS-dependent and p53-mediated mitochondrial apoptosis. Overall, HCUA could be applicable for the development of anticancer agents against human oral cancer.

• Food Science of Animal Resources
• /
• v.43 no.1
• /
• pp.10-24
• /
• 2023

In this study, a antioxidant activity peptide fraction was separated and purified from metabolites of whey protein fermented by Lactobacillus rhamnosus B2-1. The fermentation sample was separated by macroporous resin D101 and Sephadex G-15. The collected fractions were tested for antioxidant and antitumor activities. In order to test the antioxidant activity of fractions, Hydroxyl (·OH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and Oxygen Radical Absorbance Capacity (ORAC) were used. The final purified peptide B11 showed highest ABTS and ·OH radical scavenging rate by 84.36±1.89% and 62.43±2.64%, respectively, and had an ORAC activity of 1,726.44±2.76 μM Trolox equivalent/g. Further, the inhibitory effect of B11 on the proliferation of LoVo human colon cancer cells, KB and Cal-27 human oral cancer cells were enhanced with increasing concentrations of B11. B11 contains 51.421% amino acids, with Glu and Asp being the major constituents. In this study, we obtained peptide fraction B11 with antioxidant activity, which is promising for development.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.5
• /
• pp.3237-3241
• /
• 2013

Background: Under-ascertainment and over-ascertainment are common phenomena in surveillance and registry systems of health-related events. Capture-recapture is one of the methods which is applied to determine the sensitivity of surveillance or registry systems to recognize cancer cases. This study aimed to estimate the number of cancers using data available both in the Cancer Registry Center of Northwestern Iran and in the Population-based Cancer Registry Center of Iran. Material and Methods: The studied population consisted of all cancerous cases in the northwest of Iran from 2008 to 2010. All data were extracted from two resources and entered into Microsoft Excel software. After removing common and repeat cases the data were statistically analyzed using a capture-recapture studies' specific software "CARE 1.4". Estimations were calculated by Chapman and Petersen methods with the approximate confidence interval of 95%. Results: From 2008 to 2010, the number of all cancer cases was estimated to be 21,652 (CI 95%: 19,863-22,101). Sensitivity rate of all cancer cases was 83.9% and that of Population-based Cancer Registry Center of Iran was 52%. It was 93.1% considering both resources. Conclusion: Using two resources and the capture-recapture method rather than a single resource may be a more reliable method to estimate the number of cancer cases.