• 근관절건강학회지
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• 제20권3호
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• pp.214-224
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• 2013

Purpose: The purpose of this study was to identify the differences in preference for terminal care between hospitalized patients and nurses. Methods: A cross-sectional descriptive design was used in 79 patients and 107 nurses. The data were collected from August to October 2011, using the Preference for Care near the End of life Scale - Korean Version (PCEOL-K) with 5-point scale of 26 items. The reliability of the tool was Cronbach's ${\alpha}=.74$. Results: The mean score (SD) of PCEOL-K's sub-dimensions in nurses' priority was: (a) pain $3.70{\pm}0.63$, (b) spirituality $3.63{\pm}0.61$, (c) family $3.40{\pm}0.70$, (d) autonomous decision making $2.30{\pm}0.66$, and (e) decision making by healthcare professionals $2.14{\pm}0.64$. In patients' priority, the $M{\pm}SD$ score of each sub-dimension was: (a) pain $3.86{\pm}0.65$, (b) family $3.83{\pm}0.57$, (c) decision making by healthcare professionals $3.37{\pm}0.85$, (d) spirituality $3.01{\pm}0.80$, and (e) autonomous decision making $2.43{\pm}0.63$. Results indicated significant differences between nurses and patients regarding decision making by healthcare professionals (t=-11.28, p<.001), family (t=-4.66, p<.001), and spirituality (t=5.71, p<.001). Conclusion: The PCEOL-K of patients was higher than nurses'. A terminal care program for hospitalized patients at the end of life should be planned according to the results of PCEOL-K in nurses and patients.

• Asian Pacific Journal of Cancer Prevention
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• 제15권11호
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• pp.4475-4482
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• 2014

Background: Cisplatin, a DNA damaging agent, induces apoptosis through increasing DNA fragmentation. However, identification of intrinsic resistance molecules against Cisplatin is vital to estimate the success of therapy. Bag-1 (Bcl-2-associated anthanogene) is one anti-apoptotic protein involved in drug resistance impacting on therapeutic efficiency. Elevated levels of this protein are related with increase cell proliferation rates, motility and also cancer development. For this reason, we aimed to understand the role of Bag-1 expression in Cisplatin-induced apoptosis in HeLa cervix cancer cells. Cisplatin decreased cell viability in time- and dose-dependent manner in wt and Bag-1L+HeLa cells. Although, $10{\mu}M$ Cisplatin treatment induced cell death within 24h by activating caspases in wt cells, Bag-1L stable transfection protected cells against Cisplatin treatment. To assess the potential protective role of Bag-1, we first checked the expression profile of interacting anti-apoptotic partners of Bag-1. We found that forced Bag-1L expression prevented Cisplatin-induced apoptosis through acting on Mcl-1 expression, which was reduced after Cisplatin treatment in wt HeLa cells. This mechanism was also supported by the regulation of heat shock protein (Hsp) family members, Hsp90 and Hsp40, which were involved in the regulation Bag-1 interactome including several anti-apoptotic Bcl-2 family members and c-Raf.

• 보건의료산업학회지
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• 제10권3호
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• pp.51-61
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• 2016

Objectives : The purpose of this study was to find factors influencing compliance with the national cancer screening program in middle-aged men. Methods : The data were collected from July 28, to October 31, 2015. Total subjects were 615 middle-aged men living in Busan. Results : The Rate of compliance with the NCSP(National Cancer Screening Program) for middle-aged men was 52.2%. There were significant differences in the compliance with the NCSP for the following barrier of exam(${\chi}^2=7.327$, p=.007), self-efficacy(${\chi}^2=23.074$, p<.001), age(${\chi}^2=38.823$, p<.001), marital status(${\chi}^2=19.012$, p<.001), cancer diagnosis in family(${\chi}^2=7.615$, p=.006), smoking(${\chi}^2=9.012$, p=.011), drinking(${\chi}^2=7.073$, p=.008), exercise(${\chi}^2=14.615$, <.001). Factors influencing the rate of compliance for the NCSP in middle-aged men were self-efficacy, age, marital status, exercise, and cancer diagnosis in family. Conclusion: To increase the rate of compliance to the NCSP in middle-aged men it is necessary to elevate the self-efficacy. Additional more positive support needed in men who are younger have no cancer diagnosis in their family are smokers and not m married encourage and improvve paticipation in the examination.

• 한국사회복지학
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• 제62권2호
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• pp.209-233
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• 2010

이 연구의 목적은 입양가족들의 뿌리찾기 경험을 이해하고자 하는 것이다. 이러한 목적을 달성하기 위해, 연구자들은 뿌리찾기를 시도한 입양가족들과 접촉하여 심층면접을 실시하고 다양한 자료들을 수집하였으며 질적 사례연구 접근을 통해 분석하였다. 최종 다섯 가족을 통해 수집한 자료들을 가지고 사례 내 분석과 사례 간 분석을 실시하였다. 사례 간 분석을 통해 나타난 주제들은 '입양됨의 인식', '호기심 폭발', '불안한 기다림', '진실을 만나는 순간', '그래, 내가 진짜 엄마야', '그리고 아무 말도 없었다' 등이었다. 연구결과를 근거로, 입양가족들의 뿌리찾기를 지원하기 위한 정책과 실천 지침들을 제언하였으며, 연구의 한계를 극복하고 더 풍부한 정보를 확보하기 위해 필요한 후속연구들에 대해서도 제언하였다.

• 한국발생생물학회지:발생과생식
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• 제21권3호
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• pp.237-247
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• 2017

Mammalian spermatogenesis occurs in a precise and coordinated manner in the seminiferous tubules. One of the attempts to understand the detailed biological process during mammalian spermatogenesis at the molecular level has been to identify the testis specific genes followed by study of the testicular expression pattern of the genes. From the subtracted cDNA library of rat testis prepared using representational difference analysis (RDA) method, a complimentary DNA clone encoding type III member of a DnaJ family protein, DnaJC18, was cloned (GenBank Accession No. DQ158861). The full-length DnaJC18 cDNA has the longest open reading frame of 357 amino acids. Tissue and developmental Northern blot analysis revealed that the DnaJC18 gene was expressed specifically in testis and began to express from postnatal week 4 testis, respectively. In situ hybridization studies showed that DnaJC18 mRNA was expressed only during the maturation stages of late pachytene, round and elongated spermatids of adult rat testis. Western blot analysis with DnaJC18 antibody revealed that 41.2 kDa DnaJC18 protein was detected only in adult testis. Immunohistochemistry study further confirmed that DnaJC18 protein, was expressed in developing germ cells and the result was in concert with the in situ hybridization result. Confocal microscopy with GFP tagged DnaJC18 protein revealed that it was localized in the cytoplasm of cells. Taken together, these results suggested that testis specific DnaJC18, a member of the type III DnaJ protein family, might play a role during germ cell maturation in adult rat testis.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9753-9757
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• 2014

Purpose: To study the quality of life and to identify associated factors among breast cancer patients undergoing treatment in national cancer centers in Nepal. Materials and Methods: One hundred breast cancer patients were selected and interviewed using a structured questionnaire. European Organization of Research and Treatment of Cancer EORTC-QLQ-C30 and EORTC-QLQ-BR23 were used to assess quality of life and modified Medical Outcome Study -Social Support survey(mMOS-SS) was used to assess social support. Only multi-item scales of EORTC C30 and BR23 were analyzed for relationships. Independent sample T-tests and ANOVA were applied to analyze differences in mean scores. Results: The score of global health status/quality of life (GHS/GQoL) was marginally above average (mean=52.8). The worst performed scales in C-30 were emotional and social function while best performed scales were physical and role function. In BR-23, most of the patients fell into the problematic group regarding sexual function and enjoyment. Almost 90% had financial difficulties. Symptom scales did not demonstrate many problems. Older individuals, patients with stage I breast cancer and thosewith good social support were found to have good GHS/GQoL. Of all the influencing factors, social support was established to have strong statistical associations with most of the functional scales: GHS/GQoL (0.003), emotional function (<0.001), cognitive function (0.020), social function (<0.001) and body image function (0.011). Body image was significantly associated with most of the influencing factors: monthly family income (0.003), type of treatment (<0.001), type of surgery (<0.001), stage of cancer (0.017) and social support (0.011). Conclusions: Strategies to improve social support of the patients undergoing treatment should be given priority and financial difficulties faced by breast cancer patients should be well addressed from a policy making level by initiating health financing system.

• 한국콘텐츠학회논문지
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• 제16권9호
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• pp.482-490
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• 2016

한국에서 성년후견제도가 시행되고 3년이 경과하였다. 하지만, 다른 국가들과 비교해 제도 정착이 지연되고 있으므로 최적의 제도를 실현할 수 있는 실질적인 방안을 조속히 마련해야 한다. 이에 본 연구에서는 Anderson & Newman의 행동모델을 적용하여 장애인 및 치매노인 등 요보호자의 부양가족들을 대상으로 성년후견제도 이용에 영향을 미치는 요인을 분석하였다. 본 연구를 위해서 SPSS 18.0을 이용하였으며, 주요 연구결과는 다음과 같다. 첫째, 성년후견제도의 이용 의사는 보통수준으로 나타났다(M=3.08). 둘째, 성년후견제도 이용에 큰 영향을 미치는 요인은 욕구요인에서의 사회적 낙인, 가능요인에서의 경제상태, 선행 요인에서의 부양자와의 관계, 교육수준 등으로 나타났다. 이러한 실증적 분석결과를 토대로 성년후견제도가 필요한 요보호자와 그 가족들에게 제도 이용을 위한 구체적인 실천전략을 제시하였고, 나아가 성년후견제도의 조속한 정착과 올바른 운영을 위한 기초자료를 제공하였다는데 본 연구의 의의가 있다.

• 지역사회간호학회지
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• 제16권2호
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• pp.115-126
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• 2005

Purpose: The aims of this study were to describe general characteristics and needs of home health care, and to find the differences between home health care needers and non-needers. Method: In this study, 642 subjects participated who lived in Muan, Jollanam-do. Data were collected in August 2001 using a self-reported questionnaire. The questionnaire was a revised and simplified form of the Organization of Community Health System Program at the Seoul National University. Collected data were analyzed through Kruskal-Wallis test. t-test. and Chi-squire for cross-sectional analysis. Result: The average age of the subjects was 52.6 years and 33.3% of them aged over 65 years. Twenty six percent of them had chronic degenerative diseases. The percentages of hypertension patients and D.M. patients were 6.4% and 2.5%, respectively. The number of family members was 2.95 on the average, 2.19 in cases of families with the elderly and 3.33 in cases of families without the elderly. The rate of disability of the elderly was 10.5%. Marital status (p=.000), the number of family members (p=.000), education (p=.000), job (p=.000) and health insurance (p=.027) were significantly different between home care needers and non-needers. Home care needers had less living expenses (p=.001), more frequent hospital admissions (p=.004), higher chronic disease rate (p=.000) and more frequent visits to public health center (p=.027) than non-needers. Home care needers who wanted free service were twice as many as non-needers. Conclusion: Home care need was very high in rural areas and the needers had worse characteristics (low educational level. low income, no job and no family). Therefore, it is necessary to develop cheaper and more accessible services for home care needers in rural areas.

• 가족자원경영과 정책
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• 제14권1호
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• pp.57-71
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• 2010

The purpose of this study was to explore perceptions and awareness of traditional Korean wedding ceremonies. For this purpose, I began a literature review and investigated the consciousness about traditional Korean wedding ceremonies among unmarried people. As a result, I discussed the future of Korean wedding culture. Data were analyzed from the sample of 206 unmarried people collected from April 20 to Jun 13, 2009. The data were analyzed by making use of the SPSS program and included Frequency analysis, ANOVA and the $\chi^2$-test. The summary of these results was as follows. First, unmarried people want a special wedding ceremony. They think the appropriate age of marriage is between their 20s and mid-30s. The traditional wedding ceremony is changing, but they think that the meanings behind them will continue. If they married a foreigner, they would want to have a modem wedding ceremony and each of their traditional wedding ceremonies. Second, they have no educational experience about traditional wedding culture(85.4%). Some people who have educational experience learned about traditional wedding culture from their parents or grandparents. Third, most traditional wedding procedures were influenced by Korean customs. Most men did not know about traditional Korean wedding procedures. But if they get married, they will follow traditional wedding procedures (M=3.35). In the future, we will have to succeed Korean wedding culture, for example, Peau back(幣帛), Ham(函), and traditional wedding ceremony.

• Journal of Preventive Medicine and Public Health
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• 제38권2호
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• pp.170-174
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• 2005

Objectives: The aim of this study was to evaluate the response to a hepatitis B vaccination, and investigate the HBV DNA in subjects with isolated anti-HBc. Methods: 34 subjects with persistent isolated anti-HBc were included in the study. 32 subjects negative for HBsAg, anti-HBs and anti-HBc were included as a control group. They were all vaccinated with Hepaccine at 0, 1 and 2 months, and anti-HBs titers were measured 1 month after the 1st and 3rd vaccinations (1 and 3 months). The HBV-DNA was tested by polymerase chain reaction in subjects with isolated anti-HBc. Results: After the 1st & 3rd vaccinations, the anti-HBs titers$\geq$10mIU/ml were 70.6 & 70.6% in isolated anti-HBc group, and 34.4 & 81.2% in the control group, respectively. There were statistically significant differences after the 1st vaccination, but none after the 3rd, between the two groups. In the isolated anti-HBc and control groups, the primary, amnestic and no responses were 0 vs. 46.9%, 55.9 vs. 6.3% and 29.4 vs. 18.8%, respectively. The HBV DNA was not detected in all subjects with isolated anti-HBc. Conclusion: None of the subjects with isolated anti-HBc had a false positive result (primary response); therefore, they should be excluded from vaccination programs in Korea. To differentiate between immunity and occult infections, a single dose of vaccine, with a follow-up anti-HBs test, is preferable for subjects with isolated anti-HBc. An amnestic response indicates late immunity, and no response a suspect occult infection.