• Toxicological Research
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• 제33권1호
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• pp.63-69
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• 2017

Transmembrane protein 39A (TMEM39A) belongs to the TMEM39 family. TMEM39A gene is a susceptibility locus for multiple sclerosis. In addition, TMEM39A seems to be implicated in systemic lupus erythematosus. However, any possible involvement of TMEM39A in cancer remains largely unknown. In the present report, we provide evidence that TMEM39A may play a role in brain tumors. Western blotting using an anti-TMEM39A antibody indicated that TMEM39A was overexpressed in glioblastoma cell lines, including U87-MG and U251-MG. Deep-sequencing transcriptomic profiling of U87-MG and U251-MG cells revealed that TMEM39A transcripts were upregulated in such cells compared with those of the cerebral cortex. Confocal microscopic analysis of U251-MG cells stained with anti-TMEM39A antibody showed that TMEM39A was located in dot-like structures lying close to the nucleus. TMEM39A probably located to mitochondria or to endosomes. Immunohistochemical analysis of glioma tissue specimens indicated that TMEM39A was markedly upregulated in such samples. Bioinformatic analysis of the Rembrandt knowledge base also supported upregulation of TMEM39A mRNA levels in glioma patients. Together, the results afford strong evidence that TMEM39A is upregulated in glioma cell lines and glioma tissue specimens. Therefore, TMEM39A may serve as a novel diagnostic marker of, and a therapeutic target for, gliomas and other cancers.

• 한국환경생태학회지
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• 제22권4호
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• pp.396-408
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• 2008

국립산림과학원에서 발간된 임상도에 따르면 파주시 광탄면에 위치한 본 연구대상지는 활엽수 Ⅳ영급으로 분류되었으나 식생조사 결과 영급판정이 어려운 활엽수 천연림으로 구성되어 정밀 임상도 작성의 필요성이 제기되었다. 이에 정밀 현존식생 조사와 식생구조 및 연륜 분석 자료를 기초로 한 정밀 임상도 작성방안을 제안하고자 하였다. 정밀 현존식생유형 분석결과 22개 유형이었으며 자연림은 신갈나무림, 굴참나무림 등 11개 유형, 인공림은 밤나무림 등 6개 유형으로 구분되었다. 영급 판정을 위해 정밀 현존식생도를 바탕으로 방형구 42개와 89개 표본목의 목편을 채취하여 수령을 측정한 결과, 저지대에 입지한 인공림, 참나무류 소경목 지역은 II영급(29.8%), 나머지 지역은 III영급(57.6%)으로 토지이용이 가능하였고 Ⅳ영급 이상(8.8%)은 경계부의 급경사 능선부에 분포하여 토지이용은 불가능하였다. 이상과 같이 소규모 개발 예정지가 활엽수 자연림으로 판정된 경우 보전과 이용 판정에 있어 정밀 현존식생 조사, 식물군집구조 및 표본목 분석을 통한 정밀 임상도를 작성하여야 할 것이다. 정밀 임상도에는 식생의 자연성, 희소성, 다양성 등을 종합적으로 판단할 수 있는 자료가 포함되어 소규모 부지의 개발적정성 판단에 유용할 것으로 사료된다.

• 대한약리학회지
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• 제10권2호
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• pp.1-11
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• 1974

Results of an experiment on the behavior of rats and mice in order to explore the possible pharmacological actions of Panax ginseng upon the central nervous system can be summarized as follows: 1. Spontaneous motor activity. In the case of mice, those groups who were administered 2.5 mg and 5.0mg of ginseng saponin per kilogram of body weight were observed to have increased their activity compared with the control group, while the 50.0 mg and 100.0 mg per kilogram body weight groups demonstrated lower levels of activity, with the peak of activity appearing at 30 minutes after administration of drugs. In the case of rats, those groups of animals who were given injections in the dosage of 2.5 mg, 5.0 mg and 50.0 mg per kilogram body weight demonstrated higher activity than the control group, while the 100.0 mg per kilogram group appeared to have decreased in their activity, with the peak action appearing 30 minutes after the administration of ginseng saponin. The 50.0 mg per kilogram group demonstrated no significant differential. 2. General behavior analysis. In the case of mice, decrease in sleeping component of behavior and increase in the walking and roaring components, compared those with the control group, turned out to be a common phenomenon among the groups who were administered 2.5 mg, 5.0 mg and 50.0 mg of ginseng saponin per kilogram body weight, with the 5.0 mg per kilogram group standing out of all the other groups in terms of their reactions. In the case of rats, ginseng saponin appeared to reduce sleeping component with 2.5 mg, 5.0 mg and 50.0 mg per kilogram body weight groups, while increased the walking and rearing components. It was observed that administratoin of ginseng saponin in a dose of 2.5 mg per kilogram appeared to markedly increase the lying and grooming components of animal behavior. 3. Open-field exploratory behavior. Adminstration of ginseng saponin to mice in doses of 5.0 mg, 50.0 mg and 100.0 mg per kilogram body weight decreased activity, but increased their exploratory behavior. In the case of rats, however, administration of ginseng saponin in the doses of 2.5 mg and 5.0 mg per kilogram body weight markedly increased their activities, while decreased activities with the 50.0 mg per kilogram and 100.0 mg per kilogram groups. The exploratory behavior of rats appeared to have decreased, while grooming increased ramarkably. 4. The above findings from a series of experiment appear to suggest a stimulating effect on the central nervous system when ginseng saponin is administered in small doses, but that larger doses might result in an inhibitory effect, though differential results can be anticipated with modification of experimental conditions.

• 한국건강관리협회지
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• 제2권1호
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• pp.1-8
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• 2004

Background : Since 2001 the Korean Association of Health Promotion has attempted to establish her own reference valves that can be used in her all fifteen branch laboratories instead of using those adapted from the published data or there commended data by the reagent companies supplied as inserts. However, the previous two reference values derived from the statistics(year 2001 and 2002) were need to adjust to apply to actual practice. Besides there was an unavoidable situation that the reagent has to be changed to other companies in 2002 that creates another statistical problem. Subsequently, the third attempt to derive the reference ranges of tests in KAHP to solve those problems and define common)v acceptable reference ranges was done and and reported here. Methods : Al1 the results performed during January 2, 2003 through September 30, 2003 were collected in Excel tile format. All the data include dthe necessary information such as age and sex. The age was grouped in six; baby(0-3y), children(4-l2y), adolescent(13-l8y), adult(19-S4y), younger elderly (65-79y),old elderly(oyer 80y), with references of statistics in medical informatics and WHO classification. The data were statistically analyzed with SAS 6.04 for-Gaussian distribution as the previous two occasions. None of the tests showed Gaussian distribution. These procedures had been repeated twice or three times after trimming out the results lying outside three standard deviations. Though, all the tests showed non-Gaussian distribution. Subsequently, the reference ranges were defined in the range from the point of lower 2.5% to the point of higher 97.5 %. And in case the lower range could be "0", the reference ranges were defined in the range of 0 to 95%.Results : The reference ranges of most of 56 test items were newly assigned. Also with adaptation of the recommendation of WHO etc. on fasting blood sugar, hemoglobin, cholesterol. Among these there were eight tests that needed reference ranges by the age groups and nine tests by the sex. Conclusions : The third attempt will credit more the reference range of all15 laboratories of Korean Association of Health Promotion, which will be essential part of the better service to the patient and clients to visit KAHP.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2008년도 학술대회 1부
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• pp.426-432
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• 2008

회화는 2차원 평면 위에 색과 선을 사용하여 여러 가지 형상을 표현하는 조형예술이다. 본 논문에서는 이러한 회화의 평면적 특성에 입각하여 3차원 물체들로 구성된 장면을 화가가 캔버스 위에 붓을 놀려 채색한 것과 같은 회화 스타일로 렌더링하는 방법을 소개하고, 카메라의 시점과 시선이 변화하는 동적인 장면에서 여전히 평면적 특성을 유지하면서 붓질의 방향이 처음에 지정된 방향을 유지하도록 변화하는 방법을 제안한다. 회화의 정의에 띠라 캔버스와 같은 2차원 평면 위에 붓으로 칠한듯한 효과를 연출하기 위해서 본 논문에서는 화면 공간 위에서 크기가 동일한 빌보드를 사용하여 붓질-붓을 한번 놀려 색을 칠하는 것-을 한다. 화면 전체에 붓질을 하여 장면을 렌더링 하여도 장면을 바라보는 카메라가 움직이면 처음의 붓질 방향을 유지하기 위하여 붓질의 방향 역시 변하여야 한다. 만일 붓질이 변하지 않고 동일한 방향을 유지한다면 마치 일정한 붓질 모양의 패턴이 있는 유리 뒤로 물체들이 움직이는 것 같은 시각적 오류가 있는 결과를 얻게 된다. 이것을 막기 위하여 본 논문에서는 장면 안에서 시점이나 시선의 방향이 바뀌는 애니메이션이 일어날 때 그에 맞춰 물체 위의 붓질이 함께 회전하는 방법을 제안한다. 붓질이 회전할 각도는 첫 프레임의 장면과 현재 프레임의 장면의 샘플 포인트들에 대하여 위치 차이를 비교하는, least-square solution을 사용하는 Horn의 2차원 유사성 검사를 수행하여 얻는다. 본 논문에서는 실험을 통해, 처음에 회화 스타일로 렌더링된 장면에서 실시간으로 카메라를 움직이며 붓질의 방향이 변화하는 모습을 관찰하였고, 처음에 지정된 방향을 유지하도록 회전하는 것을 확인하였다.

• 대한정형도수물리치료학회지
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• 제4권1호
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• pp.71-82
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• 1998

The purpose of this study is to analyze the phases of back pain occurring on pregnant women, and to raise the necessity of the pain management on the basis of the former analysis. The objective group is 284 pregnant women who visited department of OBGY of hospital located both in Seoul and Andong. The results are as follows; 1. 204(71.8%) pregnant women were suffering from back pain. The ratio of pain occurrance in terms of the duration of pregnancy shows that 78.3% within 3 pregnant months, 68.4% between four and six months and 72.1% over seven month. Most common ares of pain was low back area rating 60.5%. 2. The most painful postural for the suffering women was lying on the back rating 35.9% and the next painful posture was standing rating 34.4%. And the most painful movement was to maintaining continues movement(57.8%). Twisting back rates the second(17.2%). These two variables were relevant each other(p<0.05). 3. 46.7% of pregnant women were experiencing nocturnal pain. Among women experienced the pain before pregnancy, 39.9% were suffering during the pregnancy. The occurrence of nocturnal pain was related to the pain before and after the pregnancy(p<0.05). 4. 58.8% of pregnant women who experience back pain take the pain for granted as a normal proceeding of pregnancy while 3.9% recognize the symptom as an abnormal. Pain recognition in accordance with the phases does not show much difference(p<0.05). 5. It is shown that the more one delivers the number of babies, the faster back pain occurs(p<0.01). 6. 32.3% of the pain-suffering women have family member(s) having back pain. Family member(s) of the women who does not experience the pain don't have the pain either. This case reports 46.1%. Statistically, these two variables are relevant(p<0.01). 7. 43.0% of back pain experiencing women does not have any particular management plan against the pain. 20.7% is exercising as for prevention. Women who recognize the necessity of some means of therapy for their pain marked 42.9%. The majority(65.8%) of women responded exercise gymnastic work-out are most appropriate pain management. The above results show that a great number of pregnant women is experiencing back pain, however, they properly managed. This span suggests that appropriate advocacy and education for pregnant women is necessary. It is recommended that positive contribution can be made to better health of pregnant women when pain management by physical therapist is given.

• 한국전문물리치료학회지
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• 제18권3호
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• pp.67-75
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• 2011

The purpose of this study was to assess the agreement of manual muscle testing (MMT) and test-retest reliability of a hand held dynamometer for the posterior gluteus medius muscle, with and without lumbar stabilization, using a pressure biofeedback unit for patients with low back pain. The pressure biofeedback unit was used to minimize the substitute motion of the lumbopelvic region during hip abduction in patients lying on their side. Fifteen patients with low back pain participated in this study. A tester determined the MMT grades of the posterior gluteus medius with and without the pressure biofeedback unit. Active hip abduction range of motion with an inclinometer and the strength of their posterior gluteus medius using a hand held dynamometer were measured with and without the pressure biofeedback unit in the MMT position. The agreement of the grade of muscle strength in the MMT, and intra-rater reliability of both the active hip abduction range of motion and the strength of posterior gluteus medius were analyzed using the weighted kappa and intraclass correlation coefficient (ICC), respectively. The agreement of MMT with the pressure biofeedback unit (weighted kappa=.92) was higher than the MMT (weighted kappa=.34)(p<.05). The inclinometer with pressure biofeedback unit measurement of the active hip abduction range of motion had an excellent intra-rater reliability (ICC=.90). Also, the hand held dynamometer with pressure biofeedback unit measure of strength of the posterior gluteus medius had a good intra-rater reliability (ICC=.85). Therefore, the test for muscle strength with pressure biofeedback unit will be a reliable method for the determination of the MMT grades or amount of posterior gluteus medius muscle strength and the measurement of the range of motion for hip abduction in patients with low back pain.

• 자원환경지질
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• 제13권2호
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• pp.91-103
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• 1980

In spite of the fact that the Okcheon system has been rather intensively studied by many geologists since 1945, it still remains as a controversal problem as to its stratigraphy and geologic age. Present study has mainly focused on the upper members of the Okcheon system, namely the Hwanggangri and the Kunjasan formations so as to clarify the lithology, the depositional environment and the tectonic evolution of the formations. The Kunjasan formation lying unconformably over the Hwanggangri formation which is supposed to be a meta-tillite is interpreted as a metamorphosed calcareous argillaceous and/or arenaceous sediments on contract to the idea postulated by some geologists that it was a derivative of silicified Hwanggangri formation. Lithology of the Kunjasan and the Hwanggangri formation is quite different in that the former is white in color, contains few pebbles, and mostly composed of diopside and detrital quartz, whereas the latter is black to dark in color, contains abundant and variable kinds of pebbles, and composed of more argillacous matrix that has been metamorphosed to hornfels. The Hwanggangri and the Kunjasan formations were deposited in the rather deep sea which has transgressed toward northeast from southwest in the late Precambrian time, and the writer (1970) had formerly designated it as Okcheon Paleogeosyncline. With the beginning of Paleozoic era, Okcheon neogeogyncline was formed to the northeast of the old paleogeogyncline area. The transgression of the sea had proceeded toward southwest in which Cambrian strata were accumulated. During this period the area occupied formerly by the paleogeosyncline was uplifted, so that most of the Hwanggangri and the Kunjasan formations were eroded away except in the area close to the neogeosyncline sea coast. This is the reason why the Hwanggangri and the Kunjasan formations are cropped out presently in the area of the vicinity of contact zone of the paleo- and neogeosyncline zones. The age of the Okcheon system has been reconfirmed to be Precambrian from the view of the facts that 1) the Hanggangri formation, the upper member of the Okcheon system is meta-tillite and correlated to the Precambrian tillite in the Yantze basin in China, 2) the Okcheon system has been moderately metamorphosed while other formations of the same age, if it is Paleozoic or later, have not been metamorphosed, and 3) tectonic history and limited areal distribution of the Hwanggangri and the Kunjasan formations is suggestive of Precambian age.

• The Journal of Korean Physical Therapy
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• 제17권4호
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• pp.575-588
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• 2005

Family and parents which serve as a primary group for the children's development also play important role in their cerebral palsy children's treatment. This study wants to know how the parents' participation in their children's physical therapy and satisfaction degree have an impact on their children's improvement of the motor function. For that purpose, a home made self filling survey was conducted of 156 cerebral palsy children's parents whose children were treated in 4 university general hospitals and 3 welfare centers from the 1st of April 2004 to the 31th of march 2005. The gross motor function was employed to evaluate the cerebral palsy children's motor function improvement. In this study, those questioned were divided into two groups according to the time of treatment. 'Group A' is consist of the patients whose parents attended to the treatment more than one hour at home. The patients who belonged to 'Group B' were treated less than one hour at home. The general features of the cerebral palsy children and their parents and the characteristics of their physical disability, the parents' participation and their satisfaction degree were examined by survey. Evaluating the difference between two groups' motor function according to their parents participation degree in the physical therapy leads to the following results. First, 'Group A' was better than 'Group B' in their satisfaction degree with the physical therapy and participation degree. Statistically 'Group A' was superior to 'Group B' in the requirements of the information and education for the children with cerebral palsy. Second, after two months of treatment, 'Group A' showed more statistically significant improvement than 'Group B' in every items as like lying in item 1, sitting in item2, crawling and kneeling in item 3, standing in item 4, walking,running, jumping in item 5. Third, parents' participation in physical therapy and satisfaction degree have some relevance to their children' motor function improvement. The satisfaction degree is related to motor function like crawling and kneeling in item 3, walking,running, jumping in item 5. It is showed that the parents' participation degree and information about handicapped children.

• 한국정보과학회논문지:정보통신
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• 제36권1호
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• pp.12-23
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• 2009

전장에서 군 작전을 지원하거나 희귀 동물을 모니터링 하는 센서 네트워크에서는 전송 정보의 보안뿐만 아니라 그러한 관심 대상(asset)들의 위치를 적이나 악의적 추적으로부터 보호할 수 있어야 한다. 본 논문에서는 위치가 보호되어야 할 대상에 근접한 센서 노드들 즉, 휴면(dormant) 소오스들이 존재하는 환경에서, 활동 소오스(즉, 메시지 발생 노드)의 위치 보호를 강화하는 라우팅 프로토콜 GSLP(GPSR-based Source-Location Privacy)를 제안한다. GSLP는 단순하면서도 scalable한 라우팅 기법인 GPSR(greedy perimeter stateless routing)을 확장하여, 확률적으로 임의의 이웃 노드를 메시지 전달 노드로 선정하여 경로의 다양성을 제고하면서 퍼리미터(perimeter) 라우팅을 적용하여 휴면 소오스 노드들을 우회하도록 함으로써 안전 기간(safety period)으로 정의되는 활동 소오스의 위치 보호 능력이 강화되도록 하였다. 휴면 소오스들의 수가 전체 노드의 1.0%에 이르기까지 시뮬레이션을 수행한 결과, 기존의 대표적인 소오스 위치 보호 프로토콜인 PR-SP(Phantom Routing, Single Path)의 안전 기간은 휴면 소오스 노드들이 증가에 따라 급속히 감소하나 제안된 GSLP는 휴면 소오스 노드들의 수와 거의 무관하게 높은 안전 기간을 제공하면서도 평균 전달 지연(delivery latency)은 도착지와의 최단 거리의 약 두 배 이내에 머무는 것으로 확인되었다.