• Kidney Research and Clinical Practice
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• 제37권4호
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• pp.384-392
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• 2018

Background: A very low protein diet (VLPD) with ketoacid analogs of essential amino acids (KA/EAA) administration can remarkably influence protein synthesis and metabolic disturbances of patients with advanced chronic kidney disease (CKD), and may also slow the decline in renal function. Methods: A retrospective cohort study was carried out to monitor renal progression and metabolic and nutritional status among 140 patients with CKD stage III or IV. One group (n = 70) was on a low protein diet (LPD) with 0.6 g of protein intake, and another group (n = 70) was on a VLPD with 0.3 g of protein and KA/EAA supplementation of 100 mg/kg/day for 12 months. Results: At 12-month follow-up, estimated glomerular filtration rate (GFR) significantly decreased from $41.6{\pm}10.2$ to $36.4{\pm}8.8mL/min/1.73m^2$ (P < 0.001) and urine protein increased from $0.6{\pm}0.5$ to $0.9{\pm}1.1g/day$ (P = 0.017) in the LPD group, but no significant changes in estimated GFR and urine protein were found in the VLPD plus KA/EAA group. A significant mean difference in rate of change in estimated GFR ($-5.2{\pm}3.6mL/min/1.73m^2$ per year; P < 0.001) was observed between the two groups. After Cox regression analysis, treatment with VLPD plus KA/EAA significantly protected against the incidence of declining GFR > 10% annually (adjusted hazard ratio, 0.42; 95% confidence interval, 0.23-0.79; P = 0.006) and significant correlations were found between using VLPD plus KA/EEA and increased GFR. Conclusion: VLPD supplementation with KA/EAA is associated with delayed renal progression while preserving the nutritional status in the patients with CKD. Co-administration of VLPD and KA/EAA may prove an effective alternative to conservative management of CKD.

• 융합보안논문지
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• 제17권5호
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• pp.133-142
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• 2017

군보안상 해킹에 대응하기 위하여 군조직문화의 특성과, 군조직내 물리보안의 개념, 정보통신상의 해킹 개념을 이해하고, 군보안상 해킹사례를 분석하여, 문제점을 도출하고 대응방안을 통해 군의 물리보안활동을 강화해야 한다. 군내부망에 대한 맹신에서 벗어나 H/W적인 보강방안, 군내 정보통신자산에 대한 통제방안, 국방망과 인터넷망과의 연동이 되는 접점에 대한 보안통제 강화방안, 법적인 보완장치, 군에 지원되는 외주용역업체 및 외부민간업체에 대한 인원 시설 보안측면에서의 보안관리방안 등이 요구된다. 군조직에서 해킹의 위험성과 실제 발생한 해킹사례의 분석을 통해 국방망에 대한 해킹보안을 위한 강화대책과 법규적 보완장치 및 외주용역직원 통제방안 등에 대한 정책수립이야말로 정보통신기술적인 H/W 안전장치와 연계하여 물리적인 접근차단방식 등의 적용보다도 오히려 군조직 특성에 효율적으로 기능할 수 있는 해킹 대응방안이라고 할 수 있다.

• 디지털융복합연구
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• 제17권5호
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• pp.399-405
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• 2019

본 연구 목적은 유산소운동과 크리신섭취가 고지방식이동물의 간 조직에서 비만억제 효과를 규명하는데 있다. 집단은 정상식이, 고지방식이, 고지방식이와 크리신섭취, 고지방식이와 유산소운동 4집단으로 하였다. 크리신은 체중당 50mg/kg을 구강투여 하였고, 유산소운동은 트레드밀운동으로 주5회 60분 16주간 실시하였다. SPSS(20.0)프로그램을 이용해 일원변량분석(One-way ANOVA)을 하였고, 사후분석은 LSD로 하였다. 연구결과 간 조직에서 대식세포 마커 F480와 M1대식세포 마커 CD11c는 정상식이 그룹과 비교해 고지방식이, 크리신투여 그룹에서 유의하게 증가했고 운동집단에서는 유의하게 감소하였다. 지방분해 마커 PRDM은 정상식이집단과 비교해 고지방식이, 크리신투여 집단에서 유의하게 감소했으나 운동집단에서만 유의하게 증가하였다. 결론적으로 고지방식이와 중강도 운동은 간 조직에서 발생되는 대사적불균형을 억제하는데 효과적인 것으로 나타났다. 하지만 고지방식이와 크리신 섭취는 비만억제 기능이 미비한 것으로 나타났다. 따라서 향후 기능성식품을 이용한 비만개선 연구는 투여용량, 기간 등을 고려해 다양한 분자적 기전을 살펴보는 연구가 보강되어야 할 것이다.

• Animal Bioscience
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• 제34권5호
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• pp.844-854
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• 2021

Objective: The potential of extra virgin olive oil (EVOO), betaine (BET), and ginger (GIN), as natural antioxidants, in reducing negative effects of heat stress on physiological responses, antioxidant capacity, semen quality and fertility of bucks under heat stress were investigated. Methods: Forty adult Animal Production Research Institute line rabbit bucks were distributed randomly into four experimental treatments of ten rabbits each. The first treatment was fed the commercial pellet diet (CPD) without supplementation and served as a control. The other three treatments were fed CPD supplemented with EVOO (300 mg), BET (1,000 mg), and GIN (200 mg) per kg diet for 3 consecutive months during the summer season. Results: Supplementation of EVOO, BET, or GIN improved (p<0.05) the sexual desire, progressive motility, vitality, intact acrosome and membrane integrity, sperm cell concentration, sperm outputs and fertility. Seminal plasma total proteins, globulin, total antioxidant capacity, glutathione and glutathione S-transferase, and initial fructose increased (p<0.05), while total lipids, aspartate and alanine aminotransferases and malondialdehyde decreased (p<0.05) compared with the control. In comparing the natural antioxidants treatments, GIN evoked the largest improvement. Conclusion: The inclusion of GIN (200 mg/kg diet) appeared to improve the sexual desire, semen quality and oxidative stress of bucks. This may be a beneficial supplement for the management of rabbit bucks used in natural mating or artificial insemination.

• 한국식품저장유통학회지
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• 제30권1호
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• pp.15-27
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• 2023

Jeju Sasa borealis (S. borealis) is indigenous to the Halla Mountain area of Jeju Island, Republic of Korea. However, its dominance has retarded the development of other plant species and lowered biodiversity in this region. The aim of this study was to determine whether S. borealis silage (SS) supplementation affects the chemical composition and antioxidant activity in the fresh meat of Korean native goats (Capra hircus coreanae). The experiment was conducted on 12 Korean native goats at the finisher stage. The feeding groups were the Control (total mixed ration, TMR) and the Treatment (80% TMR + 20% SS). The animals were adapted for two weeks and then subjected to a six-month breeding experiment. Meat samples were excised from the neck, loin, rib, front leg, and hind leg of the slaughtered animals. The meat derived from the treatment group contained more taurine and anserine than that derived from the control group. Both groups did not significantly differ in terms of ω-6/ω-3 fatty acid ratio. The loin and front leg of the treatment group contained significantly higher vitamin E levels than those of the control group. DPPH, ABTS, and FRAP analyses disclosed that the loin and front leg had significantly higher antioxidant activity (p<0.05) than the other parts. Moreover, the loin and front leg cuts of the treatment group had higher antioxidant activity than those of the control group. The present study demonstrated that S. borealis supplementation could effectively improve Korean native goat meat quality.

• Archives of Plastic Surgery
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• 제43권6호
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• pp.506-511
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• 2016

Background The indications for surgical airway management in patients with Robin sequence (RS) and severe airway obstruction have not been well defined. While certain patients with RS clearly require surgical airway intervention and other patients just as clearly can be managed with conservative measures alone, a significant proportion of patients with RS present with a more confusing and ambiguous clinical course. The purpose of this study was to describe the clinical features and objective findings of patients with RS whose airways were successfully managed without surgical intervention. Methods The authors retrospectively reviewed the medical charts of infants with RS evaluated for potential surgical airway management between 1994 and 2014. Patients who were successfully managed without surgical intervention were included. Patient demographics, nutritional and respiratory status, laboratory values, and polysomnography (PSG) findings were recorded. Results Thirty-two infants met the inclusion criteria. The average hospital stay was 16.8 days (range, 5-70 days). Oxygen desaturation (<70% by pulse oximetry) occurred in the majority of patients and was managed with temporary oxygen supplementation by nasal cannula (59%) or endotracheal intubation (31%). Seventy-five percent of patients required a temporary nasogastric tube for nutritional support, and a gastrostomy tube placed was placed in 9%. All patients continued to gain weight following the implementation of these conservative measures. PSG data (n=26) demonstrated mild to moderate obstruction, a mean apneahypopnea index (AHI) of $19.2{\pm}5.3events/hour$, and an oxygen saturation level <90% during only 4% of the total sleep time. Conclusions Nonsurgical airway management was successful in patients who demonstrated consistent weight gain and mild to moderate obstruction on PSG, with a mean AHI of <20 events/hour.

• Journal of Nutrition and Health
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• 제45권3호
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• pp.252-263
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• 2012

The present study was performed to evaluate dietary behavior, food intake, and satisfaction with food-related life regarding the elderly residing in different regions of Korea. The survey was conducted on 631 individuals over 55 years old in either urban or rural areas. The survey was carried out using a questionnaire including dietary behavior, mini dietary assessment, and a food frequency questionnaire. The average age of the rural elderly was higher than that of the urban elderly whereas, education level and economic status were higher in the urban elderly compared to the rural elderly. The intake of dairy products, meats, instant foods, snacks, and the use of nutrient supplementation were significantly higher in the urban elderly than those of the rural elderly (p = 0.000). The intake of vegetables was significantly higher in the rural elderly (p = 0000). Furthermore, the rural elderly were more satisfied with food-related life and had better balanced diets than those of the urban elderly. Taken together, the results of this study revealed that customized nutritional management and education for adequate meals in different regions should be developed and provided in order to improve the quality of healthy living for the elderly.

• 정보처리학회논문지D
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• 제10D권1호
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• pp.67-76
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• 2003

소프트웨어의 재사용은 소프트웨어의 생산성을 향상시키기 위해 미리 만들어진 소프트웨어의 컴포넌트를 이용하는 것이다. 전자상거래의 발달은 비즈니스 모델의 변화를 신속하게 변경하여 반영할 수 있는 소프트웨어를 요구하게 된다. 이런 전자상거래의 변화하는 환경에 신속히 대응하기 위해 재사용은 필수적인 해결책이다. 이러한 재사용 비즈니스 모델은 버전 관리에서 제공하지 못하는 난전이 있다. 이를 보완하여 본 논문에서는 재사용 비즈니스 모델에 대한 신속한 변경 관리를 도입하여 컴포넌트를 재사용함으로써 소프트웨어 개발비용을 절감하고 개발기간을 단축시킬 수 있도록 한다. 새로운 재사용 비즈니스 모델에 의해 컴포넌트를 재사용함으로써 소프트웨어 설계에서 구현까지의 위험요소를 최소화시킬 수 있는 장점을 가진다. 소프트웨어의 재사용을 구현하기 위한 기술로 컴포넌트를 도입하여 컴포넌트에 대한 구성요소를 글 버전으로 관리함으로써 재사용의 효율성을 높일 수 있는 방법을 버전 관리를 이용하여 제시하고자 한다.

• 한국안전학회지
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• 제34권3호
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• pp.96-101
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• 2019

Chemicals Control Act have been strengthened to control more safely hazardous chemicals from 2015. In particular, the standards for the installation and management of handling facilities was enhanced with specific regulations depending on type of the facilities and the hazardous chemicals. However, some standards for handling facilities caused difficulties in implementing the strengthened standards due to various field conditions, such as lack of physical space. The Ministry of Environment is implementing Safety Assessment System (SAS) to solve these problems since 2018. However, many plants have difficulties in preparing alternative methods to pass the safety evaluation. The purpose of this study was to review and analyze the SAS and to suggest alternative measures in terms of management and technical aspects through the case study of hydrochloric acid storage tanks. The following safety solutions were suggested for handling facilities that had insufficient the space and capacity for the retaining wall due to physical space. Firstly, insufficient space was resolved by introducing equipment relocation or demolition, and retaining wall expansion. Secondly, the wall of the surrounding buildings was used as an alternative to the retaining wall with additional chemical resistant treatment. Finally, sensor installation and facility inspection were suggested as ways to improve chemical safety. Therefore, improvement of chemical accident prevention system is required not only in terms of facilities supplementation but also management aspect. The results of this study are expected to be available for similar facilities and will be based on the preparation of additional safety assessment as alternatives measures in the future.

• 생명과학회지
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• 제21권5호
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• pp.729-733
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• 2011

본 연구에서는 두 가지 투여그룹을 비교하여 ergogenic aid로서 D-ribose의 효과를 운동영양학적으로 규명하는데 그 목적이 있었고, 이를 위하여 2,000 m 조정운동 전, 운동종료 직후, 그리고 운동 종료 후 회복기 30분의 변화를 연구하였으며, 다음과 같은 결론을 얻었다. 첫째, 투여그룹에 따른 2,000 m 조정운동 수행력의 차이는 없었으며 둘째, 투여그룹에 따른 젖산과 암모니아 수치의 차이도 나타나지 않았다. 셋째, 회복 30분에서 무기인산은 PS에 비해서 RS투여그룹의 수치가 더 낮게 나타났으며, 마지막으로 회복 30분에서 hypoxanthine의 축적은 PS투여그룹에 비해 RS투여그룹의 수치가 더 낮게 나타났다. 따라서, 7-8분 정도의 고강도 운동 시 운동기록의 단축에 D-ribose 구강투여의 효과는 없었지만, 휴식 기 피로회복에 긍정적인 효과를 줄 수 있을 것이라 사료된다.