Food Engineering Progress (산업식품공학)

Korean Society for Industrial Food Engineering (한국산업식품공학회)
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Improvement of Lipid Homeostasis Through Modulation of Low-density Lipoprotein Receptor Family by Functional Ingredients

천연 기능성 물질(Functional Ingredients)을 활용한 LDL 수용체과(科) 조절과 지질항상성 개선

  • Jeong, Jeongho (Department of Foods and Nutrition, Kookmin University) ;
  • Ryu, Yungsun (Department of Foods and Nutrition, Kookmin University) ;
  • Park, Kibeum (Department of Foods and Nutrition, Kookmin University) ;
  • Go, Gwang-woong (Department of Foods and Nutrition, Kookmin University)
  • 정정호 (국민대학교 식품영양학과) ;
  • 류융선 (국민대학교 식품영양학과) ;
  • 박기범 (국민대학교 식품영양학과) ;
  • 고광웅 (국민대학교 식품영양학과)
  • Received : 2017.01.17
  • Accepted : 2017.02.08
  • Published : 2017.02.28
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Abstract

Dyslipidemia, defined as elevated triglyceride (TG), total- and LDL-C, and/or decreased HDL-C levels, is considered a principal risk factor for cardiovascular disease. The low-density lipoprotein receptor (LDLR) family has been considered a key player in the prevention of dyslipidemia. The LDLR family consists of cytoplasmic membrane proteins and plays an important role not only in ligand-receptor binding and uptake, but also in various cell signaling pathways. Emerging reports state that various functional ingredients dynamically modulate the function of the LDLR family. For instance, oats stimulated the LDLR function in vivo, resulting in decreased body weight and improved serum lipid profiles. The stimulation of LRP6 by functional ingredients in vitro activated the Wnt/${\beta}-catenin$ pathway, subsequently suppressing the intracellular TG via inhibition of SREBP1, $PPAR{\gamma}$, and $C/EBP{\alpha}$. Furthermore, the extract of Cistanchetubulosa enhanced the expression of the mRNA of VLDLR, followed by a reduction in the serum cholesterol level. In addition, fermented soy milk diminished TG and total cholesterol levels while increasing HDL-C levels via activation of LRP1. To summarize, modulating the function of the LDLR family by diverse functional ingredients may be a potent therapeutic remedy for the treatment of dyslipidemia and cardiovascular diseases.

Keywords

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