Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of L-carnitine on the orchidectomized rats

  • Received : 2010.11.13
  • Accepted : 2011.03.22
  • Published : 2011.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

This was conducted to determine the effects of body weight, organ weight, hematological values and biochemical parameters by L-carnitine (Carn) on the orchidectomized (Orch) rats. The animals were divided into 4 groups. Intact group (n=10) received no treatment and operation. Sham group (n=10) received only sham operation and no treatment. Orch group received operation and no treatment. Orch+Carn received operation and L-carnitine. The body weights of each group increased, but that of the Orch+Carn group were significantly lower than those in all the other groups. There were significant differences (P<0.05, P<0.001) of body weights between Orch+Carn group and all the other groups. Also, organ weights such as heart, liver, spleen and kidney were measured. The heart weights were significantly lower (P<0.001) in the Orch+Carn group than those in Intact and Sham groups, respectively. The weights of liver and kidney in the Orch+Carn group were significantly differences (P<0.001) in comparison with those in all the other groups. Also, the spleen weights were significantly lower (P<0.05) in the Orch+Carn group than those in Intact and Sham groups, respectively. The hematological values of mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were significantly differences (P<0.05, P<0.01, P<0.001) in comparison with those in all the other groups. On the other hand, the hematological values of white blood cell (WBC), red blood cell (RBC) and mean corpuscular hemoglobin concentration (MCHC) were not significantly different in any other groups. The concentrations of total cholesterol (T-chol), triglyceride (TG) and high density lipoprotein (HDL) decreased significantly (P<0.05) in the Orch+Carn group as compared to those in the Orch group. We conclude that L-carnitine was significantly decreased the body weight in the orchidectomized rats. Our findings suggest that L-carnitine may influence the process of lipid packaging and absorption in the orchidectomized rats.

Keywords

References

  1. Bremer J. 1983. Carnitine-metabolism and functions. Physiol Rev 63(4): 1420-1480. https://doi.org/10.1152/physrev.1983.63.4.1420
  2. Broderick TL, Quinney HA, Lopaschuk GD. 1992. Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart. J Biol Chem 267(6): 3758-3763.
  3. Costa ND, Labuc RH. 1994. Case report: efficacy of oral carnitine therapy for dilated cardiomyopathy in boxer dogs. J Nutr 124(12S): 2687S-2692S.
  4. Dayanandan A, Kumar P, Panneerselvam C. 2001. Protective role of L-carnitine on liver and heart lipid peroxidation in atherosclerotic rats. J Nutr Biochem 12(5): 254-257. https://doi.org/10.1016/S0955-2863(00)00151-0
  5. Derin N, Izgut-Uysal VN, Agac A, Aliciguzel Y, Demir N. 2004. L-carnitine protects gastric mucosa by decreasing ischemia- reperfusion induced lipid peroxidation. J Physiol Pharmacol 55(3): 595-606.
  6. Guyton AC, Hall JE. 1996. In: Guyton AC (ed) Textbook of medical physiology. Saunders, Philadelphia: 869-899.
  7. Holloway GP, Lally J, Nickerson JG, Alkhateeb H, Snook LA, Heigenhauser GJ, Calles-Escandon J, Glatz JF, Luiken JJ, Spriet LL, Bonen A. 2007. Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle. J Physiol 582(1): 393-405. https://doi.org/10.1113/jphysiol.2007.135301
  8. Keene BW, Panciera DP, Atkins CE, Regitz V, Schmidt MJ, Shug AL. 1991. Myocardial L-carnitine deficiency in a family of dogs with dilated cardiomyopathy. J Am Vet Med Assoc 198(4): 647-650.
  9. Keene BW. 1992. L-Carnitine deficiency in canine dilated cardiomyopathy. In: Current Veterinary Therapy XI: Small Animal Practice (Kirk RW, Bonagura JD). WB Saunders, Philadelphia, PA: 780-783.
  10. Kim YJ, Kim KY, Kim MS, Lee JH, Lee KP, Park T. 2008. A mixture of the aqueous extract of Garcinia cambogia, soy peptide and L-carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet. Genes Nutr 2(4): 353-358. https://doi.org/10.1007/s12263-007-0070-1
  11. Rebouche CJ, Engel AG. 1983. Kinetic compartmental analysis of carnitine metabolism in the dog. Arch Biochem Biophys 220(1): 60-70. https://doi.org/10.1016/0003-9861(83)90387-9
  12. Zou W, Noh SK, Owen KQ, Koo SI. 2005. Dietary L-carnitine enhances the lymphatic absorption of fat and alpha-tocopherol in ovariectomized rats. J Nutr 135(4): 753-756. https://doi.org/10.1093/jn/135.4.753