• Food Engineering Progress
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• v.21 no.1
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• pp.1-11
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• 2017

Dyslipidemia, defined as elevated triglyceride (TG), total- and LDL-C, and/or decreased HDL-C levels, is considered a principal risk factor for cardiovascular disease. The low-density lipoprotein receptor (LDLR) family has been considered a key player in the prevention of dyslipidemia. The LDLR family consists of cytoplasmic membrane proteins and plays an important role not only in ligand-receptor binding and uptake, but also in various cell signaling pathways. Emerging reports state that various functional ingredients dynamically modulate the function of the LDLR family. For instance, oats stimulated the LDLR function in vivo, resulting in decreased body weight and improved serum lipid profiles. The stimulation of LRP6 by functional ingredients in vitro activated the Wnt/${\beta}-catenin$ pathway, subsequently suppressing the intracellular TG via inhibition of SREBP1, $PPAR{\gamma}$, and $C/EBP{\alpha}$. Furthermore, the extract of Cistanchetubulosa enhanced the expression of the mRNA of VLDLR, followed by a reduction in the serum cholesterol level. In addition, fermented soy milk diminished TG and total cholesterol levels while increasing HDL-C levels via activation of LRP1. To summarize, modulating the function of the LDLR family by diverse functional ingredients may be a potent therapeutic remedy for the treatment of dyslipidemia and cardiovascular diseases.

• Journal of Life Science
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• v.24 no.2
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• pp.128-136
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• 2014

Alginates are linear acidic polysaccharides composed with (1-4)-linked ${\alpha}$-L-guluronic acid and ${\beta}$-Dmannuronic acid. Alginate can be degraded by diverse alginate lyases, which cleave the alginate using a ${\beta}$-elimination reaction and produce unsaturated uronate oligomers. A gene for a polyMG-specific alginate lyase possessing a novel structure was previously identified and cloned from Stenotrophomonas maltophilia KJ-2. Homology modeling of KJ-2 polyMG-specific alginate lyase showed it belongs to the PL6 family, whereas three Azotobacter vinelandii polyMG lyases belong to the PL7 family of polysaccharide lyases. From $^1H$-NMR spectra data, KJ-2 polyMG lyase preferably degraded the M-${\beta}$(1-4)-G glycosidic bond than the G-${\alpha}$(1-4)-M glycosidic bond. Seventeen mutants were made by site-directed mutagenesis, and alginate lyase activity was analyzed. Lys220Ala, Arg241Ala, Arg241Lys, and Arg265Ala lost alginate lyase activity completely. Arg155Ala, Gly303Glu, and Tyr304Phe also lost the activity by 60.7-80.1%. These results show that Arg155, Lys220, Arg241, Arg265, Gly303, and Tyr304 are important residues for catalytic activity and substrate binding.

• The Korean Journal of Malacology
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• v.26 no.1
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• pp.51-62
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• 2010

The ultrastructures of germ cells and the accessory cells during spermatogenesis and mature sperm ultrastructure in male Gomphina veneriformis, which was collected on the coastal waters of Yangyang, East Sea of Korea, were investigated by transmission electron microscope observations. The morphology of the spermatozoon has a primitive type and is similar to those of other bivalves in that it contains a short midpiece with four mitochondria surrounding the centrioles. Accessory cells are observed to be connected to adjacent germ cells, they contain a large quantity of glycogen particles and lipid droplets in the cytoplasm. Therefore, it is assumed that they are involved in the supplying of the nutrients for germ cell development, while any phenomena associated with phagocytosis of undischarged, residual sperms by lysosomes in the cytoplasm of the accessory cells after spawning was not observed in this study. The morphologies of the sperm nucleus type and the acrosome shape of this species have a cylindrical and modified long cone shape, respectively. In particular, the axial filaments in the lumen of the acrosome, and subacrosomal granular materials are observed in the subacrosomal space between the anterior nuclear fossa and the beginning part of axial filaments in the acrosome. The spermatozoon is approximately $50-55{\mu}m$ in length including a long sperm nucleus (about $7.80{\mu}m$ in length), an acrosome (about $1.13{\mu}m$ in length) and tail flagellum ($40-45{\mu}m$). The axoneme of the sperm tail flagellum consists of nine pairs of microtubules at the periphery and a pair at the center. The axoneme of the sperm tail shows a 9+2 structure. Some charateristics of sperm morphology of this species in the family Veneridae are (1) acrosomal morphology, (2) the number of mitochondria in the midpiece of the sperm,. The axial filament appears in the acrosome as one of characteristics seen in several species of the family Veneridae in the subclass heterodonta, unlikely the subclass pteriomorphia containing axial rod instead of the axial filament. As some characteristics of the acrosome structures, the peripheral parts of two basal rings show electron opaque part (region), while the apex part of the acrosome shows electron lucent part (region). These charateristics belong to the family Veneridae in the subclass heterodonta, unlikely a characteristic of the subclass pteriomorphia showing all part of the acrosome being composed of electron opaque part (region). Therefore, it is easy to distinguish the families or the subclasses by the acrosome structures. The number of mitochondria in the midpiece of the sperm of this species are four, as one of common characteristics appeared in most species in the family Veneridae.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.8
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• pp.4059-4062
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• 2016

Frequencies of polymorphisms of genes BRCA1 and ТР53 in breast cancer (BC) patients with a BC family history and radiation history were assessed and compared in the Semey region of Kazakhstan. The study included 60 women directly irradiated by the activities of the Semipalatinsk test site with a calculated effective equivalent dose of 500 mSv and their first generation descendants (group BC+Her+Exp); 65 women with family BC and absence of radiological history - the effective equivalent dose due to anthropogenic sources not exceeding 50 mSv (group BC+Her-Exp). The comparison group consisted of 65 women patients with breast cancer without family and radiological history (BC-Her-Exp). The control group comprised 60 women without breast cancer and without family and radiological history (nonBC). We carried out the genotyping of the polymorphisms c.2311T>C, c.4308T>C and 5382insC of the BRCA1 gene and rs1042522 of the ТР53 gene. The frequency of the polymorphism c.2311T>C was significantly higher in patients of the group BC+Her+Exp than in healthy women, and of the polymorphism 5382insC in BC+Her+Exp compared to all other groups. The frequency of the rs1042522 polymorphism of ТР53 was significantly higher in all groups of patients with breast cancer compared with the control group. Differences between groups of women with breast cancer were significant only in BC+Her+Exp vs. BC+Her-Exp. Combinations of polymorphisms of the genes BRCA1 and TP53 predominated in women with a family and radiological history.

• Land and Housing Review
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• v.2 no.4
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• pp.415-427
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• 2011

This study is aiming at estimating the demolition cost of deterioration housing by the rational method in order to provide for the demolition and new build project of the rental multi-family housing of LH. We investigated the actual state of demolition construction and work process of small size housing, and analysed an actual condition of estimation for the demolition cost through an advice by the expert of construction cost estimate. Furthermore, the 'estimation standard for the predetermined amount', 'estimation standard for the disposal cost of construction wastes' and precedent studies in public construction work were considered. As one of results in this study, cost accounting system, breakdown system and construction cost for the demolition work based on the standard of estimate were proposed and the predetermined amount of demolition construction for the multi-family housing with 2 or 3 floors could be produced by them. Eventually, It is estimated that the demolition cost per a multi-family housing is about 18,331,000(won) and 104,000(won) per floorage($m^2$). To the details, the result indicated that the direct demolition cost needs about 14,339,000(won) per a multi-family housing and the consignment disposal cost of wastes needs 3,992,000(won) per one. The results of the study will be used as the fundamental data to estimate the project cost in the phase of budget establishment for demolition and new build project of the deteriorated rental multi-family housings, and also cost accounting system of demolition construction and breakdown system are expect to be used effectively at the ordering of public construction work.

• Korean Journal of Plant Taxonomy
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• v.36 no.2
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• pp.153-161
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• 2006

Two Unrecorded species from Jeju Province are reported: Maesa japonica of Maesaceae which is unrecorded family and Cardamine tanakae of Brassicaceae. Monotypic family Maesaceae, is distinguished from Myrsinaceae and Primulaceae by having pedicels with a pair of bracteoles, flowers without staminodia, semi-inferior ovary and indehiscent fruits with many seeds. M. japonica is readily distinguishable from M. salicifolia in China and M. montana var. formosana in Taiwan and Japan by shapes of blades, corolla and bracteoles, the presence/absence of serrulation of leaf margins, ratio of length of corolla tube and corolla lobes, feature and color of fruit surface. C. tanakae is most similar to Korean endemic C. glechomifolia in morphology, however, the two taxa are readily distinguishable by the number of leaflets of cauline leaves, size of terminal leaflets, number of flowers per inflorescence, the presence of whitish hairs on ovary and fruits.

• Bulletin of the Korean Mathematical Society
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• v.45 no.1
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• pp.59-66
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• 2008

Keskin and Harmanci defined the family B(M,X) = ${A{\leq}M|{\exists}Y{\leq}X,{\exists}f{\in}Hom_R(M,X/Y),\;Ker\;f/A{\ll}M/A}$. And Orhan and Keskin generalized projective modules via the class B(M, X). In this note we introduce X-local summands and X-hollow modules via the class B(M, X). Let R be a right perfect ring and let M be an X-lifting module. We prove that if every co-closed submodule of any projective module P contains Rad(P), then M has an indecomposable decomposition. This result is a generalization of Kuratomi and Chang's result [9, Theorem 3.4]. Let X be an R-module. We also prove that for an X-hollow module H such that every non-zero direct summand K of H with $K{\in}B$(H, X), if $H{\oplus}H$ has the internal exchange property, then H has a local endomorphism ring.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.12 no.3
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• pp.95-102
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• 2002

Interactive hashing is a protocol introduced by Naor, Ostrovsk Venkatesan, $Yung^{[1]}$ with t-1 round complexity and $t^2$ - 1 bits communication complexity for given t bits string. In this paper, we propose more efficiently extended interactive hashing protocol with t/m- 1 round complexity and $t^2$/m - m bits communication complexity than NOVY protocol when m is a divisor of t, and prove the security of this.

• Journal of Family Resource Management and Policy Review
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• v.20 no.4
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• pp.35-47
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• 2016

This research aimed to observe adolescent children's use of time and to discover the parent-related factors that affect adolescent children's use of time. The subjects included 2,092 fourth-grade elementary school students and 2,108 first-grade middle school students. We used data from the Korean Children and Youth Panel Survey. We tested sociodemographic factors, parents characteristics, and time usage, and we studied these factors using SPSS version 23.0; the results are as follows. Firstly, in the subordinate scope of the child-rearing attitude of parents, affection fourth-grade elementary school students(M = 1.83) and first-grade middle school students(M = 2.02). Inconsistency had an effect on fourth-grade elementary school students(M = 1.99), and first-grade middle school students(M = 2.12). Excessive expectations had an effect on fourth-grade elementary school students(M = 2.40) and first-grade middle school students(M = 2.55). Over-involvement had an effect on fourth-grade elementary school students(M = 2.68)and first-grade middle school students(M = 2.80). Finally, giving reasonable explanations had an effect on fourth-grade elementary school students(M = 1.51)and first-grade middle school students(M = 1.68). Secondly, in fourth-grade elementary school students(M = 463.35) and first-grade middle school students(M = 378.75). Further, studying hours during weekdays had an effect on fourth-grade elementary school students(M = 456.15) and first-grade middle school students(M = 460.86). Free activity hours during had an effect on fourth-grade elementary school students(M = 390.54) and first-grade middle school students(M = 387.11). Sleeping hours during holidays had an effect on fourth-grade elementary school students(M = 544.85) and first-grade middle school students (M = 511.74). Studying hours during holidays had an effect on fourth-grade elementary school students (M = 484.86) and first-grade middle school students (M = 511.74). Free activity hours during holidays had an effect on fourth-grade elementary school students(M = 518.68) and first-grade middle school students(M = 509.73). Thirdly, by observing the relative influence of related factors on adolescent children's use of time, grade(${\beta}$ = -.284), gender(${\beta}$ = -.208), over-involvement(${\beta}$ = -.380), supervising(${\beta}$ = -.217), and (${\beta}$ = .243) in terms of the child-rearing attitudes of parents was found to affect study hours($F=2.595^{**}$). The education level of fathers(${\beta}$ = -.144) results in(${\beta}$ = 1.991) and longer free activity hours for children($F= 4.116^{***}$). This research can be used to study the influence of parents'child-rearing attitudes on adolescent children's use of time and to suggest the role of parents in adolescents' ability to manage time effectively using practical.

• Bulletin of the Korean Mathematical Society
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• v.45 no.2
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• pp.321-338
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• 2008

Let $\bar{M}$ be a smoothly bounded pseudoconvex complex manifold with a family of almost complex structures $\{L^{\tau}\}_{{\tau}{\in}I}$, $0{\in}I$, which extend smoothly up to bM, the boundary of M, and assume that there is ${\lambda}{\in}C^{\infty}$(bM) which is strictly subharmonic with respect to the structure $L^0|_{bM}$ in any direction where the Levi-form vanishes on bM. We obtain explicit estimates for the $\bar{\partial}$-Neumann problem in Sobolev spaces both in space and parameter variables. Also we get a similar result when $\bar{M}$ is strongly pseudoconvex.