• Journal of mucopolysaccharidosis and rare diseases
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• v.2 no.1
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• pp.13-16
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• 2016

Mucolipidosis (ML) II/III are autosomal recessive diseases caused by deficiency of post-translational modification of lysosomal enzymes. The mannose-6-phosphate (M6P) residue in lysosomal enzymes synthesized by N-acetylglucosamine 1-phosphotransferase (GlcNAc-phosphotransferase) serves as recognition marker for trafficking in lysosomes. GlcNAc-phosphotransferase is encoded by GNPTAB and GNPTG. Mutations in GNPTAB cause severe ML II alpha/beta and the attenuated ML III alpha/beta. Whereas mutations in GNPTG cause the ML III gamma, the attenuated type of ML III variant. For the diagnostic approaches, increased urinary oligosaccharides excretion could be a screening test in clinically suspicious patients. To confirm the diagnosis, instead of measuring the activity of GlcNAc phosphotransferase, measuring the enzymatic activities of different lysosomal hydrolases are useful for diagnosis. The activities of several lysosomal hydrolases are decreased in fibroblasts but increased in serum of the patients. In addition, the sequence analysis of causative gene is warranted. Therefore, the confirmatory diagnosis requires a combination of clinical evaluation, biochemical and molecular genetic testing. ML II/III show complex disease manifestations with lysosomal storage as the prime cellular defect that initiates consequential organic dysfunctions. As there are no specific therapy for ML to date, understanding the molecular pathogenesis can contribute to develop new therapeutic approaches ultimately.

• Proceedings of the Korean Society for Quality Management Conference
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• 1998.11a
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• pp.419-428
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• 1998

In this paper, we analyzed two methodologies to evaluate the total quality management activities comparatively. One of them is the traditional scoring system (TSS) by analytic hierarchy process (AHP) and the other is the efficiency measuring system (EMS) by data envelop analysis (DEA), It is demonstrated that the index by TSS and the efficiency index by EMS are not correlated. Also, the efficiency index by EMS in terms of company characteristics such as the size of company and ISO certifications is different from the index by TSS. The result implies that to evaluate the quality activities by EMS is needed as a supplementory methodology.

• Journal of Korean Society for Quality Management
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• v.31 no.4
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• pp.1-18
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• 2003

Quality is a critical competitive factor in today's environment because of the impact of quality on costs and delivery. Many companies regard quality as a key concept of company strategy in order to achieve the competitive edge. Measuring and reporting quality cost is the first step in quality management program. The supposition of quality cost model is that investment in prevention activities will bring rewards from reduced failure costs, and that further investment in prevention activities will show profits from reduced appraisal costs. In this study, the degree of quality cost deviation is conceptualized. This means a deviation between the ideal and present ranking in the amounts of quality cost categories. This study analysed that the effect of its deviation on quality management activity and performance variables. However, there are no difference in these variables. The major reason is that most of companies are endeavoring for quality management but operating quality cost system unsystematically. The review against a prevention and appraisal activity is necessary.

• Journal of The Korean Association For Science Education
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• v.20 no.2
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• pp.193-199
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• 2000

The textbook is a predominant feature of most classrooms. Because the textbook is an important aspect of educational experience, it is essential that the content of the texts be carefully scrutinized. The purpose of this study was to examine the visual portrayal of gender groups in elementary $"Chay{\tilde{o}}n"$ textbooks developed by the 6th National Science Curriculum. An instrument was developed to analyze the nature and type of activity engaged in by these groups as well as how often members of these groups were portrayed. Data were collected from 8 elementary $"Chay{\tilde{o}}n"$ textbooks. The results show the following two different features. While the elementary $"Chay{\tilde{o}}n"$ textbooks do not show gender-biases in representing science learning activities such as observing, experimenting, measuring, they show distinct gender-stereotyped roles and activities. It is expected that the results of this study are considered in developing the new elementary "Science" textbooks which show gender-fairness.

• YAKHAK HOEJI
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• v.54 no.5
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• pp.387-391
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• 2010

Polygonum cuspidatum which is widely distributed in Korea has been used as treatments of dermatitis, gonorrhea and inflammation in traditional medicine. We examined anti-inflammatory activities by the inhibition of NO production in RAW264.7 murine macrophages cells. Phytochemical examination of Polygonum cuspidatum led to the isolation and characterization of emodin (1), emodin 8-O-${\beta}$-D-glucopyranoside (2), emodin 1-O-${\beta}$-D-glucopyranoside (3). Antioxidative activities of these compounds were determined by measuring the radical scavenging effects on DPPH radicals. Compounds 1 and 3 showed potent activities compared with L-NMMA. These results suggested that the antraquinone compounds isolated from Polygonum cuspidatum might be used as antiinflammatory agents.

• Biotechnology and Bioprocess Engineering:BBE
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• v.3 no.1
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• pp.6-10
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• 1998

A plasmid vector containing two reporter genes, mer-lux and lac-GFP, was transformed to both Escherichia coli and Pseudomonas putida. Their cellular activities and biofilm characteristics were investigated in flow-cell units by measuring bioluminescent lights and fluorescent levels of GFP. Bioluminescence was effective to monitor temporal cell activities, whereas fluorescent level of GFP was useful to indicate the overall cell activities during biofilm development. The light production rates of E. coli and P. putida cultures were dependent upon concentrations of HgCl2. Mercury molecules entrapped in P. putida biofilms were hardly washed out in comparison with those in E. coli biofilms, indicating that P. putida biofilms may have higher affinity to mercury molecules than E. coli biofilms. It was observed that P. putida expressed GFP cDNA in biofilms but not in liquid cultures. This may indicate that the genetic mechanisms of P. putida were favorably altered in biofilm conditions to make a foreign gene expression possible.

• Journal of Life Science
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• v.5 no.4
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• pp.203-210
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• 1995

Fibrinolytic activity of fermented kimchi and ingredients used for the preparation were assayed by measuring the lysis area on plasminogen-rich fibrin plate. Fermented kimchi and picked fish sauces from changlan, prwan, and anchovy showed the activity, and the activity of pickled fish sauces were high in the order of pickled changlan, picked anchovy(pickled mulchi), and pickled prawn. However, the activity of kimchi may not be attributed to pickled fish sauce because kimchi containing fish sauce did not possess activities were determined from the samples heated for 30min at 100$\circ$C. There was no changes in activities before and after heat treatment indicating the agents may be components other than protein. Since major changes occur during kimchi fermentation were increased sour taste due to production of organic acids such as lactic, citric, oxalic, and succinic acids, the authentic organic acids present were examined for fibrinolytic activities. The results indicates that the major component posses the activity is lactic acid.

• The Journal of the Korea Contents Association
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• v.20 no.7
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• pp.292-301
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• 2020

This study explored the changes in nutrition knowledge and eating habits formation of infants through vegetable gardening activities in early childhood education institutions. children from H nursery school located in Suwon-si, Gyeonggi-do, and H nursery school located in Hwaseong-si, Gyeonggi-do, were divided into 18 experimental groups and 18 people from comparison group and pre-post analysis was conducted. The research tool analyzed the data collected using the nutrition knowledge measuring tool and the eating habits measuring tool using the program SPSS, and the analysis method was conducted with t-test(verification) to verify the homogeneity of the experimental group and the comparative group. Analysis result, first. Infants aged 3 to 4 in experimental groups who have experienced vegetable gardening activities have higher nutritional knowledge than infants in comparison groups. In the case of nutrition knowledge, there was no statistically significant difference between the experimental group and the comparative group before the vegetable gardening activities were carried out. But after the experimental treatment, the experimental group showed statistically significant differences in improving the concept of nutritional knowledge (the reason for eating food, the type and function of food, hygiene, and garden) in the post-examination of the comparative group. Second, it can be seen that infants aged 3 to 4 in experimental groups who experienced vegetable gardening activities showed significant differences in table manners and eating behavior among sub-factors of eating habits compared to infants in comparison groups who had never experienced them. In conclusion, vegetable gardening activities are educationally useful in terms of expecting positive changes in the nutrition knowledge and eating habits formation of infants.

• Journal of Korean Society for Quality Management
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• v.32 no.4
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• pp.92-102
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• 2004

In this era of intense competition, TQM has become the key program in organizations as they strive for a competitive advantage. It has been applied to manufacturing and service sector since BNQA model was established in 1987. TQM literature for manufacturing sector abounds with empirical studies on the critical dimensions of TQM, but there is few empirical studies on the TQM evaluation for service sector. In this paper, two methodologies are applied to evaluate the TQM activities of service companies comparatively One of them is the traditional scoring system(TSS) by analytic hierarchy process(AHP). The other is the efficiency measuring system(EMS) by data envelopment analysis(DEA). DEA outperformed other alternative methods to measure the efficiency and it can be applied to evaluate the TQM activities. The objective of this paper is to evaluate TQM activities of domestic service companies by applying TAE(Total quality management Activities Evaluation) model to them. The result of this study is that TSS scores are not significantly correlated with EMS scores. It means that service organizations must not only make efforts to get the higher scores in terms of TSS but also take necessary steps to enhance their efficiencies.

• Korean Journal of Human Ecology
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• v.17 no.4
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• pp.601-608
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• 2008

The purpose of this study was to examine the effects of science activities using drawing on young children's scientific inquiry competences and scientific attitudes. The subjects of this research were a total of 40 young children at age 5 from two classes in G and C child care center which located in G city. The subjects were randomly assigned to two groups. The collected data were analyzed by t-test using SPSS program. The results of this study were as follow: First, experimental group which conducted the science activities using drawing showed significantly higher improvement in sub-factors of scientific inquiry competences, 'perseverance', 'creative', 'critical', and 'volunteering'. Second, experimental group which conducted the science activities using drawing showed significantly higher improvement in sub-factors of scientific attitudes, 'observing', 'measuring', and 'discussion'. Therefor, it might be concluded that science activities using drawing contributed to the development of scientific inquiry competences and scientific attitudes of young children.