• 대한방사선기술학회지:방사선기술과학
• /
• 제33권1호
• /
• pp.45-50
• /
• 2010

본 연구는 T2고속스핀에코 3.0T 자기공명영상에서 지방조직 소거기법인 SPAIR와 STIR기법의 임상적 유용성에 관한 비교연구를 시행하였다. SPAIR와 STIR 프로토콜을 사용하여 뇌의 축방향 영상(20개), 요추의 시상단면영상(20개), 고관절의 관상단면영상(17개), 무릎관절의 축방향 영상(25개)을 획득하였다. 검사부위별로 지방억제기법의 지방소거능력과 화질을 파악하기위해 지방조직의 신호강도와 불균일성을 측정하였다. 지방조직에서 불균일치는 측정된 지방 신호의 평균치(mean)에 대한 표준편차(SD)로서 그 산출은 SD/mean으로 계산하였다. 수집된 자료는 SPSS(Statistical Package for the Social Science) WIN 13.0 프로그램을 이용하여 분석한 결과 다음과 같은 결론을 얻었다. 첫째, 뇌 검사는 SPAIR가 STIR보다 지방억제능력과 화질면에서 우수한 결과를 나타냈으며, 둘째, 요추, 고관절, 무릎관절 검사는 지방의 신호억제능력은 STIR가 우수하고, 화질면에서는 SPAIR가 우수한 결과를 나타냈다.

• 한국지하수토양환경학회지:지하수토양환경
• /
• 제8권2호
• /
• pp.87-91
• /
• 2003

본 연구는 산업시설에서 배출되는 대기오염물질이 인접한 주거지역에 영향을 미칠 것으로 예상되는 시화공업단지 주변의 공단지역, 주거지역 및 녹지지역의 토양을 대상으로 As, Cd, Co, Cr, Cu, Hg, Ni, Pb 및 Zn 함량을 조사하였다. 토양 중 중금속 함량의 범위는 As 0.58~3.81, Cd ND~0.91, Co 0.15~6.33, Cr ND~1.86, Cu 0.14~110.27, Hg ND~l.17, Ni 0.04~10.59, Pb 1.16~86.48 및 Zn 1.83~212.65 mg/kg으로서 전 지역에서 토양환경보전법의 토양오염기준이나 식물독성 유발기준에 비하여 매우 낮은 값을 나타내었다. As 함량은 전 지역에 걸쳐 비슷하였으나, Cd와 Cr 함량은 공단지역이 주거지역이나 녹지지역보다 각각 약 10배 및 5배정도 높았으며, 주거지역과 녹지지역은 비슷한 경향이었다. Co, Cu, Hg, Ni, Pb 및 Zn 함량은 공단지역이 주거지역이나 녹지지역보다 약 2~3배정도 높았으며, 주거지역과 녹지지역은 비슷한 경향이었다.

• Biomolecules & Therapeutics
• /
• 제14권1호
• /
• pp.50-55
• /
• 2006

The objective of the study was to evaluate the bioequivalency between the $Rozid^{TM}$ Tablet (Ilhwa Pharm. Co., Ltd.) as a test formulation and the $Rulid^{TM}$ Tablet (Handok Pharm. Co., Ltd) as a reference formulation. Twenty-four healthy male volunteers were administered the formulations by the randomized Latin square crossover design, and the plasma samples were determined by a high performance liquid chromatography (HPLC) with fluorescence detector. $AUC_t,\;C_{max}\;and\;T_{max}$ were obtained from the time-plasma concentration curves, and log-transformed $AUC_t\;and\;C_{max}$ and log-untransformed $T_{max}$ values for two formulations were compared by statistical tests and analysis of variation. $AUC_t$ was determined to be $63.30{\pm}25.57{\mu}g.hr/ml$ for the test formulation and $64.02{\pm}29.27mg.hr/ml$ for the reference formulation. The mean values of $C_{max}$ for the test and reference formulations were $5.07{\pm}2.14\;and\;5.53{\pm}2.60{\mu}g/ml$, respectively. The $AUC_t,\;and\;C_{max}$ ratios of the test $Rozid^{TM}$ Tablet to the reference $Rulid^{TM}$ Tablet were -1.12% and -8.32%, respectively, showing that the mean differences were satisfied the acceptance criteria within 20%. The results from analysis of variance for log-transformed $AUC_t,\;and\;C_{max}$ indicated that sequence effects between groups were not exerted and 90% confidence limits of the mean differences for $AUC_t,\;and\;C_{max}$ were located in ranges from log 0.80 and log 1.25, satisfying the acceptance criteria of the KFDA bioequivalence. The RozidTM Tablet as the test formulation was considered to be bioequivalent to the RulidTM Tablet used as its reference formulation, based on $AUC_t,\;and\;C_{max}$ values.

• 한국동물위생학회지
• /
• 제34권1호
• /
• pp.69-73
• /
• 2011

This was conducted to determine the effects of body weight, organ weight, hematological values and biochemical parameters by L-carnitine (Carn) on the orchidectomized (Orch) rats. The animals were divided into 4 groups. Intact group (n=10) received no treatment and operation. Sham group (n=10) received only sham operation and no treatment. Orch group received operation and no treatment. Orch+Carn received operation and L-carnitine. The body weights of each group increased, but that of the Orch+Carn group were significantly lower than those in all the other groups. There were significant differences (P<0.05, P<0.001) of body weights between Orch+Carn group and all the other groups. Also, organ weights such as heart, liver, spleen and kidney were measured. The heart weights were significantly lower (P<0.001) in the Orch+Carn group than those in Intact and Sham groups, respectively. The weights of liver and kidney in the Orch+Carn group were significantly differences (P<0.001) in comparison with those in all the other groups. Also, the spleen weights were significantly lower (P<0.05) in the Orch+Carn group than those in Intact and Sham groups, respectively. The hematological values of mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were significantly differences (P<0.05, P<0.01, P<0.001) in comparison with those in all the other groups. On the other hand, the hematological values of white blood cell (WBC), red blood cell (RBC) and mean corpuscular hemoglobin concentration (MCHC) were not significantly different in any other groups. The concentrations of total cholesterol (T-chol), triglyceride (TG) and high density lipoprotein (HDL) decreased significantly (P<0.05) in the Orch+Carn group as compared to those in the Orch group. We conclude that L-carnitine was significantly decreased the body weight in the orchidectomized rats. Our findings suggest that L-carnitine may influence the process of lipid packaging and absorption in the orchidectomized rats.

• 한국해양학회지
• /
• 제28권2호
• /
• pp.114-120
• /
• 1993

입도분포의 특징분석에 종래의 조직특성치 대신 수치해석적인 분해법의 적용을 시 도하였다. 그 결과 이 방법이 제주해협의 대륙붕 표층퇴적물과 같은 복모드형 입 도분포의 분석에 매우 유용함이 입증 되었다. 복모드형 입도분포 퇴적물은 제주해협 대륙붕에서는 86%의 높은 비율을 점한다. 종래의 입도특성치(평균, 표준편차, 왜도, 첨도)는 복모드형 입도분포에 대해서는 왜곡된 값을 보인다. 따라서 입도분포의 모드 에 대체로 대응되는 정규성분으로 분해해서 각 정규성분의 특성치를 해석함으로써 입 도특성치에서와 같은 특징의 누락이나 왜곡을 피할 수 있다. 제주해협 대륙붕의 167개 퇴적물 입도분포곡선을 비선형 최소자승법을 사용하여 정규성분으로 분해해서 총 387 개의 정규성분을 얻었다. 정규성분의 평균은 1-3 phi 8-9 phi에 집중되는 것이 많다. 이중 조립질 정규성분의 평균치는 복잡하고 특징적인 지리적 분포를 보인다. 이러한 분포는 퇴적물 총층후 분포와 매우 유사하며 해저면의 지질과 지형을 면밀하게 반영하 고 있다. 해저면을 형성하는 퇴적층은 플라이스토세 후기의 해침성 모래층이며 해저지 형은 플라이스토세말 빙하기 저해수면시기의 침식에 의해 형성된 것으로 보인다.

• 디지털융복합연구
• /
• 제16권1호
• /
• pp.431-438
• /
• 2018

본 연구는 잠재평균분석을 통해 취업정신장애인의 근로시간 형태에 따른 지각된 낙인감, 심리적 역량강화, 직무만족의 차이를 알아보며, 지각된 낙인감과 직무만족 간의 구조적 관계에서 심리적 역량강화가 갖는 매개효과를 분석하는데 목적이 있다. 이를 위해 취업한 정신장애인을 대상으로 낙인감, 심리적 역량강화, 직무만족 척도를 이용하여 설문조사 하였고, 주요 분석결과는 다음과 같다. 첫째, 낙인감과 직무만족 사이 그리고 심리적 역량강화와 직무만족 사이에 직접적인 영향관계가 있는 것으로 나타났고, 둘째, 심리적 역량강화는 낙인감과 직무만족의 영향관계에서 부분매개효과가 있는 것으로 분석되었다. 셋째, 잠재평균분석 결과, 전일제 근로 정신장애인이 지각된 낙인감 수준이 더 높고, 직무만족 수준이 더 낮은 것으로 나타났고, 시간제 근로 정신장애의 심리적 역량강화 수준이 전일제 근로 정신장애인보다 더 낮은 것으로 분석되었다. 이 결과를 토대로 취업정신장애인의 근로시간 형태를 고려한 직무만족 향상, 낙인감 감소, 심리적 역량강화 방안들을 제안하였다.

• Imaging Science in Dentistry
• /
• 제39권4호
• /
• pp.185-189
• /
• 2009

Purpose : The purpose of this study was to investigate how to detect proximal caries using line profile and validate linear measurements of proximal caries lesions by basic digital manipulation of radiographic images. Materials and Methods : The X-ray images of control group (15) and caries teeth (15) from patients were used. For each image, the line profile at the proximal caries-susceptible zone was calculated. To evaluate the contrast as a function of line profile to detect proximal caries, a difference coefficient (D) that indicates the relative difference between caries and sound dentin or intact enamel was measured. Results : Mean values of D were $0.0354{\pm}0.0155$ in non-caries and $0.2632{\pm}0.0982$ in caries (p<0.001). Conclusion : The mean values of caries group were higher than non-caries group and there was correlation between proximal dental caries and D. It is demonstrated that the mean value of D from caries group was higher than that of control group. From the result, values of D possess great potentiality as a new detection parameter for proximal dental caries.

• 한국항해항만학회지
• /
• 제29권4호
• /
• pp.327-333
• /
• 2005

Sea level (MSL, MHWL, or MLWL) change has been main concern to scientists and engineers and it can be primarily due to both change of climate and vertical movement of land. This paper reports the intensive analysis of the sea level changes and broad discussion of the future at the southwestern coast of Korean peninsula. Regression analysis was conducted to investigate general tendency and periodicity of the sea levels at the six different study sites such as Gunsan-I(inner port), Gunsan-O(outer port), Mokpo, Yeosu, Heuksan and Jeju and the results were compared with global values. Besides the changes of sea levels due to global warming, the influence of the man-made structure such as seadike and seawall was attempted to quantify using the minimization of the Root Mean Square(RMS) error. The results show that it is a general tendency that the values of mean sea level rise at the southwestern coast of Korean Peninsula, especially at Gunsan-I and Jeju, are somewhat larger compared to global average values. There is also some evidence that tidal amplifications are found just after construction of man-made structure at Gunsan-I and Mokpo. However, both sites show different mechanism in relation to tidal choking, tidal flat and river discharge. The impact due to construction of man-made structure is considerably larger at Mokpo site, while the impacts due to man-made structure and the effect of sea level rise are relatively identical at Gunsan-I site. This study is expected to provide some intuition to future design.

• 한국지능시스템학회논문지
• /
• 제16권3호
• /
• pp.332-337
• /
• 2006

It has been suggested that the endoscopic color of intramucosal gastric carcinoma is correlated with mucosal vascularity within the carcinomatous tissue. The development of electronic endoscopy has made it possible to quantitatively measure the mucosal hemoglobin volume, using a hemoglobin index. The aim of this study was to make a software program to calculate the hemoglobin index (IHb) and then investigate whether the mucosal IHb determined from the electronic endoscopic data is a useful marker for evaluating the color of intramucosal gastric carcinoma, in particular with regard to its value for discriminating between the histologic types. The mean values of IHb for the carcinoma (IHb-C) and the mean values of IHb for the surrounding non-cancerous mucosa (IHb-N) were calculated in 75 intestinal-type and 34 diffuse-type gastric carcinomas. Then, we analyzed the ratio of the IHb-C to IHb-N. The mean IHb-C/IHb-N ratio in the intestinal-type carcinoma group was higher than that in the diffuse-type carcinoma group (1.28$\pm$0.19 vs. 0.81$\pm$0.18, respectively, p<0.001). When the cut-off point of the C/N ratio was set at 1.00, the accuracy rate, the sensitivity, the specificity, and the positive and negative predictive values of a C/R ratio below 1.00 for the differential diagnosis of diffuse-type carcinoma from intestinal-type carcinoma were 94.5%, 94.1%, 94.7%, 88.9% and 97.3%, respectively. IHb is useful for quantitative measurement of the endoscopic color in intramucosal gastric carcinoma and the IHb-C/IHb-N ratio would be helpful in distinguishing diffuse-type carcinoma from intestinal-type carcinoma.

• 약학회지
• /
• 제52권3호
• /
• pp.172-175
• /
• 2008

Stable isotope ratio of carbon and nitrogen ($\delta^{13}C$ & $\delta^{15}N$), and $\Delta^{9}$-tetrahydrocannabinol (THC) contents were measured on 37 Korean cannabis and 10 commercial grade marijuana seized in Korea. Factors influencing on the measured values and their variations were investigated. $\delta^{13}C$ value of cannabis is specified mainly by water availability. Korean cannabis showed relatively low $\delta^{13}C$ values ranging -33.29$\sim$-27.01% (mean=-31.01%), which reflect geographic conditions of Korea where is rainy, especially during summer. $\delta^{15}N$ values, which reflect individual planting conditions, were relatively high up to -0.5$\sim$18.0% (mean=6.44%). It reflects characteristics of Korean cannabis growing wild in forest or cultivated in fertile soil. Tetrahydrocannabinol is the major hallucinogenic compound of cannabis. Ethanol extracts of cannabis leaves were derivatized by N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), and the derivatives were analyzed by GC-MS in selected ion monitoring (SIM) mode. THC contents of Korean cannabis ranged 0.11$\sim$4.34% (mean=1.47%), which were relatively low compared with commercial grade marijuana.