• Title/Summary/Keyword: low-field NMR

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Discriminating the Geographical Origin of Sesame Seeds by Low Field NMR (Low field NMR을 이용한 참깨의 원산지 판별)

  • Rho, Jeong-Hae;Lee, Sun-Min
    • Korean Journal of Food Science and Technology
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    • v.34 no.6
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    • pp.1062-1066
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    • 2002
  • Low field NMR was employed to discriminate the geographical origin of sesame seeds from Sudan, China, and Korea. Sudan sesame seeds had the lowest contents of moisture and crude fat. Chemical components of Korean and Chinese sesame seeds were similar, whereas relaxation times $(T_1-IR,\;T_1-SR)$ measeured through spin-lattice relaxation pluse techniques using 20 MHz NMR showed significant difference (p0.05). Canonical discriminant analysis could be used to identify the habitat of sesame seeds with over 90% accuracy of NMR results. Non-destructive and fast NMR techniques can be applied to classify Korean sesame seeds from those of other origins.

Measuring T1 contrast in ex-vivo prostate tissue at the Earth's magnetic field

  • Oh, Sangwon;Han, Jae Ho;Kwon, Ji Eun;Shim, Jeong Hyun;Lee, Seong-Joo;Hwang, Seong-Min;Hilschenz, Ingo;Kim, Kiwoong
    • Journal of the Korean Magnetic Resonance Society
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    • v.23 no.1
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    • pp.12-19
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    • 2019
  • A former study has shown that the spin-lattice relaxation time ($T_1$) in cancerous prostate tissue had enhanced contrast at an ultra-low magnetic field, $132{\mu}T$. To study the field dependence and the origin of the contrast we measured $T_1$ in pairs of ex-vivo prostate tissues at the Earth's magnetic field. A portable and coil-based nuclear magnetic resonance (NMR) system was adopted for $T_1$ measurements at $40{\mu}T$. The $T_1$ contrast, ${\delta}=1-T_1$ (more cancer)/$T_1$(less cancer), was calculated from each pair. Additionally, we performed pathological examinations such as Gleason's score, cell proliferation index, and micro-vessel density (MVD), to quantify correlations between the pathological parameters and $T_1$ of the cancerous prostate tissues.

Mini-review on fabrication of nitrogen vacancy center in diamond and its application to NMR

  • Oh, Sangwon
    • Journal of the Korean Magnetic Resonance Society
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    • v.23 no.3
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    • pp.73-80
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    • 2019
  • Nitrogen-vacancy (NV) is one of the most popular solid-state spin systems for quantum sensing. NV has been used for vector magnetometry with nanometer spatial resolution and sensors for nuclear magnetic resonance (NMR) in samples with small volume, less than 10 pL. Various studies are in progress to make NV a complementary sensor for current NMR technique. Fabricating and improving diamond itself are one of the research topics. This mini-review contains recent develops in diamond fabrication and treatment for higher NV yield. Additionally, we briefly introduce the development status of NV in NMR.

Recent NMR developments for pharmaceutical research

  • Lee, Kwanghwan
    • Journal of the Korean Magnetic Resonance Society
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    • v.20 no.1
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    • pp.27-35
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    • 2016
  • NMR spectrometer has been regarded as essential tool for structure elucidation in variable scientific field as like organic synthesis, natural product and macro protein research. Also NMR can be applied for defining dynamic behavior like ligand and receptor binding. One of advantage of research with NMR is that to be great confident to confirm structure and the measured sample could be recovered. Nevertheless NMR also has a weak points than other spectroscopic methods that require a lot of time for interpreting acquired spectrum and running time due to low sensitivity. For last two decade Bruker has developed hardware and software solution for overcome those weak points. In order to overcome low sensitivity Bruker introduced Cryo and Micro diameter probe head technology. And researcher can reduce the time for routine spectrum processing and interpretation works due to lots of introductions in software solutions for quantification, identification and statistics analysis. With four examples, this article describing those new hardware and software solutions in field of recent pharmaceutical research as follows. - New Horizons for NMR in the Biopharmaceutical Industry - The development and application of solid-state NMR spectroscopy (SSNMR) in pharmaceutical analysis - Assisted NMR Data Interpretation in Synthetic Chemistry - Complete Analysis of New Psychoactive Substances Using NMR.

Low Fiele Measurement of 0.1 mT by Rabi's NMR Method (Rabi법 핵자기 공명에 의한 0.1 mT의 저자장 측정)

  • 유권상;김철기;우병칠;김창석
    • Journal of the Korean Magnetics Society
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    • v.3 no.2
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    • pp.139-142
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    • 1993
  • The Rabi's NMR experiment using polarized flowing water was performed in order to measure the low field and the good NMR signal was obtained in the range of 0.1 mT. There was a change in amplitude and phase of signal due to the sinusoidal variation with the increasing RF field. The nominal field could be determined within a few tens ppm uncertainty by the NMR signal under the optimized RF condition.

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NMR Measurement by Induction Method in a Low Magnetic Field (저자장에서 자기유도법에 의한 핵자기공명 측정)

  • 유권상;김창석
    • Journal of the Korean Magnetics Society
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    • v.4 no.3
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    • pp.277-281
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    • 1994
  • The NMR signal by induction method was observed in a solenoid field of 1.0 mT. The center frequeocy and the half width at the half maximum of NMR signal were 42.588 Hz and 2.2 Hz in a field gradient of 3 ppm/cm. The NMR signals in different field gradients were compared with the theoretical values by considering the weighting factor of sample.

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Field gradient calculation of HTS double-pancake coils considering the slanted turns and the splice

  • Baek, Geonwoo;Kim, Jinsub;Lee, Woo Seung;Song, Seunghyun;Lee, Onyou;Kang, Hyoungku;Ko, Tae Kuk
    • Progress in Superconductivity and Cryogenics
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    • v.19 no.1
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    • pp.51-55
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    • 2017
  • To obtain Nuclear Magnetic Resonance (NMR) measurement of membrane protein, an NMR magnet is required to generate high intensity, homogeneity, and stability of field. A High-Temperature Superconducting (HTS) magnet is a promising alternative to a conventional Low-Temperature Superconducting (LTS) NMR magnet for high field, current density, and stability margin. Conventionally, an HTS coil has been wound by several winding techniques such as Single-Pancake (SP), Double-Pancake (DP), and layer-wound. The DP winding technique has been frequently used for a large magnet because long HTS wire is generally difficult to manufacture, and maintenance of magnet is convenient. However, magnetic field generated by the slanted turns and the splice leads to field inhomogeneity in Diameter of Spherical Volume (DSV). The field inhomogeneity degrades performance of NMR spectrometer and thus effect of the slanted turns and the splice should be analyzed. In this paper, field gradient of HTS double-pancake coils considering the slanted turns and the splice was calculated using Biot-Savart law and numerical integration. The calculation results showed that magnetic field produced by the slanted turns and the splice caused significant inhomogeneity of field.

($^{11}$B NMR study of vortex dynamics in LuNi$_2$B$_2$C

  • Lee, K.H.;Seo, S.W.;Kim, D.H.;Khang, K.H.;Seo, H.S.;Hwang, C.S.;Cho, B.K.;Lee, Moo-Hee
    • 한국초전도학회:학술대회논문집
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    • v.10
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    • pp.107-110
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    • 2000
  • ($^{11}$B NMR measurements have been performed on single crystals of LuNi$_2$B$_2$C superconductor to investigate vortex lattice structures and dynamical behavior. The spectrum in the superconducting state is significantly broadened by local field inhomogeneity due to the vortex lattice and the peak point of the spectrum shifts toward low magnetic field due to the imperfect field penetration. The linewidth of the spectrum reflecting local field variation is much smaller than expected for conventional vortex lattices and shows peculiar increase at low temperature. Furthermore, the transverse relaxation rate, 1/T$_2$, probing the slow motion of vortices, exhibits a single peak as temperature decreases. These prominent results highlight significant fluctuation of vortices even for this low T$_c$, and nearly isotropic 3D superconductor.

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NMR/MRI Superconducting Magnet Technologies: Recent Activities at MIT Francis Bitter Magnet Laboratory

  • Yukikazu Iwasa;Lee, Haigun
    • Progress in Superconductivity and Cryogenics
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    • v.5 no.1
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    • pp.1-12
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    • 2003
  • In this paper we present a brief description and summary results of each of our recent activities in three areas, all devoted to NMR and MRI superconducting magnet technologies: 1) development of a high-field LTS / HTS NMR magnet; 2) development of a novel digital flux injector for slightly resistive NMR magnets; and 3) a proposal fer a low-cost MRI magnet system based on $MgB_2$ composite and an innovative cryogenic design / operation concept.