• 한국비블리아학회지
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• 제29권1호
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• pp.233-252
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• 2018

1884년 한국에 온 최초의 의료선교사 Horace Allen이 우리나라 최초의 서양식 병원인 제중원을 세운 뒤에 John Heron, Oliver Avison 등 외국인 의사들이 선교를 목적으로 차례로 입국하였다. 이들은 병원과 의과대학을 설립하고 진료와 교육활동을 통하여 근대의학을 보급하고 발전시켰다. 또한 체류기간동안 파송기관과 교회에 공적 기록물을 작성하여 보고하였고 동료, 후원자, 그리고 가족들에게는 개인적인 기록물을 남겼다. 개화기 이후 내한선교사들의 기록, 즉 보고서, 기행문, 편지, 일기, 사진, 구술자료 등은 우리나라 근대사 연구에 필수적인 사료이다. 특히 일기나 기행문이 자세한 기록이기는 하지만, 일방적인 기록이기 때문에 과장되거나 불확실한 경우가 있는 것에 비해 편지는 수신자와 발신자 사이의 기록이기 때문에 사실 확인이 가능하고 회고록처럼 후일의 상황변동에 따라 수정하거나 변개할 수 없다. 그러나 이러한 학술적 가치에도 불구하고 내한 의료선교사들의 1차적인 기록인 편지를 보다 포괄적으로 발굴하고 이를 체계적으로 정리하는 일은 본격적으로 이루어지지 않았다. 이 연구는 북미지역 29개 기관에 소장된 49개의 기록물 컬렉션을 조사하고 분석한 것이다. 또한 이들의 자료적 가치를 살피고 이를 바탕으로 한 디지털 인문학적 활용 방안을 모색하여 향후 근대사 연구에 활용하고자 하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4417-4421
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• 2012

Objective: The results from studies on associations of the glutathione S-transferase T1 (GSTT1) gene polymorphism and hepatocellular carcinoma (HCC) risk in Chinese populations are still conflicting. This meta-analysis was performed to evaluate the relationship in detail. Methods: Eligible reports were recruited into this meta-analysis from the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database). Results were expressed with odds ratios (OR) for dichotomous data, and 95% confidence intervals (CI) were also calculated. Results: Eighteen investigations were identified for the analysis of association between polymorphic deletion of GSTT1 and HCC, consisting of 2,693 patients with HCC and 4,696 controls. Null genotype of GSTT1 was associated with HCC susceptibility in Chinese (OR=1.53, 95%CI: 1.28-1.82; P<0.00001). Conclusion: The GSTT1 null genotype is associated with HCC susceptibility in Chinese.

• BMB Reports
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• 제45권8호
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• pp.482-487
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• 2012

To identify the novel inhibitors of endoplasmic reticulum stress-induced cell death, we performed a high throughput assay with a chemical library containing a total of 3,280 bioactive small molecules. Cyclosporine A and bromocriptine were identified as potent inhibitors of thapsigargiin-induced cell death (cut-off at $4{\sigma}$ standard score). However, U74389G, the potent inhibitor of lipid peroxidation had lower activity in inhibiting cell death. The inhibition effect of cyclosporine A and bromocriptine was specific for only thapsigargin-induced cell death. The mechanism of inhibition by these compounds was identified as modification of the expression of glucose regulated protein-78 (GRP-78/Bip) and inhibition of phosphorylation of p38 mitogen activated protein kinase (MAPK). However, these compounds did not inhibit the same events triggered by tunicamycin, which was in agreement with the cell survival data. We suggest that the induction of protective unfolded protein response by these compounds confers resistance to cell death. In summary, we identified compounds that may provide insights on cell death mechanisms stimulated by ER stress.

• BMB Reports
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• 제37권3호
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• pp.356-361
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• 2004

To develop a simplified method that can rapidly prepare DNA microarray probes in a massive scale, a lambda phage genomic DNA-fragments library was constructed for the microarray-probes collection. Four methods of DNA band recovery from the first PCR products were tested and compared. The DNA microarray probes were collected by a novel method of nested PCR that was mediated by gel isolation of the first PCR products. This method was named GIN-PCR. The probes that were prepared by this GIN-PCR technique were used as subjects to fabricate a DNA microarray. The results showed that a wooden toothpick was superior to the other 3 methods, since this technique can steadily transfer the DNA bands as the template of the second PCR after the first PCR. A group of probes were successfully collected and DNA microarrays were constructed using these probes. Hybridization results demonstrated that this technique of DNA recovery and probe preparation was rapid, efficient, and effective. We developed a cost-effective and less labor-intensive method for DNA microarray probe preparation by nested PCR that is mediated by wooden toothpick transfer of the DNA bands in the gel after electrophoresis.

• 대한한의진단학회지
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• 제19권2호
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• pp.65-74
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• 2015

Objectives As a method of body temperature distribution diagnosis, palpation of infants' forehead had been widely introduced in ancient East Asian medical classics. However, few attention have been paid to this diagnostic method - so called 'emaizhenduan (額脈診斷)'. So we studied the history of emaizhenduan and it's implication in modern clinical field. Materials and methods: To search the medical classic that contains any contents of emaizhenduan, we mainly used the electronic texts of Zhonghuayidian (中華醫典). To search modern study article on emaizhenduan, we used China National Knowledge Infrastructure (www.cnki.net), National Digital Science Library (ndsl.kr) etc. Results 20 kinds of East Asian medical classics were found to contain contents on emaizhenduan. The oldest one was Huoyoukouyi (活幼口議) which was written in Yuan dynasty of China. Only one modern TCM book was found to have comments on emaizhenduan, while some textbooks of pediatrics in Korean Medicine was found to have relatively sound introduction on emaizhenduan. Conclusion It is shown in ancient East Asian medical classics that infants' forehead temperature palpation was introduced as early as late 13th century in China, and have continuously been referred in many East Asian medical classics before modern era.

• 대한한방소아과학회지
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• 제19권1호
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• pp.83-102
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• 2005

Objectives : This study aimed to investigate acupuncture trend of childhood nocturnal enuresis in current Traditional Chinese Medical Journals. Methods : During the period from January 2000 to August 2004, we searched all Traditional Chinese Medical Journals in oriental medical library in dongguk university. We selected 28 literatures on acupuncture treatment for nocturnal enuresis in children Results : 28 studies are included and classified by diagnosis criteria and outcome criteria. And reclassified into two large groups, case report and comparison study. Totally 2324 cases, complete cures are 1701, significant improvements 2239, complete cure rate 73.2%, total improvement rate 97.3% 33 acupuncture points are used and main meridians are bladder, conception vessel and governor vessel. Conclusion : There remains a debate about diagnosis and outcome criteria. But Acupuncture is very effective and safe in the treatment of enuretic children.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3503-3505
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• 2014

Background: Interleukin-33 (IL-33) has recently been implicated in tumor development. Methods: Data was obtained from PubMed, EMBASE, Clinical trial, Cochrane Library, Web of Science, CNKI and Wanfang databases. After quality assessment and data extraction, a meta-analysis was performed using Review Manager 5.2 software. Results: There were eight documents included in this meta-analysis. The results showed IL33 levels to be higher in tumor patients than that in health people, but no correlations tumor stage, metastasis and survival time of tumor patients were evident. Conclusion: IL33 may be useful as an alarm factor in tumor detection and prognosis.

• 대한암한의학회지
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• 제13권1호
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• pp.43-54
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• 2008

Objectives: The purpose of this study is to suggest better directions in experimental researches about finding new drug derived from herbs in South Korea. Methods: We investigated available manuscripts on anti-lung cancer herbal extracts which is used in South Korea by using available electric library, and made diagrams. Results: Many herbs are used in treatment of lung cancer based on traditional oriental medical theory. In Korea, researches for this field have been activated since 2000. But we haven't found the substance showing remarkable anti-tumor effect on lung cancer. And many of the experiment have been designed similar way and also have similar weak points in explanation about the apoptotic mechanism. Conclusions: From this results, we have found 10 herbs, 4 pharmacopunctures and 13 herbal decoctions to be conducted experimental studies for lung cancer from 2000 to 2008 in South Korea.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.947-950
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• 2013

Background: We performed this meta-analysis to assess the effectiveness and safety of axillary dissection in old women. Methods: The Cochrane Library, PubMed, EMBASE and Chinese Biomedical Literature Database were searched and all randomized controlled trials of axillary dissection in old women (at least 60 years old) were considered. Meta-analyses were completed using RevMan5.1. Results: Three eligible randomized controlled trials (RCTs) including 5,337 patients were considered. There was weak evidence in favour of axillary dissection (AD) in old women. The meta-analysis showed that the overall survival (OS) after 1, 3, 5 and 7 years and the disease free survival (DFS) after 1, 3 and 5 year were not statistically significantly different between AD and no AD groups. However, there was a difference in the 7 year DFS. Conclusions: Axillary dissection did not provide survival benefit to the old women with breast cancer analysed. Therefore, axillary dissection is not well-indicated in old women with breast cancer.

• 한국도서관정보학회지
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• 제39권4호
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• pp.171-188
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• 2008

이 연구는 식품영양학의 학문적 특성과 문헌분류 체계를 분석한 후, 이를 토대로 KDC 식품영양학의 분류체계를 개선할 수 있는 방안을 제시하고자 시도되었다. 이 연구결과를 요약하면 아래와 같다. 첫째, 식품영양학의 학문분류는 대체로 영양학, 식품학, 급식경영학의 3개영역으로 구분되어 있으며, 한국학술진흥재단의 연구분류표에서도 이와 유사하게 구분되어 있다. 둘째, 식품영양학의 문헌분류 체계에서는 학문분류 체계와는 달리 대체로 영양학과 식품학이 별개의 학문으로 구분되어 있다. 즉, 영양학은 의학의 하위학문으로, 식품학은 가정학의 하위학문으로 배치되어 있으며, 식품학에서 급식경영학을 함께 다루고 있다. 셋째, KDC 식품영양학의 분류체계는 DDC나 NDC와 같이 영양학과 식품학이 별개의 학문으로 구분되어 있지만, 실제로는 분류하는 사람에 따라 혼란을 일으키고 있다. 그리고 일부 항목은 학문발전의 추세에 부응하지 못하고 있거나 한글 및 영문표기의 오류가 나타나고 있다. 따라서 이러한 문제점을 해결하기 위해 영양학과 식품학의 분류혼란은 해당 항목에 주기를 첨가하여 혼란을 최소화할 수 있도록 하였으며, 학문발전의 추세를 반영하여 급식경영 관련 항목 및 한방요리 등과 같은 새로운 주제를 추가하거나 현대적인 용어로 대치하여 수정 전개방안을 제시하였다.