• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7085-7088
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• 2015

Background: The high incidence of prostate cancer as the most common malignancy in males in many countries raises the question of developing reliable detection tests. The prostate specific antigen (PSA) test is the most widely used for screening for prostate cancer; however, its low specificity elevates the number of unnecessarily biopsies. Serum human kallikrein-2 (hK2) is considered as a promising marker, and especially its ratio to fPSA, for predicting the presence of malignancy to select the best choice referring to biopsy or surveillance. In this study, we investigated the role of hK2 and its combinations with other markers to discriminate prostate cancer from benign diseases in Syrian patients. Materials and Methods: In this prospective oriented cross-sectional cohort study, serum samples were collected from patients referred to many Hospitals in Damascus, Syria, between May 2011 and March 2012, and diagnosed with biopsy proven benign prostate hyperplasia (BPH) or prostate cancer (PCa). Serum was analyzed for hK2, PSA and fPSA, and the ratios of fPSA/PSA and hK2/fPSA were calculated. Results: We found that mean hK2/fPSA ratios were significantly higher (P=0.01) in prostate cancer patients than in the BPH or control groups. Also the ratio hk2/fPSA gave the largest area under the curve (AUC:0.96) which was significantly larger than for fPSA/PSA (AUC:0.41) indicative of higher specificity. Conclusions: Our results demonstrate that the ratio of hK2/fPSA might be superior to the use of fPSA/PSA alone. The hK2 could be shown to enhance the early detection of prostate cancer; especially the ratio hK2/fPSA improves specificity and hence may reduce the number of negative biopsies.

• Smart Structures and Systems
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• 제15권2호
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• pp.355-373
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• 2015

An optimal sensor placement (OSP) method based on structural subsection technique (SST) and model reduction technique was proposed for modal identification of truss structures, which was conducted using genetic algorithm (GA). The constraints of GA variables were determined by SST in advance. Subsequently, according to model reduction technique, the optimal group of master degrees of freedom and the optimal objective function value were obtained using GA in a case of the given number of sensors. Correspondingly, the optimal number of sensors was determined according to optimal objective function values in cases of the different number of sensors. The proposed method was applied on a scaled jacket offshore platform to get its optimal number of sensors and the corresponding optimal sensor layout. Then modal kinetic energy and modal assurance criterion were adopted to evaluate vibration energy and mode independence property. The experiment was also conducted to verify the effectiveness of the selected optimal sensor layout. The results showed that experimental modes agreed reasonably well with numerical results. Moreover the influence of the proposed method using different optimal algorithms and model reduction technique on optimal results was also compared. The results showed that the influence was very little.

• 한국융합학회논문지
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• 제7권4호
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• pp.123-131
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• 2016

본 연구는 2016 구글 딥마인드 챌린지 매치에서 최고 수준의 딥러닝 인공신경망을 갖고 있는 인공지능 알파고와 인간지능의 대표로 상징되는 바둑 최고수의 대국 분석 및 문헌 연구로 인공지능 시대에 적합한 학습자의 역량 교육에 대해 논의했다. 알파고는 지금까지 알려져 있는 바둑의 정석과 상식을 넘어서는 새로운 바둑의 패러다임을 보여주는 기발한 수를 두었고, 이세돌은 알파고도 생각하지 못한 '신의 한 수' 로 인공지능 수퍼 컴퓨터를 이길 수 있었다. 이는 인간의 집념과 도전, 인간 본성의 통찰과 직관의 승리였다. 인공지능 시대에 기계를 조정하고 통제할 수 있는 학습자 역량을 기르기 위한 융합과학 교육은 자연으로부터의 감성적 체험과 토포필리아 교육으로 인공지능이 갖지 못한 인간 본성의 다채로운 감성과 통찰, 긍정적 정서를 함양시킬 수 있는 방향이어야 한다.

• 한국가금학회:학술대회논문집
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• 한국가금학회 2006년도 제23차 정기총회 및 학술발표회
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• pp.90-91
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• 2006

To reduce the economic impact and control Low pathogenic avian influenza (LPAI), vaccination with inactivated vaccine has been considered in this country. We tried to develop inactivated vaccine with reassorted H9N3 AI virus which has different type of neuraminidase compare to those of field AI virus. Before reassorted vaccine was produced, we confirm the virus as master seed by limiting dilution, RT-PCR and sequencing method. Also, we evaluate the biological characteristics of the virus to find out the possibility of prevention against field infection of AI virus. Finally, we evaluate the safety and efficacy of the vaccine made of reassorted AI virus in the specific pathogen free (SPF) chickens. After limiting dilution, we choose RV7CE4 as a vaccine candidate and compare the gene sequence of this vaccine strain to those of AI05GA which is parents strain. Compared to amino acid sequences of specific gene of AI05GA and RV7CE4, exhibited a high degree of amino acid sequence homology. In the safety and efficacy test, there were no specific clinical signs or mortality. Reassorted H9N3 viruses were reisolated in cloaca swab on 5 days post inoculation. In the vaccine study, once or twice vaccination was performed and challenged with H9N2 field virus (01310). Vaccine has no adverse effect on birds and formed good immune capability which reduce viral shedding in the birds infected with 01310. Based on the above result, we developed reassorted H9N3 vaccine which will efficiently prevent the low pathogenic AIV (H9N2) infection in the poultry farms.

• 인지과학
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• 제4권2호
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• pp.85-114
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• 1994

지능형 교수 시스템(ITS:lntelligent Tutoring System)의 개발에 관한 연구에서 중요한 분야 중 하나의 교수법의 제어에 관한 연구이다. 즉 전체 학습목적 또는 학습주제의 선정(curriculmplan),선정된 학습목적에 적합한 레슨플랜(lesson plan),자연스런 대화진행(discourse plan) 방법에 관한 연구이다.본 논문에서는 위의 세가지 플랜 중 레슨플랜에 케이스 기반 플랜기법(casebased planing)을 적용하여 생성하는 방법을 제안하였다.기존의 레슨플랜생성기는 학습목적이 결정될 때마다 그에 적합한 레슨플랜을 생성하였다.이와달리 본 연구에서는 이미 기억된 플랜이 있으면 그 플랜을 그대로 사용하거나 수정하여 사용하고 기억된 플랜이 없으면 새로 생성할 수 있는 학습목적에 적응력 있는 레슨 플랜생성기를 개발하였다.연구의 대상으로는 미적분학의 부정적분으로 하였고 제시된 문제의 일반형을 유추하기 위하여 기술언어와 커리큘럼트리(curriculum tree)를 고안하였다.본 연구결과는 다른 분야 ITS의 레슨플랜생서기 개발에 이용할 수 있으며 또한 적분을 교육하는 실제 학습현장에서도 사용될 수 있을 것이다.

• The Journal of Korean Physical Therapy
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• 제18권3호
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• pp.59-70
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• 2006

Purpose: This study is intended to examine the aquatic exercise on the improvement of muscle atrophy and motor function in an ischemic stroke model induced by middle cerebral artery occlusion. Methods: We used 60 Sprague-Dawely rats which were divided into 4 groups; the subjects were divided into group of 5 rats. Group I was a group of high dose aquatic exercise after inducing ischemic stroke; Group II was a group of low dose aquatic exercise after inducing ischemic stroke; Group III was a control group, Group IV was a sham group without ischemic stroke. Results: Muscle weight of gastrocnemius muscle was significantly difference in Group II compared to Group III on 8 weeks(p<0.05). For the changes in relative muscle weight of gastrocnemius muscle, there was significant increase in Group II compared to Group III on 8 weeks(p<0.05). For neurologic exercise behavior test, Group II generally had the highest score, compared to other groups. The results of behavior test that Group II improved in degeneration and inflammation of muscle fiber and decreased in destruction of nerve cells and cerebral infarction, indicating a similar state of muscle fiber and brain to Group III. Conclusion: Based on these results, aquatic exercise may improve muscle atrophy and contribute to the improvement of motor function.

• The Journal of Korean Physical Therapy
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• 제18권3호
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• pp.9-21
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• 2006

Purpose: This study was intended to examine the effects of electroacupuncture and therapeutic exercise on muscle atrophy and exercise function in an ischemic stroke model induced by middle cerebral artery occlusion. Methods: This study selected 120 Sprangue-Dawley rats, 8-week of age, divided them into six groups, and assigned 5 rats to each group. Experiments were conducted for 1, 3 days, 1, and 8 weeks, respectively. Group I was a group of electroacupuncture and therapeutic exercise after inducing ischemic stroke; Group II was a group of therapeutic exercise after inducing ischemic stroke; Group III was a group of electroacupuncture after inducing ischemic stroke; Group IV was a sham group of electroacupuncture after inducing ischemic stroke; Group V was a control group and Group VI was a sham group without ischemic stroke. In each group, changes in weight of muscle and relative muscle of TA muscle, neurologic motor behavior test, histologic observations were observed and analyzed. Results: For the changes in muscle weight of unaffected and affected sides of TA muscle, muscle atrophy was seen in an affected side 3 days after ischemic stroke was induced. There was statistically significant difference in Group I 1 week and 8 weeks after ischemic stroke was induced, compared to Group V (p<0.05). For the changes in relative muscle weight of unaffected and affected sides of tibial anterior muscle, there was significant decrease in each group 3 days after ischemic stroke was induced, compared to Group IV, while there was statistically significant increase in Group I 1 week after ischemic stroke was induced, compared to Group V (p<0.05). For neuologic exercise behavior test, Group I generally had the highest score, compared to other groups. Conclusion: electroacupuncture and therapeutic exercise may improve muscle atrophy and change in histologic observations expression of ischemic stroke rats and contribute to the improvement of exercise function.

• 대한의생명과학회지
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• 제17권3호
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• pp.231-238
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• 2011

During pregnancy, stress induces maternal glucocorticoid secretion, which in turn is known to affect structural malformation, retardation of growth, reduced birth weight of the fetus. As Hox genes are master transcription factors which fulfill critical roles in embryonic development, we aimed to explore the possibility that alterations of the Hox gene expression might be involved in stress-induced malformation. The pregnant mice were injected with dexamethasone at a dose of 1 mg/kg or 10 mg/kg on day 7.5, 8.5 and 9.5 p.c. (post coitum), as well as saline as control. Embryos of E11.5 and E18.5 were obtained by sacrificing pregnant animals. Weight and crown-rump length (CRL) were measured. RT-PCR was performed to examine the Hox gene expression levels. Embryos given dexamethasone at day 7.5~9.5 p.c. had small CRL and weighed less both in E11.5 and E18.5. The percentage of embryos showing abnormalities was high in groups received high dose of dexamethasone. To define the molecular basis for abnormal embryonic development, we analyzed the Hox gene expression pattern and found that many Hox genes display altered expression. Effects of prenatal dexamethasone treatment on embryonic development might be associated with the aberrant Hox gene expression.

• 한국학교수학회논문집
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• 제12권4호
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• pp.473-492
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• 2009

이 연구는 2007년을 시발점으로 내용교수지식(PCK) 및 수업컨설팅 지원에 관하여 3개년에 걸친 중장기 연구로서, KICE-TLC 고유의 PCK 연구 방법과 PCK에 대한 관점을 정립하고자 하였다. 이와 관련하여 수학 교과의 경우, 일차년도인 2007년도 연구에서는 개정 교육과정에 따른 수학과 PCK의 의미를 탐색하여 수학과 PCK 분석틀을 설정하고 이를 기반으로 다양한 유형의 PCK를 마련하였다. 이차년도인 2008년 연구에서는 중학교 수학 교과의 초임 및 경력교사 각각 3명씩을 대상으로 이들의 수업 사례를 통해 문제점을 도출하고 이에 대한 진단 및 대안을 모색하고자 하였으며, 본 논문에서는 이러한 초임교사를 위한 수업컨설팅(안)을 '학습자 이해'에 관한 지식 측면에 초점을 두어 제시하였다.

• 한국정보과학회논문지:시스템및이론
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• 제35권4호
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• pp.150-157
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• 2008

본 논문에서는 높은 해상도를 제공하기 위하여 여러 대의 PC와 모니터를 연결한 타일드-디스 플레이(Tiled-Display) 시스템 상에서 동작하는 실시간 동영상 상영기를 설계 및 구현하였다. 제안한 동영상 상영기는 하나의 동영상을 기가 비트(Giga bit) 폐쇄 이더넷으로 연결된 여러 PC에 UDP 멀티캐스트를 사용하여 전송하고 각 수신기는 받은 동영상 데이타의 압축을 푼 후 이미지를 자신의 영역에 분할하여 시간적인 동기화를 맞추어서 재생할 수 있도록 설계되었다. 본 시스템은 미디어 데이타의 전송 중 발생하는 패킷 손실 및 지터(jitter) 문제를 동영상의 비트레이트에 따라서 방송량을 결정하는 흐름 제어 방법과 필요한 만큼 미리 받은 뒤 재생을 시작하는 버퍼링 방법을 통하여 해결하였으며, 서로 다른 PC의 상영기간의 동기화를 위하여 별도의 오버헤드 없이 시작 시간만 동기화하고 각 PC의 상영기들의 리퍼런스 클럭의 속도를 동일하도록 하여 안정적인 실시간 스트리밍 및 상영이 가능하도록 하였다. 또한 여러 전송포맷 및 압축 포맷을 지원하기 위하여 Microsoft DirectShow 구조상에서 구현되었다.