• Journal of Korean Clinical Nursing Research
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• v.24 no.2
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• pp.209-226
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• 2018

Purpose: This purpose of this study was to develop evidence-based practice guideline for isolation in health care settings to prevent transmission of infectious diseases utilizing guideline adaption process. Methods: The process of guideline adaptation was performed according to the Korean hospital nurses association's guideline adaptation manual which consisted of three main phases, 9 modules, and 24 steps. Results: The adapted isolation guideline consisted of introduction, overview of isolation guideline, summary of recommendations, recommendations, references, and appendices. The guideline includes 224 recommendations in 4 sections which are organizational administration, standard precautions, transmission-based precautions, and education/counselling. Conclusion: The adapted isolation guideline is recommended to be disseminated and utilized by nurses and clinicians nationwide to improve the isolation practices for infected or colonized patients with communicable diseases and to decrease the transmission of infections in the healthcare settings.

• Journal of Yeungnam Medical Science
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• v.31 no.2
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• pp.82-88
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• 2014

Background: Lung cancer is the most common cause of cancer-related death worldwide and in Korea, and small cell lung cancer (SCLC) is the most deadly tumor type in the different lung cancer histology. Chemotherapy is the main strategy of the treatment for SCLC, and etoposide and platinum regimen has been the only standard chemotherapy for about 30 years. To test feasibility of weekly divided dose irinotecan and carboplatin for Korean patients is the aim of this study. Methods: Patients with histologically or cytologically confirmed extensive stage SCLC were included. Patients with limited stage (LD), who could not tolerate concurrent chemoradiotherapy were also included. All the patients received irinotecan $60mg/m^2$, carboplatin 2 area under the curve at day 1, 8, and 15 every 4 weeks. Study regimen was discontinued when the disease progressed or intolerable side effects occurred. No more than 6 cycles of chemotherapy were given. Results: Total 47 patients were enrolled, among them 9 patients were LD. Overall response rate was 74.5% (complete response, 14.9%; partial response, 59.6%). Side effects greater than grade 3 were neutropenia (25.5%), fatigue (12.8%), thrombocytopenia (8.5%), sepsis (4.3%), and pancytopenia (2.1%). There was no treatment related death. Conclusion: Weekly divided irinotecan and carboplatin regimen is effective, and safe as a first line therapy for both stage of SCLC. Large scaled, controlled study is feasible.

• The Journal of Korean Society for School & Community Health Education
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• v.18 no.3
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• pp.69-82
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• 2017

Objectives: This study was conducted to investigate the relationship between general characteristics and oral health behavior, oral health knowledge, and oral health literacy for adult workers. Methods: This study chose some adult workers located D City by convenience sampling method, and accepted those who understood the purpose of the study and agreed with a survey as subjects. The final study subjects were 297 except 24 with unsound questionnaires among a total of 321 questionnaires. The contents of a survey were demographic characteristics, oral health behavior, oral health knowledge, and oral literacy, and the survey was done by a self-administered questionnaire. Results: In the verbal oral health literacy distribution based on REALM standard of the subjects, a scale of 7-8, 45-60 points by score was the highest with 62.0%. In average monthly household income and oral health knowledge level of general characteristics, oral health literacy was statistically significant, and was statistically significant according to oral health literacy, monthly income of house hold, and marital status as well, and was statistically significant in oral health knowledge and oral health literacy level according to oral health behavior and in the oral health knowledge level depending on a regular checkup. And In experience existence and nonexistence of oral health education and understanding and misunderstanding of dentistry and dental health education, and main body of the decision of dental treatment, verbal oral health literacy of oral health knowledge and oral health literacy was significant. It can be seen that based on correlation among general characteristics, oral health knowledge level, verbal oral health literacy, and functional oral health literacy, there is a correlation among gender and education level, age and average monthly income, and age and marital status. Conclusions: This study presented the need for oral health literacy along with the oral health knowledge of oral health behavior affecting adult workers' oral health, and tried to establish the connection among them. Accordingly, it is thought that an improvement plan of oral health literacy for the prevention and promotion of adult workers' dental disease in the future.

• Research in Plant Disease
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• v.27 no.3
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• pp.120-127
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• 2021

Plant viruses cause significant yield losses, continuously compromising crop production and thus representing a serious threat to global food security. Tomato spotted wilt virus (TSWV) is the most harmful plant virus that mainly infects horticultural crops and has a wide host range. Reverse-transcription quantitative real-time PCR (RT-qPCR) has been widely used for detecting TSWV with high sensitivity, but its application is limited owing to the lack of standardization. Therefore, in this study, a sensitive and accurate reverse transcription droplet digital polymerase chain reaction (RT-ddPCR) method was established for TSWV detection. Additionally, we compared the sensitivities of RT-qPCR and RT-ddPCR for TSWV detection. Specificity analysis of RT-ddPCR for TSWV showed no amplification for main pepper viruses and negative control. TSWV transcripts levels measured by RT-ddPCR and RT-qPCR showed a high degree of linearity; however, the former yielded results that were at least 10-fold more sensitive and detected lower TSWV copy numbers than the latter. Collectively, our findings show that RT-ddPCR provides improved analytical sensitivity and specificity for TSWV detection, making it suitable for identifying low TSWV concentrations in field samples.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.3
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• pp.247-254
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• 2021

Acne vulgaris is a chronic inflammatory skin disease related to pilosebaceous unit. In acne lesions, hyperseborrhea, dysseborrhea, inflammatory event, and an imbalance in skin microflora, particularly an increase in Cutibacterium acnes (C. acnes) colonization comparing to other bacteria, have been observed. The objective of this study was to evaluate anti-acne effects of Artemisia annua extract (AAE) on antibacterial activity related to preservation of the balance in skin microbiome, inhibition of inflammation, and reduction of excessive sebum production. When C. acnes and Staphylococcus epidermidis (S. epidermidis) were co-cultured in the presence of AAE, the reduction of C. acnes growth by AAE was greater than that of S. epidermidis. In addition, when C. acnes was cultured in a medium containing AAE (C. acnes AAE), levels of cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and IL-6 and toll-like receptors-2 activity were decreased in comparison with C. acnes cultured in a medium without AAE (C. acnes CM). Moreover, AAE significantly inhibited excessive sebum production induced by palmitic acid. These results suggest that AAE, as a natural extract with various targets, can inhibit selective growth of C. acnes and inflammatory reactions derived from C. acnes, which are the main causes of acne, and consequently can be used as a substance to alleviate acne by reducing excessive sebum formation.

• Journal of Convergence for Information Technology
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• v.11 no.8
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• pp.160-167
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• 2021

This study was conducted to empirically analyze the prevalence and risk of chronic diseases in the family history of chronic diseases using data from the Korea National Health and Nutrition Examination Survey 2019. Based on 5,691 people, after controlling for socio-demographic variables that were related to family history of chronic diseases, logistic regression analysis was performed to verify the odds ratio, which was the risk of family history of chronic diseases for the prevalence of chronic diseases. The main results were founded that Odds ratio, which was the risk of chronic diseases in groups with a family history compared to those without a family history, was statistically significant at hypertension(2.623), dyslipidemia(1.868), diabetes(1.964), and arthritis(1.435) when gender, age, income status, education level and residence were controlled. These results suggest that it is not only necessary to develop a standardization tool for family history tests, but also a health and disease management system for members with a family history in terms of preventive medicine in health care. This study is significant in that it proposed a practical plan in terms of health care by controlling variables that affect the prevalence of chronic diseases and empirically identifying the risk of family history of chronic diseases.

• Korean Journal of Food Science and Technology
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• v.53 no.6
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• pp.715-721
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• 2021

Cognitive impairment and Alzheimer's disease are serious social problems associated with the rising elderly population in Korea. 1,2,3,4,6-Penta-O-galloyl-β-ᴅ-glucopyranose (PGG) is a gallotannin isolated from medicinal plants such as Rhus chinensis. This study was performed to evaluate the effect of PGG on biomarkers related to cognitive function in human neuroblastoma SK-N-SH cells. Inhibition of acetylcholinesterase (AChE) activity is considered to be one of the main therapeutic strategies. PGG inhibited AChE activity in the test tube as well as in SK-N-SH cells. In addition, PGG induced protein and mRNA expression of brain-derived neurotrophic factor (BDNF), which is a mammalian neurotrophin that plays major roles in the development, maintenance, repair, and survival of neuronal populations. As one of the underlying molecular mechanisms that induce BDNF expression, PGG induced the activation of Ca²⁺/calmodulin (CaM)-dependent protein kinase II (CaMKII)-cAMP response element binding protein (CREB) pathway. In conclusion, PGG may be an useful material for improving cognitive function.

• Korean Journal of Breeding Science
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• v.40 no.2
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• pp.173-177
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• 2008

A new peanut variety "Pungsan" (Arachis hypogaea ssp. hypogaea L.) was developed at the Yeongnam Agricultural Research Institute, NICS, in Milyang in 2007. It was derived from a cross between a short stem cultivar "Satonoka" and a high-yielding local cultivar "Yecheon". "Pungsan" is the Virginia plant type. It has 18 branches per plant and 40 cm of main stem height. Each pod with long-ellipse shaped large kernel has two grains with light-brown testa and 100 seed weight was 95g in the regional yield trials (RYT). "Pungsan" showed more resistant to web blotch compared with check variety. In the regional yield trials "Pungsan" was outyielded in grain yield to the check variety by 16% with 4.45 MT/ha for grain.

• Journal of Digital Convergence
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• v.17 no.6
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• pp.267-277
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• 2019

The purpose of this study is to investigate the burden of caring for the care-givers of the elderly in Korea by using an integrated literature review method. A total of 23 studies were analyzed using a search database. When care-givers had higher sense of filial and guilt or more than two diseases, they showed high level of feeling of burden. Also, they had high level of feeling of physical burden by their oldness, service period (especially at the period of 1-3 years). In the feeling of economic burden, they had high level of feeling of burden by their oldness, or elderly's disease periods. The feeling of burden by psychological condition was found in elderly in aged and the beginning of admission of nursing home. The feeling of burden by environment situation was found when the functional status of the elderly was bad. Therefore, we need to concern care-givers's feeling of burden with elderly people in the nursing home. In the future, I believe that the findings of this study will be helpful for development of the intervention program for alleviate burden for the care-giver.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.1
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• pp.15-25
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• 2019

The development of reliable and objective definitions as well as automated processes for the detection of health care-associated infections (HAIs) is crucial; however, transformation to an automated surveillance system remains a challenge. Early outbreak identification usually requires clinicians who can recognize abnormal events as well as ongoing disease surveillance to determine the baseline rate of cases. The system screens the laboratory information system (LIS) data daily to detect candidates for health care-associated bloodstream infection (HABSI) according to well-defined detection rules. The system detects and reserves professional autonomy by requiring further confirmation. In addition, web-based HABSI surveillance and classification systems use discrete data elements obtained from the LIS, and the LIS-provided data correlates strongly with the conventional infection-control personnel surveillance system. The system was timely, acceptable, useful, and sensitive according to the prevention guidelines. The surveillance system is useful because it can help health care professionals better understand when and where the transmission of a wide range of potential pathogens may be occurring in a hospital. A national plan is needed to strengthen the main structures in HAI prevention, Healthcare Associated Prevention and Control Committee (HAIPCC), sterilization service (SS), microbiology laboratories, and hand hygiene resources, considering their impact on HAI prevention.