• 제목/요약/키워드: marginal model

검색결과 598건 처리시간 0.023초

Effects of topical application of Phospholipid derivatives on the secretion of sebum on the skin of the fuzzy rats

  • Y. A. Hwang;Park, W. K.;Park, C. Y.;Kim, J. W.;Park, C. S.
    • 대한화장품학회:학술대회논문집
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    • 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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    • pp.578-589
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    • 2003
  • The fuzzy rat that expresses hypersecretion of sebum and hyperplastic sebaceous glands is a genetic mutant for the study of many pharmacological aspects especially human acne. Through this model, we examined the effects of several phospholipids on the secretion of sebum after topical application. The phospholipid derivatives were phosphatidylcholine (PC), hydrogenated phosphatidylcholine (HPC), phosphati dylserine (PS) and hydrogenated phosphatidylserine(HPS). All agents were dissolved into the vehicle (1, 3-Butanediol, ethanol and water) at 0.5% weight volume and applied on the dorsal area of the fuzzy rat. To observe histological changes, the skin biopsies were stained with Oil Red O and the size and morphology of sebaceous gland was observed under microscope. Topical treatment with PC and/or HPC showed a marked decrease in sebum excretion. Especially hydrogenated PC (HPC) appeared to have more predominant sebosuppressive function than any other treatment. The other agents such as PS and HPS showed a marginal effect on sebum secretion. With the sebosuppressive activity, HPC and PC seem to have a good potential application on acne treatment. In order to obtain more insights into possible mechanisms behind the above observations, effects of each phospholipid on the expression of peroxisome proliferator-activated receptor (PPAR) genes were investigated. Recently, it has been demonstrated that expression and activation of PPAR subtypes appear to modulate the accumulation of cytoplasmic fat droplets that characterizes the sebocyte differentiation(1). It was also previously suggested that PPAR${\gamma}$ antagonist would seem possible to interfere sebum production without side effects (2). In this study we examined the diverse effects of the tested phospholipids on the expression of several PPAR genes based on reverse transcription-polymerase chain reaction (RT-PCR) from the topically treated skin of fuzzy rats. The results and possible implications are discussed.

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The comparison of the accuracy of temporary crowns fabricated with several 3D printers and a milling machine

  • Junsik Lee;Sungwon Ju;Jihyung Kim;Sion Hwang;Jinsoo Ahn
    • The Journal of Advanced Prosthodontics
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    • 제15권2호
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    • pp.72-79
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    • 2023
  • PURPOSE. The purpose of this in vitro study was to compare the accuracy of various 3D printers and a milling machine. MATERIALS AND METHODS. The die model was designed using CAD (Autodesk Inventor 2018 sp3). The 30 ㎛ cement space was given to the die and the ideal crown of the mandibular left first molar was designed using CAD (ExoCAD). The crowns were produced using the milling machine (Imes-icore 250i) and the 3D printers (Zenith U, Zenith D, W11) and they were divided into four groups. In all groups, the interior of each crown was scanned (Identica blue) and superimposed (Geomagic Control X) with the previously designed die. The difference between the die and the actual crown was measured at specific points. The Kruskal-Wallis test, the Mann-Whitney test, and Bonferroni's method were performed with a statistical analysis software (P < .008 in inter-group comparison P < .001 in intra-group comparison). RESULTS. In all groups, the center of the occlusal area and the anti-rotational dimple area showed significantly greater difference and the marginal area showed the smallest difference comparatively. The mean value of the difference in each area and the sum of the differences were higher in order of W11, Imes-icore 250i, Zenith D, and Zenith U. CONCLUSION. The digital light processing (DLP) method shows higher accuracy compared to the sereolithography (SLA) method using the same resin material.

Novel Genome-Wide Interactions Mediated via BOLL and EDNRA Polymorphisms in Intracranial Aneurysm

  • Eun Pyo Hong;Dong Hyuk Youn;Bong Jun Kim;Jae Jun Lee;Sehyeon Nam;Hyojong Yoo;Heung Cheol Kim;Jong Kook Rhim;Jeong Jin Park;Jin Pyeong Jeon
    • Journal of Korean Neurosurgical Society
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    • 제66권4호
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    • pp.409-417
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    • 2023
  • Objective : The association between boule (BOLL) and endothelin receptor type A (EDNRA) loci and intracranial aneurysm (IA) formation has been reported via genome-wide association studies. We sought to identify genome-wide interactions involving BOLL and EDNRA loci for IA in a Korean adult cohort. Methods : Genome-wide pairwise interaction analyses of BOLL and EDNRA involving 250 patients with IA and 296 controls were performed using the additive effect model after adjusting for confounding factors. Results : Among 512575 single-nucleotide polymorphisms (SNPs), 23 and 11 common SNPs suggested a genome-wide interaction threshold (p<1.25×10-8) involving rs700651 (BOLL) and rs6841581 (EDNRA). Rather than singe SNP effect of BOLL or EDNRA on IA development, they showed a synergistic effect on IA formation via multifactorial pair-wise interactions. The rs1105980 of PTCH1 gene showed the most significant interaction with rs700651 (natural log-transformed odds ratio [lnOR], 1.53; p=6.41×10-11). The rs74585958 of RYK gene interacted strongly with rs6841581 (lnOR, -19.91; p=1.64×10-9). Although, there was no direct interaction between BOLL and EDNRA variants, two EDNRA-interacting gene variants of TNIK (rs11925024 and rs1231) and FTO (rs9302654), and one BOLL-interacting METTL4 gene variant (rs549315) exhibited marginal interaction with BOLL gene. Conclusion : BOLL or EDNRA may have a synergistic effect on IA formation via multifactorial pair-wise interactions.

Clinical evaluation of 3.0-mm narrow-diameter implants: a retrospective study with up to 5 years of observation

  • InKyung Hwang;Tae-Il Kim;Young-Dan Cho
    • Journal of Periodontal and Implant Science
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    • 제54권1호
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    • pp.44-52
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    • 2024
  • Purpose: This study aimed to evaluate the clinical outcomes of a single type of narrow-diameter implant (NDI) by investigating its survival rate and peri-implant marginal bone loss (MBL). In addition, variables possibly related to implant survival and MBL were investigated to identify potential risk factors. Methods: The study was conducted as a retrospective study involving 49 patients who had received 3.0-mm diameter TSIII implants (Osstem Implant Co.) at Seoul National University Dental Hospital. In total, 64 implants were included, and dental records and radiographic data were collected from 2017 to 2022. Kaplan-Meier survival curves and a Cox proportional hazard model were used to estimate the implant survival rate and to investigate the effects of age, sex, jaw, implant location, implant length, the stage of surgery, guided bone regeneration, type of implant placement, and the surgeon's proficiency (resident or professor) on implant survival. The MBL of the NDIs was measured, and the factors influencing MBL were evaluated. Results: The mean observation period was 30.5 months (interquartile range, 26.75-45 months), and 6 out of 64 implants failed. The survival rate of the NDIs was 90.6%, and the multivariate Cox regression analysis showed that age was associated with implant failure (hazard ratio, 1.17; 95% confidence interval, 1.04-1.31, P=0.01). The mean MBL was 0.44±0.75 mm, and no factors showed statistically significant associations with greater MBL. Conclusions: NDIs can be considered a primary alternative when standard-diameter implants are unsuitable. However, further studies are required to confirm their long-term stability.

Time Perception and Memory in Mild Cognitive Impairment and Alzheimer's Disease: A Preliminary Study

  • Sung-Ho Woo;Jarang Hahm;Jeong-Sug Kyong;Hang-Rai Kim;Kwang Ki Kim
    • 대한치매학회지
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    • 제22권4호
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    • pp.148-157
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    • 2023
  • Background and Purpose: Episodic memory is a system that receives and stores information about temporally dated episodes and their interrelations. Our study aimed to investigate the relevance of episodic memory to time perception, with a specific focus on simultaneity/order judgment. Methods: Experiment 1 employed the simultaneity judgment task to discern differences in time perception between patients with mild cognitive impairment or dementia, and age-matched normals. A mathematical analysis capable of estimating subjects' time processing was utilized to identify the sensory and decisional components of temporal order and simultaneity judgment. Experiment 2 examined how differences in temporal perception relate to performance in temporal order memory, in which time delays play a critical role. Results: The temporal decision windows for both temporal order and simultaneity judgments exhibited marginal differences between patients with episodic memory impairment, and their healthy counterparts (p = 0.15, t(22) = 1.34). These temporal decision windows may be linked to the temporal separation of events in episodic memory (Pearson's ρ = -0.53, p = 0.05). Conclusions: Based on our findings, the frequency of visual events accumulated and encoded in the working memory system in the patients' and normal group appears to be approximately (5.7 and 11.2) Hz, respectively. According to the internal clock model, a lower frequency of event pulses tends to result in underestimation of event duration, which phenomenon might be linked to the observed time distortions in patients with dementia.

식품소비행태조사를 이용한 수입산 돼지고기 섭취의향 결정요인 분석 (Examining Factors Influencing the Consumption of Imported Pork Using the Consumer Behavior Survey for Food)

  • 오병무;오지혜;윤수민;조원주;서홍석;김선웅
    • 한국식품영양학회지
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    • 제37권3호
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    • pp.162-170
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    • 2024
  • The domestic swine industry is currently facing a threat due to the recent increase in pork imports. This study aims to determine what factors influence consumers' intention to consume imported pork and suggest measures to support the domestic pork industry. To achieve this, we analyzed data from the Korea Rural Economic Institute's Food Consumption Behavior Survey using a binary logistic regression model. The results revealed that a higher intention to consume imported pork is linked to a higher intention to consume imported rice, purchasing meat online, frequent purchases of HMR, and procuring U.S. beef, especially among urban residents. On the other hand, a lower intention to consume imported pork is associated with a higher awareness of animal welfare certification, frequently dining out, and older age. Based on these findings, we propose the following response measures for the domestic swine industry: implementing educational programs, marketing, and advertising specifically targeting urban residents to improve their perception of domestic agricultural products; enhancing price competitiveness through distribution optimization; and developing policies to promote the use of domestic pork as an ingredient in processed foods.

배출권거래제에서 무상할당 비율을 낮추는 것이 항상 바람직한가?: 한계 비효율성의 관점에서 (Is Reducing Free Allocation Always Desirable in Emissions Trading Schemes?: A Perspective on Marginal Inefficiencies)

  • 강판상;이지웅
    • 자원ㆍ환경경제연구
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    • 제33권2호
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    • pp.179-201
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    • 2024
  • 많은 국가에서 배출권거래제를 도입할 때 기업의 급격한 비용부담을 완화하고 정책의 수용성을 제고하기 위해 도입 초기에는 높은 비율로 무상할당을 시행하고, 이후에는 탄소누출의 위험을 고려하며 점차 그 비율을 낮추어 가는 것이 일반적이다. 이는 '오염자 부담 원칙(Polluter-Pays Principle)'에 따른 것으로, 낮은 무상할당 비율을 고도화된 배출권거래제의 요소 중 하나로 흔히들 간주한다. 이에 본 연구는 배출권 시장이 완전경쟁시장이 아닌 경우, 무상할당 비율을 낮추는 것이 한계 비효율성의 관점에서 바람직하지 않을 수 있음을 간단한 배출권 시장 모형을 통하여 확인한다. 특히 특정 시장 조건에서 배출권 시장의 왜곡으로부터 초래되는 비효율성을 최소화하는 무상할당 비율이 존재함을 입증함으로써 낮은 무상할당 비율이 반드시 배출권거래제의 개선을 의미하는 것은 아님을 보인다.

Impact of incidence angle of seismic excitation on vertically irregular structures

  • Md. Ghousul Ansari;Sekhar C. Dutta;Aakash S. Dwivedi;Ishan Jha
    • Earthquakes and Structures
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    • 제27권3호
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    • pp.227-237
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    • 2024
  • The incidence angle of seismic excitation relative to the two orthogonal major axes of structures has been a subject of considerable research interest. Previous studies have primarily focused on single-storey symmetric and asymmetric structures, suggesting a minimal effect of incidence angle on structural behavior. This research extends the investigation to multi-storey structures, including vertically irregular configurations, using a comprehensive set of 20 near fault and 20 far field seismic excitation. The study employs nonlinear time-history analysis with a bidirectional hysteresis model to capture inelastic deformations accurately. Various structural models, including one-storey and two- storey regular structures (R1, R2) and vertically irregular structures with setbacks in one direction (IR1) and both directions (IR2), are analysed. The analysis reveals that the incidence angle has no discernible impact over the response of regular multi-storey structures. However, vertically irregular structures exhibit notable responses at corner columns, which decrease towards central columns, irrespective of the incidence angle. This response is attributed to the inherent mass distribution and stiffness irregularities rather than the angle of seismic excitation. The findings indicate that for both near fault and far field seismic excitation, the incidence angle's impact remains marginal even for complex structural configurations. Consequently, the study suggests that the angle of incidence of seismic excitation need not be a primary consideration in the seismic design of both regular and vertically irregular structures. These conclusions are robust across various structural models and seismic excitation characteristics, providing a comprehensive understanding the impact of incidence angle on seismic response.

V2G 시스템에 대한 잠재적 소비자의 선호 평가 (Assessment of the Potential Consumers' Preference for the V2G System)

  • 임슬예;김희훈;유승훈
    • 에너지공학
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    • 제25권4호
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    • pp.93-102
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    • 2016
  • V2G (Vehicle-to-Grid)는 전기자동차 배터리에 저장된 전기를 전력판매사의 전력망을 통해 되파는 양방향 전력 전송 기술이다. V2G 시스템을 활용하는 전기자동차 운전자는 전기요금이 저렴한 심야에 충전한 뒤 출퇴근시 사용하고 남은 전력을 전력사용량이 많고 전기요금이 높은 주간에 판매하므로, 피크시 전력수급의 안정성이 향상된다. 이에 정부는 V2G 인프라 구축 및 지원 대책을 마련하면서 V2G 시스템에 대한 잠재적 소비자의 선호 정보를 요구하고 있다. 본 논문에서는 잠재적 소비자인 일반 국민 1,000명을 대상으로 한 일대일 개별면접 설문조사를 통해 수집된 자료를 수집하였다. 소비자의 선호를 분석하기 위해 경제학적 기법인 선택실험법을 적용한다. V2G 시스템의 속성으로 잔존 전력량, 전력 판매시간, 의무접속시간, 현행 차량가액에 추가하는 가격으로 평가된 지불의 사액이라는 4개를 고려하였다. 분석모형으로는 우선 다항로짓모형을 적용하였는데 '비관련 대안의 독립성' 가정이 위배되어, 이 가정을 요구하지 않는 중첩로짓모형을 최종적으로 적용하였다. 효용함수의 모든 추정계수는 유의수준 10%에서 통계적으로 유의하였다. 속성별 분석결과, 전력 판매가능시간이 1시간 증가하는 것에 대한 한계지불의사액(MWTP, marginal willingness to pay)은 1,601,057원이었다. 그러나 잔존 전력량이 1% 감소 및 의무접속시간 1시간 증가에 대한 MWTP는 각각 -91,911원 및 -470,619원으로 분석되었다. 본 연구에서 도출한 V2G 시스템에 대한 정량적인 소비자 선호 정보는 향후 V2G 시스템 도입 및 관리정책에 유용하게 활용될 수 있다.

병원의 활동기준원가를 이용한 총체적 질관리 모형 및 질비용 산출 모형 개발 (Development of the Model for Total Quality Management and Cost of Quality using Activity Based Costing in the Hospital)

  • 조우현;전기홍;이해종;박은철;김병조;김보경;이상규
    • 보건행정학회지
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    • 제11권2호
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    • pp.141-168
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    • 2001
  • Healthcare service organizations can apply the cost of quality(COQ) model as a method to evaluate a service quality improvement project such as Total Quality Management (TQM). COQ model has been used to quantify and evaluate the efficiency and effectiveness of TQM project through estimation between cost and benefit in intervention for a quality Improvement to provide satisfied services for a customer, and to identify a non value added process. For estimating cost of quality, We used activities and activity costs based on Activity Based Costing(ABC) system. These procedures let the researchers know whether the process is value-added by each activity, and identify a process to require improvement in TQM project. Through the series of procedures, health care organizations are service organizations can identify a problem in their quality improvement programs, solve the problem, and improve their quality of care for their costumers with optimized cost. The study subject was a quality improvement program of the department of radiology department in a hospital with n bed sizes in Metropolitan Statistical Area (MSA). The principal source of data for developing the COQ model was total cases of retaking shots for diagnoses during five months period from December of the 1998 to April of the 1999 in the department. First of the procedures, for estimating activity based cost of the department of diagnostic radiology, the researchers analyzed total department health insurance claims to identify activities and activity costs using one year period health insurance claims from September of the 1998 to August of the 1999. COQ model in this study applied Simpson & Multher's COQ(SM's COQ) model, and SM's COQ model divided cost of quality into failure cost with external and internal failure cost, and evaluation/prevention cost. The researchers identified contents for cost of quality, defined activities and activity costs for each content with the SM's COQ model, and finally made the formula for estimating activity costs relating to implementing service quality improvement program. The results from the formula for estimating cost of quality were following: 1. The reasons for retaking shots were largely classified into technique, appliances, patients, quality management, non-appliances, doctors, and unclassified. These classifications by reasons were allocated into each office doing re-taking shots. Therefore, total retaking shots categorized by reasons and offices, the researchers identified internal and external failure costs based on these categories. 2. The researchers have developed cost of quality (COQ) model, identified activities by content for cost of quality, assessed activity driving factors and activity contribution rate, and calculated total cost by each content for cost for quality, except for activity cost. 3. According to estimation of cost of quality for retaking shots in department of diagnostic radiology, the failure cost was ₩35,880, evaluation/preventive cost was ₩72,521, two times as much as failure cost. The proportion between internal failure cost and external failure cost in failure cost is similar. The study cannot identify trends on input cost and quality improving in cost of qualify over the time, because the study employs cross-sectional design. Even with this limitation, results of this study are much meaningful. This study shows possibility to evaluate value on the process of TQM subjects using activities and activity costs by ABC system, and this study can objectively evaluate quality improvement program through quantitative comparing input costs with marginal benefits in quality improvement.

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