• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.22 no.2
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• pp.281-286
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• 2013

As the product lifecycle is getting shorter and various models should be released to respond to the needs of customers and markets, automation-based flexible production line has been recognized as the core competitiveness. According to these trends, system vendors supply cell-level systems such as FMC(Flexible Manufacturing Cell) that is integration of core functions of FMS(Flexible Manufacturing System) and RMC(Reconfigurable Manufacturing Cell) that can easily extend components of FMC. In the cell-based environment, flexible management for shop floor composed of existing job shop, FMCs and RMCs from various system vendors has emerged as an important issue. However, there could be some problems on integrated operation between heterogeneous cells to use vendor-specific cell controllers and on seamless information flow with high level systems such as ERP(Enterprise Resource Planning). In this context, this paper proposes process management systems supporting integrated shop operation of heterogeneous multi-cell based flexible manufacturing environment: First of all, (1) Integrated Shop Operation System to apply the process management system is introduced, and (2) Multi-Layer BOP(Bill-Of-Process) model, a backbone of the process management system, is derived with its data structure. Finally, application of the proposed model is illustrated through system implementation results.

• Journal of Institute of Control, Robotics and Systems
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• v.5 no.6
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• pp.724-733
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• 1999

An effective method of system modeling and dynamic scheduling for the back-end line of semiconductor manufacturing is proposed. The virtual factory, describing semiconductor manufacturing line, is designed in detail, and then a Petri net model simulator is developed for operation and control of the modular cells of the virtual factory. The petri net model is a colored timed Petri nets (CTPNs). The simulator will be utilized to analyze and evaluate various dynamic status and operatons of manufacturing environments. The dynamic schedulaer has a hierarchical structure with the higher for planning level and the lower for dynamic scheduling level. The genetic algorithm is applied to extract optimal conditions of the scheduling algorithm. The proposed dynamic scheduling is able to realize the semiconductor manufacturing environments for the diversity of products, the variety of orders by many customers, the flexibility of order change by changing market conditions, the complexity of manufacturing processes, and the uncertainty of manufacturing resources. The proposed method of dynamic scheduling is more effective and useful in dealing with such recent pressing requirements including on-time delivery, quick response, and flexibility.

• International Journal of Stem Cells
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• v.16 no.4
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• pp.438-447
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• 2023

Recently, ex-vivo gene therapy has emerged as a promising approach to enhance the therapeutic potential of mesenchymal stem cells (MSCs) by introducing functional genes in vitro. Here, we explored the need of using selection markers to increase the gene delivery efficiency and evaluated the potential risks associated with their use in the manufacturing process. We used MSCs/CD that carry the cytosine deaminase gene (CD) as a therapeutic gene and a puromycin resistance gene (PuroR) as a selection marker. We evaluated the correlation between the therapeutic efficacy and the purity of therapeutic MSCs/CD by examining their anti-cancer effect on co-cultured U87/GFP cells. To simulate in vivo horizontal transfer of the PuroR gene in vivo, we generated a puromycin-resistant E. coli (E. coli/PuroR) by introducing the PuroR gene and assessed its responsiveness to various antibiotics. We found that the anti-cancer effect of MSCs/CD was directly proportional to their purity, suggesting the crucial role of the PuroR gene in eliminating impure unmodified MSCs and enhancing the purity of MSCs/CD during the manufacturing process. Additionally, we found that clinically available antibiotics were effective in inhibiting the growth of hypothetical microorganism, E. coli/PuroR. In summary, our study highlights the potential benefits of using the PuroR gene as a selection marker to enhance the purity and efficacy of therapeutic cells in MSC-based gene therapy. Furthermore, our study suggests that the potential risk of horizontal transfer of antibiotics resistance genes in vivo can be effectively managed by clinically available antibiotics.

• Journal of Powder Materials
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• v.29 no.4
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• pp.297-302
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• 2022

This study compares the characteristics of a compact TiO₂ (c-TiO₂) powdery film, which is used as the electron transport layer (ETL) of perovskite solar cells, based on the manufacturing method. Additionally, its efficiency is measured by applying it to a carbon electrode solar cell. Spin-coating and spray methods are compared, and spray-based c-TiO₂ exhibits superior optical properties. Furthermore, surface analysis by scanning electron microscopy (SEM) and atomic force microscopy (AFM) exhibits the excellent surface properties of spray-based TiO₂. The photoelectric conversion efficiency (PCE) is 14.31% when applied to planar perovskite solar cells based on metal electrodes. Finally, carbon nanotube (CNT) film electrode-based solar cells exhibits a 76% PCE compared with that of metal electrode-based solar cells, providing the possibility of commercialization.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2012.10a
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• pp.25-26
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• 2012

• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.103-103
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• 2000

In this paper to cope with the reduction of products life-cycle as the variety of products along with the various demands of consumers, a virtual simulator is developed to make the changeover of manufacturing line efficient to embody a virtual simulation similar to a real manufacturing line. The developed virtual simulator can design a layout of a factory and make the time scheduling. Every factory has one simulator so that one product can be manufactured in the factories to use them as virtual factories. We suggest a scheme that heightens the agility to the diversity of manufacturing models by making the information of manufacturing lines and products models to be shared. The developed unit simulator can construct a proper virtual manufacturing line along with the required process of products using several kinds of operator and work cell. A user with the simulator can utilize an interface that makes one to manage the separate task process for each manu(acturing module, change operator components and work cells, and easily teach tasks of each task module. The developed simulator was made for users convenience by Microsoft Visual C++ 6.0 that can develop a program supplying graphic user interface environment and by OpenGL of the Silicon Graphics as a graphic library to embody 3D graphic environment. Also, we show that the simulator can be used efficiently for the agile manufacturing by the communication among the factories being linked by TCP/IP and a hybrid database system made by a hierarchical model and a relational model being developed to standardize the data information.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.35 no.1
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• pp.58-65
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• 2022

The field of liquid crystal display (LCD) is constantly in the spotlight and the process of depositing an alignment layer in the LCD manufacturing process is very important to obtain excellent performance such as low-power driving and high-speed response to improve LCD performance. Therefore, research on liquid crystal (LC) alignment is being actively conducted. When manufacturing LCD, it is necessary to consider the effect of the alignment layer thickness as one of the factors affecting various LCD performances. In addition, previous studies confirmed the LC alignment characteristics correlate with the rotation speed in the spin coating process. Therefore, the electro-optical properties of the LCD were investigated by manufacturing a polyimide alignment layer by varying the rotation speed in the spin coating process in this study. It was confirmed that the thickness of the polyimide alignment layer was controlled according to the spin coating conditions. The average transmittances of anti-parallel LC cells at the spin coating speed of 2,500 rpm and 3,000 rpm are about 60%, which indicates that the LC cell has relatively higher performance. At the spin coating speed of 3,000 rpm, the voltage-transmittance curve of twisted nematic (TN) LC cell was below 1.5 V, which means that the TN LC cell operated at a low power. In addition, high-speed operating characteristics were confirmed with a response time of less than 30 ms. From these derived data, we confirmed that the ideal spin coating speed is 3,000 rpm. And these results provide an optimized polyimide alignment layer process when considering enhanced future LCD manufacturing.

• Industrial Engineering and Management Systems
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• v.7 no.2
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• pp.160-170
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• 2008

This paper proposes a mathematical model for converting conveyor assembly line to cellular manufacturing in complex production environments. Complex production environments refer to the situations with multi-products, variant demand, different batch sizes and the worker abilities varying with work stations and products respectively. The model proposed in this paper aims to determine (1) how many cells should be formatted; (2) how many workers should be assigned in each cell; (3) and how many workers should be rested in shortened conveyor line when a conveyor assembly line should be converted, in order to optimize system performances which are defined as the total throughput time and total labor power. We refer the model to a new production system. Such model can be used as an evaluation tool in the cases of (i) when a company wants to change its production system (usually a belt conveyor line) to a new one (including cell manufacturing); (ii) when a company wants to evaluate the performance of its converted system. Simulation experiments based on the data collected from the previous documents are used to estimate the marginal impact that each factor change has had on the estimated performance improvement resulting from the conversion.

• Journal of the Korean Society for Precision Engineering
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• v.28 no.4
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• pp.513-520
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• 2011

The NIL processes have been studied to implement low cost, high throughput and high resolution application. A RNIL(roller NIL) is an alternative approach to flat nanoimprint lithography. RNIL process is necessary to transfer patterns on flexible substrates. Compared with flat NIL, RNIL has the advantages of better uniformity, less pressing force, and the ability to repeat the patterning process continuously on a large substrate. This paper studies the design, construction and verification of a thermal RNIL system. The proposed RNIL system can easily adopt the flat shaped hot plate which is one of the most important technologies for NIL. The NIL system can be used to transfer patterns from a flexible stamp to a flexible substrate, from a flexible stamp to a Si substrate, and from a roller stamp to a flexible substrate, etc. Patterning on flexible substrates is one of the key technologies to produce bendable displays, solar cells and other applications.

• Progress in Superconductivity and Cryogenics
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• v.26 no.1
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• pp.25-30
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• 2024

High-temperature superconducting rotors offer advantages in terms of output-to-weight ratio and efficiency compared to conventional phase conduction motors or generators. The rotor can be cooled by conduction cooling, which attaches a cryocooler, and by refrigerant circulation, which uses circulating liquid or gas neon, helium and hydrogen. Recent work has focused on environmental issues and on high-temperature superconducting motors cooled with liquid hydrogen that can be combined with fuel cells. However, to ensure smooth supply and return of the cryogenic cooling fluid, a cryogenic rotational coupling between the rotating and stationary parts is necessary. Additionally, the development of a sealing structure to minimize fluid leakage applicable to the coupling is essential. This study describes the design and performance evaluation of a non-contact sealing method, specifically a labyrinth seal, which avoids power loss and heat load caused by friction in contact sealing structures. The seal design incorporates a spiral flow path to reduce leakage using centrifugal force, and computational fluid dynamics (CFD) simulations were conducted to analyze the flow path and rotational speed. A performance evaluation device was configured and employed to evaluate the designed seal. The results of this study will be used to develop a cryogenic rotational coupling with supply and return flow paths for cryogenic applications.