• 제목/요약/키워드: measurement instrument

검색결과 986건 처리시간 0.043초

현장관측용 분광 광도계의 상대 검교정 시스템 개발 (Development of relative radiometric calibration system for in-situ measurement spectroradiometers)

  • 오은송;안기범;강혁모;조성익;박영제
    • 대한원격탐사학회지
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    • 제30권4호
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    • pp.455-464
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    • 2014
  • 천리안해양관측위성(Geostationary Ocean Color Imager, GOCI)이 2010년 6월에 발사된 이후, 영상 자료의 보정과 검증을 위한 여러 차례의 현장 관측이 한반도 주변에서 수행되었다. 한국해양과학기술원 해양위성센터(Korea Ocean Satellite Center, KOSC)에서는 Analytical Spectral Devices (ASD)사의 분광 광도계 FieldSpec3나 TriOS사의 분광 광도계 RAMSES와 같은 현장관측장비의 특성 변화를 확인하기 위하여 미국국립표준기술원(National Institute of Standards and Technology, NIST)의 표준화 절차를 거친 광원과 표준 분광 광도계를 이용하여 각각의 현장 관측 마다 기기의 성능을 측정하였다. 본 논문에서는 해양위성센터에 구축된 광학 실험실과 현장관측 분광 광도계의 상대적 복사 검교정 방법에 대해서 소개하고 있다. 광학 실험실은 98% 이상의 광원 균질성을 지니는 20인치 적분구(USS-2000S, LabSphere)와 360 nm 부터 1100 nm 까지 1.6 nm 파장 간격으로 측정이 가능한 표준 분광 광도계(MCPD9800, Photal), 그리고 ${\pm}0.1mm$의 편평도를 가지는 광학테이블($3600{\times}1500{\times}800mm^3$)을 기본으로 구성되어 있다. 실험실 내부는 정확한 검교정 실험을 위하여 일정한 온습도를 유지하고 있으며, 동일한 광원에 동일한 위치에서 표준과 현장관측용 분광 광도계를 동시에 측정하는 방법을 기본으로 한다. 해양위성센터가 보유하고 있는 ASD 를 측정한 결과, 현장관측용 분광광도계의 결과가 푸른 가시광 영역에서 미세한 차이가 측정 시 마다 나타나는 것을 확인하였고, 더불어 1년간의 상대 검교정 실험에 따르면 평균적으로 4.41% 정도의 파장별 광특성이 변화하는 것을 확인하였다. 이러한 결과는 측정 정확도를 유지하고, GOCI 자료의 신뢰도를 확보하기 위하여 지속적인 검교정 실험을 수행해야 하는 이유를 보여주고 있다.

근로자의 산업보건 지식과 태도에 관한 조사연구 (A Survey on the Knowledge and Attitude of Workers Concerning Occupational Health)

  • 박영식;조수열;남철현
    • 한국환경보건학회지
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    • 제18권2호
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    • pp.3-18
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    • 1992
  • This research was carried out on 1,017 production workers for four months from May to August, 1991, to search more effective management method of their health by grasping their knowledge and attitude on industrial health. The results of this study can be summarized as follows: 1. As for general characteristics, 74.2% were male and 25.8% were female among the 1,017 workers. The two largest age groups were 30~39, 38.7%. As for education level, graduation from high school was 58.6%, 61.2% were married, 35.9% owned their house, and workers who worked more than 1 year less than 5 years was 52.9%, workers who worked 8 hours a day was 46.7%, the largest group income level was 60~69 thousand won 21.2%, and the degree of satisfaction with work was ordinary, 45.6%. 2. The degree of recognition concerning occupational diseases was 92.5% at a very high rate. Causes of occupational diseases under the present work field were in order of noise, dust, heavy metal. The largest group of the counterplan for prevention was an improvement of working environment, 62.0%. 3. The major cause that threatens worker's health was poor working environment, 31.4%. As the best method for workers' health management, working environment management was pointed. 4. As for health examination result, the response that it is of use to health management was 53.8%. As for examination method and result, 42.7% responded that they are formal. The practice period was more than once every six months as the largest group, and the highest desire for improvement was that they wants an exact information of the result. 5. 49.3% of the respondents know about the measurement of working environment an the response that the measurement is necessary to improve working environment was 57.9%, and that the results from the measurement were reflected on improvement an management 57.5%. Appropriate period to take a measurement was more than once per six months, 40.2% and per three months, 29.1%. 6. As for safety and halth instruction, 34.5% were educated for both, 38.2% for only safety education and just 4.6% for only health education. 51.9% responded that they had never been educated out of work place. The period of its practice was more than once a month, 39.5% and every three months, 21.3%. 7. The importance of safety and health showed that the one is equal to the other, 59.8%, that the one is more important, 29.6%, and that other is more important, 7.6%. 67.7% said the necessity of a safety and health manager. 8. In spite of more or less health obstacle of work environment, 14.9% of the respondents wanted to overwork to gain an allowance for over-time work, 39.9% didn't, and 40.2% according to condition and state. 9. As the most important cause of industrial accident, 40.2% indicated unsafe behavior. As for the individual protective instrument, 66.1% of all the respondents said they have worn it to protect industrial diseases. 10. As for the degree of understanding of the contents in Industrial Safety and Health Law and Industrial Law of Accident Insurance, an affirmative response was respectively 49.3% and 50.8% and the sources of safety-health information were televisions and radios, 28.0%. Therefore, it is necessary that we do positive working environmental improvement, continuous management and health education's inforcement to increase their health and prevent occupational diseases.

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MFW 치료 시 ViewRay의 표면선량 측정에 따른 임상 적용 가능성 평가 (Evaluation of the possibility of clinical application by surface dose measurement of ViewRay in MFW treatment)

  • 선거준;손상준;이양훈;이제희
    • 대한방사선치료학회지
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    • 제30권1_2호
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    • pp.169-176
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    • 2018
  • 목 적 : Bolus 적용 유, 무와 치료기에 따른 피부 선량을 측정, 비교하여 Malignant Fungating Wound와 같이 높은 피부 선량을 요구하는 경우 피부 선량 증가 목적으로 Co-60 ViewRay 치료계획의 임상 적용 가능성을 검토하였다. 대상 및 방법 : 표면선량을 측정하기 위해 Rando phantom을 이용하여 좌측유방 중심부를 기준으로 2.5 cm 격자 배열의 9개의 내측 측정지점과, 유방과 피부와 접하는 상하, 좌우 4개의 외측 측정지점을 포함한 총 13개 측정지점을 표시하였다. CT를 촬영을 하여 Eclipse와 ViewRay-TPS를 통해 각각의 치료계획을 수립하였으며, 좌측유방 V2Gy = 95 %가 전달되도록 Fixed beam-IMRT 치료계획을 수립하였다. 측정 전 QED 검출기를 교정하였으며 Phantom에 표시된 13개의 측정지점에 QED 검출기를 위치시켜 각 치료계획 별 표면선량을 True-beam과 View-ray를 이용하여 5 mm Bolus 적용 전과 후, 각각 3회 측정하여 비교하였다. 결 과 : 5 mm Bolus를 적용 전 Co-60 Viewray와 선형가속기의 표면선량은 $76.8%{\pm}5.2%$ vs. $67.3%{\pm}7.5%$로 나타났으며, 5 mm Bolus 적용 후 표면선량은 각각 $87.6%{\pm}8.9%$ vs. $80.3%{\pm}10.2%$로 측정되었다(p<0.001). 결 론 : 각 치료기의 표면선량 측정결과, Co-60 ViewRay는 Bolus를 사용하지 않았음에도 불구하고 표면 선량이 일반 5 mm Bolus를 사용한 6 MV 선형가속기의 95.6 % 수준 달하는 것을 확인하였다(p<0.001). 또한 매 회 치료마다 자기공명영상을 이용하여 피폭 문제없이 치료 부위 변화를 관찰할 수 있어 적응형 치료계획을 수립하기 쉽고 피부 선량 확보가 수월하므로, 크기 변화가 빠르고 높은 피부선량을 요구하는 Malignant Fungating Wound 환자의 경우 Co-60 ViewRay가 선형가속기에 비해 유용할 것으로 사료된다.

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모혈(募穴)의 탄력(彈力) 상태(狀態) 측정(測定)에 의한 허실(虛實) 진단(診斷) 연구(硏究) (Study for the Deficiency and Excessiveness Diagnosis in the Front Point by Elastic State)

  • 나창수;윤여충;박현철;이동규;최찬헌;장경선;소철호
    • Journal of Acupuncture Research
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    • 제17권1호
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    • pp.27-41
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    • 2000
  • The meridian system is the most essential and basic connecting structure that maintains the vital activities of viscera and bowels by connecting them with each part of body's surface. Doctors can understand the healthy condition, and the region and deficiency-excessiveness of disease by observing the condition of Qi flowing. Deficiency and excessiveness could be differentiated by various symptoms expressed in meridian system. Especially there could be several clues like pain, heat-cold, protuberance-depression, change of color and shine in the line of channel leads to the judgment of deficiency-excessiveness The diagnosis of deficiency and excessiveness can be generalized by quantification of elastic status in skin surface along the meridian system. By comparing data from measurement of elastic condition with those from traditional deficiency and excessiveness, it could be utilized for the development of oriental medicine. All biological activities in the human body are based on meridian system according to the oriental medicine. Also the meridian system is viewed as basic and essential structure connecting internal viscera and each part of body. The areas of expressed channel phenomena are muscle to bone, muscle to muscle and bone to bone. These areas are called depression where meridian system is present and any changing state on those points can be measured. It could be difficult in diagnosing the reaction of meridian system because doctor can depend on his own judgment. Therefore, it is necessary to quantify and indexate channel reactions. To quantify the channel reactions, specially manufactured instrument was used to quantify the protuberance and depression to differentiate the deficiency and excessiveness. The results follow as below; 1. The elastic index measurement by the equipment proved a pattern of agreement showing the values that ranged within standard deviation 0.05kgf/cm throughout the experiment except few cases' measurement in CV-17. 2. To evaluate the state of deficiency & excessiveness of elastic index measurements in frontal point, elastic index measurements in the front paint were compared to the elastic index measured surrounding the point within 2.5 cm. Such result of indexing procedure was closely matched to the concept of palpitation. 3. If the elastic index values in the surrounding front point closely located to the elastic index values in the front point, the judgement on the state of deficiency and excessiveness was delayed. Otherwise, it was judged as deficiency or excessiveness. 4. Out of total 12 cases of comparing the elastic index values to the elastic index values in the surrounding front point, Three to nine front points were judged as either in the state of deficiency or excessiveness. 5. Among the nine front points judged as either in the state of deficiency or excessiveness, Four cases were matched to the electric index measured by EAV that evaluating the internal organs by five different phases. If more clinical cases are accumulated, it is expected to systematically theorize and improve the concept of deficiency and excessiveness in the internal organs using the front point.

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치아 순면 형태가 측색 기기를 이용한 치아 색상 측정 결과에 미치는 영향 (INFLUENCE OF THE LABIAL SURFACE IRREGULARITY ON THE MEASUREMENT OF THE TOOTH COLOR BY SPECTROMETER)

  • 최용진;박수정;조현구;황윤찬;오원만;박병주;황인남
    • Restorative Dentistry and Endodontics
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    • 제32권5호
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    • pp.411-418
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    • 2007
  • 본 연구는 치아 순면의 굴곡 정도가 측색기를 이용한 치아 측색 결과에 어떠한 영향을 미치는지 확인하고자 시행하였다. 고른 치열을 가진 20대 성인 11명으로부터 채득한 인상에 A2색상의 임시 금관 제작용 레진 (Luxatemp Automix Plus, DMG, Germany)을 충전하여 치아 모형을 제작하고, 중절치, 측절치, 견치, 그리고 제1소구치의 절단부, 중앙부, 치경부의 색상을 1 mm 직경의 측정구를 가진 Specbos 2100 (JETI, Germany) spectrometer를 사용해 측정하고, 디스크 형태로 제작된 대조군과의 색차를 환산하여 다음의 결과를 얻었다. 모든 치아 모형에서 $L^*$값과 $b^*$값은 절단부에서 치경부로 갈수록 낮아지는 경향을 보이나 $a^*$값은 증가하는 경향을 보였다. 디스크 형태의 대조군과의 색차는 모든 치아의 절단부가 가장 큰 값을 보였으며, 치경부가 가장 작은 값을 보였으며, 견치가 다른 치아들에 비해 디스크 형태의 대조군과 작은 색차를 보인 반면, 중절치가 가장 큰 색차를 보였다 (p < 0.01). 이상의 결과는 본 실험에 적용한 optic-fiber를 통해 색을 측정하는 기기를 치아 측색에 적용하기 위해서는 먼저 일정한 측색 조건의 표준화와 치아와 접촉하는 측정부의 치아 표면의 굴곡을 극복할 수 있는 형태의 개발이 필요함을 시사한다.

벼논에서 미량 아산화질소 플럭스의 정량을 위한 실용적 방법 (A Practical Method to Quantify Very Low Fluxes of Nitrous Oxide from a Rice Paddy)

  • 주옥정;강남구;소호섭;박중수
    • 한국농림기상학회지
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    • 제24권4호
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    • pp.285-294
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    • 2022
  • 본 연구에서는 벼 재배 부문 질소 비료 시용에 따른 N2O 배출량 평가를 위해 경기도 화성시 경기도농업기술원 내 벼논에서 폐쇄형 챔버법으로 측정하였으며, 미량의 N2O 배출량이 과소평가되지 않도록 현장 측정 플럭스 자료에 대한 방법검출한계(MDL; Method Detection Limit)와 실용정량한계(PQL; Practical Quantitation Limit)를 산정하고 이를 바탕으로 QA/QC 방법을 설정하여 원시자료와 QA/QC 방법을 수행한 N2O 배출량을 비교하였다. 벼 재배 표준시비량인 3요소 N-P2O5-K2O = 90-45-57 kg ha-1 기준 질소 0배, 1배, 1.5배, 2배로 4처리하여 평가한 N2O 배출량 변화에서는 N2O 배출량이 가장 적었던 질소 0배 처리구 외에는 원시자료와 QA/QC 방법을 수행한 자료 모두 유의한 차이가 없었으며, 질소 비료 시용량이 많을수록 N2O 배출량이 높게 나타나 질소 1배 처리구 대비 질소 2배 처리구는 191% 높게 나타났다. 질소 시비량에 따른 N2O 배출량의 회귀관계 분석에서는 지수회귀모형에서 결정계수가 가장 높았으며, 선형회귀모형으로 산정한 기본배출계수는 IPCC에서 제공하는 기본배출계수 값과 동일하게 나타났다. 본 연구결과는 농업부문 온실가스 배출량 산정을 위해 보편적으로 사용하고 있는 폐쇄형 챔버법의 플럭스 자료에 대한 QA/QC 방법을 제시하고, 원시자료와의 비교분석을 통해 질소 비료 시비에 따른 벼논에서 발생하는 N2O 배출량에 대한 신뢰성 있는 평가가 가능한 것으로 판단할 수 있다.

모유수유교육과 추후간호방법이 산모의 모유수유실천율과 모유수유방법에 미치는 효과 - 가정방문과 전화상담을 중심으로 - (Effect of Breast-feeding Education and Follow-up care on the Breast-feeding Rate and the Breast-feeding Method - Focused on Home Visit and Phone Counselling -)

  • 박숙희;고효정
    • 여성건강간호학회지
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    • 제7권1호
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    • pp.30-43
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    • 2001
  • This was a pre-experimental study to confirm the breast-feeding ability and effect of follow up care on the breast-feeding rate and the breast-feeding method by the mother-infant breast-feeding assessment tool for the mothers who got the breast-feeding education. The subjects were 46 mothers who experienced normal delivery of infants at a college hospital in K-city, Kyungsangbuk-do, from July 1 to October 21, 2000. The instrument for data obtainment were The Mother-Infant Breast-Feeding Assessment Tool of Johnson et al. (1999), and The Breast- Feeding Method Measurement Tool of Jeong, Geum-hee(1997). This instrument was reliable, showing Cronbach $\alpha$.751. This study classified them into 3 groups: at high risk for breast-feeding failure, at risk for breast-feeding problems, and at low risk for breast-feeding failure by the mother-infant breast-feeding assessment tool on the day of discharge from the hospital after delivering individual breast-feeding education to the subjects. This study investigated the breast-feeding rate and the breast-feeding method through mail questionnaire at the four week after childbirth, and through the phone counselling and the home visit for follow up care at the first week and the second week after childbirth. The sixth week after childbirth, this study investigated the breast-feeding rate by phone. The data analyzed the hypothesizes by $x^2$-test, paired t-test, ANOVA, Wilcoxon signed rank test, Wilcoxon rank sum test and trend analysis using SPSS/PC+ WIN 10.0 program. The results were as follows : 1) Hypothesis 1-1, "there won't be any difference the breast-feeding rate of a group at risk for breast-feeding failure by the time elapsed" was supported through constant the breast-feeding rate, because changes in the breast-feeding rate by the time elapsed after childbirth wasn't statistically significant(t= -1.501, p=.270). Hypothesis 1-2, "there won't be any difference the breast-feeding rate of group at low risk for breast-feeding failure by the time elapsed" was supported through constant the breast-feeding rate, because changes in the breast-feeding rate by the time elapsed after childbirth wasn't statistically significant(t=-1.732, p=.225). 2) Hypothesis 2-1, "there won't be any difference between the breast-feeding method of group at risk for breast-feeding failure for four weeks after childbirth and just after childbirth” was rejected, because the mean point of post test appeared to be higher than that of pre test(t=-7.267, p=.000). Hypothesis 2-2, "there won't be any difference between the breast-feeding method of the group at low risk for breast-feeding failure for four weeks after childbirth and just after childbirth" was rejected, because the mean point of post test appeared to be higher than that of pre test(t=-2.501, p=.012). 3)The 3rd hypothesis, "there won't be any difference between breast-feeding method of groups at risk for breast-feeding problems and at low risk for breast-feeding failure at the 4th week after childbirth and just after childbirth" didn't show any difference between the breast-feeding method of groups at risk for breast-feeding problems and at low risk for breast-feeding failure in the advance test(t=-1.521, p=.130) but there was difference between them in post test (t=-2.012, p=.044). As a result, the 3rd hypothesis was supported by pre test, but it was rejected by post test. In conclusion, this study confirmed breast- feeding education and follow up care just after childbirth were effective for the breast-feeding rate and method. Accordingly, it is proposed that successful nursing intervention of breast-feeding to be necessary by continuously providing follow up care through the mother-infant breast-feeding assessment tool as well as to execute individual breast-feeding education to mothers just after childbirth.

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OMI 위성자료를 활용한 서울 지표 이산화질소 혼합비 추정 연구 (Estimation of surface nitrogen dioxide mixing ratio in Seoul using the OMI satellite data)

  • 김대원;홍현기;최원이;박준성;양지원;류재용;이한림
    • 대한원격탐사학회지
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    • 제33권2호
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    • pp.135-147
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    • 2017
  • 본 연구에서는 처음으로 한반도 서울지역에서 OMI (Ozone Monitoring Instrument) 센서로 관측된 대류권 이산화질소 칼럼농도를 이용하여 OMI 센서의 관측시간인 13:45에서의 월 평균 및 일별 위성 지표 이산화질소 혼합비를 추정하였다. 본 연구에서는 세 가지 회귀모델들이 이용되었다. 첫 번째 회귀모델(M1)은 OMI 대류권 이산화질소 칼럼농도와 지점 측정값과의 선형회귀를 통한 회귀계수로 구성되어있다. 두번째 회귀모델(M2)은 OMI 대류권 이산화질소 칼럼농도와 AIRS (Atmospheric Infrared Sounder) 센서로 관측한 행성경계층 높이, 온도, 압력 자료 모두가 반영된 회귀모델이다. 세 번째 회귀모델(M3M, M3D)은 다중회귀모델로서 앞서 고려된 이산화질소 칼럼농도와 행성경계층 높이와 다양한 기상변수를 추가적으로 반영하는 회귀모델이다. 본 연구에서는 2009년에서 2011년까지를 회귀모델의 훈련기간으로 하여서 각 회귀식의 회귀계수를 도출하였으며 2012년도는 검증기간으로서 훈련기간에 도출된 회귀모델들의 성능을 평가하였다. 회귀모델들로 추정된 월 평균 지표 이산화질소 혼합비와 지점 관측소에서 지점 측정장비로 측정된 월평균 지표 이산화질소 혼합비와 가장 높은 상관성(avg. R = 0.77)을 보이는 회귀분석방법은 다중회귀분석방법(M3M)이다. 또한, 회귀모델들로 추정된 13:45에서의 일 지표 이산화질소 혼합비와 지점 관측소에서 지점장비로 측정된 지표 이산화질소 혼합비와 가장 좋은 상관성(avg. R = 0.55)을 보인 것도 다중회귀분석방법(M3D)이다. 회귀모델들로 추정된 지표 이산화질소 혼합비는 지점 측정값에 비해 과소추정 되는 경향이 나타났다. 회귀모델들로 추정된 지표 이산화질소 혼합비를 평가하기 위해 지점 측정값과의 RMSE (Root Mean Square Error), mean bias, MAE (Mean Absolute Error), percent difference와 같은 통계분석을 실시하였다. 본 연구는 위성을 통한 지표 이산화질소 혼합비 산출 가능성을 보여준다.

한방병동과 일반병동 간호사의 직무만족도의 비교연구 (Comparative Study on the Nurses' Job Satisfaction between the Oriental Medicine Ward and the General Ward)

  • 변창자;최상순;백승남;이미애
    • 간호행정학회지
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    • 제1권1호
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    • pp.97-111
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    • 1995
  • In our society today, a variety of medical caring system, along with a scientific development in the area of oriental medical science plus national demand, has increased the augmentation and the opening of oriental wards and hospitals (Han Bang), which has come to create an additional requirement of nursing activity at oriental medicine wards should be different from that of the general wards or the same as the other. In view of this, various studies need to be made in this connection. The purpose of this study is to comprehend the number of nurses who want to work at oriental medicine wards and measure job satisfaction in nursing as compared with those working at general wards so as to provide basic materials for future assignment and supplementary training for the nurses. An attempt was made to contribute toward nursing administration on the one hand improving nursing training course on the other hand. A total of 72 nurses currently working at two oriental medicine hospitals available in Seoul and 82 general nurses were selected for this study using the questionaire from December 1993 to January 1994. An instrument for the study was based on the measurement of work satisfaction developed by Paula L. Stamps including 37 questions complemented by Kim for revision (1993) and 14 questions regarding general characteristics and oriental medicine wards. The instrument to test dependability showed Cronbach's=0.7711. The collected data have been processed by computer package SPSS. General characteristics of the two groups and the matters involved in oriental medicine wards were calculated into real figure and percentage an similarities between the two groups were analyzed by t-test and F-test according to the characteristics of variables. The comparative test on work satisfaction among the two groups including general characteristics and work factors were conducted by t-test and F-test. The major findings as a result of the study are as follows : 1. As general characteristics, age group of $26{\sim}30$ years are more than any segment of age. As to marital status, the number of those in single status is slightly higher than the married. Approximately 80% of them are graduates of nursing schools and nursing colleges. They are mostly in service for one to three years. There is no significant difference between the two groups. 2. The number of those who want to work at oriental medicine wards represents 40.3% against 58.4%, being in favor of general wards. 3. The reason for service at oriental medicine wards is that "there is room for potential research" which happened to rank first, followed by "easy job," "good working atmosphere" and "growing interest in oriental medicine." 4. Work satisfactions among nurses who work at oriental medicine wards prove greater than that of nurses who work at general wards. 5. Work satisfaction between the two groups by work factors is reflected with significant difference statistically on task requirement, interaction and doctor-nurse relationships. 6. The general charcateristics and the work satisfaction by work factors prove that there are significant difference in age, marital status, education and the period of work. They tend to be more satisfied with the work as they grow in age. Significant differneces are found in the work factors such as autonomy, adiministration and professional job in the relationship with doctor-nurse. As to marital status, the married are more satisfied than the unmarried. There are significant differneces in the factors respecting administration and doctor-nurse college graduates are highly satisfied with task requirement. However, satisfaction with the professional level has proven the highest degree for those having master degree. The period of work and satisfaction : There are significant differneces in task requirement, administration, interactions, professional level and doctor-nurse relationships. As a general rule, the degree of satisfactions is in proportion to the lengrh of service. The following conclusions are drawn based on the fndings mentioned above. Even though the work satisfaction of the nurse who work at oriental medicine ward is relatively high, it is desired that personal consultation be given as to disposition of nurses when they are assigned to oriental medicine wards. It is also recommended that lectures on oriental medicine be conducted through supplementary training and/or basic nursing course in order that they may be motivated for ingenious activities with an increasing sense of self-esteem which will eventually enhance positive changes for the patients who are in need of oriental medicine nursing and for the medical teams. In addition, joint reseaches involvingclinical care and education should be in constant process for unique and scientific development for those who are subject to oriental medicine nursing care.

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약물검사에서 관리시료의 농축을 이용한 보고 가능 범위의 설정에 대한 연구 (A Study of Reportable Range Setting through Concentrated Control Sample)

  • 장상우;김남용;최호성;박용원;윤근영
    • 대한임상검사과학회지
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    • 제36권1호
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    • pp.13-18
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    • 2004
  • This study was designed to establish working range for reoportable range in own laboratory in order to cover the upper and lower limits of the range in test method. We experimented ten times during 10 days for setting of reportable range with between run for method evaluation. It is generally assumed that the analytical method produces a linear response and that the test results between those upper and lower limits are then reportable. CLIA recommends that laboratories verify the reportable range of all moderate and high complexity tests. The Clinical Laboratory Improvement Amendments(CLIA) and Laboratory Accreditation Program of the Korean Society for Laboratory Medicine states reportable range is only required for "modified" moderately complex tests. Linearity requirements have been eliminated from the CLIA regulations and from others accreditation agencies, many inspectors continue to feel that linearity studies are a part of good lab practice and should be encouraged. It is important to assess the useful reportable range of a laboratory method, i.e., the lowest and highest test results that are reliable and can be reported. Manufacturers make claims for the reportable range of their methods by stating the upper and lower limits of the range. Instrument manufacturers state an operating range and a reportable range. The commercial linearity material can be used to verify this range, if it adequately covers the stated linear interval. CLIA requirements for quality control, must demonstrate that, prior to reporting patient test results, it can obtain the performance specifications for accuracy, precision, and reportable range of patient test results, comparable to those established by the manufacturer. If applicable, the laboratory must also verify the reportable range of patient test results. The reportable range of patient test results is the range of test result values over which the laboratory can establish or verify the accuracy of the instrument, kit or test system measurement response. We need to define the usable reportable range of the method so that the experiments can be properly planned and valid data can be collected. The reportable range is usually defined as the range where the analytical response of the method is linear with respect to the concentration of the analyte being measured. In conclusion, experimental results on reportable range using concentrated control sample and zero calibrators covering from highest to lowest range were salicylate $8.8{\mu}g/dL$, phenytoin $0.67{\mu}g/dL$, phenobarbital $1.53{\mu}g/dL$, primidone $0.16{\mu}g/dL$, theophylline $0.2{\mu}g/dL$, vancomycine $1.3{\mu}g/dL$, valproic acid $3.2{\mu}g/dL$, digitoxin 0.17ng/dL, carbamazepine $0.36{\mu}g/dL$ and acetaminophen $0.7{\mu}g/dL$ at minimum level and salicylate $969.9{\mu}g/dL$, phenytoin $38.1{\mu}g/dL$, phenobarbital $60.4{\mu}g/dL$, primidone $24.57{\mu}g/dL$, theophylline $39.2{\mu}g/dL$, vancomycine $83.65{\mu}g/dL$, valproic acid $147.96{\mu}g/dL$, digitoxin 5.04ng/dL, carbamazepine $19.76{\mu}g/dL$, acetaminophen $300.92{\mu}g/dL$ at maximum level.

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