• 대한수의학회지
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• 제8권2호
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• pp.110-116
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• 1968

The mature guinea pigs were grouped as indicated in the table 1. Radio-active iodine(I-131)in dose of 4.5mci, was administered to the experimental groups. The animals were killed for examination in 1, 7, 14, 28, 42, and 55 days after the administration the radio-active iodine. The thyroid and adrenal glands were observed histologically. The results obtained were as follows; 1. One day after the administration, thyroid epithelial cells were abnormally enlarged. After seven days, specimens taken from the middle of the thyroid showed that the follicles and epithelial cells were changing to fibrous tissue, however, some follicles still remained in the verge of the thyroid. Follicles were not observed after fourteen days. After twenty-eight days, the follicles had all changed to fibrous tissue, and had lost their function. 2. The size of the zonas gromerulosa of adrenal cortex epually, in both male and female, showed slight fluctuation in size with no tendency to be changed. 3. Among the zones of the adrenal glands, zona fasciculata showed marked changes. Zona fasciculata was atrophied in Process of time. In females, it was atrophied significantly(P<0.05) after fourteen days, and highly significant (P<0.01) in twenty-eight and fifty-six days after the administration of radioactive iodine. In males, it also decreased significantly(P<0.05) in seventy-eight days and highly significant(P<0.01) in forty-two and fifty-six days after the administration. 4. The size of the Zona reticularis of adrenal cortex in the females increased significantly (P<0.05) in twenty-eight days after the administration. In males, it showed slight fluctuation until twenty-eight days, but it increased significantly(P<0.05) in forty-two and fifty-six days after the administration. 5. The size of the adrenal medulla increased significantly(P<0.05) in twenty-eight and forty-two days in females. It was increased significantly(P<0.05) in fourth-two days and high significantly(P<0.01) in fifty-six days after the administration.

• IMMUNE NETWORK
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• 제3권3호
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• pp.242-247
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• 2003

Background: Psoriasis is an inflammatory skin disorder that is characterized by a marked proliferation of keratinocytes, vascular dilation and leukocyte infiltration. Cytokines play important roles in the pathogenesis of inflammatory disorders. An overexpression of proinflammatory cytokines was characterized in psoriasis plaque. Among these cytokines, IL-$1{\beta}$ is major pro-inflammatory cytokine synthesized during the infection and inflammatory process. The IL-1 receptor antagonist (IL-1Ra) competes for the same IL-1 receptor for $IL-1{\alpha}$ and $-1{\beta}$, which prevents activation of the target cells. Three single nucleotide polymorphisms (SNPs) in the IL-$1{\beta}$ gene have been reported at position -31, -511 and +3954. Within the IL-1Ra gene (IL-1RN), there is a variable number of tandem repeats (VNTR) of an 86 bp length in intron 2. These polymorphisms related to cytokine production and associated with various diseases. Methods: We investigated the polymorphisms of IL-1B (promoter -511 and +3954) and IL-1RN on 114 psoriasis patients and 311 healthy normal controls in Korean. We performed PCR-RFLP on single nucleotide polymorphisms (SNPs) of IL-1B (promoter -511 and +3954) and fragment analysis on IL-1RN 86 bp VNTR polymorphism. Results: The frequency of IL-1B $-511^*1$ allele (patients vs. controls; 50.0% vs. 42.3%, RR=1.4) was significantly increased and IL-1B $-511^*2$ allele (patients vs. controls; 50.0% vs. 57.7%, RR=0.7) decreased in psoriasis patients compared to normal controls. We also analyzed the IL-1B -511 polymorphism according to patients' characters (age of onset, sex and family history). The IL-1B -511 alleles were significantly associated in patients with male and family history than health normal controls. There were no significant associations of IL-1B +3954 and IL-1RN polymorphisms with psoriasis patients. Conclusion: These results suggest that the polymorphism of IL-1B -511 could be genetic susceptibility to psoriasis in Koreans.

• Journal of Periodontal and Implant Science
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• 제31권1호
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• pp.109-122
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• 2001

Gingival fibroblasts(GF) and periodontal ligament fibroblasts(PDLF) are the major cellular components of periodontal soft connective tissues, but the precise molecular biological differences between these cells are not yet known. In the present study, we investigated the expression of S100A4, S100A2 calcium-binding protein and osteoblast-specific factor 2(OSF-2, Periostin) mRNA in GF and PDLF in vitro through the process of reverse transcription-polymerase chain reaction(RT-PCR) and Northern blot analysis in each. Human GF and PDLF were isolated from the gingival connective tissue and the middle third of freshly extracted healthy third molars. They were cultured in Dulbecco's Modified Eagle Medium(DMEM) containing 10% fetal bovine serum and cells in the third passage were used in the experiments. After extracting total RNA from cultured cells, RT-PCR and Northern analysis were performed using S100A4-, S100A2- and Periostin-specific oligonucleotide primers and subcloned cDNA probes in each. In PT-PCR and Northern analysis, the expression of S100A4 and Periostin mRNA in GF was slightly detectable. Interestingly, the expression of S100A4 and periostin mRNA in PDLF was much higher than that in GF. On the other hand, S100A2 mPNA was highly expressed in both GF and PDLF. Since there was a marked difference of S100A4 and Periostin expression between GF and PDLF in vitro, these data suggest that S100A4 and periostin could be used as a useful marker for distinguishing cultured gingival fibroblasts and periodontal ligament cells.

• 해양환경안전학회지
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• 제22권5호
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• pp.417-422
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• 2016

항로표지란 해상교통의 안전을 도모하고 선박운항 능률을 향상시키기 위한 해양교통안전시설로 새로운 위험물(New Danger)은 측방표지, 방위표지, 고립장해표지 등을 이용하거나 비상침선표지(Emergency Wreck Marking Buoy)를 사용하여 적절하게 표시하여야 한다. 그러나, 침선표지의 경우 설치의 신속성, 정확성, 부표의 특성 등의 문제로 인해 실질적인 설치 운영상의 문제가 제기 되고 있으며, 선박침몰 사고의 경우 기상악화, 해역의 특성, 사고 위치의 확인이 어려워 신속한 신위험물표지(New Danger Mark) 설치가 어려운 실정이다. 이 연구는 항상 선박 상갑판에 부착된 해양안전설비 중 하나로 Maritime Buoyage System(MBS)에 근거한 자동이탈식 비상침선표지를 개발하였다. 자동이탈식 비상침선표지Auto Releasing Emergency Wreck Marking Buoy)는 총 3개의 세부기술(자동이탈, 자동릴체인, 자동구동등명기)로 구성되며, 선박 상갑판에 부착된 자동이탈식 비상침선표지가 선박의 좌초 전복 침몰 등 해양사고 발생 시 일정수압에 의해 자동으로 이탈(Auto Release) 후 자기 부상(Auto Buoyance)하여 사고 발생 지점에 신속하고 정확하게 설치된다. 이러한 자동이탈식 비상침선표지는 선박의 항해안전을 위협하는 장해물로부터 해당 해역에서의 2차 사고를 방지하고, 신속한 수색 및 구조가 이루어질 수 있도록 한다.

• 대한불안의학회지
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• 제5권1호
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• pp.21-28
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• 2009

Objective : Using patterns of change in heart rate variability (HRV), we investigated the effects of stress exposure and type of anger expression on cardiovascular diseases. Methods : Eighty-nine medical students were evaluated by STAXI-K, BDI, BAI, and measured HRV. According to the scores of anger expression questions in STAXI-K, objects are comparted to three groups. Each group is compared with others on the levels of depression, anxiety and HRV. Additionally objects are divided into two groups of functional anger expression group and dysfunctional anger expression group, and each group also divided into two groups, depending on the exposure of stressful situation or not. Members who took part in the stress exposure groups, they've got a serial arithmetic process for five minutes. We surveyed patterns of HRV in 4 each groups and estimated interactions between existence of stressful situation or type of anger expression and HRV. Results : Irrespective of stress manipulation, the dysfunctional anger expression group showed a marked increase in the LF/HF ratio in comparison to the functional anger expression group. Also, under conditions of stress manipulation, the stress exposure group exhibited a relatively increased level of TP. It can't be discriminated any correlations between stress manipulation and type of anger expression. Conclusion : Both of them, exposure to the stressful situation and type of anger expression, have influence on cardiovascular diseases. By controlling anger and way of express that, it is possible to diminish the incidence of cardiovascular diseases.

• The Journal of Korean Physical Therapy
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• 제19권2호
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• pp.41-55
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• 2007

Purpose: This study aimed to compare the effect on nerve regeneration of ultrasound irradiation in rats with peripheral nerve injury. Methods: To investigate alterations of the NCAM immunoreactivity in non-crushed part and crushed part of the spinal cord, the unilateral sciatic nerve of the rats were crushed. The expression of NCAM was used as the marked of peripheral nerve regeneration, and also plays an important role in developing nerve system. Experimental animals were sacrificed by perfusion fixation at post-injury 1, 3, 7, 14 days after ultrasound irradiation. The pulsed US was applied at a frequency of 1MHz and a spatial average-temporal average Intensity of 0.5W/of (20% pulse ratio) for 1 mins. The Luxol fast blue-cresyl violet stain were also done to observe the morphological changes. Results: Alteration of NCAM immunoreactivity in the crushed part and the non-crushed part of lower lumbar spinal cord were observed. NCAM-immunoreactivity cells were some increased in the dorsal horn lamina I, III and cell ventral horn at 1 day after unilateral sciatic nerve injury. However, there was not significant difference in the relationship between crushed part and non-crushed part. NCAM-inmmunoreactivity was remarkably increased at 3 days after unilateral sciatic nerve injuryin the gray matter and white matter. NCAM-immunoreactivity was increased in the ventral horn and post horn of experimental crushed part. Also, NCAM-immunoreactivity in large motor neurons in ventral horns lamina VIII, IX were increased at 7 days after unilateral sciatic nerve injury. At 14 days after sciatic nerve crushed injury, there was no significant difference. All group were decreased for 14 days. In the time course of NCAM expression, all groups showed a significant difference at 3day groups(p<0.05). Whereas, CC group was noted a significant difference between 3day and 7 day group respectively. In NCAM expression, there were significantly increased in all group. In the relationship between CNC group and ENC group, significant difference was detected among 3, 7, 14 day group(p<0.05). The difference between CC group and ENC group were noted in all groups(p<0.05). Conclusion: It is consequently suggested that the effects of the ultrasound irradiation may increase the NCAM immunoreactive neurons and glial cell in the spinal cord after unilateral sciatic nerve crushed injury. Therefore, the increased NCAM immunoreactivity in the spinal cord may reflect the neuronal damage and healing process induced by a ultrasound irradiation after peripheral nerve injury in rat.

• 대한정형외과 초음파학회지
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• 제4권2호
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• pp.111-122
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• 2011

혈소판 풍부 혈장은 자가 혈액으로부터 농축된 혈소판을 이용하여 성장 인자들을 제공함으로써 손상된 조직의 재생과 치유를 도모한다는 이론적 근거를 배경으로, 근골격계 손상의 치료를 위해 최근 많이 사용되고 있다. 성장 인자를 통한 조직 치유 효과는 여러 기초 과학적 연구를 통해 규명되어 왔고, 혈소판 풍부 혈장을 이용한 동물 연구 및 임상 연구들도 좋은 결과를 보고하고 있다. 그러나, 대부분의 연구들이 혈소판 풍부 혈장의 적용 방법 및 결과 측정 방법 등에서 문헌 별로 차이가 커서 서로 비교가 어렵고, 연구 대상 환자 수가 너무 적거나 대조 군이 없는 등 연구로서의 한계가 있다. 특히 잘 디자인 된 전향적 무작위 대조 연구들은 거의 없는 상황이다. 따라서, 현재까지의 결과를 확증하고 혈소판 풍부 혈장의 임상적 사용에 대한 과학적 근거를 제시하기 위해서는 좀 더 높은 수준의 잘 디자인 된 전향적 무작위 연구가 필요하다 할 수 있다. 결론적으로, 혈소판 풍부 혈장의 임상적 적용은 아직 과학적 근거가 부족한 상황이고, 따라서 혈소판 풍부 혈장을 사용하여 근골격계 질환을 치료할 때는 신중을 기해야 할 것이다.

• 환경영향평가
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• 제13권3호
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• pp.125-135
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• 2004

Environmental Impact Assessment(EIA) in Korea has been used to improve environmental conservation and decision-making. Since environmental impact statement(EIS) was introduced in 1981 with the promulgation of the Environmental Preservation Act in 1977, which replaced the Pollution Control Act legislated in 1963. With a rapid growth of environmental perception as well as the diversification of development activities, however, it has recently bring about a strong demand for a new assessment process related to the strategic level of policies, plan, programs. Method of this study includes analyses of the situation of local EIA and its problematic issues through survey and analysis of information and data, analysis of the level of environmental awareness of professionals and case studies including analysis of foreign strategic environmental assessment. Accordingly, I have elicited a concept of SEA. In addition, I have studied on costs of environmental assessment, and efficiency of internalization of HIA. The survey was carried between September and November 2003, and 177 professionals were asks to complete a questionnaire. As a result of questionnaire survey of environmental pundits, it revealed that 83.8% of participants were in favor of introduction of strategic assessment. This result demonstrated more or less higher approval rate than those of awareness survey done by the Ministry of Environment, i.e. 86.0% ayes, and 14.0% nays. 22.8% of participants agreed to the opinion; "For introduction of this system, earlier is better," 50% reported having an opinion such as, "Will introduce this system in an earliest possible time after correcting problems," 26.3% reported having an opinion such as, "Let's decide the time for introduction of this system after correcting problems first,' and 0.9% reported having an opinion, "it's too early to introduce this system." Specifically, the ratio of ayes on introduction of the system marked 72.8%, and it revealed that a majority of respondents have an opinion such as, "Will introduce this system in an earliest possible time after correcting problems." As means of solutions for the problem regarding the limits of applications that existed in SEA System, factors, such as collecting a wide variety of opinions, securing experts, and faithful implementation, etc. were reported important, and in addition to these factors, respondents revealed having opinions such as, consistent research and development, reflection of public interest, establishment of professional organization, enforcement of after-management service, expanding investments in large, systemizing reference materials, and encouraging public participation, etc. To improve problems involving with present EIA system, it has been identified through this study that SEA is efficient and useful. In order to have SEA introduced successfully, it has been cleared that internalization of effectiveness of environmental cost together with HIA must be accomplished.

• 정보관리연구
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• 제31권4호
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• pp.50-70
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• 2000

인터넷으로 접근할 수 정보의 형태가 텍스트는 물론 이미지나 사운드까지 포함되면서 다양한 웹 이미지 검색엔진들이 개발되고 있다. 그러나 이 검색엔진들은 검색 특성과 효율성 면에서 상당한 차이를 보이고 있다. 이에 본 연구에서는 현재 개발된 이미지정보를 탐색하는 검색엔진들의 유형을 살펴보고 이들의 특성과 성능을 비교 평가하여 이용자로 하여금 정보요구에 적합한 이미지 검색엔진을 선택할 수 있도록 하는데 그 목적이 있다. 본 연구의 비교대상 검색엔진으로는 현재 가장 널리 쓰이고 있는 AV Photo Finder, Lycos MultiMedia, Amazing Picture Machina Image Surfer, WebSeek, Ditto를 선정하였다. 먼저 문헌연구를 통해 이미지 검색엔진의 평가기준을 마련하였다. 그리고 마련된 기준에 따라 각 검색엔진들의 데이터베이스 및 색인 방법, 검색 기능, 출력 형태, 이용자 인터페이스를 조사하였고 검색성능을 평가하기 위해 상대적 재현율과 정확률을 측정하였다. 그 결과 AV Photo Finder의 정확률이 가장 높았고 Ditto와 WebSeek의 정확률은 비교적 높은 편이었다. 그리고 Lycos MultiMedia와 Image Surfer의 정확률 값이 그 뒤를 이었으며 Amazing Picture Machine의 정확율이 가장 낮았다.

• 대한지리학회지
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• 제29권4호
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• pp.377-401
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• 1994

지난 30여년간 국제경제와 긴밀하게 연관을 맺으면서 급성장해온 우리나라의 경우, 세계시장에서의 경쟁력을 지속적으로 강화시키기 위하여 산업 구조를 조정하면서 경제의 재구조화과정을 겪고 있다. 특히 1980년대에 들어오면서 생산직 노동력의 부족, 임금 인상과 더불어 선진국들의 보호무역주의가 강화되자 정부는 산업정책 을 기술, 지식집약적 산업을 육성하는 정책을 실시하게 되었다. 즉 국제적으로 기술우위에 있는 선진국가들과의 경쟁 속에서 국제시장확보를 위해 중화학공업에 치중하던 국내의 산업 을 "고부가가치 산업인 첨단 산업의 육성과 정보집약적인 서비스산업의 육성"으로 재구조화 시키는 정책을 시행하였다. 본 연구의 목적은 기술, 지식 집약적 산업의 육성책과 더불어 점차 정보화되어가는 경제의 재구조화과정이 지역성장에 미친 영향을 분석하려는 것이었다. 지난 10년동안 우리나라는 전반적으로 정보화가 상당히 진전되어왔다고 볼 수 있다. 그러나 정보화의 진전도와 그 수준은 지역간에 상당히 차이가 나고 있는 것으로 알려져왔다. 본 연 구에서는 정보화수준의 지역격차를 비교하고, 또 어느 분야에서의 격차가 더 크게 나타나고 있는가를 분석하기 위하여 경제적, 사회적, 하부구조의 세 가지 측면에서 정보화수준을 측정 하였다. 분석결과에 의하면, 경제적 측면에서의 지역간의 정보화수준은 사회적, 하부구조적 측면에서의 정보화수준보다 그 격차가 가장 크게 나타나고 있다. 본 논문에서는 서울의 정 보화수준이 다른 지역들과 비교하여 두드러지게 높게 나타나고 있는 요인들을 규명해 보고 자하였다. 또한 우리나라의 경우 정보화수준은 경제발전과도 상당히 상관성을 갖고 있는 것 으로 나타났다. 따라서 경제가 재구조화되어가는 과정에서 지역간의 경제성장의 격차가 야 기된 것 처럼, 지역의 경제구조는 차별적인 정보화를 진전시키고 있다고 말할 수 있다. 그러 므로 정보화사회로 점차 진전됨에 따라 경제활동이 점차로 정보집약적으로 진전되어간다고 볼 경우 차별적인 정보화수준은 지역성장의 격차를 더욱 심화시키게 될 것이라고 전망해 볼 수 있다. 서울로의 정보집약적 활동의 과도한 집중과 재벌 그룹들이 가지고 있는 경제통제 력, 그리고 점점 심화되어가는 노동의 공간적 분업화는 앞으로 경제적, 사회적 그리고 공간 적인 마찰을 가져을 것이다. 따라서 우리나라가 직면한 가장 큰 문제는 국제적으로는 국가 의 경쟁력을 유지하고 수출력을 신장시키면서도 국내적으로는 보다 균형적인 지역발전을 가 져올 수 있거나, 적어도 지금보다는 더 심각한 지역격차를 야기시키지 못하게 하는 정책을 마련하는 것이다. 본 논문에서는 주변지역의 잠재적인 성장을 유도하며 정보화사회로의 진 전을 촉진시킬 수 있는 다차원적인 측면에서의 지역정보화 전략에 대해 모색하였다.