• Analytical Science and Technology
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• v.37 no.1
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• pp.25-38
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• 2024

The study aimed to investigate a novel approach by utilizing liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC-MS) to separate, identify and characterize very nominal quantities of degradation products (DPs) of balsalazide along with its process related impurities without isolation from their reaction mixtures. The impurities along with balsalazide were resolved on spherisorb ODS2 (250×4.6 mm, 5.0 ㎛) column at room temperature using 0.2 M sodium acetate solution at pH 4.5 and methanol in the ratio of 55:45 (v/v) as mobile phase pumped isocratically at 1.0 mL/min as mobile phase and UV detection at 255 nm. The method shows sensitive detection limit of 0.003 ㎍/mL, 0.015 ㎍/mL and 0.009 ㎍/mL respectively for impurity 1, 2 and 3 with calibration curve liner in the range of 50-300 ㎍/mL for balsalazide and 0.05-0.30 for its impurities. The balsalazide pure compound was subjected to stress studies and a total of four degradation products (DPs) were formed during the stress study and all the DPs were characterized with the help of their fragmentation pattern and the masses obtained upon LC-MS/MS. The DPs were identified as 3-({4-[(E)-(4-hydroxyphenyl) diazenyl]benzoyl}amino)propanoic acid (DP 1), 4-[(E)-(4-hydroxyphenyl)diazenyl] benzamide (DP 2), 5-[(E)-(4-carbamoylphenyl)diazenyl]-2-hydroxybenzoic acid (DP 3) and 3-({4-[(E)-phenyldiazenyl]benzoyl}amino)propanoic acid (DP 4). Based on findings, it was concluded that, the proposed method was successfully applicable for routine analysis of balsalazide and its process related impurities in pure drug and formulations and also applicable for identification of known and unknown impurities of balsalazide.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.24 no.1
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• pp.69-78
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• 2011

In this study, an optimization method using multi-objective genetic algorithm(MOGA) has been proposed to develop a fuzzy control algorithm that can effectively control a smart tuned mass damper(TMD). A 76-story benchmark building subjected to wind load was selected as an example structure. The smart TMD consists of 100kN MR damper and the natural period of the smart TMD was tuned to the first mode natural period of the example structure. Damping force of MR damper is controlled to reduce the wind-induced responses of the example structure by a fuzzy logic controller. Two input variables of the fuzzy logic controller are the acceleration of 75th floor and the displacement of the smart TMD and the output variable is the command voltage sent to MR damper. Multi-objective genetic algorithm(NSGA-II) was used for optimization of the fuzzy logic controller and the acceleration of 75th story and the displacement of the smart TMD were used as objective function. After optimization, a series of fuzzy logic controllers which could appropriately reduce both wind responses of the building and smart TMD were obtained. Based on numerical results, it has been shown that the control performance of the smart TMD is much better than that of the passive TMD and it is even better than that of the sample active TMD in some cases.

• Journal of Korean Tunnelling and Underground Space Association
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• v.20 no.1
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• pp.211-224
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• 2018

It is important to design tunnel support system considering the various loads acting on the tunnel because they have a direct impact on the stability of tunnels. In Korea, standardized support patterns are defined based on the rock mass classification system depending on the project, and it is stated that it should be modified appropriately considering the behavior of tunnel during construction. In this study, the tunnel support pattern optimization method is suggested based on the convergence-confinement method, earth pressure, axial force of rock bolt, and moment acting on the shotcrete. The length and spacing of the rock bolts and the thickness of the shotcrete were optimized by using the differential evolution algorithm (DEA) and the results were compared to the standard support pattern III for railway tunnel. Rock bolt length can be reduced and the installation interval can be widened for shallow tunnel. As the depth of tunnel increases, the thickness of shotcrete increases linearly. Therefore, the thickness of shotcrete should be thicker than the standard support pattern as the depth of tunnel increases to secure the stability of tunnel.

• Industry Promotion Research
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• v.9 no.1
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• pp.21-29
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• 2024

In the rapidly advancing information society, electronic devices, including smartphones and tablets, are increasingly digitized and equipped with high-performance features such as flexible displays. This study focused on optimizing the manufacturing process for Transparent Conductive Films (TCF) by using the cost-effective conductive polymer PEDOT and transparent substrate PET as alternatives to expensive materials in flexible display technology. The variables considered are production speed (m/min), coating maximum temperature (℃), and PEDOT supply speed (rpm), with surface resistivity (Ω/□) as the response parameter, using Response Surface Methodology (RSM). Optimization results indicate the ideal conditions for production: a speed of 22.16 m/min, coating temperature of 125.28℃, and PEDOT supply at 522.79 rpm. Statistical analysis validates the reliability of the results (F value: 18.37, P-value: < 0.0001, R²: 0.9430). Under optimal conditions, the predicted surface resistivity is 145.75 Ω/□, closely aligned with the experimental value of 142.97 Ω/□. Applying these findings to mass production processes is expected to enhance production yields and decrease defect rates compared to current practices. This research provides valuable insights for the advancement of flexible display manufacturing.

• Biotechnology and Bioprocess Engineering:BBE
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• v.9 no.6
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• pp.459-464
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• 2004

The objective of this study is to improve cephalosporin C (CPC) production byoptimization of medium and culture conditions. A statistical method was introduced to optimize the main culture medium. The main medium for CPC production was optimized using a statistical method. Glucose and corn steep liquor (CSL) were found to be the most effective factors for CPC production. Glucose and CSL were optimized to 2.84 and $6.68\%$, respectively. CPC produc­tion was improved $50\%$ by feeding of $5\%$ rice oil at day 3rd and 5th day during the shake flask culture of C acremonium M25. The effect of agitation speeds on CPC production in a 2.5-L bio­reactor was also investigated with fed-batch mode. The maximum cell mass (54.5 g/L) was obtained at 600 rpm. However, the maximum CPC production (0.98 g/L) was obtained at 500 rpm. At this condition, the maximum CPC production was improved about $132\%$ compared to the re­sult with batch flask culture.

• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.2
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• pp.99-105
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• 2000

Cell-Cell interaction and the extracellular matrix (ECM) are belisved to play essential roles during in vitro culturing of primary hepatocytes in the control of differentiation and in the maintenance of tissue spcific functions. The objective of this study was to examine the effects of degree of cell-cell contact (DCC) on liver sperific function of rat promary hepatocytes. Hepatocyte aggregates with various with various degrees of cell-cell contantact, I. e., dispersed cell, longish aggregate, rugged aggregate, and smooth spheroid were obtained at 1, 5-6, 15-20, and 36-48 hrs, respectively in suspension cultures grown in spinner flasks embedded in Caalginate bead and collagen gel in order. The may result from mass transfer limitation and shear damage caused by agitation during aggregation. The rugged aggregate showed a higer viability and albumin secretion rate than the dispersed cells or the other aggregates. This result indicates the possible enhancement of a bioartificial liver's (BAL) performance using primary hepatocytes and the reduction in time to prepare a BAL through optimization of the immobilization time.

• Solar Energy
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• v.10 no.3
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• pp.35-45
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• 1990

An analytical equation to estimate the Rankine power cycle efficiency at maximum power for the given mass flow rates of heating and cooling fluids is derived. The accuracy of the result is shown by comparing the analytical values with those calculated one using detailed thermodynamic data. The results indicate that the thermal efficiency at maximum power depends primarily on the initial temperatures of the heating and cooling fluids, and it also depends on the pinch-temperature differences between the working fluid and the heating and cooling fluids. The efficiency at maximum power provides a measure of the power available in a practical Rankine heat engine.

• The Journal of Korea Robotics Society
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• v.3 no.4
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• pp.287-299
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• 2008

People have expected a humanoid robot to move as naturally as a human being does. The natural movements of humanoid robot may provide people with safer physical services and communicate with persons through motions more correctly. This work presented a methodology to generate the natural motions for a humanoid robot, which are converted from human motion capture data. The methodology produces not only kinematically mapped motions but dynamically mapped ones. The kinematical mapping reflects the human-likeness in the converted motions, while the dynamical mapping could ensure the movement stability of whole body motions of a humanoid robot. The methodology consists of three processes: (a) Human modeling, (b) Kinematic mapping and (c) Dynamic mapping. The human modeling based on optimization gives the ZMP (Zero Moment Point) and COM (Center of Mass) time trajectories of an actor. Those trajectories are modified for a humanoid robot through the kinematic mapping. In addition to modifying the ZMP and COM trajectories, the lower body (pelvis and legs) motion of the actor is then scaled kinematically and converted to the motion available to the humanoid robot considering dynamical aspects. The KIST humanoid robot, Mahru, imitated a dancing motion to evaluate the methodology, showing the good agreement in the motion.

• Earthquakes and Structures
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• v.5 no.2
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• pp.225-237
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• 2013

Excessive vibrations induced by earthquake excitation and wind load are an obstacle in design and construction of tall and super tall buildings. An innovative vibration control structure system (Mega-Sub Controlled Structure System-MSCSS) was recently proposed to further improve humans comfort and their safeties during natural disasters. Preliminary investigations were performed using a two dimensional equivalent simplified model, composed by 3 mega-stories. In this paper, a more reasonable and realistic scaled model is design to investigate the dynamical characteristics and controlling performances of this structure when subjected to strong earthquake motion. The control parameters of the structure system, such as the modulated sub-structures disposition; the damping coefficient ratio (RC); the stiffness ratio (RD); the mass ratio of the mega-structure and sub-structure (RM) are investigated and their optimal values (matched values) are obtained. The MSCSS is also compared with the so-called Mega-Sub Structure (MSS) regarding their displacement and acceleration responses when subjected to the same load conditions. Through the nonlinear time history analysis, the effectiveness and the feasibility of the proposed mega-sub controlled structure system (MSCSS) is demonstrated in reducing the displacement and acceleration responses and also improving human comfort under earthquake loads.

• JSTS:Journal of Semiconductor Technology and Science
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• v.14 no.5
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• pp.525-536
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• 2014

Recently, the first generation of mass production of FinFET-based microprocessors has begun, and scaling of FinFET transistors is ongoing. Traditional capacitance and resistance models cannot be applied to nonplanar-gate transistors like FinFETs. Although scaling of nanoscale FinFETs may alleviate electrostatic limitations, parasitic capacitances and resistances increase owing to the increasing proximity of the source/drain (S/D) region and metal contact. In this paper, we develop analytical models of parasitic components of FinFETs that employ the raised source/drain structure and metal contact. The accuracy of the proposed model is verified with the results of a 3-D field solver, Raphael. We also investigate the effects of layout changes on the parasitic components and the current-gain cutoff frequency ($f_T$). The optimal FinFET layout design for RF performance is predicted using the proposed analytical models. The proposed analytical model can be implemented as a compact model for accurate circuit simulations.