• Title/Summary/Keyword: medical foods

검색결과 474건 처리시간 0.025초

Prevention of Lung Cancer: Future Perspective with Natural Compounds

  • Brandes, Johann C.;Amin, A.R.M. Ruhul;Khuri, Fadlo;Shin, Dong-Moon
    • Tuberculosis and Respiratory Diseases
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    • 제69권1호
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    • pp.1-15
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    • 2010
  • Lung cancer remains the most common cause of cancer death in the United States and worldwide. About 80~90% of cases are smoking-related and smoking cessation programs are of great importance in reducing lung cancer risk. However, the lifetime risk for lung cancer remains elevated even in ex-smokers. Chemoprevention holds the promise to further reduce this risk and thus to decrease lung cancer incidence and mortality. Over the last decades, most chemoprevention trials for lung cancer have yielded negative outcomes. Population-based studies suggest that high intake of certain foods such as soy, red wine or green vegetables may be associated with decreased cancer risk. Because of these observations and their general safety, a plethora of natural compounds is currently being studied for the chemoprevention of cancer. In this review we discuss promising in vitro and in vivo data of novel natural compounds, their interference with molecular mechanisms responsible for lung cancer development and potential implications for their further preclinical and clinical investigation.

Epidemiology, Incidence and Mortality of Breast Cancer in Asia

  • Ghoncheh, Mahshid;Mahdavifar, Neda;Darvishi, Efat;Salehiniya, Hamid
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권sup3호
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    • pp.47-52
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    • 2016
  • Breast cancer is the most common malignancy in women in Asia and its incidence is rapidly increasing. Information on the incidence and mortality of breast cancer is essential for planning health and more studies. This study aimed to investigate the age-specific incidence and mortality of breast cancer in Asia in 2012. A total of 639,824 cases of breast cancer were recorded in Asian countries, those with the five highest standardized incidence rates being Israel, Lebanon, Armenia, Singapore, and Kazakhstan. The highest number of deaths was observed in India, China, Indonesia, Pakistan, and Japan, respectively. Tith increasing income and improving living standards in developing countries, the incidence of breast cancer increases. This may be due to longer life, higher exposure to risk factors, eating more fatty foods and obesity, and lower pregnancy rates. The variation in incidence rates of breast cancer is very pronounced in Asia (from 80.5 in Israel to 4.6 in Bhuta). A similar situation exists for mortality rates (from 1.8 in Bhutan to 25.2 in Pakistan).

Soy Supplementation Does Not Affect Serum Adiponectin Levels in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  • Jahangir Karimian;Parivash Shekarchizadeh-Esfahani
    • Clinical Nutrition Research
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    • 제13권2호
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    • pp.130-138
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    • 2024
  • Numerous studies have indicated that low levels of serum adiponectin are linked with the development of various chronic diseases. While some recent research has suggested that soy has a positive impact on serum adiponectin levels, the results are inconsistent. Therefore, we aim to conduct a thorough systematic review and meta-analysis of randomized controlled trials (RCTs) that investigate the effects of soy on serum adiponectin levels in adults. The search was conducted until March 2024 on PubMed, Scopus, Web of Science, and Cochrane Library databases to identify RCTs that studied the effects of soy supplementation on serum adiponectin levels. A random-effects model was used to pool the weighted mean differences (WMDs). Ten and nine RCTs were selected for the systematic review and meta-analysis, respectively. After analyzing data from 9 eligible RCTs, it was found that soy supplementation did not significantly impact the concentrations of adiponectin (WMD = -0.24㎍/mL; 95% confidence interval, -1.56 to 1.09; p = 0.72). However, there was significant heterogeneity between the studies (I2 = 89.8%, p < 0.001). Sensitivity analysis showed that overall estimates were not affected by the elimination of any study. We did not observe any evidence regarding publication bias. In conclusion, soy supplementation did not have a significant effect on adiponectin levels in adults. However, further RCTs are needed with longer intervention duration, higher doses, and studies conducted in different countries.

토종 복분자와 외래종 복분자 추출물의 항염증효과 비교 (Comparison of the Anti-inflammatory Effects of the Extracts from Rubus coreanus and Rubus occidentalis)

  • 양현모;임순성;이연실;신현경;오양석;김진경
    • 한국식품과학회지
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    • 제39권3호
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    • pp.342-347
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    • 2007
  • 본 연구의 목적은 수세기에 걸쳐 발기부전(impotence), 정액루(spermatorrhea), 유뇨증(enuresis), 천식(asthma) 및 알레르기 관련 질병의 치료제로 사용되고 있는 토종 복분자 (R. coreanus)와 외래종 복분자(R. occidentalis)의 항염증활성을 비교, 분석해 보고자 했다. 그 결과 토종 복분자의 에탄올 추출물이 외래종 복분자의 에탄올 추출물에 비교해 LPS 처리에 의한 NO의 생성을 현저히 억제시키는 것을 관찰 할 수 있었으며, NO와 $PGE_{2}$ 생합성효소인 iNOS와 COX-2 단백질의 발현 또한 억제시킴을 확인할 수 있었다. LPS 유도에 의한 $TNF-{\alpha}$와 IL-6의 생성억제 효과도 토종 복분자 에탄올 추출물이 외래종 복분자 추출물에 비해 탁월함이 관찰 되었다. 이러한 연구결과로 볼 때 토종 복분자 에탄올 추출물이 macrophage에 의해 생성되는 염증반응의 매개물질인 NO, $PGE_2$, 염증성 cytokine 등의 생성을 억제함으로 염증반응을 완화시켜 줄 것으로 판단된다. 차후 항염증활성을 갖는 복분자 추출물의 성분을 동정하는 연구가 더욱더 필요할 것으로 사료되며, 토종 복분자가 천연 항염증활성을 갖는 제품 개발에 있어 유용한 식물자원 원료로 사용될 수 있을 것으로 생각된다.

Present Status of Fermented Milk Products in Japan

  • Hosono, Akiyoshi
    • 한국유가공학회:학술대회논문집
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    • 한국유가공기술과학회 2004년도 제58회 춘계유가공심포지움 - 세계 우유의 날 기념 국제 심포지움
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    • pp.21-39
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    • 2004
  • Fermented milks have been recognized as healthy foods since ancient times, but those using intestinal bacteria such as Bifidobacterium and lactic acid bacteria (LAB) are even more valuable from the standpoint of view of maintaining health. They have also now come to be recognized as important in the field of preventive medicine. Although advances in the medical sciences in the last 50 years have significantly increased the human lift span, an unfortunate fact is that many of us are now living long enough to experience chronic disorders such as coronary heart disease, hypertension, osteoporosis, diabetes and cancer. In recent years there has been renewed interest in health promotion and disease prevention by incorporating probiotic bacteria into foods to counteract harmful bacteria in the intestinal tract. Therefore, there are now a wide variety of commercial products containing prospective probiotics that claim health-promoting effects, such reductions in large botvel carcinogens and mutagens, antitumor properties, cholesterol-lowering effects, increased lactose digestion, relief from con-stipation, stimulation of immunocomponent cells and enhancement of phagocytosis. Two well-known representative probiotic is LAB and Bifidobaclerium. Traditional probiotic dairy strains of LAB which have been designated as GRAS (Generally Recognized As Safe) bacteria have a long history of safe use and most strains are considered comestible microorganisms with no pathogenic potential. Accordingly, there is considerable interest in extending the range of foods containing probiotic organisms from dairy foods to infant formulas, baby foods, and pharmaceuticals. In addition, the ingestion of probiotics, prebiotics, and symbiotic as wll as combinations of pro- and prebiotics has recently aroused renewed interest as enhancing the beneficial relationship between the host and intestinal microflora in both healthy and diseased indivisuals. Non-communicable chronic diseases such as cancer, cerebral hemorrhage, is chemic heart disease, and diabetes mellitus has recently been recognized as adult diseases in Japan as well as other countries. and are considered to be inevitably associated with aging. These diseases occur as a result of individual life styles. The Japanes Government. Ministry of Health, Labor and Welfare has proposed substituting the term 'adult diseases' with 'lifestyle-related diseases'. It has emphasized the importance of prevention rather than treatment. since the well-known increase in the elderly population in Japan is predicted to result in a variety of socioeconomic problems. n this lecture on the Present status of fermented milk products in Japan, I will report a strategy for the development of fermented milk products in Japan from the standpoint of view of research in Japan on LAB and Bifidobacteria. They could play an important role in preserving human health by controlling intestinal microflora capable of producing toxic effects on the host.

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『식료찬요(食療纂要)』에서 오곡(五穀)을 이용한 식치(食治) 연구(硏究) (A Review on the Food-Therapy with Five-Grain in 『Sikryochanyo』)

  • 윤서현;이성진;조은희;송지청
    • 한국의사학회지
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    • 제24권2호
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    • pp.105-116
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    • 2011
  • Objective : Foods could be materia medica through food-therapy in oriental medicine. "Sikryochanyo" is a food-therapy book totally. Therefore, there are many kinds of food are treated as materia medica. Method : Finding out cases of food-therapy with Five-Grain(RIce, Barley, Millet, Soy, Panicum miliaceum) in "Sikryochanyo" Result : In "Sikryochanyo", there were many methods of food-therapy with Five-Grain. Five-Grain were treated as materia medica even though they were usual food as normal meal. Conclusion : Five-Grain used in "Sikryochanyo" as many types of themselves and they had objectively effects comparing with "Materia Medica".

Suppressive Effects of Various Antioxidants on Melamine-induced Oxidative DNA Damage in Human Lymphocytes

  • Park, Seul-Ki;Lee, Mi-Young
    • Molecular & Cellular Toxicology
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    • 제5권3호
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    • pp.243-249
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    • 2009
  • Melamine, which is used to produce melamine resin for various industrial applications, has a high nitrogen content by mass. For this reason, it has been illegally added to foods to increase their apparent protein content. In the present investigation, melamine-induced oxidative damage of human lymphocyte DNA was evaluated by Comet assay. The in vitro oxidative DNA damage caused by melamine increased in a dose-dependent manner. This DNA damage was significantly inhibited by treatment with ascorbate. Moreover, the traditional Korean medicinal herb, named Acanthopanax, red ginseng and green tea markedly reduced the DNA damage. Various edible plant extracts also inhibited melamine-induced oxidative DNA damage in vitro. Melamine enhanced intracellular ROS generation, and this effect was suppressed by treatment with various antioxidants.

한국상용식품중(韓國常用食品中)의 무기물함량(無機物含量)에 관(關)한 연구(硏究) (특(特)히 Lithium, Sodium 및 Potassium함량(含量)) (A Study on the Contents of Some Minerals in Korean Daily Foods)

  • 이영우;류종근
    • Journal of Nutrition and Health
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    • 제12권2호
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    • pp.95-98
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    • 1979
  • In order to observe the contents of some minerals in Korean daily food, the lithium, sodium and potassium were determined by E.E.L flame photometry. The results obtained are summarized as follows: 1) The lithium content was most higher (13. 8 to 16.8mg/100g) in sodium chloride, the contents of the lithium End sodium in each food were increased according to supplement of sodium chloride. 2) The potassium contents in garlic and bean paste were 137.6 mg and 186.3 mg per 100g sample, respectively, therefore these values were higher than the values in other samples. 3) The contents of lithium, sodium and potassium in rice, barley pressed and boiled rice lower than other samples.

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어머니의 임신기 동안 식품섭취와 영유아의 아토피피부염 유무와의 관계 (Comparison of Maternal Food Intakes during Pregnancy in Children with and without Atopic Dermatitis)

  • 이희진;안강모;한영신;정상진
    • 대한영양사협회학술지
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    • 제18권2호
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    • pp.141-154
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    • 2012
  • The prevalence of atopic dermatitis (AD), chronic cutaneous disease, has increased rapidly worldwide. Since AD is the most common disease affecting infants, maternal food intake during pregnancy as well as lactation is important. The purpose of this research was to examine the difference in maternal food intake during pregnancy between mothers having children with or without AD. One hundred forty-eight mothers with children aged under 2 years with AD (AD group, n=74) or without AD (non-AD group, n=74) were included in the study. Diet during pregnancy was examined using a food frequency questionnaire. There were no differences in the status of mothers' food consumption during pregnancy between the AD and non-AD groups. Mothers in the AD group consumed significantly less white fish (P<0.05), carrot & pumpkin (P<0.01), walnut & pine nut (P<0.05), mandarin & orange (P<0.05), and peach (P<0.05) than those in the non-AD group. As food frequencies were categorized according to <1/month, 1~3/month, 1~6/week, and 1~3/day, lower consumption of carrot & pumpkin (Odds Ratio (OR)=6.67, 95% Confidence Interval (CI)=1.98~22.44), tomato (OR=5.11, 95% CI=1.62~16.08), mandarin & orange (OR=8.64, 95% CI=1.59~46.81), and walnut & pine nut (OR=3.85, 95% CI=1.26~11.77) increased the risk of childhood AD. According to the results, maternal food intakes during pregnancy were significantly different between the AD and non-AD groups. Therefore, further studies are necessary to examine the causal relationship between maternal food intake and prevalence of AD in children.

Inhibitory Effects of Rice Bran Water Extract Fermented Lactobacillus plantarum due to cAMP-dependent Phosphorylation of VASP (Ser157) on human Platelet Aggregation

  • Kim, Hyun-Hong;Lee, Dong-Ha;Hong, Jeong Hwa;Ingkasupart, Pajaree;Nam, Gi Suk;Ok, Woo Jeong;Kim, Min Ji;Yu, Young-Bin;Kang, Hyo-Chan;Park, Hwa-Jin
    • 대한의생명과학회지
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    • 제21권2호
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    • pp.103-114
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    • 2015
  • In this study, we investigated the effect of rice bran water extract fermented with Lactobacillus plantarum KCCM-12116 (RBLp) on ADP ($20{\mu}M$)-, collagen ($10{\mu}g/mL$)-, and thrombin (0.2 U/mL)-stimulated platelet aggregation. RBLp dose-dependently inhibited ADP-, collagen-, and thrombin-induced platelet aggregation, with $IC_{50}$ values of 501.1, 637.2, and > $2,000{\mu}g/mL$, respectively. The platelet aggregation induced by ADP plus RBLp ($750{\mu}g/mL$) was increased by the adenylate cyclase inhibitor, SQ22536, and the cAMP-dependent protein kinase (A-kinase) inhibitor, Rp-8-Br-cAMPS. Treatment with RBLp increased the phosphorylation of VASP ($Ser^{157}$), an A-kinase substrate, which was also inhibited by SQ22536 and Rp-8-Br-cAMPS. It is thought that the RBLp-induced increases in cAMP contributed to the phosphorylation of VASP ($Ser^{157}$), which in turn resulted in an inhibition of ADP-induced platelet aggregation, thereby indicating that RBLp has an antiplatelet effect via cAMP-dependent phosphorylation of VASP ($Ser^{157}$). Thus, RBLp may have therapeutic potential for the treatment (or prevention) of platelet aggregation-mediated diseases, such as thrombosis, myocardial infarction, atherosclerosis, and ischemic cerebrovascular disease.