• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2006.03a
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• pp.125-132
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• 2006

To estimate the local site effects at two town fortress areas where stone parapets were collapsed during historical earthquakes, site characteristics were evaluated using borehole drillings and seismic tests and equivalent-linear site response analyses were conducted based on the shear wave velocity (Vs) profiles determined from site investigations. The study sites are categorized as site classes C and B according to the mean Vs to 30 m ranging from 500 to 850 m/s, and their site periods are distributed in short period range of 0.06 to 0.16 sec. For site class C in the study areas, the short-period (0.1-0.5 sec) and mid-period (0.4-2.0 sec) site coefficients, $F_{\alpha}$ and $F_\nu$ specified in the Korean seismic design guide, underestimate the ground motion in short-period band and overestimate the ground motion in mid-period band, respectively, due to the characteristics showing high amplification in short period range, which can result in the collapse of stone parapets having the short natural period.

• Progress in Medical Physics
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• v.24 no.3
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• pp.176-182
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• 2013

Through this research, we measure the data for several SUVs such as SUVLBM, SUVBW, and SUVBSA using volume of interest in order to enhance the diagnostic level in whole-body image for healthy examinees via F-18 FDG PET/CT. Maximum value, mean value, standard deviation, and threshold value for each SUVs are shown. The measurement of SUVs are carried out with 31 examinees who have taken whole-body examination with F-18 FDG PET/CT from July, 2012 to August, 2012. To secure the preciseness of measurement, we selected 26 healthy examinees as a subject of measurement according to diagnostic view of a nuclear-medical doctor. We see from the measurement of SUVs of PET/CT that the value of SUVBW is hightest and followed by SUVLBM and SUVBSA in turn regardless of the use of contrast media. By comparing the SUVLBM-maximum data for the group used contrast media with those for the group used no contrast media, there found a trend that the measured values increase when the contrast media are used. Among them, liver, aorta, lumbar-5, and Cerebellum exhibit significant difference (p<0.05). We conclude that our data for SUVs would be basic references in overall image interpretation, and hope that the research using VOI would be active.

• Journal of Ecology and Environment
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• v.29 no.3
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• pp.247-252
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• 2006

For the spring ephemeral and myrmecochorous perennia, Corydalis filistipes Nakai (Fumariaceae), rare and narrow endemic to Ullung Island in Korea, genetic diversity and structure of 4 subpopulations of the species were investigated with allozyme markers. Levels of genetic diversity (A=1.73, $P_{95%}$=61..2%, Ho=0.201, He=0.167) were relatively lower than those of other endemic species with widespread distribution range, but considerably higher than other endemic species with similar life history traits isolated in island. The moderate level of genetic diversity within subpopulations in C. filistipes is characteristic of the species with predominantly outcrossing, myrmecochorous seed dispersal by dual function of the elaisome and mode of sexual and asexual reproduction by the cleistogamy. The analysis of fixation indices showed an overall excess of heterozygotes (mean $F_{IS}=-0.1889,\;F_{IT}=-0.1226$) relative to H-W expectations. About 5.6% of the total genetic variation was found among subpopulations ($F_{ST}$=0.0557). The strategies of reasonable conservation and management, and the maintenance mechanism of genetic diversity of Corydalis filistipes Nakai, endemic plant species in Korea were discussed.

• Journal of the Korea Safety Management & Science
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• v.15 no.4
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• pp.427-433
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• 2013

Recently, 18F-FDG PET based CT scan was a critical examination that the after, before plan diagnosis and treatment of tumors. But, due to the distortion of SUV that should be proportional to the metabolic rate of glucose in the tumor, the other measurement methods are being on study. In this study, compared the degree of distortion of SUV that according to the volume of the tumor analysis ROI and VOI using the NEMA IEC Phantom. The results, the SUVmax, mean value are rapidly decreased with threshold value 500 mm2 interval of the ROI analysis, 1500 mm3 interval of the VOI analysis. When compared SUVmax value SUVmean, ROI and VOI analysis VOI measurements was 1.077 times higher SUVmax was 0.981 times highe compared to the value of the ROI measurement. Compare MTV, SUV 2.0 as measured by the volume of the VOI to Volume showed a slightly higher results(Volume / MTV = $93.4 %{\pm}14.8 %$). Considering the above results, Tumor evaluation by 18F-FDG PET / CT scan Consider each threshold value should be analyzed due to larger SUV's Distortion depending on the size of the tumor. VOI analysis is recommended. because it showed the VOI analysis is higher than the ROI analysis SUVmax and lower SUVmean due to VOI analysis than once as a measure of the wider area as measured ROI analysis. MTV (R2 = 0.999), a result close to the actual size of the tumor. but, more research is needed in this regard, because SUV according to the standards of value are affected.

• Korean Journal of Clinical Pharmacy
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• v.18 no.1
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• pp.60-67
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• 2008

This study aimed to compare a microparticle enzyme immunoassay (MEIA) with a liquid chromatography-tandem mass spectrometry (LC/MS/MS) technique for the measurement of tacrolimus concentrations in adult liver transplant recipients, to investigate how the assay choice influenced the population pharmacokinetics of tacrolimus and to identify patient characteristics that affected pharmacokinetic parameters in each assay. Tacrolimus concentrations from 29 liver (n=52 paired-samples) transplant recipients measured by both MEIA and LC/MS/MS were used to evaluate the performance of these methods in the clinical setting. Tacrolimus pharmacokinetics was studied independently using MEIA and LC/MS/MS data in 70 adult patients using a population approach performed with NONMEM. Patient characteristics which influenced pharmacokinetic parameters in each assay were compared. The relation between LC/MS/MS and MEIA measurements was best described by the regression equation MEIA=1.465*LC/MS/MS-1.336 (r=0.91). Multiple linear regression analysis showed significant inverse relationships between assay difference and hematocrit (Hct) (p<0.025) in liver graft recipients. In MEIA, the population estimate of tacrolimus CL/F and apparent volume of distribution (Vd/F) were found to be 10.1 L/h and 226 L, and in LC/MS/MS, 13 L/h and 305 L respectively. Neither patient's age, weight, gender, grafted hepatic weight, albumin concentration, nor markers of liver function influenced tacrolimus CL/F The final model of CL/F was found to be 10.1+(Hct/Hct mean)$^{12.0}$ in MEIA and 13+(1+Hct/578) in LC/MS/MS indicating that CL/F was influenced by hematocrit.

• Earthquakes and Structures
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• v.10 no.5
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• pp.1125-1141
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• 2016

The direct displacement based design (DDBD) approach is spreading in the field of seismic design for many types of structures. This paper is carried out to present a robust approach for the DDBD procedure for single degree of freedom (SDOF) concentrically braced frames (CBFs). Special attention is paid to the choice of an equivalent viscous damping (EVD) model that represents the behaviour of a series of full scale shake table tests. The performance of the DDBD methodology of the CBFs is verified by two ways. Firstly, by comparing the DDBD results with a series of full-scale shake table tests. Secondly, by comparing the DDBD results with a quantified nonlinear time history analysis (NLTHA). It is found that the DDBD works relatively well and could predict the base shear forces ($F_b$) and the required brace cross sectional sizes of the actual values obtained from shake table tests and NLTHA. In other words, when comparing the ratio of $F_b$ estimated from the DDBD to the measured values in shake table tests, the mean and coefficient of variation ($C_V$) are found to be 1.09 and 0.12, respectively. Moreover, the mean and $C_V$ of the ratios of $F_b$ estimated from the DDBD to the values obtained from NLTHA are found to be 1.03 and 0.12, respectively. Thus, the DDBD methodology presented in this paper has been shown to give accurate and reliable results.

• The Journal of Korean Academic Society of Nursing Education
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• v.18 no.2
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• pp.239-247
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• 2012

Purpose: This study is to assess the level of student perceptions, academic achievement, satisfaction, and their relationships in a medical-surgical nursing course using team-based learning (TBL). Method: Four-hour TBL sessions were given in a structured three-phase sequence in a cohort of 261 second year nursing students. Results: Mean perceptions of TBL was $6.64{\pm}5.11$, and $8.30{\pm}4.11$ for perceptions of teamwork. On a 7-point scale, the mean satisfaction score was $4.85{\pm}1.41$, and 64.0% of nursing students were satisfied with TBL compared to lecture. Group readiness assurance test score was significantly higher than individual readiness assurance test score (t=-16.76, p<.001). Perceptions of TBL (F=1.40, p=.245), perceptions of team work (F=1.55, p=.202) and satisfaction (F=0.81, p=.489) was not different by the level of students' academic achievement on items related TBL. Conclusion: Results indicates that TBL was an effective instructional strategy including favorable perceptions and satisfaction for nursing students. TBL could be an adjunct educational strategy for undergraduate nursing education.

• YAKHAK HOEJI
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• v.45 no.2
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• pp.190-204
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• 2001

This study was conducted to investigate for its effects on reproductive and developmental toxicity of recombinant human epidermal growth factor (rhEGF) in Sprague-Dawley rats. Male rats were administered rhEGF at doses of 1, 10, 100, and 1000$\mu$g/kg/day, respective1y, by subcutaneous injection from 63 days before and throughout to mating period until the day before sacrifice. Female rats were administered rhEGF at the same doses from 14 days before mating to day 20 of gestation or to day 21 of lactation. We examined the male and female fertility indices and maternal toxicity of F0 parental animals. Also, we examined the external, visceral, or skeletal malformation of fetuses, growth and development, behavior, and/or reproductive performance of F1 animals. At the highest dose (1,000 $\mu$g/kg), the mean body weights of F0 animals were significantly increased in males and females at 3 or 2 weeks after treatment, respective1y. No clinical signs and food intakes were observed at any time during the experimental period by rhEGF treatment. In autopsy examination, the relative and absolute liver weights significantly increased in both sexes of 1,000 $\mu$g/kg. At the highest dose (1,000 $\mu$g/kg), there was a statistically significant increase of pregnancy period and the number of dead fetuses. Moreover, significant increase of mean fetal body weight and decrease of number of live fetuses, which related to the difficult dilivery were observed in highest dose group. In Fl examination, no adverse effects on external, visceral, and skeletal malformation, physical and functional development, behavior or reproductive ability of Fl animals were observed in any group. Also, there was no significant difference between control and treated groups in copulation or fertility indices of Fl animals. These results indicate that rhEGF had no adverse effect on fertility and reproductive ability of Sprague-Dawley rats.

• Solar Energy
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• v.7 no.2
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• pp.86-97
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• 1987

Natural convection in the annulus between a horizontal conducting tube and a cylinder with spacers has been studied by 2-dimensional numerical method with finite difference techniques. The effects of Rayleigh number, conductivities of conducting tube and spacer, and position of spacers were studied analytically. In case of vertical spacers, the maximum local Nusselt number appears at ${\theta}{\approx}50^{\circ}$ in a conducting tube and ${\theta}{\approx}30^{\circ}$ in an outer cylinder, The local Nusselt numbers show positive values on the lower spacer, but negative values on the surface of the upper spacer. In case of horizontal spacers, the flow over the spacer is more active than that of under the spacer as the Rayleigh number increases. The maximum local Nusselt appeares at ${\theta}=180^{\circ}$ in a conducting tube and at ${\theta}=0^{\circ}$ in an outer cylinder. The local Nusselt numbers show positive values on the upward surface, but negative values on the downward surface of spacer. As the dimensionless conductivity increases, the mean Nusselt number remarkably increases at $K_w/K_f<48$ and show almost even at $K_w/K_f{\ge}48$. The mean Nusselt number of a conducting tube with vertical spacers is 5.12 percent less and with horizontal spacers is 11.33 percent less than that of a conducting tube without spacer at $Ra=10^4$, Pr = 0.7 and $K_w/K_f=48$.

• Transactions of the Korean Society of Mechanical Engineers
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• v.15 no.2
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• pp.654-660
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• 1991

Natural convection heat transfer in a horizontal annulus from an inner tube with two vertical fins has been studied for the effects of dimensionless fin length and Rayleigh number. The maximum local Nusselt number of inner tube was obtained at .theta. = 145.deg. and that of outer cylinder at .theta. = 0.deg. for the case of $l_{F}$=0.3 Local Nusselt number distributions for the lower fins show higher values than that of the upper fins. The mean Nusselt number of inner tube was increased with the values of dimensionless fin length. The mean Nusselt number can be represented in an exponential function of Grashof number at various fin lengths. As compared with experimental and numerical results, isotherms and local Nusselt number show good agreement.t.