• Korean Journal of Veterinary Research
• /
• v.43 no.4
• /
• pp.657-666
• /
• 2003

The present study was undertaken to evaluate the potential adverse effects of 2-BP on pregnant dams and embryo-fetal development after maternal exposure during the gestational days (GD) 6 through 19 in Sprague-Dawley rats. The test chemical was administered subcutaneously to pregnant rats at dose levels of 0, 375, 750 and 1250 mg/kg/day. During the test period, clinical signs, mortality, body weights and food consumption were examined. All dams were subjected to caesarean section on GD 20 and their fetuses were examined for external, visceral and skeletal abnormalities. At above 750 mg/kg, toxic effects including signs of toxicity, suppressed body weight, decreased gravid uterine weight and reduced food intake were observed in pregnant dams. An increase in the fetal deaths, a decrease in the litter size, a reduction in the fetal body weight and an increase in the incidence of fetal morphological alterations were also found. There were no adverse effects on either pregnant dams or embryo-fetal development at a dose level of 375 mg/kg. These results suggest that a 14-day subcutaneous dose of 2-BP is embryolethal and teratogenic at above 750 mg/kg/day in pregnant rats. In the present experimental condition, the no-observed-adverse-effect level of 2-BP is considered to be 375 mg/kg/day for dams and embryo-fetuses, respectively.

• Child Health Nursing Research
• /
• v.5 no.1
• /
• pp.84-96
• /
• 1999

The purpose of this study was to find whether the educational program contributed to the increase of caring confidence and rearing attitude of the newborn mothers. The subjects for this study were 40 newborn mothers-20 control group and 20 experimental group-who delivered a normal neonate and were gotten general informations from the nurses at the K medical center in Seoul. Especially, the experimental group was educated for 30-40 minutes in maternal educational program through lectures, demonstrations, discussion with textbooks and visual materials by a researcher at 2-3 days after delivery. The data were collected two times-at 2-3 days after delivery and at 4 weeks after discharge-from October, 1998 to January, 1999 by investigators interviewing with a structured questionnaire. Pharis(1978)'s self confidence scale was used after some modification to measure caring confidence and Cohler's maternal attitude scale to check mother's rearing attitude. Analysis of data was done by using of frequency, %, x²-test, Independent sample t-test. The results of this study were as follows ; 1. The Confidence of the experimental group was significant higher than the control group (t=2.519, p=.016) and the rearing attitude changed more positively(t=5.545, p=.000). 2. In the confidence scale, the statements having a significant change were holding a baby, changing diapers, feeding, and caring umblicus. 3. In the rearing attitude scale, the statements having a significant change were 12 of 20 statements.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.4 no.2
• /
• pp.73-88
• /
• 2009

This research is to observe the misbehavior of child, and identify relevance maternal propensity for perfection - one of parents factors that affect the misbehavior of child - to the misbehavior of child. The objects of this study 274 children of 3-5 years who were attending nursery schools and kindergartens in Gyeonggi province and Busan City as well as their mothers of the same number. The result of the research provides the fundamental data about the mother and child relationship with the parent's factor which gives an effect to child's misbehavior and reveals mother's psychological nature of the functional parts of a perfectionism and the disfunction as part of this.

• The Korean Journal of Community Living Science
• /
• v.21 no.1
• /
• pp.33-51
• /
• 2010

The purpose of this study was to examine the effects of parenting efficacy, parenting stress on elementary school children's self-efficacy and daily stress. The subjects were 355 children selected from 4 elementary schools and their mothers. Data was collected using the parenting efficacy index, parenting stress index, children's self-efficacy inventory and children's daily stress inventory. Data was statistically analyzed using the t-test, one way ANOVA(Duncan test), correlation analysis and multiple regression analysis. The study showed that there were some significant differences in children's self-efficacy according to the child's grade, gender, scholastic achievement, mother education, father education, and income. There were some significant differences in children's daily stress according to the child's grade, gender, and scholastic achievement. Correlation analysis indicated that the maternal parenting efficacy and children's self-efficacy, especially self-confidence had a significant positive correlation, and indicated a negative correlation with children's daily stress. Correlation analysis indicated that maternal parenting stress and children's self-efficacy had a significant negative correlation, and indicated a positive correlation with children's daily stress. It was also found that scholastic achievement, educational distress of the mother, father education were significant predictors of the children's self-efficacy, and healthy parenting ability, father education, stress of a difficult child, scholastic achievement, gender were all significant predictors of the children's daily stress.

• Anxiety and mood
• /
• v.9 no.1
• /
• pp.19-24
• /
• 2013

Objectives: The objective of this study is to examine the association between the children's psychopathology and age, intellectual quotient, and parental psychopathology in children with post-traumatic stress disorder (PTSD). Methods: The emotional and behavioral problems of 35 children with PTSD (23 boys, 12 girls, mean age, $10.26{\pm}2.47$ years) were investigated by retrospective chart review. Their parents' anxiety and depression symptoms were also investigated. We examined the correlations between children's psychopathology and their parents' anxiety and depression symptoms, as well as their age and IQ. Results: There were positive correlations between maternal trait anxiety and depression, and children's emotional problems. State and trait anxiety of children with PTSD were positively correlated with age, and attention-deficit hyperactivity disorder symptoms were negatively correlated with age. Conclusion: Our results suggest that psychiatric manifestation of children who experienced trauma could differ according to the development stage, and the treatment of children with PTSD should involve parental education about the effect of maternal emotional states on children.

• Asian-Australasian Journal of Animal Sciences
• /
• v.15 no.9
• /
• pp.1371-1377
• /
• 2002

During a 5-yr period, 1994-1998, pre-weaning and weaning data were collected on 591 calves produced by mating either straightbred Jersey, straightbred Limousin or $F_1$ (Limousin${\times}$Jersey) bulls to mature purebred Jersey or Limousin cows. Traits recorded included birth and weaning weight, height, length, girth, fat depth and a measure of muscle (ratio of stifle to hip width expressed as a percentage). All traits were analyzed assuming a model with sire and dam random effects that included effects of year and date of birth, sex, breed and year${\times}$sex interaction. Main effects were generally significant with few exceptions. Direct genetic effects were large for weight, height, girth and muscle with a breed trend from purebred Jersey (small) to purebred Limousin (large). At weaning, the maternal effect of the Jersey dam was positive for weight (10.9${\pm}$4.9 kg), girth (3.7${\pm}$1.0 cm) and muscle (6.0${\pm}$0.9%). Heterosis was highly significant and positive only for fat depth (1.5${\pm}$0.2 mm) with the $F_1$ progeny being the fattest, followed by the backcrosses, then purebred Jersey and purebred Limousin. Also, significant (p<0.001) but negative heterosis was observed for weight, girth and muscle. The change in ranking for fat depth relative to other traits is a reflection of the large heterotic effects relative to direct effects on fat depth. Epistatic effects were not significant on any trait at birth or weaning. This study has indicated the possibility of exploiting the positive heterotic and maternal effects for fat depth and muscularity to meet specific meat quality and quantity demand by consumers.

• Journal of Animal Science and Technology
• /
• v.59 no.1
• /
• pp.1.1-1.11
• /
• 2017

Background: Intrauterine environment plays a pivotal role in the origin of fatal diseases such as the metabolic syndrome. Diabetes is associated with low-grade inflammatory state and dysregulated adipokines production. The aim of this study is to investigate the effect of maternal diabetes on adipocytokines (adiponectin, leptin and TNF-${\alpha}$) production in F1 offspring in rats. Methods: The offspring groups were as follows: F1 offspring of control mothers under control diet (CD) (CF1-CD), F1 offspring of control mothers under high caloric diet (HCD) (CF1-HCD), F1 offspring of diabetic mothers under CD (DF1-CD), and F1 offspring of diabetic mothers under HCD (DF1-HCD). Every 5 weeks post-natal, 10 pups of each subgroup were culled to obtain blood samples for biochemical analysis. Results: The results indicate that DF1-CD and DF1-HCD groups exhibited hyperinsulinemia, dyslipidemia, insulin resistance and impaired glucose homeostasis compared to CF1-CD (p > 0.05). DF1-CD and DF1-HCD groups had high hepatic and muscular depositions of TGs. The significant elevated NEFA level only appeared in offspring of diabetic mothers that was fed HCD. DF1-CD and DF1-HCD groups demonstrated low serum levels of adiponectin, high levels of leptin, and elevated levels of TNF-${\alpha}$ compared to CF1-CD (p > 0.05). These results reveal the disturbed metabolic lipid profile of offspring of diabetic mothers and could guide further characterization of the mechanisms involved. Conclusion: Dysregulated adipocytokines production could be a possible mechanism for the transgenerational transmittance of diabetes, especially following a postnatal diabetogenic environment. Moreover, the exacerbating effects of postnatal HCD on NEFA in rats might be prone to adipcytokine dysregulation. Furthermore, dysregulation of serum adipokines is a prevalent consequence of maternal diabetes and could guide further investigations to predict the development of metabolic disturbances.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• v.22 no.4
• /
• pp.219-227
• /
• 2011

Objectives : This study examined maternal object relations, child's and mother's perception on rearing attitude, and children's self-esteem in children with attention-deficit hyperactivity disorder (ADHD) and their mothers. Methods : 64 children with ADHD and their mothers were included in the study group. In the control group, there were 85 children and their mothers. Mothers completed the following tests : Bell object relation inventory (BORI), maternal behavior research instrument (MBRI), Beck Depression Inventory (BDI), and Korean ADHD Rating Scale (K-ARS). Children completed Children's Report of Parental Behavior Inventory (CRPBI) and Rosenberg self-esteem scale. Results : Mothers of ADHD children displayed more rejecting and controlling parenting style than mothers in the control group. ADHD children showed lower self-esteem and perceived their parents as not affectionate, but rejecting and controlling. Mothers with ADHD children who belonged to object relations pathological group showed more rejecting rearing attitude and their children believed that they were more controlling, compared with children and mothers in other conditions. Among factors in mother's object relations, insecure attachment and ego-centricity impacted the rearing attitude. In turn, affective rearing attitude mainly influenced children's self-esteem. Conclusion : This study suggests that the approach focused on mother's object relations may help with the treatment of children with ADHD.

• Korean Journal of Veterinary Research
• /
• v.51 no.2
• /
• pp.151-158
• /
• 2011

The study evaluated whether a transgenic carrot vaccine could induce a K88-specific immune response in sows and whether the resultant maternal antibody could protect piglets against enterotoxigenic Escherichia coli (ETEC) K88ac infection. Sows (n = 15) selected randomly from a farm in Korea were assigned to three groups (n = 5 per group: control [untreated]), group A (orally inoculated with a nontransgenic and transgenic carrot vaccines at 2 and 4 weeks ante partum, respectively), and group B (conventionally vaccinated according to the manufacturer's instructions). After 7 days of lactation, 5 piglets selected randomly from each group were challenged with $1{\times}10^{10}$ colony forming units/mL ETEC K88ac. Group C had the lowest mean fecal consistency score on post-challenge days 1 and 7. Histiologically, On post-challenge day 7, group C showed an increased duodenum and ileum villus:crypt ratio, compared to group A in the duodenum, with group B displaying the highest ratio. Groups B and C had more increased villus width than group A in the jejunum. Group C displayed the greatest increase in villus width in the ileum. The colostrums and serum from groups B and C displayed higher concentrations of IgA and IgG against ETEC K88, compared to group A. Based on the results, it was concluded that the transgenic carrot vaccine in sow per oral may have an effect on preventing piglet diarrhea as good as commercial recombinant vaccine.

• Journal of Korean Medical Science
• /
• v.33 no.48
• /
• pp.311.1-311.10
• /
• 2018

Background: In postmenopausal women, there is rapid bone loss due to estrogen depletion. In women, reproductive factors such as age at menarche, breastfeeding, and parity are considered risk factors of osteoporosis. Many reports suggest that obesity is associated with a reduced risk of osteoporosis. This nationwide, population-based study aims to identify the association between maternal age and osteoporosis risk in postmenopausal women of different obesity classifications. Methods: We assessed data from the Korean National Health and Nutrition Examination Survey 2010-2012. The study included 1,328 postmenopausal women, after excluding women with missing data for reproductive history among 4,546 postmenopausal women in the survey. Multivariate regression was used to identify the association between childbirth age and postmenopausal bone mineral density after adjustments for confounding factors. Results: The prevalence of postmenopausal osteoporosis was 35.24% (n = 468). After dividing the subjects into obese and non-obese groups based on body mass index (BMI) and waist circumference, there were significant differences between non-osteoporosis and osteoporosis groups with regard to age at first childbirth, age at last childbirth, and parity in the BMI-based general obesity group. The prevalence of osteoporosis was highest in women older than 35 years old at last childbirth. The prevalence of osteoporosis was also greater in women with parity ${\geq}4$ compared to those with lower parity levels. Conclusion: Postmenopausal women of older age at last childbirth and higher parity were at increased risk of osteoporosis in the BMI-based non-general obesity group.